Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1526 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0929 | 0.568 | 0.5989 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0929 | 0.568 | 0.5989 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1526 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1455 | 0.9484 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0442 | 0.2163 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1455 | 0.9484 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0146 | 0.0027 | 0.0028 |
Brugia malayi | dihydrofolate reductase family protein | 0.1455 | 0.9484 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1455 | 0.9484 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.6046 | 0.0962 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1455 | 0.9484 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1526 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1455 | 0.9484 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1455 | 0.9484 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1526 | 1 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0146 | 0.0027 | 0.0028 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0442 | 0.2163 | 0.2281 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1526 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0929 | 0.568 | 0.5989 |
Brugia malayi | Dihydrofolate reductase | 0.1455 | 0.9484 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0299 | 0.1132 | 0.5 |
Onchocerca volvulus | 0.0929 | 0.568 | 0.5 | |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0299 | 0.1132 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1455 | 0.9484 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0299 | 0.1132 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0146 | 0.0027 | 0.0028 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1455 | 0.9484 | 1 |
Brugia malayi | thymidylate synthase | 0.0929 | 0.568 | 0.4805 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0299 | 0.1132 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.