Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0061 | 0.0277 | 0.0277 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0403 | 0.688 | 0.8837 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0291 | 0.0291 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0062 | 0.0291 | 0.0291 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0448 | 0.7749 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0177 | 0.2508 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0062 | 0.0291 | 0.1153 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0062 | 0.0291 | 0.0064 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0177 | 0.2508 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0177 | 0.2508 | 0.337 |
Trypanosoma brucei | trypanothione reductase | 0.0177 | 0.2508 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0061 | 0.0277 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0061 | 0.0277 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0177 | 0.2508 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0062 | 0.0291 | 0.0392 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0061 | 0.0277 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0177 | 0.2508 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0061 | 0.0277 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0403 | 0.688 | 0.8837 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0178 | 0.2528 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0291 | 0.0291 |
Trichomonas vaginalis | set domain proteins, putative | 0.0491 | 0.8594 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0291 | 0.0291 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.006 | 0.0247 | 0.0978 |
Loa Loa (eye worm) | glutathione reductase | 0.0177 | 0.2508 | 0.337 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0448 | 0.7749 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0403 | 0.688 | 0.8837 |
Plasmodium vivax | SET domain protein, putative | 0.0062 | 0.0291 | 0.0064 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0177 | 0.2508 | 0.2985 |
Treponema pallidum | NADH oxidase | 0.0061 | 0.0277 | 0.5 |
Leishmania major | trypanothione reductase | 0.0177 | 0.2508 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0432 | 0.7441 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0177 | 0.2508 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0403 | 0.688 | 0.8837 |
Brugia malayi | glutathione reductase | 0.0177 | 0.2508 | 0.337 |
Brugia malayi | Thioredoxin reductase | 0.0177 | 0.2508 | 0.337 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0061 | 0.0277 | 0.1096 |
Onchocerca volvulus | 0.0491 | 0.8594 | 1 | |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0403 | 0.688 | 0.8837 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0061 | 0.0277 | 0.1096 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0448 | 0.7749 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0061 | 0.0277 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0403 | 0.688 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0448 | 0.7749 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0061 | 0.0277 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0062 | 0.0291 | 0.1153 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0432 | 0.7441 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0061 | 0.0277 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0291 | 0.0392 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0178 | 0.2528 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0061 | 0.0277 | 0.0372 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0177 | 0.2508 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0062 | 0.0291 | 0.1153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.