Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | polyprenyl synthetase | 0.1186 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.061 | 0.2693 | 0.5 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.061 | 0.2693 | 1 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.061 | 0.2693 | 0.2693 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.061 | 0.2693 | 0.1861 |
Brugia malayi | Polyprenyl synthetase family protein | 0.061 | 0.2693 | 0.1861 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0478 | 0.1022 | 0.1022 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1186 | 1 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1186 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1186 | 1 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.061 | 0.2693 | 0.2693 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1186 | 1 | 0.5 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.061 | 0.2693 | 0.262 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.061 | 0.2693 | 0.1861 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.061 | 0.2693 | 0.1861 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.061 | 0.2693 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0405 | 0.0099 | 0.0099 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.061 | 0.2693 | 0.1861 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0478 | 0.1022 | 0.1022 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0478 | 0.1022 | 0.1022 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1186 | 1 | 0.5 |
Schistosoma mansoni | trans-prenyltransferase | 0.061 | 0.2693 | 0.2693 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0478 | 0.1022 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1186 | 1 | 1 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0397 | 0 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.0405 | 0.0099 | 0.0099 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.061 | 0.2693 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1186 | 1 | 1 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Leishmania major | polyprenyl synthase, putative | 0.0478 | 0.1022 | 0.0932 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.061 | 0.2693 | 0.2693 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1186 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0405 | 0.0099 | 0.0099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9 uM | Inhibitory activity of the compound against Wt-MCF7 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 9 uM | Inhibitory activity of the compound against Wt-MCF7 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 18 uM | Inhibitory activity of the compound against MDA-MB-435 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 18 uM | Inhibitory activity of the compound against MDA-MB-435 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 38 uM | Inhibitory activity of the compound against MCF-12A human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 38 uM | Inhibitory activity of the compound against MCF-12A human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MDA-MB-231 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MCF-10A human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MDA-MB-231 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MCF-10A human breast cell line | ChEMBL. | 12825923 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12825923 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.