Detailed information for compound 1569543

Basic information

Technical information
  • TDR Targets ID: 1569543
  • Name: N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2- oxoethyl]-N-(phenylmethyl)thiadiazole-4-carbo xamide
  • MW: 438.518 | Formula: C23H23FN4O2S
  • H donors: 1 H acceptors: 4 LogP: 4.14 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(N(C(=O)c1nnsc1)Cc1ccccc1)C(=O)NC1CCCC1
  • InChi: 1S/C23H23FN4O2S/c24-18-12-10-17(11-13-18)21(22(29)25-19-8-4-5-9-19)28(14-16-6-2-1-3-7-16)23(30)20-15-31-27-26-20/h1-3,6-7,10-13,15,19,21H,4-5,8-9,14H2,(H,25,29)
  • InChiKey: FAEUSWIRQGDEQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxo-ethyl]-N-(phenylmethyl)thiadiazole-4-carboxamide
  • N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(phenylmethyl)-4-thiadiazolecarboxamide
  • N-(benzyl)-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-keto-ethyl]thiadiazole-4-carboxamide
  • N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxo-ethyl]-N-(phenylmethyl)-1,2,3-thiadiazole-4-carboxamide
  • ASN 06563155

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0065
Entamoeba histolytica hypothetical protein 0.004 0.0384 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0738 0.0737
Loa Loa (eye worm) DR-78 0.0032 0.028 0.03
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Echinococcus multilocularis hypothetical protein 0.0019 0.011 0.0109
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Echinococcus granulosus dnaJ subfamily B 0.0471 0.5875 0.5874
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus granulosus Smad4 0.0017 0.009 0.0088
Echinococcus multilocularis cpg binding protein 0.0035 0.0317 0.0315
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.011 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0738 0.0794
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0068 0.0738 0.0792
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0068 0.0738 0.0737
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Brugia malayi nuclear receptor NHR-88 0.0068 0.0738 0.0794
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0396 0.0426
Schistosoma mansoni nuclear receptor 0.0032 0.028 0.0192
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.011 0.0109
Brugia malayi nuclear receptor NHR-67 0.0032 0.028 0.0301
Schistosoma mansoni hypothetical protein 0.0041 0.0396 0.0309
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Loa Loa (eye worm) hypothetical protein 0.0041 0.0396 0.0424
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0032 0.028 0.0279
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0019 0.011 0.0109
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0068 0.0738 0.0654
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.011 0.002
Brugia malayi Smad1 0.0017 0.009 0.0097
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.011 0.002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0068 0.0738 0.0654
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0738 0.0794
Brugia malayi tailless protein 0.0032 0.028 0.0301
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0114 0.0113
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0686 0.8617 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0083 0.009
Onchocerca volvulus 0.0032 0.028 0.02
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0019 0.011 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0068 0.0738 0.0794
Brugia malayi conserved hypotetical protein 0.0032 0.028 0.0301
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0068 0.0738 0.0737
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.0738 0.0794
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0032 0.028 0.0192
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Schistosoma mansoni hypothetical protein 0.0124 0.1452 0.1374
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0068 0.0738 0.0794
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0019 0.011 0.0109
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0739 0.9297 0.9297
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0019 0.011 0.0119
Schistosoma mansoni RAR-like nuclear receptor 0.0068 0.0738 0.0654
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0384 1
Brugia malayi Protein-tyrosine phosphatase 0.0019 0.011 0.0119
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0019 0.011 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.0068 0.0738 0.0794
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0083 0.0088
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.011 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0738 0.0737
Brugia malayi nuclear receptor NHR-88 0.0032 0.028 0.0301
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0019 0.011 0.0109
Schistosoma mansoni retinoic acid receptor RXR 0.0418 0.5209 0.5166
Brugia malayi steroid hormone receptor 0.0068 0.0738 0.0794
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0068 0.0738 0.0737
Schistosoma mansoni cpg binding protein 0.0033 0.0293 0.0205
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0068 0.0738 0.0654
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0036 0.0329 0.0241
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0019 0.011 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0068 0.0738 0.0792
Onchocerca volvulus 0.0031 0.0267 0.0184
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0739 0.9297 1
Echinococcus granulosus nuclear receptor nhr 48 0.0032 0.028 0.0279
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0278
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Brugia malayi Protein-tyrosine phosphatase 0.0019 0.011 0.0119
Brugia malayi hypothetical protein 0.0019 0.011 0.0119
Brugia malayi hypothetical protein 0.0019 0.011 0.0119
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Brugia malayi hypothetical protein 0.0019 0.011 0.0119
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) nuclear receptor NHR-67 0.0032 0.028 0.03
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0019 0.011 0.0117
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0019 0.011 0.0117
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0019 0.011 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0068 0.0738 0.0792
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0068 0.0738 0.0792
Echinococcus multilocularis Smad4 0.0017 0.009 0.0088
Schistosoma mansoni cpg binding protein 0.0035 0.0317 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0738 0.0737
Loa Loa (eye worm) nuclear hormone receptor 0.0032 0.028 0.03
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Schistosoma mansoni nuclear receptor 0.0032 0.028 0.0192
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0019 0.011 0.002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0114 0.0113
Schistosoma mansoni hypothetical protein 0.0019 0.0114 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Brugia malayi MH2 domain containing protein 0.0017 0.009 0.0097
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0019 0.011 0.0117
Schistosoma mansoni hypothetical protein 0.0471 0.5875 0.5837
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0068 0.0738 0.0737
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0036 0.0329 0.0328
Echinococcus granulosus transcription factor btf3 0.004 0.0384 0.0383
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.009 0.0088
Schistosoma mansoni hypothetical protein 0.0019 0.0114 0.0024
Brugia malayi Steroid receptor seven-up type 2 0.0068 0.0738 0.0794
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0639 0.0688
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.011 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0068 0.0738 0.0738
Echinococcus multilocularis thyroid hormone receptor alpha 0.0068 0.0738 0.0737
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0068 0.0738 0.0737
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0738 0.0737
Brugia malayi MH2 domain containing protein 0.0252 0.3082 0.3315
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0032 0.028 0.0192
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.009 0.0088
Schistosoma mansoni protein tyrosine phosphatase 0.0019 0.011 0.002
Echinococcus granulosus cpg binding protein 0.0035 0.0317 0.0315
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0267 0.0286
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.011 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0068 0.0738 0.0794
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0738 0.0794
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0267 0.0287
Onchocerca volvulus Bile acid receptor homolog 0.0068 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0019 0.011 0.0109
Echinococcus granulosus GPCR family 2 0.0019 0.0114 0.0113
Leishmania major basic transcription factor 3a, putative 0.004 0.0384 1
Echinococcus granulosus geminin 0.0124 0.1452 0.145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.028 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Schistosoma mansoni zinc finger protein 0.0032 0.028 0.0192
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.028 0.02
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0068 0.0738 0.0654
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Brugia malayi intermediate filament protein 0.0031 0.0267 0.0287
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0384 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.028 0.0279
Loa Loa (eye worm) steroid hormone receptor 0.0068 0.0738 0.0792
Brugia malayi hypothetical protein 0.0032 0.028 0.0301
Schistosoma mansoni hypothetical protein 0.0019 0.0114 0.0024
Brugia malayi hypothetical protein 0.0019 0.011 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0068 0.0738 0.0792
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0114 0.0123
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0019 0.011 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0738 0.0794
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Brugia malayi ecdysteroid receptor 0.0068 0.0738 0.0794
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.009 0.0088
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Brugia malayi nuclear hormone receptor family member odr-7 0.0032 0.028 0.0301
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0019 0.011 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.028 0.0279
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Echinococcus granulosus protein tyrosine phosphatase n9 0.0019 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0352
Schistosoma mansoni intermediate filament proteins 0.0031 0.0267 0.0179
Echinococcus granulosus lamin 0.0031 0.0267 0.0265
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.3082 0.3314
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0114 0.0121
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0329 0.0354
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Brugia malayi Protein-tyrosine phosphatase 1 0.0019 0.011 0.0119
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Echinococcus multilocularis microtubule associated protein 2 0.0794 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0293 0.0313
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0019 0.011 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0019 0.011 0.002
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0019 0.011 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0738 0.0654
Giardia lamblia Protein tyrosine phosphatase 0.0019 0.011 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.009 0.0088
Echinococcus multilocularis GPCR, family 2 0.0019 0.0114 0.0113
Loa Loa (eye worm) protein tyrosine phosphatase 0.0019 0.011 0.0117
Schistosoma mansoni lamin 0.0031 0.0267 0.0179
Brugia malayi CXXC zinc finger family protein 0.0033 0.0293 0.0315
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0019 0.011 0.0109
Brugia malayi MH2 domain containing protein 0.0017 0.009 0.0097
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Echinococcus multilocularis 0.0019 0.011 0.0109
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0068 0.0738 0.0737
Echinococcus granulosus ecdysone induced protein 78C 0.0068 0.0738 0.0737
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0329 0.0241
Schistosoma mansoni steroid hormone receptor ad4bp 0.0068 0.0738 0.0654
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0036 0.0329 0.0352
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0384 0.5
Schistosoma mansoni hypothetical protein 0.0124 0.1452 0.1374
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0068 0.0738 0.0654
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0068 0.0738 0.0794
Loa Loa (eye worm) hypothetical protein 0.0618 0.775 0.8335
Brugia malayi nuclear receptor RXR 0.0032 0.028 0.0301
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0068 0.0738 0.0654
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0062 0.0061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0068 0.0738 0.0737
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0267 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0068 0.0738 0.0794
Brugia malayi hypothetical protein 0.0019 0.011 0.0119
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.009 0.0095
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0739 0.9297 1
Echinococcus multilocularis FTZ F1 alpha 0.0068 0.0738 0.0737
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0032 0.028 0.0301
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0114 0.0123
Brugia malayi Nuclear hormone receptor E75 0.0032 0.028 0.0301
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.028 0.0279
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0019 0.011 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0068 0.0738 0.0794
Schistosoma mansoni pcd6 interacting protein-related 0.0019 0.011 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0738 0.0794
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0032 0.028 0.0279
Brugia malayi hypothetical protein 0.0036 0.0329 0.0354
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Echinococcus granulosus FTZ F1 alpha 0.0068 0.0738 0.0737
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0352
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0738 0.0654
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.3082 0.3314
Loa Loa (eye worm) ICD-1 protein 0.004 0.0384 0.0412
Onchocerca volvulus 0.0033 0.0293 0.0215
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0068 0.0738 0.0737
Brugia malayi orphan nuclear receptor NR2E1 0.0032 0.028 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0384 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.028 0.0279
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.009 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Echinococcus multilocularis nuclear receptor nhr 48 0.0032 0.028 0.0279
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0384 1
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0329 0.0354
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0019 0.011 0.0109
Echinococcus multilocularis smad 0.0017 0.009 0.0088
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0384 0.5
Schistosoma mansoni nuclear hormone receptor 0.0032 0.028 0.0192
Echinococcus granulosus thyroid hormone receptor alpha 0.0032 0.028 0.0279
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0738 0.0654
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0738 0.0794
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0114 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0068 0.0738 0.0794
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.028 0.02
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0019 0.011 0.0109
Brugia malayi hypothetical protein 0.0032 0.028 0.0301
Loa Loa (eye worm) hypothetical protein 0.0014 0.0055 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0639 0.0686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0068 0.0738 0.0792
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0286
Brugia malayi MH1 domain containing protein 0.0017 0.009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0739 0.9297 0.9297
Brugia malayi ecdysone receptor 0.0032 0.028 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0384 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Onchocerca volvulus 0.0031 0.0267 0.0184
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0019 0.011 0.0109
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Schistosoma mansoni protein tyrosine phosphatase 0.0019 0.011 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Schistosoma mansoni protein tyrosine phosphatase 0.0019 0.011 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0068 0.0738 0.0737
Schistosoma mansoni coup transcription factor 0.0068 0.0738 0.0654
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0384 1
Brugia malayi nuclear receptor RXR 0.0036 0.0329 0.0354
Brugia malayi nuclear hormone receptor family member nhr-6 0.0032 0.028 0.0301
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.011 0.0109
Loa Loa (eye worm) nuclear receptor nhr-7B 0.065 0.8159 0.8775
Brugia malayi MH1 domain containing protein 0.0017 0.009 0.0097
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Schistosoma mansoni nuclear receptor nhr-48 0.0032 0.028 0.0192
Onchocerca volvulus 0.0068 0.0738 0.0738
Echinococcus granulosus intermediate filament protein 0.0031 0.0267 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0382 0.4751 0.475
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.028 0.0279
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0114 0.0113
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.011 0.0109
Schistosoma mansoni hypothetical protein 0.0019 0.0114 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Loa Loa (eye worm) hypothetical protein 0.0014 0.0055 0.0057
Brugia malayi beta-NAC-like protein 0.004 0.0384 0.0413
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Schistosoma mansoni transcription factor btf3 0.004 0.0384 0.0297
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Schistosoma mansoni microtubule-associated protein tau 0.0794 1 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0384 1
Brugia malayi nuclear hormone receptor 0.0068 0.0738 0.0794
Echinococcus multilocularis geminin 0.0124 0.1452 0.145
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.011 0.0109
Schistosoma mansoni nuclear hormone receptor 0.0032 0.028 0.0192
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Onchocerca volvulus 0.0032 0.028 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.011 0.0119
Schistosoma mansoni cpg binding protein 0.0035 0.0317 0.0229
Echinococcus multilocularis musashi 0.0031 0.0267 0.0265
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0639 0.0688
Echinococcus granulosus smad 0.0017 0.009 0.0088
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.03
Echinococcus granulosus lamin dm0 0.0031 0.0267 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.0121
Echinococcus multilocularis lamin 0.0031 0.0267 0.0265
Echinococcus multilocularis lamin dm0 0.0031 0.0267 0.0265
Echinococcus multilocularis dnaJ subfamily B 0.0471 0.5875 0.5874
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0019 0.011 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0765 0.0681
Brugia malayi nuclear hormone receptor 0.065 0.8159 0.8775
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0418 0.5209 0.5208
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0019 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0068 0.0738 0.0792
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0036 0.0329 0.0328
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.0792
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0019 0.011 0.002
Echinococcus multilocularis transcription factor btf3 0.004 0.0384 0.0383
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.011 0.0117
Loa Loa (eye worm) hypothetical protein 0.006 0.0639 0.0686
Loa Loa (eye worm) Smad1 0.0017 0.009 0.0095
Brugia malayi Nuclear hormone receptor E75 0.0032 0.028 0.0301
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0352
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.067 1
Schistosoma mansoni lamin 0.0031 0.0267 0.0179
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0739 0.9297 0.9291
Brugia malayi hypothetical protein 0.0036 0.0329 0.0354

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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