Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hr1 repeat family protein | 0.4769 | 0.3057 | 0.3057 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.4769 | 0.3057 | 0.4632 |
Entamoeba histolytica | protein kinase, putative | 1.4298 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 1.4298 | 1 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.4769 | 0.3057 | 0.4632 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.4769 | 0.3057 | 0.4632 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.4769 | 0.3057 | 0.4632 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.9148 | 0.6248 | 0.9466 |
Brugia malayi | Protein kinase domain containing protein | 0.4769 | 0.3057 | 0.3057 |
Echinococcus granulosus | serine/threonine protein kinase | 0.9631 | 0.66 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 1.3917 | 0.9722 | 0.9722 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.4769 | 0.3057 | 0.4632 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.9631 | 0.66 | 1 |
Leishmania major | histone deacetylase, putative | 0.0573 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.4769 | 0.3057 | 0.3057 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.925 | 0.6323 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Echinococcus granulosus | protein kinase C gamma type | 0.4769 | 0.3057 | 0.4632 |
Trichomonas vaginalis | AGC family protein kinase | 0.4769 | 0.3057 | 0.0107 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.4769 | 0.3057 | 0.4632 |
Entamoeba histolytica | protein kinase 2, putative | 0.925 | 0.6323 | 0.4703 |
Giardia lamblia | Kinase, AGC PKA | 0.925 | 0.6323 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.9631 | 0.66 | 1 |
Echinococcus granulosus | nervana 2 | 0.9148 | 0.6248 | 0.9466 |
Trichomonas vaginalis | AGC family protein kinase | 1.4298 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4769 | 0.3057 | 0.3057 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.9148 | 0.6248 | 0.9466 |
Entamoeba histolytica | protein kinase, putative | 1.3917 | 0.9722 | 0.96 |
Schistosoma mansoni | serine/threonine kinase | 0.4769 | 0.3057 | 0.4632 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.9148 | 0.6248 | 0.9466 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.9631 | 0.66 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 1.3917 | 0.9722 | 0.9722 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.4769 | 0.3057 | 0.3057 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.4769 | 0.3057 | 0.4632 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.4769 | 0.3057 | 0.4632 |
Echinococcus multilocularis | serine threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 1.4298 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.4769 | 0.3057 | 0.4632 |
Brugia malayi | Protein kinase domain containing protein | 0.4769 | 0.3057 | 0.3057 |
Toxoplasma gondii | AGC kinase | 1.3917 | 0.9722 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.4769 | 0.3057 | 0.3057 |
Trichomonas vaginalis | AGC family protein kinase | 1.4298 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.925 | 0.6323 | 0.958 |
Trichomonas vaginalis | AGC family protein kinase | 1.4298 | 1 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.9631 | 0.66 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.4769 | 0.3057 | 0.0107 |
Trichomonas vaginalis | AGC family protein kinase | 1.4298 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.4769 | 0.3057 | 0.4632 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.925 | 0.6323 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.9631 | 0.66 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.9148 | 0.6248 | 0.9466 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.4769 | 0.3057 | 0.4632 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.9631 | 0.66 | 0.5103 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.4769 | 0.3057 | 0.4632 |
Trichomonas vaginalis | AGC family protein kinase | 1.4298 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.9148 | 0.6248 | 0.9466 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.4769 | 0.3057 | 0.4632 |
Trichomonas vaginalis | AGC family protein kinase | 0.515 | 0.3335 | 0.0502 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Trichomonas vaginalis | AGC family protein kinase | 0.4769 | 0.3057 | 0.0107 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.9631 | 0.66 | 0.5103 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.925 | 0.6323 | 0.958 |
Echinococcus multilocularis | nervana 2 | 0.9148 | 0.6248 | 0.9466 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Schistosoma mansoni | atypical protein kinase C | 0.4769 | 0.3057 | 0.4632 |
Echinococcus granulosus | protein kinase c epsilon type | 0.4769 | 0.3057 | 0.4632 |
Echinococcus multilocularis | protein kinase c iota type | 0.4769 | 0.3057 | 0.4632 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.925 | 0.6323 | 0.958 |
Entamoeba histolytica | protein kinase, putative | 1.4298 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.9148 | 0.6248 | 0.9466 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 1.4298 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 1.4298 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.4769 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.4769 | 0.3057 | 0.3057 |
Echinococcus granulosus | NDR protein kinase | 0.4769 | 0.3057 | 0.4632 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.925 | 0.6323 | 0.958 |
Echinococcus granulosus | protein kinase c iota type | 0.4769 | 0.3057 | 0.4632 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.4769 | 0.3057 | 0.3057 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4769 | 0.3057 | 0.4632 |
Brugia malayi | protein kinase C II. | 0.4769 | 0.3057 | 0.3057 |
Leishmania major | histone deacetylase, putative | 0.0573 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.