Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase alpha | Starlite/ChEMBL | References |
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0744 | 0.9605 | 0.96 |
Chlamydia trachomatis | biotin carboxylase | 0.007 | 0.0268 | 0.5 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0196 | 0.2007 | 0.1899 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0744 | 0.9605 | 0.96 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0376 | 0.4506 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0077 | 0.0367 | 0.5 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0126 | 0.1036 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.006 | 0.0133 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.006 | 0.0133 | 0.5 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0203 | 0.2106 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0203 | 0.2106 | 0.3786 |
Schistosoma mansoni | pyruvate carboxylase | 0.0077 | 0.0367 | 0.0448 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0077 | 0.0367 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.006 | 0.0133 | 0.5 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0077 | 0.0367 | 0.0534 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0203 | 0.2106 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0436 | 0.5343 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0196 | 0.2007 | 0.1978 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0077 | 0.0367 | 0.0448 |
Onchocerca volvulus | 0.006 | 0.0133 | 0.5 | |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0077 | 0.0367 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0077 | 0.0367 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0147 | 0.1329 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0077 | 0.0367 | 0.5 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0203 | 0.2106 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0077 | 0.0367 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.4506 | 0.8394 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0077 | 0.0367 | 0.5 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0203 | 0.2106 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0744 | 0.9605 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0203 | 0.2106 | 0.451 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.9558 | 0.995 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0376 | 0.4506 | 0.8394 |
Schistosoma mansoni | thyroid hormone receptor | 0.0436 | 0.5343 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0077 | 0.0367 | 0.1741 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0077 | 0.0367 | 0.0448 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0077 | 0.0367 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0436 | 0.5343 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0147 | 0.1329 | 0.5 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0077 | 0.0367 | 0.0448 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0203 | 0.2106 | 0.3786 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0077 | 0.0367 | 0.1741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.