Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0048 | 0.1223 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0191 | 0.9911 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0048 | 0.1223 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0048 | 0.1223 | 0.1234 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0191 | 0.9911 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0048 | 0.1223 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0193 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0191 | 0.9911 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0191 | 0.9911 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0048 | 0.1223 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0048 | 0.1223 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0048 | 0.1223 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0048 | 0.1223 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0191 | 0.9911 | 1 |
Leishmania major | trypanothione reductase | 0.0191 | 0.9911 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0048 | 0.1223 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0048 | 0.1223 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0191 | 0.9911 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0048 | 0.1223 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0048 | 0.1223 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0191 | 0.9911 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0191 | 0.9911 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0191 | 0.9911 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0191 | 0.9911 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0191 | 0.9911 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0191 | 0.9911 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.