Detailed information for compound 157003

Basic information

Technical information
  • TDR Targets ID: 157003
  • Name: 1-benzyl-4-propyl-6,7-dihydroimidazo[4,5-e][1 ,4]diazepine-5,8-dione
  • MW: 298.34 | Formula: C16H18N4O2
  • H donors: 1 H acceptors: 3 LogP: 1.61 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1C(=O)CNC(=O)c2c1ncn2Cc1ccccc1
  • InChi: 1S/C16H18N4O2/c1-2-8-20-13(21)9-17-16(22)14-15(20)18-11-19(14)10-12-6-4-3-5-7-12/h3-7,11H,2,8-10H2,1H3,(H,17,22)
  • InChiKey: HRXNTRRRYUYWIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(phenylmethyl)-4-propyl-6,7-dihydroimidazo[4,5-e][1,4]diazepine-5,8-dione
  • 1-benzyl-4-propyl-6,7-dihydroimidazo[4,5-e][1,4]diazepine-5,8-quinone
  • 1-(phenylmethyl)-4-propyl-6,7-dihydroimidazo[5,4-f][1,4]diazepine-5,8-dione
  • 1-(benzyl)-4-propyl-6,7-dihydroimidazo[5,4-f][1,4]diazepine-5,8-quinone
  • PDSP1_001148
  • PDSP2_001132

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0102 0.1332 0.1278
Plasmodium falciparum proteasome subunit beta type-5 0.0691 1 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0157 0.2136 0.172
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0102 0.1332 0.1278
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0502 0.0443
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0102 0.1332 0.1278
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1364 0.131
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0102 0.1332 0.1278
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit beta type-2, putative 0.0311 0.4406 0.4371
Toxoplasma gondii proteasome beta subunit 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0311 0.4406 0.4371
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0102 0.1332 0.1278
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0102 0.1332 0.0874
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0311 0.4406 0.4371
Leishmania major proteasome beta 5 subunit, putative 0.0691 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1364 0.131
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0102 0.1332 0.1278
Echinococcus granulosus proteasome subunit beta t family 0.0102 0.1332 0.1278
Leishmania major proteasome alpha 7 subunit, putative 0.0102 0.1332 0.1278
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1364 0.131
Plasmodium vivax proteasome subunit beta type-1, putative 0.0157 0.2136 0.2087
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0102 0.1332 0.1278
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1364 0.0037
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0102 0.1332 0.1278
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0157 0.2136 0.2087
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0102 0.1332 0.1278
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0102 0.1332 0.1278
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0102 0.1332 0.1278
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0102 0.1332 0.1278
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1364 0.131
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1536 0.1483
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit beta type-3, putative 0.0102 0.1332 0.1278
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0157 0.2136 0.2087
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0102 0.1332 0.1278
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0102 0.1332 0.1278
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0157 0.2136 0.2087
Giardia lamblia Proteasome subunit beta type 2 0.0311 0.4406 0.4371
Trypanosoma brucei proteasome alpha 7 subunit 0.0102 0.1332 0.1278
Giardia lamblia 20S proteasome alpha subunit 2 0.0102 0.1332 0.1278
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0502 0.0443
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0311 0.4406 0.4371
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0102 0.1332 0.1278
Toxoplasma gondii proteasome subunit 0.0102 0.1332 0.1278
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1528 0.1081
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0691 1 1
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0157 0.2136 0.2087
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0102 0.1332 0.1278
Brugia malayi Thioredoxin reductase 0.0046 0.0502 0.0502
Echinococcus multilocularis proteasome subunit alpha type 6 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0102 0.1332 0.1278
Brugia malayi proteasome subunit alpha type 6 0.0102 0.1332 0.1332
Brugia malayi proteasome subunit beta type 3 0.0102 0.1332 0.1332
Plasmodium vivax proteasome subunit beta type-7, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome subunit beta type 2 0.0311 0.4406 0.411
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0311 0.4406 0.3546
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0102 0.1332 0.0874
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0102 0.1332 0.1278
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0311 0.4406 0.4371
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0157 0.2136 0.2087
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0102 0.1332 0.1278
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0102 0.1332 0.1278
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0157 0.2136 0.2087
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0102 0.1332 0.1278
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0502 0.0443
Giardia lamblia Proteasome subunit beta type 1 0.0157 0.2136 0.2087
Plasmodium falciparum glutathione reductase 0.0046 0.0502 0.0443
Brugia malayi proteasome subunit alpha type 2 0.0102 0.1332 0.1332
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0102 0.1332 0.1278
Leishmania major proteasome alpha 1 subunit, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0102 0.1332 0.0874
Brugia malayi glutathione reductase 0.0046 0.0502 0.0502
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0691 1 1
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0311 0.4406 0.4371
Leishmania major proteasome alpha 7 subunit, putative 0.0102 0.1332 0.1278
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0311 0.4406 0.4371
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0102 0.1332 0.1278
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0157 0.2136 0.0927
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome subunit beta type 3 0.0102 0.1332 0.0874
Leishmania major proteasome beta 3 subunit, putative 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0502 0.0443
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0311 0.4406 0.4371
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0691 1 1
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0102 0.1332 0.1278
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0102 0.1332 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0691 1 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0102 0.1332 0.1278
Echinococcus granulosus proteasome subunit alpha type 6 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0102 0.1332 0.1278
Brugia malayi Proteasome A-type and B-type family protein 0.0102 0.1332 0.1332
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0102 0.1332 0.0874
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0102 0.1332 0.1278
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.2136 0.2087
Giardia lamblia 20S proteasome alpha subunit 1 0.0102 0.1332 0.1278
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0102 0.1332 0.1278
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0102 0.1332 0.1278
Brugia malayi Proteasome subunit alpha type 7-1 0.0102 0.1332 0.1332
Plasmodium falciparum thioredoxin reductase 0.0046 0.0502 0.0443
Mycobacterium ulcerans proteasome PrcA 0.0102 0.1332 0.1278
Onchocerca volvulus Notchless protein homolog 0.0102 0.1332 0.5
Loa Loa (eye worm) PAS-3 protein 0.0102 0.1332 0.0874
Echinococcus granulosus proteasome subunit beta type 6 0.0102 0.1332 0.1278
Leishmania major proteasome alpha 2 subunit, putative 0.0102 0.1332 0.1278
Brugia malayi Proteasome A-type and B-type family protein 0.0102 0.1332 0.1332
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0102 0.1332 0.1278
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0691 1 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0102 0.1332 0.1278
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0102 0.1332 0.0874
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0102 0.1332 0.1278
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1528 0.1081
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0102 0.1332 0.1278
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit beta type-6, putative 0.0102 0.1332 0.1278
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0102 0.1332 0.0874
Toxoplasma gondii heat shock protein hslv, putative 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit beta type-5, putative 0.0691 1 1
Brugia malayi proteasome subunit alpha type 3 0.0102 0.1332 0.1332
Toxoplasma gondii peptidase, T1 family protein 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0102 0.1332 0.0874
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0102 0.1332 0.1278
Brugia malayi proteasome subunit beta type 2 0.0311 0.4406 0.4406
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0102 0.1332 0.1278
Echinococcus granulosus subfamily T1A non peptidase ue 0.0102 0.1332 0.1278
Echinococcus multilocularis proteasome subunit beta type 6 0.0102 0.1332 0.1278
Leishmania major proteasome beta 2 subunit, putative 0.0102 0.1332 0.1278
Echinococcus granulosus Proteasome subunit alpha type 7 0.0102 0.1332 0.1278
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0691 1 1
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0691 1 1
Brugia malayi 20S proteasome alpha5 subunit 0.0102 0.1332 0.1332
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0102 0.1332 0.1278
Brugia malayi Proteasome A-type and B-type family protein 0.0102 0.1332 0.1332
Echinococcus granulosus proteasome prosome macropain 0.0691 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0502 0.0443
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0102 0.1332 0.1278
Brugia malayi proteasome subunit alpha type 4 0.0102 0.1332 0.1332
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0102 0.1332 0.1278
Giardia lamblia 20S proteasome alpha subunit 7 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0691 1 1
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0102 0.1332 0.1278
Trypanosoma cruzi 20S proteasome subunit 0.0311 0.4406 0.4371
Brugia malayi MH2 domain containing protein 0.0115 0.1528 0.1528
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0102 0.1332 0.1278
Brugia malayi Proteasome subunit alpha type 1 0.0102 0.1332 0.1332
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0102 0.1332 0.1278
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0102 0.1332 0.1278
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1364 0.131
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0102 0.1332 0.1278
Toxoplasma gondii proteasome subunit alpha1, putative 0.0102 0.1332 0.1278
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0102 0.1332 0.1278
Giardia lamblia 20S proteasome alpha subunit 5 0.0102 0.1332 0.1278
Giardia lamblia Proteasome subunit beta type 3 0.0102 0.1332 0.1278
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0102 0.1332 0.1278
Leishmania major proteasome alpha 1 subunit, putative 0.0102 0.1332 0.1278
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0102 0.1332 0.1278
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0102 0.1332 0.1278
Echinococcus multilocularis proteasome (prosome, macropain) 0.0691 1 1
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0102 0.1332 0.1278
Toxoplasma gondii thioredoxin reductase 0.0046 0.0502 0.0443
Mycobacterium ulcerans proteasome PrcB 0.0691 1 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1536 0.0234
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0691 1 1
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0102 0.1332 0.1278
Trypanosoma brucei proteasome beta 6 subunit 0.0157 0.2136 0.2087
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0157 0.2136 0.2087
Leishmania major proteasome beta-1 subunit, putative 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Echinococcus granulosus proteasome subunit alpha type 2 0.0102 0.1332 0.1278
Echinococcus multilocularis proteasome subunit alpha type 2 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0157 0.2136 0.2087
Leishmania major trypanothione reductase 0.0046 0.0502 0.0443
Brugia malayi proteasome subunit alpha type 1 0.0102 0.1332 0.1332
Plasmodium vivax glutathione reductase, putative 0.0046 0.0502 0.0443
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0102 0.1332 0.1278
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0102 0.1332 0.1278
Leishmania major proteasome beta 7 subunit, putative 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0102 0.1332 0.1278
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0691 1 1
Echinococcus granulosus proteasome subunit beta type 7 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0102 0.1332 0.0874
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0102 0.1332 0.1278
Giardia lamblia 20S proteasome alpha subunit 4 0.0102 0.1332 0.1278
Leishmania major proteasome alpha 3 subunit, putative 0.0102 0.1332 0.1278
Toxoplasma gondii proteasome subunit beta type, putative 0.0691 1 1
Plasmodium falciparum proteasome subunit beta type-4 0.0102 0.1332 0.1278
Trypanosoma brucei proteasome beta 7 subunit 0.0102 0.1332 0.1278
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0102 0.1332 0.1278
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1536 0.1483
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0102 0.1332 0.1278
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0311 0.4406 0.4371
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0062 0.5
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0102 0.1332 0.1278
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0102 0.1332 0.0874
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0102 0.1332 0.1278
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0311 0.4406 0.4371
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0102 0.1332 0.1278
Echinococcus multilocularis proteasome subunit beta type 7 0.0102 0.1332 0.1278
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.1332 0.1278
Giardia lamblia 20S proteasome alpha subunit 3 0.0102 0.1332 0.1278
Giardia lamblia 20S proteasome alpha subunit 6 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0102 0.1332 0.1278
Echinococcus granulosus Proteasome subunit alpha beta 0.0102 0.1332 0.1278
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0311 0.4406 0.4371
Treponema pallidum NADH oxidase 0.0016 0.0062 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0062 0.0062
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0102 0.1332 0.1278
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0102 0.1332 0.1278
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0102 0.1332 0.1278
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0102 0.1332 0.1278
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0102 0.1332 0.1278
Mycobacterium tuberculosis Probable reductase 0.0104 0.1364 0.131
Leishmania major proteasome beta 2 subunit, putative 0.0311 0.4406 0.4371
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1536 0.1483
Plasmodium vivax proteasome subunit beta type-4, putative 0.0102 0.1332 0.1278
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0102 0.1332 0.1278
Brugia malayi proteasome subunit beta type 1 0.0157 0.2136 0.2136
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0102 0.1332 0.1278
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0102 0.1332 0.1278
Toxoplasma gondii proteasome subunit alpha type, putative 0.0102 0.1332 0.1278
Trypanosoma brucei trypanothione reductase 0.0046 0.0502 0.0443

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 32 uM Binding affinity for Adenosine A1 receptor from rat brain using [3H]-PIA as radioligand ChEMBL. 2213834
Ki (binding) = 32 uM Binding affinity for Adenosine A1 receptor from rat brain using [3H]-PIA as radioligand ChEMBL. 2213834
Ki (binding) = 151 uM Binding affinity for Adenosine A2 receptor from rat striatum using [3H]-NECA as radioligand ChEMBL. 2213834
Ki (binding) = 151 uM Binding affinity for Adenosine A2 receptor from rat striatum using [3H]-NECA as radioligand ChEMBL. 2213834
Ki (functional) = 163 uM Antagonism of N-ethylcarboxamido adenosine-stimulated adenylate cyclase associated with stimulation of Adenosine A2 receptor of rat PC12 membranes ChEMBL. 2213834
Ki (functional) = 163 uM Antagonism of N-ethylcarboxamido adenosine-stimulated adenylate cyclase associated with stimulation of Adenosine A2 receptor of rat PC12 membranes ChEMBL. 2213834

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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