TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.811 | Formula: C17H11ClF2N4S
H donors: 2 H acceptors: 1 LogP: 4.59 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: S=C(Nc1c(F)cccc1F)N/N=C/c1cc2ccccc2nc1Cl
InChi: 1S/C17H11ClF2N4S/c18-16-11(8-10-4-1-2-7-14(10)22-16)9-21-24-17(25)23-15-12(19)5-3-6-13(15)20/h1-9H,(H2,23,24,25)/b21-9+
InChiKey: NZQLSFUJNZOQIR-ZVBGSRNCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0148	0.4656	1
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0016	0.0104	0.0047
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0197	0.0127
Entamoeba histolytica	hypothetical protein	0.0019	0.0197	0.0127
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0097	0.0168
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0047
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0035	0.0748	0.0916
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0035	0.0748	0.1453
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.023	0.7487	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0035	0.0748	0.1549
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0015	0.007	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.015	0.4734	1
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0015	0.007	0.0112
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0015	0.007	0.0112
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0949	0.0768
Brugia malayi	thymidylate synthase	0.0107	0.3233	0.4266
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0035	0.0748	0.1598
Onchocerca volvulus		0.0019	0.0197	0.0276
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.1076	0.1013
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0303	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0748	0.0916
Onchocerca volvulus		0.0019	0.0197	0.0276
Echinococcus multilocularis	lamin dm0	0.0028	0.0516	0.1058
Brugia malayi	Dihydrofolate reductase	0.0043	0.1053	0.1327
Brugia malayi	hypothetical protein	0.0051	0.1304	0.1664
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0035	0.0748	0.0999
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.015	0.4734	1
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0016	0.0104	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0197	0.0271
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0748	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0019	0.0197	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Onchocerca volvulus		0.0035	0.0748	0.1917
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0097	0.0129
Schistosoma mansoni	nAChR subunit	0.0016	0.0104	0.0072
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0035	0.0748	0.1549
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0035	0.0748	0.1598
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0094
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0035	0.0748	0.0999
Onchocerca volvulus		0.0028	0.0516	0.1227
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.1076	0.1013
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1273	0.17
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0197	0.0172
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0097	0.0038
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0197	0.0172
Echinococcus multilocularis	thymidylate synthase	0.0107	0.3233	0.6819
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0043	0.1053	0.1921
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0783	0.1623
Echinococcus multilocularis	nAChR subunit	0.0035	0.0748	0.1549
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2912	0.389
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Echinococcus multilocularis	nAChR subunit	0.0019	0.0197	0.038
Schistosoma mansoni	nAChR subunit	0.0035	0.0748	0.1453
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0748	0.0916
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0035	0.0748	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0453	0.0566
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0035	0.0748	0.0916
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0015	0.007	0.0094
Onchocerca volvulus		0.0028	0.0516	0.1227
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0197	0.0127
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0197	0.5
Brugia malayi	follicle stimulating hormone receptor	0.023	0.7487	1
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0107	0.3233	0.6051
Brugia malayi	excitatory GABA receptor EXP-1A	0.0035	0.0748	0.0916
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0453	0.0566
Treponema pallidum	fructose-bisphosphate aldolase	0.0303	1	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.015	0.4734	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0035	0.0748	0.0916
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0748	0.0916
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.1076	0.2316
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0097	0.0129
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0702	0.0636
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.015	0.4733	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Mycobacterium ulcerans	thymidylate synthase	0.0107	0.3233	0.681
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0949	0.0885
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0015	0.007	0.0002
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0016	0.0104	0.0139
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0035	0.0748	0.1598
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.1076	0.1938
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0035	0.0748	0.1549
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0035	0.0748	0.0999
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0057
Leishmania major	hypothetical protein, conserved	0.0026	0.0453	0.0566
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0148	0.4656	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.1076	0.1938
Schistosoma mansoni	ap endonuclease	0.0019	0.0197	0.0271
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0047
Onchocerca volvulus	Putative nachr subunit	0.0035	0.0748	0.1917
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0035	0.0748	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0729	0.0973
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0057
Brugia malayi	Cation transporter family protein	0.0113	0.3464	0.4577
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0453	0.0566
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0453	0.0566
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0107	0.3233	0.681
Echinococcus multilocularis	lamin	0.0028	0.0516	0.1058
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0035	0.0748	0.1598
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0197	0.0392
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0104	0.0047
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0035	0.0748	0.1549
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0035	0.0748	0.1549
Brugia malayi	hypothetical protein	0.0017	0.0134	0.0088
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0051	0.1304	0.2439
Echinococcus granulosus	thymidylate synthase	0.0107	0.3233	0.7036
Schistosoma mansoni	nAChR subunit	0.0016	0.0104	0.0072
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0035	0.0748	0.1549
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0069	0.0092
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0016	0.0104	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0035	0.0748	0.1598
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0949	0.1658
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0015	0.007	0.0112
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0035	0.0748	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0453	0.0566
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0097	0.0173
Schistosoma mansoni	dihydrofolate reductase	0.0043	0.1053	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0035	0.0748	0.0916
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0016	0.0104	0.0047
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0748	0.0916
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0016	0.0104	0.0139
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0148	0.4656	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0729	0.1411
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.1304	0.1242
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0047
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1273	0.1623
Loa Loa (eye worm)	GABA receptor subunit	0.0019	0.0197	0.0263
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0035	0.0748	0.1598
Schistosoma mansoni	neurotransmitter gated ion channel	0.0016	0.0104	0.0072
Echinococcus multilocularis	glycine receptor subunit beta	0.0035	0.0748	0.1549
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0783	0.0963
Echinococcus multilocularis	musashi	0.0028	0.0516	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Chlamydia trachomatis	dihydrofolate reductase	0.0043	0.1053	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.015	0.4734	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.1076	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0015	0.007	0.0116
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0035	0.0748	0.1598
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0035	0.0748	0.1453
Mycobacterium tuberculosis	Hypothetical protein	0.0051	0.1304	0.2482
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Schistosoma mansoni	nAChR subunit	0.0035	0.0748	0.1453
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.015	0.4734	1
Echinococcus granulosus	lamin dm0	0.0028	0.0516	0.1091
Echinococcus multilocularis	glycine receptor subunit beta	0.0035	0.0748	0.1549
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0097	0.0168
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0035	0.0748	0.0916
Schistosoma mansoni	neurotransmitter gated ion channel	0.0016	0.0104	0.0072
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0035	0.0748	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0729	0.0889
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0783	0.1675
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0035	0.0748	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0516	0.069
Echinococcus granulosus	lamin	0.0028	0.0516	0.1091
Loa Loa (eye worm)	dihydrofolate reductase	0.0043	0.1053	0.1407
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0097	0.0168
Echinococcus granulosus	nAChR subunit	0.0035	0.0748	0.1598
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0263
Onchocerca volvulus		0.0113	0.3464	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0015	0.007	0.0002
Schistosoma mansoni	nAChR subunit	0.0035	0.0748	0.1453
Onchocerca volvulus		0.0107	0.3233	0.9314
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0047
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0097	0.0173
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0197	0.038
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0035	0.0748	0.1549
Brugia malayi	Cation transporter family protein	0.0035	0.0748	0.0916
Echinococcus multilocularis	dihydrofolate reductase	0.0043	0.1053	0.2196
Loa Loa (eye worm)	thymidylate synthase	0.0107	0.3233	0.4319
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0097	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0035	0.0748	0.1598
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0047
Echinococcus granulosus	glycine receptor subunit beta	0.0035	0.0748	0.1598
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0016	0.0104	0.0072
Giardia lamblia	Fructose-bisphosphate aldolase	0.0303	1	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0019	0.0197	0.0271
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1273	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Onchocerca volvulus		0.0113	0.3464	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Loa Loa (eye worm)	acetylcholine receptor protein	0.0016	0.0104	0.0139
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0104	0.0047
Onchocerca volvulus		0.0035	0.0748	0.1917
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0057
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0197	0.0127
Loa Loa (eye worm)	ACC-1 protein	0.0035	0.0748	0.0999
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0113	0.3464	0.7277
Loa Loa (eye worm)	ACC-1 protein	0.0035	0.0748	0.0999
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0107	0.3233	0.6783
Loa Loa (eye worm)	LGC-31 protein	0.0035	0.0748	0.0999
Schistosoma mansoni	nAChR subunit	0.0035	0.0748	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3464	0.4627
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0018	0.0024
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0035	0.0748	0.1549
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0043	0.1053	0.1921
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0516	0.069
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0015	0.007	0.0116
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0035	0.0748	0.1598
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0516	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0499	0.0666
Schistosoma mansoni	nAChR subunit	0.0035	0.0748	0.1453
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0516	0.0603
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0702	0.0636
Brugia malayi	dihydrofolate reductase family protein	0.0043	0.1053	0.1327
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0516	0.069
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3464	0.4627
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0453	0.0566
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0783	0.1046
Echinococcus granulosus	glycine receptor subunit beta	0.0035	0.0748	0.1598
Echinococcus granulosus	nAChR subunit	0.0019	0.0197	0.0392
Brugia malayi	acetyltransferase, GNAT family protein	0.015	0.4733	0.6288
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0035	0.0748	0.1598
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0019	0.0197	0.0172
Loa Loa (eye worm)	hypothetical protein	0.005	0.1273	0.17
Brugia malayi	hypothetical protein	0.0026	0.0453	0.0519
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0035	0.0748	0.1453
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0896	0.1771
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0197	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0453	0.0606
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.015	0.4733	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0035	0.0748	0.0999
Onchocerca volvulus		0.0035	0.0748	0.1917
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0035	0.0748	0.1598
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0748	0.0916
Brugia malayi	Cation transporter family protein	0.0035	0.0748	0.0916
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0453	0.0566
Loa Loa (eye worm)	acetyltransferase	0.015	0.4733	0.6323
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0015	0.007	0.0094
Schistosoma mansoni	nAChR subunit	0.0035	0.0748	0.1453
Onchocerca volvulus		0.0113	0.3464	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0035	0.0748	0.1549
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0197	0.0263
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0016	0.0104	0.0183
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0016	0.0104	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0094
Schistosoma mansoni	nAChR subunit	0.0035	0.0748	0.1453
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0035	0.0748	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0094
Schistosoma mansoni	lamin	0.0028	0.0516	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Schistosoma mansoni	acetylcholine receptor-related	0.0016	0.0104	0.0072
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.015	0.4734	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	1	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0097	0.0173
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0035	0.0748	0.1549
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0019	0.0197	0.0172
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0016	0.0104	0.0183
Echinococcus granulosus	intermediate filament protein	0.0028	0.0516	0.1091
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0146	0.4588	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0104	0.0047
Brugia malayi	intermediate filament protein	0.0028	0.0516	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0139
Schistosoma mansoni	ap endonuclease	0.0019	0.0197	0.0271
Schistosoma mansoni	lamin	0.0028	0.0516	0.0956
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0113	0.3464	0.7277
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0748	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0621	0.0829
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0016	0.0104	0.0183
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0035	0.0748	0.0999
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0896	0.1771
Echinococcus granulosus	dihydrofolate reductase	0.0043	0.1053	0.2266
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0015	0.007	0.0002
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0035	0.0748	0.0916

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 10.13 mm	Antibacterial activity against Escherichia coli measured at MIC after 18 hrs by halo zone test	ChEMBL.	21530014
MIC (functional)	= 64 ug ml-1	Antibacterial activity against Escherichia coli after 18 hrs by macro-dilution test	ChEMBL.	21530014

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1801980

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1570133