Detailed information for compound 1569312

Basic information

Technical information
  • TDR Targets ID: 1569312
  • Name: 7-methyl-5-phenyltetrazolo[1,5-a]pyrimidine
  • MW: 211.223 | Formula: C11H9N5
  • H donors: 0 H acceptors: 4 LogP: 1.72 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(nc2n1nnn2)c1ccccc1
  • InChi: 1S/C11H9N5/c1-8-7-10(9-5-3-2-4-6-9)12-11-13-14-15-16(8)11/h2-7H,1H3
  • InChiKey: BGHJBNXSXOFICP-UHFFFAOYSA-N  

Network

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Synonyms

  • 7-methyl-5-phenyl-tetrazolo[1,5-a]pyrimidine
  • 7-methyl-5-phenyl-[1,2,3,4]tetrazolo[1,5-a]pyrimidine
  • ST5452505
  • ZINC00188776
  • SR-01000638007-1
  • CBDivE_011667
  • MLS000097929
  • SMR000059947

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi RE15519p 0.0034 0.3482 0.3482
Echinococcus multilocularis g protein coupled receptor 0.0034 0.3482 0.3482
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis fmrfamide receptor 0.0034 0.3482 0.3482
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.4775 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis dna polymerase eta 0.0054 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.3482 0.3482
Echinococcus granulosus allatostatin A receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.3482 0.3482
Schistosoma mansoni opsin-like receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis g protein coupled receptor 0.0034 0.3482 0.3482
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine receptor 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Brugia malayi Serotonin receptor 0.0034 0.3482 0.3482
Brugia malayi AKH receptor 0.0034 0.3482 0.3482
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptide receptor 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Leishmania major DNA polymerase eta, putative 0.0038 0.4775 0.4775
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Echinococcus granulosus serotonin receptor 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.3482 0.3482
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.3482 0.3482
Brugia malayi G-protein coupled receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.3482 0.3482
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.3482 0.3482
Echinococcus granulosus fmrfamide receptor 0.0034 0.3482 0.3482
Echinococcus granulosus orexin receptor type 2 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi follicle stimulating hormone receptor 0.0034 0.3482 0.3482
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.3482 0.3482
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0034 0.3482 0.3482
Schistosoma mansoni DNA polymerase eta 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptide receptor A26 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.3482 0.3482
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Echinococcus multilocularis sex peptide receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni amine GPCR 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis allatostatin A receptor 0.0034 0.3482 0.3482
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.4775 0.4775
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.3482 0.3482
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Onchocerca volvulus 0.0034 0.3482 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Brugia malayi Serotonin receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi larval opioid receptor 0.0034 0.3482 0.3482
Schistosoma mansoni histamine h1 receptor 0.0034 0.3482 0.3482
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.3482 0.3482
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.3482 0.3482
Brugia malayi Dopamine receptor protein 2 0.0034 0.3482 0.3482
Brugia malayi neuropeptide F receptor 0.0034 0.3482 0.3482
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.3482 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni neuropeptide receptor 0.0034 0.3482 0.3482
Schistosoma mansoni amine GPCR 0.0034 0.3482 0.3482
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.3482 0.3482
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.3482 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptide receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.3482 0.3482
Trypanosoma brucei DNA polymerase eta, putative 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.3482 0.3482
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.3482 0.3482
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.3482 0.3482
Echinococcus multilocularis serotonin receptor 0.0034 0.3482 0.3482
Echinococcus granulosus dna polymerase eta 0.0054 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.3482 0.3482
Schistosoma mansoni hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.3482 0.3482
Brugia malayi Melatonin receptor type 1A 0.0034 0.3482 0.3482
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.3482 0.3482
Schistosoma mansoni hypothetical protein 0.0034 0.3482 0.3482
Leishmania major DNA polymerase eta, putative 0.0054 1 1
Schistosoma mansoni opsin-like receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptide receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Onchocerca volvulus 0.0034 0.3482 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.3482 0.3482
Giardia lamblia DINP protein human, muc B family 0.0023 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni amine GPCR 0.0034 0.3482 0.3482
Brugia malayi Dopamine receptor 0.0034 0.3482 0.3482
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.3482 0.3482
Schistosoma mansoni amine GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.3482 0.3482
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.3482 0.3482
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.3482 0.3482
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis g protein coupled receptor 0.0034 0.3482 0.3482
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.3482 0.3482
Echinococcus granulosus g protein coupled receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.3482 0.3482
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.3482 0.3482
Schistosoma mansoni neuropeptide receptor 0.0034 0.3482 0.3482
Brugia malayi ORL1-like opioid receptor 0.0034 0.3482 0.3482
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.3482 0.3482
Mycobacterium ulcerans DNA polymerase IV 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi Dopamine receptor protein 1 0.0034 0.3482 0.3482
Brugia malayi neuropeptide F receptor 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Schistosoma mansoni myosin xvIII 0.0034 0.3482 0.3482
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0 0.5
Brugia malayi sulfakinin receptor protein 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptide receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.3482 0.3482
Schistosoma mansoni opsin-like receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Echinococcus granulosus neuropeptide s receptor 0.0034 0.3482 0.3482
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0 0.5
Echinococcus granulosus g-protein coupled receptor 0.0034 0.3482 0.3482
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.3482 0.3482
Echinococcus granulosus hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi putative neuropeptide receptor 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine receptor 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi GnHR receptor homolog 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.3482 0.3482
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptide s receptor 0.0034 0.3482 0.3482
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0034 0.3482 0.3482
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.3482 0.3482
Schistosoma mansoni neuropeptide receptor 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Schistosoma mansoni neuropeptide receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.3482 0.3482
Echinococcus granulosus g protein coupled receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni adenoreceptor 0.0034 0.3482 0.3482
Brugia malayi hypothetical protein 0.0034 0.3482 0.3482
Brugia malayi G protein-coupled receptor 0.0034 0.3482 0.3482
Echinococcus granulosus sex peptide receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus g protein coupled receptor 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis serotonin receptor 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0054 1 1
Echinococcus multilocularis fmrfamide receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Mycobacterium ulcerans DNA polymerase IV 0.0023 0 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Loa Loa (eye worm) hypothetical protein 0.0034 0.3482 0.3482
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.3482 0.3482
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.3482 0.3482
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.3482 0.3482
Schistosoma mansoni amine GPCR 0.0034 0.3482 0.3482
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis orexin receptor type 2 0.0034 0.3482 0.3482
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.3482 0.3482
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.3482 0.3482
Onchocerca volvulus 0.0034 0.3482 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.3482 0.3482
Echinococcus granulosus somatostatin receptor 0.0034 0.3482 0.3482
Echinococcus multilocularis somatostatin receptor 0.0034 0.3482 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.3482 0.3482
Brugia malayi G-protein coupled receptor 0.0034 0.3482 0.3482
Echinococcus granulosus neuropeptide receptor A26 0.0034 0.3482 0.3482
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.3482 0.3482

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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