Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.3199 | 0.3199 |
Brugia malayi | RNA binding protein | 0.0073 | 0.3199 | 0.3862 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.19 | 0.19 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.19 | 0.2294 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.3199 | 0.3862 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0124 | 0.8283 | 0.8283 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0124 | 0.8283 | 0.7476 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.19 | 0.19 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0141 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3199 | 0.3199 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3199 | 0.3199 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.3199 | 0.3862 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3199 | 0.3199 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.19 | 0.2294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3199 | 0.3199 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0141 | 1 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0124 | 0.8283 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0141 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.3199 | 0.3199 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0141 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0124 | 0.8283 | 0.7476 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0141 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0141 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23 nM | Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay | ChEMBL. | 22030028 |
IC50 (functional) | = 39 nM | Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubated for 30 mins before glucagon challenge measured after 30 mins using [125I]-cAMP by liquid scintillation counting | ChEMBL. | 22030028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.