TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 218.292 | Formula: C14H18O2
H donors: 0 H acceptors: 2 LogP: 3.7 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCC(=O)C(=O)c1ccccc1
InChi: 1S/C14H18O2/c1-2-3-4-8-11-13(15)14(16)12-9-6-5-7-10-12/h5-7,9-10H,2-4,8,11H2,1H3
InChiKey: NWTOGXOYOXREQL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carboxylesterase 2	Starlite/ChEMBL	References
Homo sapiens	carboxylesterase 1	Starlite/ChEMBL	References
Oryctolagus cuniculus	Acyl coenzyme A:cholesterol acyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	carboxylesterase, LipT	Get druggable targets OG5_127908	All targets in OG5_127908
Mycobacterium tuberculosis	Carboxylesterase LipT	Get druggable targets OG5_127908	All targets in OG5_127908

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	acetylcholinesterase	Acyl coenzyme A:cholesterol acyltransferase	565 aa	589 aa	31.7 %
Brugia malayi	Carboxylesterase family protein	Acyl coenzyme A:cholesterol acyltransferase	565 aa	537 aa	29.1 %
Onchocerca volvulus		Acyl coenzyme A:cholesterol acyltransferase	565 aa	526 aa	21.9 %
Onchocerca volvulus	Putative nuclear protein	Acyl coenzyme A:cholesterol acyltransferase	565 aa	549 aa	32.4 %
Drosophila melanogaster	alpha-Esterase-7	Acyl coenzyme A:cholesterol acyltransferase	565 aa	518 aa	31.9 %
Brugia malayi	Carboxylesterase family protein	carboxylesterase 1	567 aa	532 aa	24.1 %
Brugia malayi	Carboxylesterase family protein	Acyl coenzyme A:cholesterol acyltransferase	565 aa	523 aa	24.5 %
Onchocerca volvulus		Acyl coenzyme A:cholesterol acyltransferase	565 aa	579 aa	26.3 %
Onchocerca volvulus	Galectin homolog	Acyl coenzyme A:cholesterol acyltransferase	565 aa	544 aa	30.5 %
Loa Loa (eye worm)	hypothetical protein	Acyl coenzyme A:cholesterol acyltransferase	565 aa	575 aa	25.4 %
Echinococcus multilocularis	neuroligin	Acyl coenzyme A:cholesterol acyltransferase	565 aa	507 aa	25.6 %
Drosophila melanogaster	alpha-Esterase-6	Acyl coenzyme A:cholesterol acyltransferase	565 aa	566 aa	29.5 %
Drosophila melanogaster	CG10175 gene product from transcript CG10175-RE	Acyl coenzyme A:cholesterol acyltransferase	565 aa	568 aa	28.4 %
Brugia malayi	Carboxylesterase family protein	Acyl coenzyme A:cholesterol acyltransferase	565 aa	531 aa	28.4 %
Schistosoma mansoni	gliotactin	Acyl coenzyme A:cholesterol acyltransferase	565 aa	575 aa	26.3 %
Echinococcus granulosus	BC026374 protein S09 family	Acyl coenzyme A:cholesterol acyltransferase	565 aa	577 aa	28.1 %
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Acyl coenzyme A:cholesterol acyltransferase	565 aa	596 aa	31.5 %
Echinococcus multilocularis	acetylcholinesterase	Acyl coenzyme A:cholesterol acyltransferase	565 aa	518 aa	30.7 %
Onchocerca volvulus	Carnitine O-palmitoyltransferase 2, mitochondrial homolog	Acyl coenzyme A:cholesterol acyltransferase	565 aa	539 aa	27.6 %
Onchocerca volvulus		Acyl coenzyme A:cholesterol acyltransferase	565 aa	573 aa	27.4 %
Loa Loa (eye worm)	acetylcholinesterase 1	Acyl coenzyme A:cholesterol acyltransferase	565 aa	516 aa	34.9 %
Schistosoma japonicum	ko:K01050 cholinesterase [EC3.1.1.8], putative	Acyl coenzyme A:cholesterol acyltransferase	565 aa	574 aa	30.0 %
Brugia malayi	Carboxylesterase family protein	carboxylesterase 2	623 aa	524 aa	24.8 %
Echinococcus multilocularis	BC026374 protein (S09 family)	Acyl coenzyme A:cholesterol acyltransferase	565 aa	575 aa	28.2 %
Brugia malayi	Carboxylesterase family protein	Acyl coenzyme A:cholesterol acyltransferase	565 aa	505 aa	28.5 %
Echinococcus granulosus	acetylcholinesterase	Acyl coenzyme A:cholesterol acyltransferase	565 aa	527 aa	30.6 %
Onchocerca volvulus	Molybdopterin synthase catalytic subunit homolog	Acyl coenzyme A:cholesterol acyltransferase	565 aa	507 aa	29.6 %
Loa Loa (eye worm)	hypothetical protein	Acyl coenzyme A:cholesterol acyltransferase	565 aa	524 aa	25.6 %
Onchocerca volvulus		Acyl coenzyme A:cholesterol acyltransferase	565 aa	549 aa	27.5 %
Echinococcus granulosus	neuroligin	Acyl coenzyme A:cholesterol acyltransferase	565 aa	569 aa	24.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0023	0.0147	0.1329
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.013	0.0153
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0192	0.0523
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0327	0.1945
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0094	0.011
Loa Loa (eye worm)	transcription factor SMAD2	0.0279	0.3137	0.5803
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0277	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Echinococcus multilocularis	geminin	0.0198	0.2201	0.2201
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0046	0.0414	0.0765
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0094	0.011
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.0147	0.0401
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.0094	0.0256
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0188	0.1118
Trichomonas vaginalis	esterase, putative	0.0038	0.0327	0.1945
Mycobacterium ulcerans	carboxylesterase, LipT	0.0546	0.627	1
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0023	0.0147	0.0401
Plasmodium vivax	importin-beta 2, putative	0.0033	0.026	0.071
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0046	0.0414	0.0765
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.026	0.071
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0796	0.1473
Onchocerca volvulus		0.0022	0.013	0.0241
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0327	0.0385
Echinococcus multilocularis	peregrin	0.0034	0.0277	0.0277
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0000053828	0.0000099563
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0284	0.0334
Echinococcus granulosus	tissue type plasminogen activator	0.0014	0.0047	0.0055
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0047	0.0433	0.1181
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0327	0.0604
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.0715	0.0842
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0245	0.2749	0.4299
Echinococcus multilocularis	jumonji domain containing protein	0.0048	0.0433	0.0433
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0252	0.2823	0.7701
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0000057299	0.00000034704
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0047	0.0433	0.0801
Loa Loa (eye worm)	carboxylesterase	0.0062	0.0606	0.112
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.028	0.0446
Brugia malayi	nuclear hormone receptor	0.0022	0.013	0.0241
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0327	0.0521
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.013	0.0153
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.028	0.0763
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0094	0.0094
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0034	0.028	0.0763
Brugia malayi	Carboxylesterase family protein	0.0062	0.0606	0.112
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0099	0.0117
Brugia malayi	PHD-finger family protein	0.0034	0.0277	0.0512
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.013	0.0153
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.0639	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0604
Echinococcus granulosus	para nitrobenzyl esterase	0.0062	0.0606	0.0713
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0023	0.0147	0.0086
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.0161	0.0189
Brugia malayi	Bloom's syndrome protein homolog	0.0028	0.0206	0.0382
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0011	0.0006	0.0017
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0504	0.0933
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0327	0.0604
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0639	0.0752
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.013	0.0241
Brugia malayi	AF-10 protein	0.0011	0.0008	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0023	0.0147	0.0235
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0053	0.0128
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0023	0.0147	0.0235
Brugia malayi	Carboxylesterase family protein	0.0062	0.0606	0.112
Schistosoma mansoni	patched 1	0.0045	0.0405	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1679	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0034	0.028	0.0763
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0159	0.0294
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.028	0.0763
Echinococcus granulosus	importin subunit beta 1	0.0033	0.026	0.0306
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0025	0.0173	0.032
Brugia malayi	beta-lactamase	0.0038	0.0327	0.0604
Loa Loa (eye worm)	thymidylate synthase	0.0324	0.3665	0.6779
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0034	0.0275	0.0324
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0327	0.0377
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0112	0.1186	0.1186
Brugia malayi	hypothetical protein	0.0472	0.5406	1
Brugia malayi	tailless protein	0.0022	0.013	0.0241
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0019	0.0099	0.0099
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0479	0.0886
Loa Loa (eye worm)	Smad1	0.0019	0.0099	0.0184
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0763
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0327	0.0377
Toxoplasma gondii	NAC domain-containing protein	0.0041	0.0357	0.0973
Brugia malayi	MH1 domain containing protein	0.0019	0.0099	0.0184
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0147	0.0401
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0154	0.1679	0.4581
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0094	0.0256
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0454
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0023	0.0147	0.0086
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0192	0.0523
Brugia malayi	hypothetical protein	0.0027	0.0192	0.0355
Schistosoma mansoni	BC026374 protein (S09 family)	0.0062	0.0606	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0046	0.0414	0.0414
Trypanosoma brucei	transcription factor BTF3, putative	0.0041	0.0357	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0033	0.026	0.0481
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.013	0.0241
Entamoeba histolytica	hypothetical protein	0.0027	0.0188	0.1698
Onchocerca volvulus		0.0014	0.0047	0.0086
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.013	0.0241
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0046	0.0414	0.0765
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.1162	0.2149
Brugia malayi	DKFZp564C0469 protein	0.001	0.0000053828	0.0000099563
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0277	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0433	0.0801
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0094	0.0256
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0062	0.0606	0.0713
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0188	0.0512
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0414	0.0414
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.028	0.4958
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0011	0.0006	0.0007
Loa Loa (eye worm)	TK/ROR protein kinase	0.0014	0.0047	0.0086
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.026	0.071
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Onchocerca volvulus		0.0062	0.0606	0.112
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.028	0.1665
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0327	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0047	0.0086
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0012	0.0013	0.0035
Brugia malayi	nuclear receptor RXR	0.0024	0.0161	0.0297
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0047	0.0433	0.0801
Trichomonas vaginalis	antibiotic synthetase, putative	0.0023	0.0147	0.0876
Onchocerca volvulus		0.0324	0.3665	0.6779
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.013	0.0153
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0748	0.0881
Giardia lamblia	PHD finger protein 15	0.0034	0.0277	0.9901
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0079	0.0804	0.0947
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0277	0.0755
Brugia malayi	hypothetical protein	0.001	0.0000053828	0.0000099563
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.028	1
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0000057299	0.00000040868
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0564	0.1043
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0094	0.0256
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0414	0.0487
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0013	0.0024
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0161	0.0189
Brugia malayi	TAR-binding protein	0.0074	0.0748	0.1384
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0019	0.0099	0.0117
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0159	0.0434
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0094	0.0094
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.028	0.0446
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0023	0.0147	0.0086
Schistosoma mansoni	nuclear receptor	0.0022	0.013	0.0153
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0062	0.0606	0.0606
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.3665	1
Onchocerca volvulus		0.0038	0.0327	0.0604
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0327	0.1945
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0277	0.0326
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0023	0.0147	0.0401
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0763
Schistosoma mansoni	Smad4	0.0019	0.0099	0.0117
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0639	0.1019
Onchocerca volvulus		0.0046	0.0414	0.0765
Schistosoma mansoni	DNA helicase recq5	0.0012	0.0013	0.0015
Leishmania major	hypothetical protein, conserved	0.0014	0.0047	0.011
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0046	0.0414	0.0765
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0079	0.0796	0.72
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0079	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0284	0.0525
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Plasmodium falciparum	thioredoxin reductase	0.0034	0.028	0.0763
Brugia malayi	nuclear receptor NHR-88	0.0046	0.0414	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0604
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0023	0.0147	0.0401
Brugia malayi	photoreceptor-specific nuclear receptor	0.0046	0.0414	0.0765
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0053	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	0.0056	0.0532	0.0984
Schistosoma mansoni	protein phosphatase 2C	0.0011	0.0006	0.0007
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0881
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0094	0.0094
Mycobacterium ulcerans	lipase LipD	0.0038	0.0327	0.0521
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	0.0056	0.0532	0.0984
Schistosoma mansoni	cpg binding protein	0.0036	0.0295	0.0347
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0032	0.0087
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0324	0.3665	0.5783
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0147	0.0086
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Schistosoma mansoni	cpg binding protein	0.0034	0.0272	0.032
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Plasmodium falciparum	glutathione reductase	0.0034	0.028	0.0763
Brugia malayi	RNA binding protein	0.0074	0.0748	0.1384
Brugia malayi	Niemann-Pick C1 protein precursor	0.0105	0.1106	0.2046
Brugia malayi	Carboxylesterase family protein	0.0062	0.0606	0.112
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0094	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0357	0.2123
Loa Loa (eye worm)	carboxylesterase	0.0062	0.0606	0.112
Echinococcus multilocularis	para nitrobenzyl esterase	0.0062	0.0606	0.0606
Trichomonas vaginalis	spcc417.12 protein, putative	0.0062	0.0606	0.3607
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0046	0.0414	0.0487
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0748	0.1384
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0079	0.0796	0.127
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0023	0.0147	0.0401
Schistosoma mansoni	zinc finger protein	0.0022	0.013	0.0153
Brugia malayi	hypothetical protein	0.0043	0.0379	0.0701
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0046	0.0414	0.0414
Echinococcus multilocularis	tissue type plasminogen activator	0.0014	0.0047	0.0046
Brugia malayi	MH2 domain containing protein	0.0279	0.3137	0.5803
Leishmania major	4-coumarate:coa ligase-like protein	0.0079	0.0796	0.216
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0504	0.0594
Echinococcus granulosus	survival motor neuron protein 1	0.0252	0.2829	0.3332
Mycobacterium tuberculosis	Probable oxidoreductase	0.0252	0.2823	0.4418
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0755	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0384	0.0709
Plasmodium falciparum	thioredoxin reductase	0.0099	0.1039	0.2834
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0405	0.0748
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0047	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0414	0.0487
Echinococcus granulosus	cpg binding protein	0.0036	0.0295	0.0347
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.0639	0.0752
Loa Loa (eye worm)	jmjC domain-containing protein	0.0011	0.0006	0.0011
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.0639	0.0639
Echinococcus granulosus	acetylcholinesterase	0.0062	0.0606	0.0713
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0414	0.0765
Brugia malayi	nuclear receptor NHR-88	0.0022	0.013	0.0241
Entamoeba histolytica	hypothetical protein	0.0079	0.0804	0.7271
Onchocerca volvulus		0.0472	0.5406	1
Brugia malayi	hypothetical protein	0.0043	0.0379	0.0701
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0025	0.0173	0.032
Brugia malayi	nuclear hormone receptor	0.0046	0.0414	0.0765
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0013	0.0024
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0277	0.0755
Trichomonas vaginalis	DNA helicase recq1, putative	0.0028	0.0206	0.1228
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0046	0.0414	0.0414
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0046	0.0414	0.0487
Loa Loa (eye worm)	hypothetical protein	0.001	0.0000053828	0.0000099563
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.013	0.013
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0226	0.2527	0.394
Echinococcus granulosus	expressed protein	0.0056	0.0532	0.0626
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0226	0.2527	0.394
Plasmodium vivax	JmjC domain containing protein	0.0011	0.0006	0.0017
Plasmodium falciparum	basic transcription factor 3b, putative	0.0041	0.0357	0.0973
Brugia malayi	hypothetical protein	0.0079	0.0804	0.1488
Plasmodium falciparum	glutathione reductase	0.0099	0.1039	0.2834
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0527	0.0701
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0479	0.0564
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0011	0.0006	0.0017
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.028	0.028
Echinococcus granulosus	bloom syndrome protein	0.0028	0.0206	0.0243
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.0166	0.0454
Echinococcus granulosus	Niemann Pick C1 protein	0.015	0.1634	0.1924
Schistosoma mansoni	hypothetical protein	0.0035	0.0284	0.0334
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0284	0.0525
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.013	0.0241
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0047	0.0433	0.0801
Echinococcus granulosus	GPCR family 2	0.0035	0.0284	0.0334
Echinococcus multilocularis	transcription factor btf3	0.0041	0.0357	0.0357
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.0147	0.0385
Schistosoma mansoni	ran	0.0024	0.0159	0.0187
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0327	0.0891
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0012	0.0013	0.0015
Brugia malayi	ecdysteroid receptor	0.0046	0.0414	0.0765
Entamoeba histolytica	hypothetical protein	0.0079	0.0804	0.7271
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0748	0.1384
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0023	0.0147	0.0401
Schistosoma mansoni	phd/f-box containing protein	0.0011	0.0006	0.0007
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0014	0.0047	0.0127
Brugia malayi	Kringle domain containing protein	0.0014	0.0047	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0504	0.0504
Schistosoma mansoni	coup transcription factor	0.0046	0.0414	0.0487
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.0161	0.0189
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.013	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0703	0.1299
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0747
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0062	0.0606	0.0829
Toxoplasma gondii	ABC1 family protein	0.0038	0.0327	0.0891
Loa Loa (eye worm)	hypothetical protein	0.001	0.0000053828	0.0000099563
Loa Loa (eye worm)	hypothetical protein	0.001	0.0000053828	0.0000099563
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1534	0.2837
Toxoplasma gondii	TIM10 family protein, putative	0.0056	0.0532	0.1451
Schistosoma mansoni	acetyl-CoA synthetase	0.0023	0.0147	0.0173
Schistosoma mansoni	jumonji domain containing protein	0.0011	0.0006	0.0007
Brugia malayi	beta-NAC-like protein	0.0041	0.0357	0.066
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0763
Brugia malayi	nuclear receptor NHR-67	0.0022	0.013	0.0241
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0414	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0252	0.2829	0.5233
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.013	0.0241
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.028	0.0301
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0147	0.0086
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0053	0.0144
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0414	0.0487
Leishmania major	4-coumarate:coa ligase-like protein	0.0079	0.0796	0.216
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0034	0.028	0.0763
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.028	0.0329
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0023	0.0147	0.0235
Echinococcus granulosus	ecdysone induced protein 78C	0.0046	0.0414	0.0487
Brugia malayi	hypothetical protein	0.0024	0.0161	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Echinococcus multilocularis	snurportin 1	0.0349	0.3967	0.3967
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0327	0.0377
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0748	0.0748
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0046	0.0414	0.0487
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.0625	0.1706
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0047	0.0433	0.1181
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0405	0.0476
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0059	0.0564	1
Brugia malayi	jmjC domain containing protein	0.0011	0.0006	0.0011
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0405	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0604
Mycobacterium ulcerans	thymidylate synthase	0.0324	0.3665	0.5846
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.028	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0523	0.0968
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0881
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0881
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0284	0.0525
Echinococcus granulosus	transcription factor btf3	0.0041	0.0357	0.042
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0527	0.0701
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0327	0.1945
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0000057299	0.0000031374
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0013	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0046	0.0414	0.0765
Toxoplasma gondii	propionate-CoA ligase	0.0023	0.0147	0.0401
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.013	0.0153
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0405	0.0476
Brugia malayi	Steroid receptor seven-up type 2	0.0046	0.0414	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0094	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0796	0.1473
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0504	0.0504
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0079	0.0796	0.127
Echinococcus multilocularis	JmjC domain containing protein 4	0.0011	0.0006	0.0006
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0013	0.003	0.0056
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0527	0.0701
Loa Loa (eye worm)	hypothetical protein	0.001	0.0000053828	0.0000099563
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0023	0.0147	0.0235
Echinococcus granulosus	geminin	0.0198	0.2201	0.2591
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0527	0.0701
Schistosoma mansoni	transcription factor LCR-F1	0.0079	0.0804	0.0947
Onchocerca volvulus		0.0038	0.0327	0.0604
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0159	0.0159
Onchocerca volvulus	Protein ultraspiracle homolog	0.0046	0.0414	0.0765
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0000053828	0.0000099563
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0023	0.0147	0.0235
Schistosoma mansoni	acetylcholinesterase	0.0062	0.0606	0.0713
Echinococcus granulosus	smad	0.0019	0.0099	0.0117
Brugia malayi	MH1 domain containing protein	0.0019	0.0099	0.0184
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0414	0.0765
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0094	0.0094
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0147	0.0272
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0023	0.0147	0.0086
Schistosoma mansoni	hypothetical protein	0.0012	0.0018	0.0021
Echinococcus granulosus	jumonji domain containing 1A	0.0011	0.0006	0.0007
Echinococcus multilocularis	carboxylesterase 5A	0.0062	0.0606	0.0606
Echinococcus multilocularis	acetylcholinesterase	0.0062	0.0606	0.0606
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0023	0.0147	0.0272
Echinococcus multilocularis	phd:f box containing protein	0.0011	0.0006	0.0006
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0252	0.2823	0.4418
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0147	0.0272
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0000057299	0.00000094686
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0384	0.0452
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0046	0.0414	0.0765
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0034	0.028	0.0763
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0062	0.0606	0.0713
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.013	0.013
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.0639	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0564	0.1043
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0159	0.0294
Schistosoma mansoni	ran	0.0024	0.0159	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Mycobacterium tuberculosis	Hypothetical protein	0.0154	0.1679	0.2567
Echinococcus multilocularis	lysine specific demethylase 5A	0.0041	0.0361	0.0361
Onchocerca volvulus		0.0062	0.0606	0.112
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0324	0.3665	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0284	0.0284
Trypanosoma cruzi	transcription factor btf3, putative	0.0041	0.0357	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0161	0.0297
Brugia malayi	AMP-binding enzyme family protein	0.0079	0.0796	0.1473
Plasmodium vivax	basic transcription factor 3b, putative	0.0041	0.0357	0.0973
Echinococcus multilocularis	Niemann Pick C1 protein	0.015	0.1634	0.1634
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.002	0.0106	0.0125
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0094	0.0239
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.013	0.0241
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0094	0.0094
Schistosoma mansoni	retinoic acid receptor RXR	0.0046	0.0414	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.0147	0.0401
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0161	0.0297
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0023	0.0147	0.0235
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0046	0.0414	0.0765
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0147	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0159	0.0434
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0094	0.0256
Schistosoma mansoni	RAR-like nuclear receptor	0.0046	0.0414	0.0487
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0112	0.1186	0.1397
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0881
Schistosoma mansoni	phosphatidylserine receptor	0.0011	0.0006	0.0007
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0147	0.0235
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0763
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.026	0.071
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0546	0.627	1
Brugia malayi	Carboxylesterase family protein	0.0062	0.0606	0.112
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0062	0.0606	0.0713
Onchocerca volvulus		0.0023	0.0147	0.0272
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0226	0.2527	0.394
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0604
Plasmodium vivax	acyl-CoA synthetase, putative	0.0059	0.0564	0.1539
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0046	0.0414	0.0487
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0161	0.0297
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.028	0.0329
Echinococcus multilocularis	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0047	0.0433	0.0433
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0023	0.0147	0.0272
Trichomonas vaginalis	DNA helicase recq, putative	0.0028	0.0206	0.1228
Loa Loa (eye worm)	jmjC domain-containing protein	0.0011	0.0006	0.0011
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0079	0.0796	0.127
Loa Loa (eye worm)	oxidoreductase	0.0023	0.0147	0.0272
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0023	0.0147	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0357	0.2123
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0414	0.0765
Brugia malayi	steroid hormone receptor	0.0046	0.0414	0.0765
Onchocerca volvulus		0.0038	0.0327	0.0604
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0327	0.0377
Schistosoma mansoni	cpg binding protein	0.0036	0.0295	0.0347
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0023	0.0147	0.0147
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0504	0.0594
Brugia malayi	RNA, U transporter 1	0.0093	0.0967	0.1788
Echinococcus granulosus	FTZ F1 alpha	0.0046	0.0414	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0564	0.1043
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0018	0.0021
Schistosoma mansoni	blooms syndrome DNA helicase	0.0022	0.0137	0.0161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0046	0.0414	0.0765
Loa Loa (eye worm)	hypothetical protein	0.001	0.0000053828	0.0000099563
Trichomonas vaginalis	DNA helicase recq, putative	0.0015	0.0053	0.0315
Leishmania major	trypanothione reductase	0.0099	0.1039	0.2822
Mycobacterium tuberculosis	Probable reductase	0.0226	0.2527	0.394
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0604
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.1162	0.2149
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0079	0.0796	0.72
Onchocerca volvulus	Bile acid receptor homolog	0.0046	0.0414	0.0765
Trypanosoma brucei	trypanothione reductase	0.0099	0.1039	0.2834
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.0639	0.1729
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0062	0.0606	0.0829
Onchocerca volvulus		0.0023	0.0147	0.0272
Brugia malayi	Importin beta-1 subunit	0.0033	0.026	0.0481
Entamoeba histolytica	recQ family helicase, putative	0.0015	0.0053	0.0479
Echinococcus multilocularis	expressed protein	0.0056	0.0532	0.0532
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0327	0.0891
Schistosoma mansoni	hypothetical protein	0.0034	0.0277	0.0326
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0046	0.0414	0.0487
Brugia malayi	AMP-binding enzyme family protein	0.0079	0.0796	0.1473
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0046	0.0414	0.0765
Plasmodium falciparum	importin beta, putative	0.0033	0.026	0.071
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0414	0.0765
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.1162	0.2149
Brugia malayi	glutathione reductase	0.0099	0.1039	0.1921
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0327	0.1945
Brugia malayi	hypothetical protein	0.0024	0.0161	0.0297
Onchocerca volvulus		0.0022	0.013	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0563	0.104
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0000057299	0.00000040868
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0796	0.1473
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0327	0.0377
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0272	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0327	0.0385
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0034	0.028	0.0763
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0147	0.0272
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0023	0.0147	0.0401
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0748	0.0881
Echinococcus multilocularis	thymidylate synthase	0.0324	0.3665	0.3665
Entamoeba histolytica	acyl-coA synthetase, putative	0.0079	0.0796	0.72
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.028	0.0517
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0059	0.0564	0.09
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.013	0.0241
Brugia malayi	Carboxylesterase family protein	0.0062	0.0606	0.112
Loa Loa (eye worm)	steroid hormone receptor	0.0046	0.0414	0.0765
Schistosoma mansoni	hypothetical protein	0.0198	0.2201	0.2591
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0639	0.1019
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0023	0.0147	0.0272
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0012	0.0013	0.0013
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.0147	0.0401
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0414	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0284	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5406	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0059	0.0564	0.0762
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0023	0.0147	0.0401
Brugia malayi	beta-lactamase family protein	0.0038	0.0327	0.0604
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0011	0.0008	0.0021
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0192	0.0523
Brugia malayi	Thioredoxin reductase	0.0099	0.1039	0.1921
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0161	0.0297
Loa Loa (eye worm)	carboxylesterase	0.0062	0.0606	0.112
Brugia malayi	CHE-14 protein	0.0045	0.0405	0.0748
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0099	0.1039	0.153
Onchocerca volvulus		0.0023	0.0147	0.0272
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.0159	0.0434
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0062	0.0606	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0564	0.1043
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0023	0.0147	0.0086
Plasmodium falciparum	acyl-CoA synthetase	0.0059	0.0564	0.1539
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0034	0.028	0.0763
Echinococcus multilocularis	FTZ F1 alpha	0.0046	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0011
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0226	0.2527	0.394
Mycobacterium ulcerans	hypothetical protein	0.0079	0.0796	0.127
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.013	0.0153
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0384	0.0452
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0011	0.0006	0.0017
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0022	0.013	0.013
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.013	0.0241
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0324	0.3665	1
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0748	0.1384
Brugia malayi	ecdysone receptor	0.0022	0.013	0.0241
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0327	0.0604
Echinococcus multilocularis	thioredoxin glutathione reductase	0.01	0.1046	0.1046
Entamoeba histolytica	transcription factor BTF3, putative	0.0041	0.0357	0.3223
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Schistosoma mansoni	hypothetical protein	0.0079	0.0804	0.0947
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.028	0.1665
Brugia malayi	Smad1	0.0019	0.0099	0.0184
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.0161	0.016
Brugia malayi	conserved hypotetical protein	0.0022	0.013	0.0241
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0079	0.0796	0.1138
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.028	0.0763
Echinococcus multilocularis	survival motor neuron protein 1	0.0252	0.2829	0.2829
Schistosoma mansoni	gliotactin	0.0062	0.0606	0.0713
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0056	0.0532	0.1451
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0046	0.0414	0.0487
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.028	0.0747
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.028	0.0763
Toxoplasma gondii	mitochondrial inner membrane translocase subunit TIM17, putative	0.0047	0.0433	0.1181
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.3665	0.4316
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0327	0.0891
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0062	0.0606	0.0606
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0327	0.0377
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0414	0.0765
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0504	0.0594
Entamoeba histolytica	Ran family GTPase	0.0024	0.0159	0.1438
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0079	0.0796	0.127
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Echinococcus multilocularis	microtubule associated protein 2	0.0736	0.8492	0.8492
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0414	0.0765
Toxoplasma gondii	kringle domain-containing protein	0.0014	0.0047	0.0127
Schistosoma mansoni	hypothetical protein	0.0051	0.0479	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0272
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0046	0.0414	0.0765
Schistosoma mansoni	smad	0.0019	0.0099	0.0117
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0046	0.0414	0.0765
Brugia malayi	hypothetical protein	0.0017	0.008	0.0149
Onchocerca volvulus		0.0062	0.0606	0.112
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0046	0.0414	0.0487
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0479	0.0479
Echinococcus multilocularis	smad	0.0019	0.0099	0.0099
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0748	0.1384
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0504	0.0933
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0011	0.0006	0.0017
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0147	0.0086
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0405	0.0405
Brugia malayi	topoisomerase	0.001	0.0000053828	0.0000099563
Loa Loa (eye worm)	MH2 domain-containing protein	0.0279	0.3137	0.5803
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0272	0.0503
Schistosoma mansoni	hypothetical protein	0.0035	0.0284	0.0334
Brugia malayi	jmjC domain containing protein	0.0011	0.0006	0.0011
Brugia malayi	AMP-binding enzyme family protein	0.0079	0.0796	0.1473
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0147	0.0086
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0013	0.0035
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0079	0.0796	0.2173
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0272
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0046	0.0414	0.0414
Brugia malayi	hypothetical protein	0.0022	0.013	0.0241
Echinococcus granulosus	carboxylesterase 5A	0.0062	0.0606	0.0713
Onchocerca volvulus		0.0034	0.0272	0.0503
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0099	0.0117
Giardia lamblia	Sgs1 DNA helicase, putative	0.0012	0.0013	0.0464
Onchocerca volvulus		0.0023	0.0147	0.0272
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0013	0.0029	0.0029
Entamoeba histolytica	hypothetical protein	0.0079	0.0804	0.7271
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0094	0.0256
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0284	0.0284
Loa Loa (eye worm)	acetylcholinesterase 1	0.0062	0.0606	0.112
Echinococcus granulosus	thymidylate synthase	0.0324	0.3665	0.4316
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0019	0.01	0.0272
Schistosoma mansoni	hypothetical protein	0.0198	0.2201	0.2591
Brugia malayi	jmjC domain containing protein	0.0011	0.0006	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5406	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.01	0.1046	0.1231
Schistosoma mansoni	hypothetical protein	0.0014	0.0047	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.028	0.0747
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0763
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0062	0.0606	0.0713
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0324	0.3665	1
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0011	0.0006	0.0017
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0277	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Brugia malayi	jmjC domain containing protein	0.0011	0.0006	0.0011
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0349	0.3967	0.7338
Echinococcus granulosus	neuroligin	0.0062	0.0606	0.0713
Loa Loa (eye worm)	MH1 domain-containing protein	0.0019	0.0099	0.0184
Echinococcus granulosus	expressed conserved protein	0.0099	0.1032	0.1215
Entamoeba histolytica	hypothetical protein	0.0079	0.0804	0.7271
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0023	0.0147	0.0235
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0327	0.0377
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0046	0.0414	0.0765
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0763
Echinococcus granulosus	microtubule associated protein 2	0.0736	0.8492	1
Brugia malayi	Carboxylesterase family protein	0.0062	0.0606	0.112
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0012	0.0013	0.0015
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.028	0.0763
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.028	1
Echinococcus granulosus	BC026374 protein S09 family	0.0062	0.0606	0.0713
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0327	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0062	0.0606	0.0713
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0192	0.0523
Echinococcus multilocularis	expressed conserved protein	0.0099	0.1032	0.1032
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0414	0.0487
Loa Loa (eye worm)	hypothetical protein	0.011	0.1162	0.2149
Loa Loa (eye worm)	glutathione reductase	0.0099	0.1039	0.1921
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.013	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0755	0.1397
Echinococcus granulosus	JmjC domain containing protein 4	0.0011	0.0006	0.0007
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	0.0056	0.0532	0.0626
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0327	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0161	0.0297
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0023	0.0147	0.0401
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0046	0.0414	0.0414
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.013	0.0241
Echinococcus multilocularis	Smad4	0.0019	0.0099	0.0099
Treponema pallidum	NADH oxidase	0.0034	0.028	1
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0094	0.0173
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0046	0.0414	0.0765
Onchocerca volvulus		0.0062	0.0606	0.112
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.013	0.0153
Onchocerca volvulus	Alhambra homolog	0.0034	0.0277	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0013	0.0032	0.0087
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0327	0.0891
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0159	0.0187
Schistosoma mansoni	hypothetical protein	0.0349	0.3967	0.4672
Echinococcus granulosus	Niemann Pick C1 protein	0.0105	0.1106	0.1303
Schistosoma mansoni	transcription factor btf3	0.0041	0.0357	0.042
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0161	0.0297
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0000057299	0.0000020667
Plasmodium falciparum	cysteine repeat modular protein 1	0.0014	0.0047	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0604
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0011	0.0008	0.0021
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0062	0.0606	0.3607
Loa Loa (eye worm)	DR-78	0.0022	0.013	0.0241
Brugia malayi	hypothetical protein	0.0154	0.1679	0.3106
Trypanosoma cruzi	trypanothione reductase, putative	0.0099	0.1039	0.2834
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0414	0.0765
Loa Loa (eye worm)	RecQ helicase	0.0028	0.0206	0.0382
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0277	0.0755
Schistosoma mansoni	hypothetical protein	0.0075	0.0755	0.0889
Leishmania major	hypothetical protein, conserved	0.0027	0.0192	0.0507
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0018	0.0018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0079	0.0796	0.1138
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.013	0.0153
Plasmodium vivax	glutathione reductase, putative	0.0099	0.1039	0.2834
Echinococcus granulosus	mothers against decapentaplegic 5	0.0019	0.0099	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0046	0.0414	0.0487
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0284	0.0334
Echinococcus multilocularis	Protein lozenge	0.0059	0.0571	0.0571
Onchocerca volvulus		0.0079	0.0796	0.1473
Leishmania major	GTP-binding protein, putative	0.0024	0.0159	0.0418
Mycobacterium ulcerans	acyl-CoA synthetase	0.0079	0.0796	0.127
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Schistosoma mansoni	lozenge	0.0059	0.0571	0.0672
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0023	0.0147	0.0086
Loa Loa (eye worm)	ICD-1 protein	0.0041	0.0357	0.066
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0324	0.3665	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0000057299	0.0000020667
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0454
Schistosoma mansoni	nuclear receptor	0.0022	0.013	0.0153
Plasmodium vivax	thioredoxin reductase, putative	0.0099	0.1039	0.2834
Echinococcus granulosus	lysine specific demethylase 6a	0.0011	0.0006	0.0007
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0000057299	0.0000020667
Mycobacterium tuberculosis	Probable dehydrogenase	0.0226	0.2527	0.394
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0107	0.1125	0.1325
Brugia malayi	beta-lactamase family protein	0.0038	0.0327	0.0604
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0023	0.0147	0.0173
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.013	0.013
Schistosoma mansoni	microtubule-associated protein tau	0.0736	0.8492	1
Schistosoma mansoni	jumonji domain containing protein	0.0089	0.0917	0.108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0564	0.1043
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.028	0.0446
Leishmania major	acetyl-CoA synthetase, putative	0.0023	0.0147	0.0385
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0192	0.0523
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0327	0.0891
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0.028	1
Entamoeba histolytica	hypothetical protein	0.0041	0.0357	0.3223
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0192	0.0523
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0284	0.0284
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0099	0.0117
Schistosoma mansoni	hypothetical protein	0.0035	0.0284	0.0334
Echinococcus multilocularis	Niemann Pick C1 protein	0.0105	0.1106	0.1106
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0327	0.0377
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0414	0.0414
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0192	0.0523
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.3665	1
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.013	0.0241
Mycobacterium ulcerans	acyl-CoA synthetase	0.0079	0.0796	0.127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.013	0.0153
Echinococcus multilocularis	jumonji domain containing 1A	0.0011	0.0006	0.0006
Onchocerca volvulus		0.0062	0.0606	0.112
Loa Loa (eye worm)	jmjC domain-containing protein	0.0011	0.0006	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0192	0.0355
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0097	0.0265
Leishmania major	hypothetical protein, conserved	0.0038	0.0327	0.0876
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0327	0.0327
Schistosoma mansoni	hypothetical protein	0.0011	0.0008	0.0009
Toxoplasma gondii	PHD-finger domain-containing protein	0.0011	0.0008	0.0021
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0056	0.0532	0.1451
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0046	0.0414	0.0487
Echinococcus multilocularis	lysine specific demethylase 6a	0.0011	0.0006	0.0006
Echinococcus granulosus	phd:f box containing protein	0.0011	0.0006	0.0007
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0023	0.0147	0.0401
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.0161	0.0297
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0047	0.0127
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0159	0.0434
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0327	0.0521
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0094	0.0173
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0188	0.1118
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0454
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0019	0.0099	0.0099
Brugia malayi	Bromodomain containing protein	0.0034	0.0277	0.0512
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0013	0.0029	0.0034
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0504	0.0594
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0327	0.0521
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.0159	0.5689
Brugia malayi	jmjC domain containing protein	0.0112	0.1186	0.2194
Loa Loa (eye worm)	runx1	0.0059	0.0571	0.1056
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0023	0.0147	0.0086
Brugia malayi	nuclear receptor RXR	0.0022	0.013	0.0241
Loa Loa (eye worm)	hypothetical protein	0.001	0.0000053828	0.0000099563
Echinococcus multilocularis	bloom syndrome protein	0.0028	0.0206	0.0206
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0079	0.0796	0.2173
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0639	0.1019
Brugia malayi	MH2 domain containing protein	0.0019	0.0099	0.0184
Echinococcus multilocularis	neuroligin	0.0062	0.0606	0.0606
Brugia malayi	F/Y-rich N-terminus family protein	0.0021	0.0128	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0357	0.2123
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0277	0.0277
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0046	0.0414	0.0487
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0188	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1106	0.2046
Loa Loa (eye worm)	thioredoxin reductase	0.0099	0.1039	0.1921
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0405	0.2409
Schistosoma mansoni	importin beta-1	0.0033	0.026	0.0306
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0046	0.0414	0.0487
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0252	0.2823	0.4418
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.028	0.0763
Leishmania major	basic transcription factor 3a, putative	0.0041	0.0357	0.0958
Brugia malayi	jmjC domain containing protein	0.0043	0.0384	0.0709
Mycobacterium ulcerans	acyl-CoA synthetase	0.0079	0.0796	0.127
Loa Loa (eye worm)	MH2 domain-containing protein	0.0019	0.0099	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0161	0.0297
Brugia malayi	PHD-finger family protein	0.0013	0.003	0.0056
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0327	0.1945
Echinococcus multilocularis	protein patched	0.0045	0.0405	0.0405
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0046	0.0414	0.0765
Schistosoma mansoni	DNA helicase recq1	0.0012	0.0013	0.0015
Echinococcus granulosus	peregrin	0.0034	0.0277	0.0326
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.028	0.0747
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0012	0.0013	0.0024
Echinococcus multilocularis	acetylcholinesterase	0.0062	0.0606	0.0606
Brugia malayi	hypothetical protein	0.0252	0.2829	0.5233
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0056	0.0532	0.1451
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0188	0.0496
Trichomonas vaginalis	ran, putative	0.0024	0.0159	0.0947
Trypanosoma cruzi	transcription factor btf3, putative	0.0041	0.0357	0.0973
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.002	0.011	0.0026
Schistosoma mansoni	hypothetical protein	0.0047	0.0433	0.051
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.0414	0.0487
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.0159	0.0434
Echinococcus multilocularis	ecdysone induced protein 78C	0.0046	0.0414	0.0414
Brugia malayi	MH2 domain containing protein	0.0019	0.0099	0.0184
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0454
Brugia malayi	hypothetical protein	0.0022	0.013	0.0241
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0019	0.0099	0.0117
Echinococcus granulosus	jumonji domain containing protein	0.0048	0.0433	0.051
Toxoplasma gondii	thioredoxin reductase	0.0099	0.1039	0.2834
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0327	0.0377
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.013	0.0153
Trichomonas vaginalis	antibiotic synthetase, putative	0.0023	0.0147	0.0876
Brugia malayi	hypothetical protein	0.001	0.0000053828	0.0000099563
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0011	0.0006	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0504	0.0594
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0046	0.0414	0.0765
Leishmania major	4-coumarate:coa ligase-like protein	0.0079	0.0796	0.216
Echinococcus multilocularis	cpg binding protein	0.0036	0.0295	0.0294
Leishmania major	acetyl-CoA synthetase, putative	0.0023	0.0147	0.0385
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0011	0.0008	0.0021
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.026	0.026
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.013	0.013
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0105	0.1106	1
Brugia malayi	hypothetical protein	0.0062	0.0606	0.112
Onchocerca volvulus		0.0051	0.0479	0.0886
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0235
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0226	0.2527	0.6894
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0023	0.0147	0.0272
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0327	0.0377
Brugia malayi	thymidylate synthase	0.0324	0.3665	0.6779
Echinococcus granulosus	acetylcholinesterase	0.0062	0.0606	0.0713
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0094	0.0256
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.013	0.013
Echinococcus granulosus	Smad4	0.0019	0.0099	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0022	0.013	0.0241
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0639	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0277	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0606	0.112
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0159	0.0434
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0324	0.3665	1
Echinococcus granulosus	snurportin 1	0.0349	0.3967	0.4672
Schistosoma mansoni	hypothetical protein	0.0035	0.0284	0.0334
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0384	0.0452

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 95.1 %	Inhibition of intestinal carboxylesterase in human U373MG cells using 4-methylumbelliferone acetate as substrate at 10 uM after 1 hrs pre-incubation by fluorimetry	ChEMBL.	21733699
Ki (binding)	= 2.19 nM	Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometry	ChEMBL.	21733699
Ki (binding)	= 28.1 nM	Inhibition of rabbit liver carboxylesterase using o-nitrophenyl acetate as substrate after for 5 mins by spectrophotometry	ChEMBL.	21733699
Ki (binding)	= 28.7 nM	Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometry	ChEMBL.	21733699
Ki (binding)	= 130 nM	Inhibition of human intestinal carboxylesterase assessed as hydrolysis of CPT-11 after 5 mins by HPLC	ChEMBL.	21733699
Ki (binding)	> 100000 nM	Inhibition of human acetylcholinesterase using acetylthiocholine as substrate by spectrophotometry	ChEMBL.	21733699
Ki (binding)	> 100000 nM	Inhibition of human butyrylcholinesterase using butyrylthiocholine as substrate by spectrophotometry	ChEMBL.	21733699

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1812864

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1569438