Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Echinococcus granulosus | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Brugia malayi | tubulin alpha chain - mouse | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0539 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0539 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0539 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0539 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0398 | 0.5368 | 0.5368 |
Echinococcus granulosus | tubulin subunit TubB | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0398 | 0.5368 | 0.5368 |
Brugia malayi | Tubulin alpha-2 chain | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Schistosoma mansoni | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Schistosoma mansoni | tubulin subunit alpha | 0.0398 | 0.5368 | 0.4392 |
Schistosoma mansoni | tubulin subunit alpha | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | BEN-1 protein | 0.0539 | 1 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Plasmodium falciparum | tubulin beta chain | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0398 | 0.5368 | 0.5368 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Schistosoma mansoni | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Plasmodium vivax | tubulin beta chain, putative | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0273 | 0.1249 | 0.1249 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Trypanosoma brucei | beta tubulin | 0.0539 | 1 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0398 | 0.5368 | 0.5368 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0539 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0539 | 1 | 1 |
Brugia malayi | Tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0539 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0539 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0288 | 0.174 | 0.174 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0398 | 0.5368 | 0.4392 |
Brugia malayi | alpha-tubulin | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Giardia lamblia | Alpha-tubulin | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | beta tubulin | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0398 | 0.5368 | 0.5368 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0398 | 0.5368 | 0.5368 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0398 | 0.5368 | 0.4392 |
Trypanosoma brucei | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Schistosoma mansoni | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0288 | 0.174 | 0.174 |
Echinococcus multilocularis | tubulin subunit beta | 0.0539 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0539 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0288 | 0.174 | 0.174 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0398 | 0.5368 | 0.5368 |
Giardia lamblia | Beta tubulin | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0288 | 0.174 | 0.174 |
Echinococcus granulosus | beta tubulin | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus granulosus | beta tubulin | 0.0539 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0539 | 1 | 1 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0398 | 0.5368 | 0.4392 |
Toxoplasma gondii | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0398 | 0.5368 | 0.4392 |
Brugia malayi | Tubulin alpha-2 chain | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin, putative | 0.0539 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5368 | 0.5368 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0398 | 0.5368 | 0.5368 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0398 | 0.5368 | 0.5368 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Trypanosoma brucei | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0398 | 0.5368 | 0.5368 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0273 | 0.1249 | 0.1249 |
Schistosoma mansoni | tubulin subunit alpha | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0398 | 0.5368 | 0.4392 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0539 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0398 | 0.5368 | 0.5368 |
Entamoeba histolytica | tubulin family protein | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0539 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0539 | 1 | 1 |
Brugia malayi | tubulin alpha-2 chain | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | alpha-tubulin | 0.0398 | 0.5368 | 0.5368 |
Schistosoma mansoni | tubulin subunit beta | 0.0539 | 1 | 1 |
Echinococcus granulosus | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Plasmodium falciparum | alpha tubulin 1 | 0.0398 | 0.5368 | 0.4392 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0398 | 0.5368 | 0.5368 |
Entamoeba histolytica | tubulin family protein | 0.0539 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0539 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0273 | 0.1249 | 0.1249 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | tubulin beta chain | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0398 | 0.5368 | 0.4392 |
Toxoplasma gondii | beta-tubulin, putative | 0.0539 | 1 | 1 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0398 | 0.5368 | 0.4392 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0398 | 0.5368 | 0.4392 |
Loa Loa (eye worm) | BEN-1 protein | 0.0539 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0398 | 0.5368 | 0.5368 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Trypanosoma brucei | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Schistosoma mansoni | tubulin subunit beta | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0273 | 0.1249 | 0.1249 |
Schistosoma mansoni | tubulin subunit beta | 0.0539 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1249 | 0.1249 |
Echinococcus multilocularis | tubulin alpha chain | 0.0398 | 0.5368 | 0.4392 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0398 | 0.5368 | 0.4392 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0539 | 1 | 1 |
Leishmania major | beta tubulin | 0.0539 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (ADMET) | = 165 uM | Apparent kinetic acvtivity measured for protein carboxyl methyltransferase in L. donavani promastigotes | ChEMBL. | 1895298 |
Ki (ADMET) | = 380 uM | Apparent kinetic acvtivity measured for protein carboxyl methyltransferase in L. donavani promastigotes | ChEMBL. | 1895298 |
Ratio (ADMET) | = 3 | It is the ratio of Ki value to that of Km. | ChEMBL. | 1895298 |
Ratio (ADMET) | = 6.9 | It is the ratio of Ki value to that of Km. | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 1161185 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA soluble material at a concentration 2.1 uM. | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 1459000 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA insoluble material at a concentration 1.25 uM in the presence of sinefungin (0.026 uM). | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 1499100 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA soluble material at a concentration 1.25 uM. | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 1556483 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA soluble material at a concentration 1.25 uM in the presence of sinefungin (0.026 uM). | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 1772064 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA insoluble material at a concentration 1.25 uM. | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 1861835 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA insoluble material at a concentration 2.1 uM in the presence of sinefungin (0.026 uM). | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 1973260 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA soluble material at a concentration 2.1 uM in the presence of sinefungin (0.026 uM). | ChEMBL. | 1895298 |
Thymidine uptake (functional) | = 3284127 c.p.m. (mg of protein)-1 | Thymidine uptake and incorporation in L. donavani promastigotes measured in the TCA insoluble material at a concentration 2.1 uM. | ChEMBL. | 1895298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.