Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0323 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0323 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0323 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0323 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0323 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5576 | 0.5576 |
Echinococcus multilocularis | acetylcholinesterase | 0.0323 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5576 | 0.5576 |
Echinococcus granulosus | geminin | 0.0205 | 0.5576 | 0.5576 |
Echinococcus multilocularis | geminin | 0.0205 | 0.5576 | 0.5576 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0323 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0323 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0323 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2311 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.