TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 314.405 | Formula: C16H18N4OS
H donors: 2 H acceptors: 2 LogP: 3.29 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCNc1nc(NCc2ccccc2)nc2c1scc2
InChi: 1S/C16H18N4OS/c1-21-9-8-17-15-14-13(7-10-22-14)19-16(20-15)18-11-12-5-3-2-4-6-12/h2-7,10H,8-9,11H2,1H3,(H2,17,18,19,20)
InChiKey: UNTOHGPOSRPRHE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1643	0.1643
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0244	0.0237
Schistosoma mansoni	survival motor neuron protein	0.0055	0.0161	0.0154
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0079	0.0071
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0062	0.3208
Loa Loa (eye worm)	runx1	0.0047	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0549	0.2098	0.2096
Echinococcus granulosus	acetylcholinesterase	0.2562	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0015	0.0008
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0019	0.002	0.0013
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0079	0.0071
Onchocerca volvulus		0.0433	0.1643	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.002	0.002
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0171	0.0617	0.061
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0079	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0015
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Echinococcus multilocularis	Protein lozenge	0.0047	0.0127	0.0125
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.2264	0.8828	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0617	0.0617
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0053	0.0152	0.2209
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0107	0.0365	0.5779
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.002	0.0023	0.0023
Echinococcus multilocularis	FTZ F1 alpha	0.0034	0.0079	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0051	0.0051
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0079	0.0076
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0433	0.1643	0.1637
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0171	0.0617	0.0678
Schistosoma mansoni	hypothetical protein	0.0047	0.0127	0.012
Echinococcus granulosus	nuclear receptor nhr 48	0.0016	0.0007	0.0005
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0106	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1643	0.1643
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0051	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1643	0.1643
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0079	0.0071
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0051	0.0512
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0052	0.2468
Echinococcus granulosus	dna polymerase kappa	0.0053	0.0152	0.015
Echinococcus multilocularis	dna polymerase kappa	0.0053	0.0152	0.015
Echinococcus granulosus	survival motor neuron protein 1	0.0272	0.1011	0.1009
Loa Loa (eye worm)	carboxylesterase	0.2562	1	1
Loa Loa (eye worm)	carboxylesterase	0.0433	0.1643	0.1643
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Echinococcus granulosus	hypothetical protein	0.0019	0.002	0.0018
Schistosoma mansoni	hypothetical protein	0.0047	0.0127	0.012
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0019	0.002	0.0013
Loa Loa (eye worm)	hypothetical protein	0.006	0.0177	0.0177
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Brugia malayi	polk-prov protein	0.003	0.0062	0.0055
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0079	0.0079
Entamoeba histolytica	hypothetical protein	0.0041	0.0106	0.1094
Loa Loa (eye worm)	hypothetical protein	0.2562	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0033	0.0073	0.0679
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0171	0.0617	0.0614
Loa Loa (eye worm)	hypothetical protein	0.002	0.0023	0.0023
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Toxoplasma gondii	histone lysine-specific demethylase	0.0171	0.0617	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0079	0.0071
Brugia malayi	hypothetical protein	0.0433	0.1643	0.1637
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0023	0.0004
Echinococcus granulosus	tumor protein p63	0.0389	0.1469	0.1467
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0079	0.0071
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.022	0.0806	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0015
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0034	0.0079	0.0076
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0079	0.0071
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0016	0.0007	0.0005
Schistosoma mansoni	lamin	0.0031	0.0065	0.0058
Echinococcus granulosus	para nitrobenzyl esterase	0.0433	0.1643	0.1641
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0051	0.0389
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0065	0.0058
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0171	0.0617	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0433	0.1643	0.1641
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0065	0.0065
Echinococcus granulosus	neuroligin	0.0433	0.1643	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0007	0.0005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0053	0.0152	0.2209
Onchocerca volvulus		0.0055	0.0161	0.0942
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0079	0.0071
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Echinococcus granulosus	thyroid hormone receptor alpha	0.0016	0.0007	0.0005
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0079	0.0079
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0244	0.0237
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Echinococcus granulosus	Protein patched homolog 1	0.0049	0.0134	0.0132
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0018	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Toxoplasma gondii	aldose reductase, putative	0.0019	0.002	0.0272
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0244	0.0244
Echinococcus granulosus	intermediate filament protein	0.0031	0.0065	0.0063
Plasmodium vivax	hypothetical protein, conserved	0.0171	0.0617	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0079	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0617	0.0617
Schistosoma mansoni	gliotactin	0.0433	0.1643	0.1637
Entamoeba histolytica	hypothetical protein	0.0041	0.0106	0.1094
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0019	0.002	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1643	0.1643
Echinococcus granulosus	expressed conserved protein	0.0106	0.0361	0.0359
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.002	0.0023	0.0023
Echinococcus multilocularis	carboxylesterase 5A	0.2562	1	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1011	0.1011
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0038	0.0093	0.0084
Echinococcus multilocularis	expressed conserved protein	0.0106	0.0361	0.0359
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.005	0.0138	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1643	0.1643
Echinococcus granulosus	sterol regulatory element binding protein	0.0049	0.0134	0.0132
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.2435	0.9501	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.0073	0.0066
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.005	0.0138	0.1983
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0033	0.0073	0.0073
Onchocerca volvulus		0.0019	0.002	0.0078
Schistosoma mansoni	hypothetical protein	0.0055	0.0161	0.0154
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.005	0.0138	0.0131
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0433	0.1643	0.1843
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.2562	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0093	0.1221
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0549	0.2098	0.2096
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0167	0.0167
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Echinococcus granulosus	aldo keto reductase	0.0019	0.002	0.0018
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0161	0.0159
Brugia malayi	TAR-binding protein	0.0076	0.0244	0.0237
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0016	0.0007	0.0007
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0079	0.0071
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0007	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0015
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0079	0.0071
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0171	0.0617	0.0614
Mycobacterium ulcerans	dehydrogenase	0.0171	0.0617	0.0629
Plasmodium falciparum	protoporphyrinogen oxidase	0.0171	0.0617	1
Echinococcus multilocularis	musashi	0.0031	0.0065	0.0063
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0051	0.0032
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0033	0.0073	0.0066
Brugia malayi	Carboxylesterase family protein	0.0433	0.1643	0.1637
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0509	0.0509
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0171	0.0617	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0162	0.0579	0.0577
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0079	0.0071
Brugia malayi	nuclear hormone receptor	0.0034	0.0079	0.0071
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0433	0.1643	0.1843
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Loa Loa (eye worm)	hypothetical protein	0.003	0.0063	0.0063
Treponema pallidum	fructose-bisphosphate aldolase	0.022	0.0806	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0034	0.0079	0.0071
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0051	0.0032
Mycobacterium ulcerans	carboxylesterase, LipT	0.0433	0.1643	0.1712
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0433	0.1643	0.1637
Leishmania major	UDP-galactopyranose mutase	0.0171	0.0617	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0106	0.0104
Onchocerca volvulus		0.0171	0.0617	0.3726
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Mycobacterium ulcerans	DNA polymerase IV	0.0053	0.0152	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0373	0.1406	0.1406
Trypanosoma brucei	unspecified product	0.0023	0.0033	0.0991
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Brugia malayi	intermediate filament protein	0.0031	0.0065	0.0058
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0053	0.0152	0.2209
Brugia malayi	MH2 domain containing protein	0.0144	0.0509	0.0503
Echinococcus multilocularis	acetylcholinesterase	0.2562	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Onchocerca volvulus		0.0019	0.002	0.0078
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0015	0.0008
Mycobacterium ulcerans	monoamine oxidase	0.0171	0.0617	0.0629
Trichomonas vaginalis	DNA polymerase eta, putative	0.0053	0.0152	0.0812
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0079	0.0076
Echinococcus granulosus	aldo keto reductase	0.0019	0.002	0.0018
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0053	0.0152	0.0812
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.005	0.0138	0.0136
Echinococcus multilocularis	para nitrobenzyl esterase	0.0433	0.1643	0.1641
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0007	0.0005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Brugia malayi	SWIRM domain containing protein	0.0171	0.0617	0.061
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0007	0.0005
Mycobacterium ulcerans	DNA polymerase IV	0.0053	0.0152	0.0139
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1643	0.1643
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0079	0.0071
Echinococcus multilocularis	aldo keto reductase	0.0019	0.002	0.0018
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0033	0.0073	0.0071
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0093	0.5525
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0079	0.0071
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0079	0.0076
Onchocerca volvulus		0.0433	0.1643	1
Trypanosoma brucei	unspecified product	0.0023	0.0033	0.0991
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Brugia malayi	hypothetical protein	0.0272	0.1011	0.1005
Echinococcus granulosus	Niemann Pick C1 protein	0.0113	0.0388	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0009	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0073	0.0894
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0171	0.0617	0.0614
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0079	0.0076
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0009	0.0002
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0079	0.0071
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0052	0.2468
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0079	0.0436
Entamoeba histolytica	hypothetical protein	0.0041	0.0106	0.1094
Onchocerca volvulus		0.0019	0.002	0.0078
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0016	0.0007	0.0007
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0007	0.0005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0079	0.0076
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.005	0.0138	0.0138
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0549	0.2098	0.2092
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0171	0.0617	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0171	0.0617	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0115	0.0395	0.0388
Loa Loa (eye worm)	carboxylesterase	0.0433	0.1643	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0015
Schistosoma mansoni	microtubule-associated protein tau	0.0794	0.3059	0.3054
Echinococcus multilocularis	lamin	0.0031	0.0065	0.0063
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0065	0.0065
Brugia malayi	Carboxylesterase family protein	0.2562	1	1
Echinococcus multilocularis	protein patched	0.0049	0.0134	0.0132
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0171	0.0617	0.0614
Onchocerca volvulus		0.0034	0.0079	0.0436
Loa Loa (eye worm)	hypothetical protein	0.002	0.0023	0.0023
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0019	0.002	0.0013
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0107	0.0365	0.0364
Brugia malayi	ecdysteroid receptor	0.0034	0.0079	0.0071
Loa Loa (eye worm)	nuclear hormone receptor	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0171	0.0617	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.0073	0.0066
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.005	0.0138	0.1983
Echinococcus multilocularis	Niemann Pick C1 protein	0.0113	0.0388	0.0386
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0007	0.0005
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0079	0.0076
Trypanosoma brucei	DNA polymerase IV, putative	0.0048	0.0132	0.8523
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0171	0.0617	0.0629
Loa Loa (eye worm)	hypothetical protein	0.2562	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0106	0.0099
Trichomonas vaginalis	spcc417.12 protein, putative	0.0433	0.1643	1
Loa Loa (eye worm)	oxidoreductase	0.0019	0.002	0.002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0015	0.0008
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0051	0.0389
Loa Loa (eye worm)	DR-78	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0051	0.0043
Onchocerca volvulus		0.0019	0.002	0.0078
Echinococcus multilocularis	dna polymerase eta	0.0033	0.0073	0.0071
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0051	0.0036
Giardia lamblia	Fructose-bisphosphate aldolase	0.022	0.0806	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0079	0.0076
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0051	0.0389
Echinococcus granulosus	microtubule associated protein 2	0.0794	0.3059	0.3057
Brugia malayi	Carboxylesterase family protein	0.0433	0.1643	0.1637
Echinococcus multilocularis	aldo keto reductase	0.0019	0.002	0.0018
Echinococcus multilocularis	tumor protein p63	0.0389	0.1469	0.1467
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0023	0.0005
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.005	0.0138	0.8974
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0049	0.0134	0.0134
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0244	0.0244
Schistosoma mansoni	hypothetical protein	0.0047	0.0127	0.012
Schistosoma mansoni	DNA polymerase eta	0.0033	0.0073	0.0066
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0079	0.0071
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0244	0.0237
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0079	0.0071
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Onchocerca volvulus		0.0031	0.0065	0.0355
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0079	0.0076
Onchocerca volvulus		0.0019	0.002	0.0078
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0051	0.0032
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0034	0.0079	0.0076
Echinococcus granulosus	aldo keto reductase	0.0019	0.002	0.0018
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0549	0.2098	0.2092
Echinococcus granulosus	transcription factor Dp 1	0.0029	0.0056	0.0054
Echinococcus multilocularis	aldo keto reductase	0.0019	0.002	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0079	0.0071
Schistosoma mansoni	aldo-keto reductase	0.0019	0.002	0.0013
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0033	0.0073	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	Carboxylesterase family protein	0.0433	0.1643	0.1637
Onchocerca volvulus		0.0373	0.1406	0.8554
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0065	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0134	0.0134
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.2435	0.9501	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0113	0.0388	0.4683
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0549	0.2098	0.2098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0079	0.0071
Echinococcus multilocularis		0.0171	0.0617	0.0614
Mycobacterium ulcerans	oxidoreductase	0.0171	0.0617	0.0629
Loa Loa (eye worm)	acetylcholinesterase 1	0.2562	1	1
Schistosoma mansoni	acetylcholinesterase	0.0433	0.1643	0.1637
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0079	0.0071
Echinococcus granulosus	FTZ F1 alpha	0.0034	0.0079	0.0076
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0079	0.0079
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0079	0.0076
Loa Loa (eye worm)	oxidoreductase	0.0019	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0617	0.0617
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Loa Loa (eye worm)	hypothetical protein	0.0373	0.1406	0.1406
Echinococcus multilocularis	neuroligin	0.0433	0.1643	0.1641
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0038	0.0093	0.1221
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0051	0.0512
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0051	0.0512
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0244	0.0242
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.005	0.0138	0.0131
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0079	0.0071
Trypanosoma brucei	DNA polymerase IV, putative	0.0053	0.0152	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0033	0.0073	0.0071
Echinococcus multilocularis	aldo keto reductase	0.0019	0.002	0.0018
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0018	0.0015	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0079	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0134	0.0704
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0033	0.0073	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0617	0.0617
Echinococcus multilocularis	acetylcholinesterase	0.2562	1	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0051	0.0032
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0244	0.0237
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0244	0.0242
Echinococcus granulosus	lamin dm0	0.0031	0.0065	0.0063
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0018	0.0015	0.0008
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0079	0.0071
Schistosoma mansoni	amine oxidase	0.0171	0.0617	0.061
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0051	0.0032
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0171	0.0617	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Schistosoma mansoni	aldo-keto reductase	0.0019	0.002	0.0013
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0107	0.0365	0.0392
Echinococcus granulosus	lamin	0.0031	0.0065	0.0063
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0171	0.0617	1
Brugia malayi	hypothetical protein	0.0041	0.0106	0.0099
Brugia malayi	amine oxidase, flavin-containing family protein	0.0171	0.0617	0.061
Schistosoma mansoni	hypothetical protein	0.0047	0.0127	0.012
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Schistosoma mansoni	amine oxidase	0.0171	0.0617	0.061
Onchocerca volvulus		0.0433	0.1643	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0433	0.1643	1
Schistosoma mansoni	pol-related	0.0019	0.002	0.0013
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0053	0.0152	0.2209
Echinococcus multilocularis	Niemann Pick C1 protein	0.0162	0.0579	0.0577
Loa Loa (eye worm)	oxidoreductase	0.0019	0.002	0.002
Schistosoma mansoni	coup transcription factor	0.0034	0.0079	0.0071
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.022	0.0806	0.4843
Brugia malayi	nuclear receptor RXR	0.0018	0.0015	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0079	0.0079
Mycobacterium tuberculosis	Probable oxidoreductase	0.0019	0.002	0.0001
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0051	0.0043
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.022	0.0806	1
Entamoeba histolytica	hypothetical protein	0.0041	0.0106	0.1094
Echinococcus granulosus	BC026374 protein S09 family	0.0433	0.1643	0.1641
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0051	0.0032
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0244	0.0237
Leishmania major	DNA polymerase eta, putative	0.0033	0.0073	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0617	0.0617
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0079	0.0076
Schistosoma mansoni	lamin	0.0031	0.0065	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0051	0.0051
Schistosoma mansoni	patched 1	0.0049	0.0134	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1643	0.1643
Brugia malayi	hypothetical protein	0.0018	0.0015	0.0008
Brugia malayi	Carboxylesterase family protein	0.0433	0.1643	0.1637
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.005	0.0138	0.1505
Onchocerca volvulus		0.0027	0.0051	0.0265
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.005	0.0138	0.1983
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0016	0.0007	0.0005
Brugia malayi	steroid hormone receptor	0.0034	0.0079	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0079	0.0071
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0052	0.2468
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0079	0.0436
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0016	0.0007	0.0005
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0509	0.0509
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0244	0.0237
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0079	0.0071
Onchocerca volvulus		0.0433	0.1643	1
Echinococcus granulosus	dna polymerase eta	0.0033	0.0073	0.0071
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0051	0.0032
Onchocerca volvulus		0.0019	0.002	0.0078
Schistosoma mansoni	hypothetical protein	0.0041	0.0106	0.0099
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0018	0.0015	0.0015
Echinococcus multilocularis	microtubule associated protein 2	0.0794	0.3059	0.3057
Echinococcus granulosus	carboxylesterase 5A	0.2562	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0433	0.1643	0.1637
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.0161	0.0154
Brugia malayi	CHE-14 protein	0.0049	0.0134	0.0127
Echinococcus granulosus	acetylcholinesterase	0.2562	1	1
Trypanosoma brucei	unspecified product	0.0048	0.0132	0.8523
Onchocerca volvulus		0.0057	0.0167	0.0976
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0079	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Brugia malayi	hypothetical protein	0.0373	0.1406	0.14
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0617	0.0617
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0433	0.1643	0.1641
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0051	0.0036
Loa Loa (eye worm)	oxidoreductase	0.0019	0.002	0.002
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0079	0.0071
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0933	0.3604	0.3603
Trypanosoma brucei	DNA polymerase kappa, putative	0.0053	0.0152	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0079	0.0071
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0433	0.1643	0.1637
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.003	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0051	0.0512
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0171	0.0617	0.061
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0079	0.0076
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0079	0.0076
Echinococcus multilocularis	transcription factor Dp 1	0.0029	0.0056	0.0054
Echinococcus multilocularis	survival motor neuron protein 1	0.0272	0.1011	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0073	0.0073
Plasmodium vivax	hypothetical protein, conserved	0.0171	0.0617	1
Schistosoma mansoni	lozenge	0.0047	0.0127	0.012
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0433	0.1643	0.1843
Brugia malayi	Niemann-Pick C1 protein precursor	0.0113	0.0388	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0079
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Brugia malayi	hypothetical protein	0.0018	0.0015	0.0008
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0016	0.0007	0.0005
Echinococcus multilocularis	sterol regulatory element binding protein	0.0049	0.0134	0.0132
Mycobacterium tuberculosis	Possible oxidoreductase	0.0171	0.0617	0.0678
Brugia malayi	RNA binding protein	0.0076	0.0244	0.0237
Echinococcus multilocularis	lamin dm0	0.0031	0.0065	0.0063
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0051	0.0512
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0079	0.0436
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0019	0.002	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0079	0.0071
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0065	0.0065
Giardia lamblia	DINP protein human, muc B family	0.0038	0.0093	0.0927
Onchocerca volvulus		0.0031	0.0065	0.0355
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0167	0.016
Schistosoma mansoni	BC026374 protein (S09 family)	0.0433	0.1643	0.1637
Trypanosoma brucei	DNA polymerase IV, putative	0.0053	0.0152	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0079	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0051	0.0051
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0051	0.0032
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0433	0.1643	0.1641
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0171	0.0617	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0033	0.0073	0.4048
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0062	0.3208
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0019	0.002	0.0018
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0171	0.0617	1
Loa Loa (eye worm)	oxidoreductase	0.0019	0.002	0.002
Onchocerca volvulus		0.0433	0.1643	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0079	0.0079
Brugia malayi	hypothetical protein	0.0171	0.0617	0.061

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.5119 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	3.6626 uM	PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.1095 uM	PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.3078 uM	PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1894586

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1569682