Detailed information for compound 157067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.536 | Formula: C27H29N3O6
  • H donors: 3 H acceptors: 6 LogP: 0.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2c(C1)cc1c(c2)onc1CCC1CCN(CC1)Cc1ccccc1.OC(=O)/C=C\C(=O)O
  • InChi: 1S/C23H25N3O2.C4H4O4/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17;5-3(6)1-2-4(7)8/h1-5,12,14,16H,6-11,13,15H2,(H,24,27);1-2H,(H,5,6)(H,7,8)/b;2-1-
  • InChiKey: CTYSKGVFLJLGGX-BTJKTKAUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0004
Schistosoma mansoni chromatin regulatory protein sir2 0.0106 0.008 0.008
Echinococcus multilocularis neuroendocrine convertase 2 0.5903 0.6306 0.7883
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Brugia malayi pregnancy-associated plasma protein-A 0.0038 0.0006 0.0006
Brugia malayi Muscle positioning protein 4 0.0041 0.001 0.001
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.0142 0.0142
Echinococcus multilocularis C type lectin domian containing protein 0.0038 0.0006 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0067 0.0037 0.0458
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0013 0.0013
Loa Loa (eye worm) Carm1-pending protein 0.0111 0.0085 0.0085
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0308 0.0296 0.3999
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0005 0.0005
Brugia malayi hypothetical protein 0.0037 0.0006 0.0006
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0111 0.0085 0.0106
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0054 0.0024 0.0024
Brugia malayi Angiotensin-converting enzyme family protein 0.0681 0.0698 0.0698
Brugia malayi Stress-activated protein kinase jnk-1 0.0227 0.0209 0.0209
Schistosoma mansoni protein kinase 0.0258 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0037 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0001
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0411 0.0408 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.0032 0.0317
Toxoplasma gondii SWIRM domain-containing protein 0.005 0.0019 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.0408 0.0668
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0722 0.0741 0.1215
Schistosoma mansoni hypothetical protein 0.0054 0.0024 0.0024
Brugia malayi hypothetical protein 0.0038 0.0006 0.0006
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.0001 0.0001
Schistosoma mansoni site-1 peptidase (S08 family) 0.0411 0.0408 0.0408
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0103 0.0076 0.0076
Schistosoma mansoni protein kinase 0.0258 0.0242 0.0242
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0722 0.0741 0.0741
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0722 0.0741 1
Schistosoma mansoni hypothetical protein 0.0054 0.0024 0.0024
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0111 0.0085 0.0889
Trypanosoma cruzi subtilisin peptidase 0.0411 0.0408 0.537
Toxoplasma gondii aspartyl protease 0.0037 0.0006 0.0139
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Schistosoma mansoni amine oxidase 0.012 0.0094 0.0094
Echinococcus multilocularis integrin beta 2 0.0935 0.097 0.1212
Giardia lamblia Furin precursor putative serine protease 0.1862 0.1965 0.5347
Mycobacterium ulcerans polyketide synthase Pks13 0.0116 0.0091 0.184
Loa Loa (eye worm) hypothetical protein 0.0164 0.0142 0.0142
Brugia malayi Protein arginine N-methyltransferase 0.0111 0.0085 0.0085
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0116 0.0091 0.2221
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0006 0.0006
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1862 0.1965 0.3222
Echinococcus granulosus furin 0.9341 1 1
Echinococcus multilocularis protein arginine methyltransferase 0.0197 0.0177 0.0221
Giardia lamblia Hypothetical protein 0.0722 0.0741 0.1983
Plasmodium falciparum subtilisin-like protease 3 0.0411 0.0408 0.9809
Echinococcus granulosus Tolloid protein 1 0.0062 0.0032 0.0032
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0042 0.001 0.001
Brugia malayi hypothetical protein 0.0038 0.0006 0.0006
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0054 0.0024 0.0029
Schistosoma mansoni hypothetical protein 0.0054 0.0024 0.0024
Plasmodium vivax LCCL domain-containing protein 0.0054 0.0024 0.0567
Brugia malayi Sushi domain 0.0038 0.0006 0.0006
Mycobacterium ulcerans NAD-dependent deacetylase 0.0106 0.008 0.1564
Brugia malayi hypothetical protein 0.0194 0.0174 0.0174
Entamoeba histolytica hypothetical protein, conserved 0.0106 0.008 0.1081
Echinococcus granulosus serine:threonine protein kinase N2 0.0077 0.0048 0.0048
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Plasmodium falciparum plasmepsin V 0.0419 0.0415 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0082 0.0054 0.1311
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0226 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0411 0.0408 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0106 0.008 0.1081
Echinococcus multilocularis discoidin domain containing receptor 2 0.0054 0.0024 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0046 0.0046
Onchocerca volvulus 0.0054 0.0024 0.0298
Toxoplasma gondii subtilisin SUB11 0.0411 0.0408 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0006 0.0006
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0021 0.0026
Echinococcus multilocularis chromatin regulatory protein sir2 0.0722 0.0741 0.0926
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5712 0.6101 0.7626
Plasmodium vivax hypothetical protein, conserved 0.0106 0.008 0.1927
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0062 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.0408 0.0668
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0021 0.0511
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0411 0.0408 0.0408
Echinococcus multilocularis 0.012 0.0094 0.0118
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0227 0.0209 0.0209
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0124 0.0124
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0036 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Plasmodium vivax subtilisin-like serine protease, putative 0.0411 0.0408 0.9809
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.0094 0.2311
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0077 0.0048 0.0748
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0258 0.0242 0.0242
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Loa Loa (eye worm) hypothetical protein 0.0042 0.001 0.001
Echinococcus granulosus integrin beta 2 0.0935 0.097 0.097
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0197 0.0177 0.0177
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0411 0.0408 0.0408
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Echinococcus granulosus protein arginine N methyltransferase 8 0.0197 0.0177 0.0177
Plasmodium falciparum apical sushi protein 0.0038 0.0006 0.0153
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0006 0.0137
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0077 0.0049 0.1189
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Loa Loa (eye worm) CUB domain-containing protein 0.0036 0.0004 0.0004
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.012 0.0094 0.2274
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Toxoplasma gondii histone deacetylase SIR2 0.0106 0.008 0.1965
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0447 0.0446 0.5905
Loa Loa (eye worm) hypothetical protein 0.004 0.0008 0.0008
Brugia malayi hypothetical protein 0.0036 0.0004 0.0004
Toxoplasma gondii F5/8 type C domain-containing protein 0.0054 0.0024 0.0578
Brugia malayi Carm1-pending protein 0.0111 0.0085 0.0085
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0411 0.0408 0.537
Brugia malayi transcriptional regulator, Sir2 family protein 0.0106 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0054 0.0024 0.0024
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0006 0.0137
Brugia malayi Protein kinase domain containing protein 0.0051 0.0021 0.0021
Toxoplasma gondii subtilisin SUB5 0.0411 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0004
Brugia malayi Kelch motif family protein 0.023 0.0213 0.0213
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0036 0.0004 0.0004
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0106 0.008 0.1081
Loa Loa (eye worm) hypothetical protein 0.0131 0.0107 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0054 0.0024 0.0039
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0681 0.0698 0.0698
Entamoeba histolytica hypothetical protein 0.0308 0.0296 0.3999
Onchocerca volvulus 0.0103 0.0076 0.1107
Echinococcus multilocularis discoidin domain receptor 0.0054 0.0024 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2273 0.2407 0.3946
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0261 0.0246 0.0246
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0027 0.0655
Mycobacterium ulcerans dehydrogenase 0.012 0.0094 0.1935
Loa Loa (eye worm) hypothetical protein 0.0157 0.0135 0.0135
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0197 0.0177 0.029
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Entamoeba histolytica protein kinase, putative 0.0033 0.0001 0.002
Brugia malayi Subtilase family protein 0.0411 0.0408 0.0408
Brugia malayi CUB domain containing protein 0.004 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0274 0.026 0.026
Schistosoma mansoni SWI/SNF complex-related 0.005 0.0019 0.0019
Plasmodium falciparum plasmepsin I 0.0037 0.0006 0.0137
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0075 0.0046 0.0046
Echinococcus multilocularis discoidin domain containing receptor 2 0.0054 0.0024 0.0029
Echinococcus multilocularis acetylcholinesterase 0.0164 0.0142 0.0177
Plasmodium vivax LCCL domain-containing protein 0.0054 0.0024 0.0567
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0054 0.0024 0.0039
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0006 0.0006
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0036 0.0004 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Echinococcus multilocularis protein will die slowly 0.0274 0.026 0.0326
Schistosoma mansoni growth factor receptor-bound protein 0.0261 0.0246 0.0246
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0039 0.0039
Brugia malayi Kringle domain containing protein 0.0051 0.0021 0.0021
Echinococcus granulosus Furin 1 0.2273 0.2407 0.2407
Onchocerca volvulus 0.0054 0.0024 0.0298
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0094 0.0066 0.0066
Echinococcus granulosus protein kinase c epsilon type 0.0094 0.0066 0.0066
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0036 0.0004 0.0004
Echinococcus granulosus discoidin domain containing receptor 2 0.0054 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Echinococcus granulosus c-Jun N-terminal kinases 0.0227 0.0209 0.0209
Toxoplasma gondii subtilisin SUB12 0.0411 0.0408 1
Loa Loa (eye worm) WD40 repeat protein 0.0274 0.026 0.026
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0009 0.0221
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0048 0.0748
Schistosoma mansoni hypothetical protein 0.0036 0.0004 0.0004
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.0054 0.0885
Toxoplasma gondii bicoid-interacting protein BIN3 0.0111 0.0085 0.2081
Schistosoma mansoni Lysine-specific histone demethylase 1 0.059 0.0599 0.0599
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0054 0.0024 0.0029
Echinococcus granulosus methyltransferase protein 5 0.0111 0.0085 0.0085
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0111 0.0085 0.0085
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0142 0.0142
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.008 0.0051 0.0051
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0048 0.118
Loa Loa (eye worm) hypothetical protein 0.0054 0.0024 0.0024
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0106 0.008 0.01
Schistosoma mansoni chromatin regulatory protein sir2 0.0722 0.0741 0.0741
Mycobacterium ulcerans monoamine oxidase 0.012 0.0094 0.1935
Onchocerca volvulus 0.0038 0.0006 0.0033
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0036 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Mycobacterium tuberculosis Possible oxidoreductase 0.012 0.0094 0.2311
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0722 0.0741 1
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0411 0.0408 0.0509
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0077 0.0048 0.0048
Schistosoma mansoni tyrosine kinase 0.0625 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0004
Echinococcus granulosus c4b binding protein beta chain 0.0038 0.0006 0.0006
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1862 0.1965 0.3222
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.0408 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Echinococcus granulosus acetylcholinesterase 0.0164 0.0142 0.0142
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0411 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.012 0.0094 0.0094
Echinococcus multilocularis integrin alpha ps 0.0066 0.0037 0.0046
Echinococcus granulosus discoidin domain containing receptor 2 0.0054 0.0024 0.0024
Brugia malayi NAD-dependent deacetylase SIRT1 0.0106 0.008 0.008
Mycobacterium ulcerans oxidoreductase 0.012 0.0094 0.1935
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0062 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.0048 0.0648
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0106 0.008 0.1081
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.0032 0.0317
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0227 0.0209 0.0261
Onchocerca volvulus 0.0139 0.0115 0.1706
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Schistosoma mansoni protein kinase 0.0258 0.0242 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0021 0.0021
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0111 0.0085 0.2081
Brugia malayi hypothetical protein 0.0103 0.0076 0.0076
Brugia malayi hypothetical protein 0.0038 0.0006 0.0006
Onchocerca volvulus Fatty acid synthase homolog 0.0144 0.012 0.1788
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0106 0.008 0.1958
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0197 0.0177 0.0177
Echinococcus multilocularis integrin alpha ps 0.0066 0.0037 0.0046
Echinococcus granulosus CUB 0.0036 0.0004 0.0004
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0111 0.0085 0.2081
Onchocerca volvulus 0.0037 0.0006 0.0022
Trichomonas vaginalis hypothetical protein 0.0054 0.0024 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Onchocerca volvulus 0.0063 0.0033 0.0449
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0077 0.0049 0.1189
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.012 0.0094 0.1935
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Brugia malayi Will die slowly protein 0.0274 0.026 0.026
Brugia malayi hypothetical protein 0.0038 0.0006 0.0006
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0258 0.0242 0.0303
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0411 0.0408 1
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0036 0.0004 0.0005
Schistosoma mansoni septate junction protein 0.0074 0.0045 0.0045
Schistosoma mansoni chromatin regulatory protein sir2 0.0106 0.008 0.008
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0033 0.0796
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.021 0.021
Echinococcus multilocularis membrane bound transcription factor site 1 0.0411 0.0408 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Brugia malayi hypothetical protein 0.0037 0.0006 0.0006
Brugia malayi Calcium binding EGF domain containing protein 0.0056 0.0025 0.0025
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0111 0.0085 0.0139
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Echinococcus multilocularis c4b binding protein beta chain 0.0038 0.0006 0.0008
Echinococcus granulosus expressed protein 0.0366 0.0359 0.0359
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0082 0.0054 0.0885
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0106 0.008 0.1081
Loa Loa (eye worm) fatty acid synthase 0.0079 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0004
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0036 0.0004 0.0004
Loa Loa (eye worm) transcriptional regulator 0.0106 0.008 0.008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0048 0.0748
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0004
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0411 0.0408 1
Echinococcus multilocularis Tolloid protein 1 0.0062 0.0032 0.004
Plasmodium vivax aspartyl protease, putative 0.0037 0.0006 0.0137
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0411 0.0408 1
Brugia malayi CUB domain containing protein 0.0036 0.0004 0.0004
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0116 0.0091 0.2221
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0054 0.0024 0.0024
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0027 0.0661
Brugia malayi proprotein convertase 2 0.5903 0.6306 0.6306
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Trypanosoma brucei subtilisin peptidase 0.0411 0.0408 0.55
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0077 0.0048 0.118
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0021 0.0501
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.0032 0.0317
Schistosoma mansoni c4b-binding protein beta chain 0.0038 0.0006 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0106 0.008 0.008
Echinococcus multilocularis adam 0.0087 0.0059 0.0074
Schistosoma mansoni hypothetical protein 0.0111 0.0085 0.0085
Echinococcus granulosus acetylcholinesterase 0.0164 0.0142 0.0142
Brugia malayi CUB domain containing protein 0.0036 0.0004 0.0004
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0106 0.008 0.01
Toxoplasma gondii type I fatty acid synthase, putative 0.0082 0.0054 0.1318
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0411 0.0408 1
Echinococcus granulosus protein will die slowly 0.0274 0.026 0.026
Leishmania major UDP-galactopyranose mutase 0.012 0.0094 0.1275
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0106 0.008 0.1927
Onchocerca volvulus 0.0037 0.0006 0.0022
Plasmodium vivax apical sushi protein, putative 0.0038 0.0006 0.0153
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0111 0.0085 0.1145
Mycobacterium ulcerans Sir2-like regulatory protein 0.0106 0.008 0.1564
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1862 0.1965 0.3222
Loa Loa (eye worm) proprotein convertase 2 0.2273 0.2407 0.2407
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0006 0.0137
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.012 0.0094 0.1935
Echinococcus granulosus cubilin 0.0036 0.0004 0.0004
Schistosoma mansoni btb and poz domain-containing protein 0.0054 0.0024 0.0024
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0197 0.0177 0.4264
Plasmodium vivax subtilisin-like protease 2, putative 0.0411 0.0408 0.9809
Plasmodium falciparum plasmepsin III 0.0037 0.0006 0.0137
Loa Loa (eye worm) hypothetical protein 0.005 0.0019 0.0019
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0038 0.0006 0.0006
Toxoplasma gondii subtilisin SUB9 0.0411 0.0408 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0197 0.0177 0.029
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2273 0.2407 0.3946
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.012 0.0094 0.1935
Loa Loa (eye worm) hypothetical protein 0.012 0.0094 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0054 0.0024 0.0108
Onchocerca volvulus 0.0038 0.0006 0.0033
Echinococcus granulosus discoidin domain containing receptor 2 0.0054 0.0024 0.0024
Loa Loa (eye worm) transcriptional regulator 0.0722 0.0741 0.0741
Loa Loa (eye worm) TK/EGFR protein kinase 0.0625 0.0637 0.0637
Echinococcus granulosus cubilin 0.0036 0.0004 0.0004
Toxoplasma gondii subtilisin SUB7 0.0411 0.0408 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0054 0.0024 0.0024
Mycobacterium ulcerans protoporphyrinogen oxidase 0.012 0.0094 0.1935
Brugia malayi hypothetical protein 0.012 0.0094 0.0094
Echinococcus granulosus protein arginine methyltransferase 0.0197 0.0177 0.0177
Echinococcus multilocularis cubilin 0.0036 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0103 0.0076 0.0076
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0722 0.0741 1
Brugia malayi Nematode astacin protease protein 30 0.0036 0.0004 0.0004
Plasmodium vivax protoporphyrinogen oxidase, putative 0.012 0.0094 0.2274
Onchocerca volvulus Putative cubilin 0.0056 0.0025 0.0326
Toxoplasma gondii subtilisin SUB4 0.0411 0.0408 1
Plasmodium falciparum plasmepsin IX 0.0037 0.0006 0.0137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.012 0.0094 0.2318
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0722 0.0741 0.1215
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0106 0.008 0.0823
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0054 0.0024 0.0024
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1339 0.1404 0.1404
Echinococcus granulosus membrane bound transcription factor site 1 0.0411 0.0408 0.0408
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0024 0.0024
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0036 0.0004 0.0004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0048 0.0748
Mycobacterium ulcerans thioesterase TesA 0.0067 0.0037 0.0458
Schistosoma mansoni hypothetical protein 0.0036 0.0004 0.0004
Brugia malayi Lectin C-type domain containing protein 0.0036 0.0004 0.0004
Schistosoma mansoni integrin alpha-ps 0.0066 0.0037 0.0037
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0014 0.0346
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0111 0.0085 0.1145
Schistosoma mansoni integrin alpha-ps 0.0034 0.0003 0.0003
Onchocerca volvulus 0.0274 0.026 0.3949
Onchocerca volvulus 0.0171 0.0149 0.2237
Loa Loa (eye worm) transcriptional regulator 0.0106 0.008 0.008
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5712 0.6101 0.6101
Loa Loa (eye worm) hypothetical protein 0.0164 0.0142 0.0142
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.012 0.0094 0.2274
Loa Loa (eye worm) hypothetical protein 0.0116 0.009 0.009
Brugia malayi SWIRM domain containing protein 0.064 0.0653 0.0653
Loa Loa (eye worm) hypothetical protein 0.0037 0.0006 0.0006
Toxoplasma gondii F5/8 type C domain-containing protein 0.0054 0.0024 0.0578
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0035 0.0035
Echinococcus granulosus MAM 0.0103 0.0076 0.0076
Schistosoma mansoni integrin beta subunit 0.0741 0.0761 0.0761
Brugia malayi CUB domain containing protein 0.0036 0.0004 0.0004
Loa Loa (eye worm) endoprotease bli-4 0.9341 1 1
Toxoplasma gondii subtilisin SUB10 0.0411 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Toxoplasma gondii histone deacetylase SIR2-like 0.0106 0.008 0.1965
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0111 0.0085 0.0139
Brugia malayi Pepsin A precursor 0.0037 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0106 0.008 0.008
Loa Loa (eye worm) TK/ALK protein kinase 0.0103 0.0076 0.0076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2273 0.2407 0.3946
Chlamydia trachomatis protoporphyrinogen oxidase 0.012 0.0094 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Schistosoma mansoni furin-1 (S08 family) 0.4041 0.4306 0.4306
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0021 0.0501
Schistosoma mansoni apoptosis regulator bax 0.0054 0.0024 0.0024
Echinococcus multilocularis protoporphyrinogen oxidase 0.012 0.0094 0.0118
Loa Loa (eye worm) integrin beta-2 0.1266 0.1326 0.1326
Echinococcus multilocularis serine:threonine protein kinase N2 0.0086 0.0058 0.0072
Onchocerca volvulus 0.0038 0.0006 0.0033
Mycobacterium ulcerans polyketide synthase 0.0082 0.0054 0.0885
Loa Loa (eye worm) sirtuin 4 0.0106 0.008 0.008
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0036 0.0004 0.0004
Leishmania major sir2-family protein-like protein 0.0106 0.008 0.1081
Schistosoma mansoni amine oxidase 0.012 0.0094 0.0094
Echinococcus granulosus integrin alpha 3 0.0113 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0082 0.0053 0.0053
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.005 0.0019 0.0024
Onchocerca volvulus 0.0038 0.0006 0.0033
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0013 0.0013
Brugia malayi astacin protease protein 30 0.0036 0.0004 0.0004
Toxoplasma gondii rhoptry neck protein RON1 0.0038 0.0006 0.0156
Echinococcus granulosus C type lectin domian containing protein 0.0038 0.0006 0.0006
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0226 0.0208 0.0208
Plasmodium falciparum plasmepsin X 0.0037 0.0006 0.0137
Brugia malayi amine oxidase, flavin-containing family protein 0.017 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0044 0.0013 0.0013
Entamoeba histolytica SWIRM domain protein 0.005 0.0019 0.026
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0111 0.0085 0.0139
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.0054 0.0885
Plasmodium vivax aspartyl protease, putative 0.0037 0.0006 0.0137
Brugia malayi protein kinase C II. 0.0094 0.0066 0.0066
Plasmodium falciparum plasmepsin IV 0.0037 0.0006 0.0137
Plasmodium falciparum plasmepsin II 0.0037 0.0006 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0032
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0722 0.0741 1
Mycobacterium ulcerans polyketide synthase 0.0077 0.0048 0.0748
Plasmodium vivax plasmepsin V, putative 0.0419 0.0415 1
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0411 0.0408 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Leishmania major subtilisin-like serine peptidase 0.0411 0.0408 0.55
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0197 0.0177 0.029
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0006 0.0137
Plasmodium falciparum LCCL domain-containing protein 0.0054 0.0024 0.0567
Plasmodium falciparum LCCL domain-containing protein 0.0054 0.0024 0.0567
Schistosoma mansoni hypothetical protein 0.1862 0.1965 0.1965
Echinococcus granulosus integrin alpha ps 0.0066 0.0037 0.0037
Trypanosoma brucei SIR2-like protein 4, putative 0.0106 0.008 0.1081
Trichomonas vaginalis hypothetical protein 0.1862 0.1965 0.3222
Toxoplasma gondii rhoptry neck protein RON9 0.0038 0.0006 0.0156
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0006 0.0006
Toxoplasma gondii F5/8 type C domain-containing protein 0.0054 0.0024 0.0578
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2273 0.2407 0.3946
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.0408 0.0668
Mycobacterium leprae Polyketide synthase Pks13 0.0116 0.0091 0.184
Toxoplasma gondii histone lysine-specific demethylase 0.012 0.0094 0.2318
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0106 0.008 0.1927
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0082 0.0054 0.0885
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Echinococcus granulosus adam 0.0087 0.0059 0.0059
Brugia malayi Carboxylesterase family protein 0.0164 0.0142 0.0142
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0054 0.0024 0.0029
Echinococcus multilocularis epidermal growth factor receptor 0.0625 0.0637 0.0797
Echinococcus multilocularis growth factor receptor bound protein 2 0.0261 0.0246 0.0307
Echinococcus multilocularis cubilin 0.0036 0.0004 0.0005
Onchocerca volvulus 0.0075 0.0046 0.0641
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0077 0.0048 0.0748
Onchocerca volvulus 0.0038 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.9341 1 1
Brugia malayi hypothetical protein 0.0038 0.0006 0.0006
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0006 0.0006
Echinococcus multilocularis MAM 0.0103 0.0076 0.0095
Brugia malayi Integrin beta pat-3 precursor 0.1266 0.1326 0.1326
Plasmodium vivax hypothetical protein, conserved 0.012 0.0094 0.2274
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Brugia malayi neuroendocrine convertase 1 precursor 0.5903 0.6306 0.6306
Loa Loa (eye worm) hypothetical protein 0.0194 0.0174 0.0174
Leishmania major hypothetical protein, conserved 0.0051 0.0021 0.0281
Loa Loa (eye worm) DPY-31 protein 0.0036 0.0004 0.0004
Loa Loa (eye worm) CUB domain-containing protein 0.0036 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0106 0.008 0.0167
Onchocerca volvulus 0.0038 0.0006 0.0033
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0197 0.0177 0.0177
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0054 0.0024 0.0569
Plasmodium vivax subtilisin-like protease 1 0.0411 0.0408 0.9809
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.0001 0.0001
Schistosoma mansoni dock 0.0054 0.0024 0.0024
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0243 0.0227 0.0227
Echinococcus granulosus lysine specific histone demethylase 1A 0.012 0.0094 0.0094
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0148 0.0125 0.0125
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0675 0.0691 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Echinococcus granulosus chromatin regulatory protein sir2 0.0722 0.0741 0.0741
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.012 0.0094 0.2274
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0197 0.0177 0.4347
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0111 0.0085 0.0889
Loa Loa (eye worm) subtilase 0.0411 0.0408 0.0408
Onchocerca volvulus 0.0103 0.0076 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Toxoplasma gondii aspartyl protease ASP5 0.0382 0.0376 0.9214
Schistosoma mansoni integrin alpha 0.0148 0.0124 0.0124
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Entamoeba histolytica hypothetical protein 0.005 0.0019 0.026
Trichomonas vaginalis WD repeat domain, putative 0.0274 0.026 0.0427
Brugia malayi Carboxylesterase family protein 0.0164 0.0142 0.0142
Echinococcus granulosus protein arginine N methyltransferase 7 0.0111 0.0085 0.0085
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0197 0.0177 0.4264
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Schistosoma mansoni growth factor receptor-bound protein 0.0261 0.0246 0.0246
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0111 0.0085 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Onchocerca volvulus 0.0411 0.0408 0.6216
Onchocerca volvulus 0.0038 0.0006 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Plasmodium falciparum subtilisin-like protease 2 0.0411 0.0408 0.9809
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0411 0.0408 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.0054 0.1311
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0411 0.0408 1
Brugia malayi CUB domain containing protein 0.0036 0.0004 0.0004
Giardia lamblia High cysteine membrane protein Group 2 0.3439 0.3659 1
Echinococcus granulosus neuroendocrine convertase 2 0.5903 0.6306 0.6306
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0447 0.0446 0.602
Echinococcus granulosus discoidin domain receptor 0.0054 0.0024 0.0024
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0308 0.0296 0.3825
Brugia malayi Furin-like cysteine rich region family protein 0.0625 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.059 0.0599 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0411 0.0408 1
Schistosoma mansoni hypothetical protein 0.0103 0.0076 0.0076
Loa Loa (eye worm) kelch domain-containing protein family protein 0.023 0.0213 0.0213
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0106 0.008 0.0131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Plasmodium falciparum protoporphyrinogen oxidase 0.012 0.0094 0.2274
Leishmania major arginine N-methyltransferase, type I 0.0111 0.0085 0.1145
Loa Loa (eye worm) hypothetical protein 0.0034 0.0003 0.0003
Echinococcus granulosus lysine specific histone demethylase 1A 0.059 0.0599 0.0599
Toxoplasma gondii subtilisin SUB2 0.0411 0.0408 1
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0308 0.0296 0.3999
Brugia malayi GCC2 and GCC3 family protein 0.0058 0.0028 0.0028
Schistosoma mansoni chromatin regulatory protein sir2 0.0106 0.008 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5712 0.6101 1
Plasmodium vivax hypothetical protein, conserved 0.012 0.0094 0.2274
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0106 0.008 0.008
Onchocerca volvulus 0.064 0.0653 1
Loa Loa (eye worm) hypothetical protein 0.064 0.0653 0.0653
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0111 0.0085 0.0889
Echinococcus multilocularis lysine specific histone demethylase 1A 0.059 0.0599 0.0749
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2273 0.2407 0.2407
Loa Loa (eye worm) hypothetical protein 0.0042 0.001 0.001
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0106 0.008 0.0823
Mycobacterium leprae Possible secreted protease 0.0411 0.0408 1
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0411 0.0408 0.0408
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0006 0.0009
Giardia lamblia Transcriptional regulator, Sir2 family 0.0106 0.008 0.0167
Loa Loa (eye worm) hypothetical protein 0.0308 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.059 0.0599 0.0599
Toxoplasma gondii subtilisin SUB8 0.0411 0.0408 1
Plasmodium vivax aspartyl protease, putative 0.0037 0.0006 0.0137
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0006 0.0006
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.012 0.0094 0.0094
Brugia malayi Sex muscle abnormal protein 5 0.0261 0.0246 0.0246
Brugia malayi hypothetical protein 0.0038 0.0006 0.0006
Schistosoma mansoni site-1 peptidase (S08 family) 0.0411 0.0408 0.0408
Schistosoma mansoni protein arginine n-methyltransferase 0.0111 0.0085 0.0085
Echinococcus granulosus growth factor receptor bound protein 2 0.0261 0.0246 0.0246
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.0142 0.0177
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0004
Echinococcus multilocularis acetylcholinesterase 0.0164 0.0142 0.0177
Entamoeba histolytica SWIRM domain protein 0.005 0.0019 0.026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0021 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Schistosoma mansoni hypothetical protein 0.0036 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5712 0.6101 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0048 0.0748
Loa Loa (eye worm) carboxylesterase 0.0164 0.0142 0.0142
Echinococcus multilocularis protein kinase c epsilon type 0.0094 0.0066 0.0083
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0056 0.0025 0.0025
Echinococcus granulosus epidermal growth factor receptor 0.0625 0.0637 0.0637
Brugia malayi hypothetical protein 0.0058 0.0028 0.0028
Echinococcus multilocularis 0.748 0.8 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.012 0.0094 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Brugia malayi SWIRM domain containing protein 0.005 0.0019 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Giardia lamblia Sirtuin type 2 0.0106 0.008 0.0167
Onchocerca volvulus 0.0051 0.0021 0.0256
Brugia malayi Protein kinase domain containing protein 0.0103 0.0076 0.0076
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0075 0.0046 0.1116
Echinococcus multilocularis CUB 0.0036 0.0004 0.0005
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.005 0.0019 0.0019
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0082 0.0054 0.1311
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0021 0.0021
Brugia malayi hypothetical protein 0.0308 0.0296 0.0296
Schistosoma mansoni discoidin domain receptor 0.0054 0.0024 0.0024
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0013 0.0016
Echinococcus multilocularis expressed protein 0.0366 0.0359 0.0449
Onchocerca volvulus 0.0038 0.0006 0.0033
Leishmania major silent information regulator 2, putative 0.0722 0.0741 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0722 0.0741 0.0741
Plasmodium falciparum subtilisin-like protease 1 0.0411 0.0408 0.9809
Schistosoma mansoni hypothetical protein 0.0036 0.0004 0.0004
Mycobacterium tuberculosis Probable thioesterase TesA 0.0067 0.0037 0.0903
Brugia malayi Nematode astacin protease protein 30 0.0036 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0058 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Plasmodium falciparum plasmepsin VI 0.0037 0.0006 0.0137
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0062 0.0032 0.0032
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0006 0.0139
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0722 0.0741 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0106 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.0103 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.0408 0.0668
Loa Loa (eye worm) hypothetical protein 0.017 0.0148 0.0148
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.9341 1 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.0054 0.0024 0.0029
Schistosoma mansoni discoidin domain receptor 0.0054 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Brugia malayi celfurPC protein 0.748 0.8 0.8
Brugia malayi transcriptional regulator, Sir2 family protein 0.0106 0.008 0.008
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0106 0.008 0.008
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0006 0.0006
Onchocerca volvulus 0.0038 0.0006 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0032
Echinococcus multilocularis fibrillin 1 0.0058 0.0028 0.0034
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0111 0.0085 0.0889
Toxoplasma gondii subtilisin SUB1 0.0411 0.0408 1
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0111 0.0085 0.1145
Mycobacterium leprae Probable polyketide synthase Pks1 0.0082 0.0054 0.0885
Toxoplasma gondii PA14 domain-containing protein 0.0054 0.0024 0.0578
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0106 0.008 0.008
Brugia malayi transcriptional regulator, Sir2 family protein 0.0722 0.0741 0.0741
Schistosoma mansoni hypothetical protein 0.0036 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0006 0.0006
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0308 0.0296 0.3825
Echinococcus multilocularis Furin 1 0.2273 0.2407 0.3009
Brugia malayi Protein kinase domain containing protein 0.0054 0.0024 0.0024
Schistosoma mansoni chromatin regulatory protein sir2 0.0722 0.0741 0.0741
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0086 0.0086
Toxoplasma gondii subtilisin SUB6 0.0411 0.0408 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2273 0.2407 0.3946
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0006 0.0139
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0111 0.0085 0.0085
Echinococcus multilocularis integrin alpha 3 0.0113 0.0087 0.0109
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0675 0.0691 0.0864
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2273 0.2407 0.3946
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0006 0.0139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Loa Loa (eye worm) reprolysin 0.0044 0.0013 0.0013
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0077 0.0048 0.118
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0021 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.363 0.3865 0.3865
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0024 0.0039
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0197 0.0177 0.0221
Schistosoma mansoni hypothetical protein 0.0051 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0011 0.0011
Echinococcus granulosus carboxylesterase 5A 0.0164 0.0142 0.0142
Plasmodium falciparum plasmepsin VII 0.0037 0.0006 0.0137
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0411 0.0408 0.0408
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.0209 0.0209
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0054 0.0024 0.0039
Plasmodium vivax NAD-dependent deacetylase, putative 0.0106 0.008 0.1927
Leishmania major arginine N-methyltransferase-like protein 0.0197 0.0177 0.2391
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0066 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0411 0.0408 0.0668
Mycobacterium ulcerans thioesterase 0.0067 0.0037 0.0458
Loa Loa (eye worm) apoptosis regulator protein 0.0054 0.0024 0.0024
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0447 0.0446 0.5905
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0722 0.0741 0.0926
Loa Loa (eye worm) hypothetical protein 0.0103 0.0076 0.0076
Trypanosoma cruzi UDP-galactopyranose mutase 0.012 0.0094 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.1862 0.1965 0.3222
Brugia malayi hypothetical protein 0.0038 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0054 0.0024 0.0024
Onchocerca volvulus 0.0038 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0028
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0006 0.0139

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.4 mg kg-1 ED50 for extracellular ACh is presented as the dose that produced a 200% increase in the area under curve over basal accumulation during the 3h after drug administration. ChEMBL. 7636841
ED50 (functional) = 26 mg kg-1 ED50 for salivation was defined as the dose required to produce a level 2 rating on a 0-4 point scale after treatment. ChEMBL. 7636841
IC50 (binding) = 0.33 nM In vitro inhibition of Acetylcholinesterase from human erythrocytes ChEMBL. 7636841
IC50 (binding) = 0.33 nM In vitro inhibition of Acetylcholinesterase from human erythrocytes ChEMBL. 7636841
IC50 (binding) = 7200 nM In vitro inhibition of Butyrylcholinesterase from human erythrocytes ChEMBL. 7636841
IC50 (binding) = 7200 nM In vitro inhibition of Butyrylcholinesterase from human erythrocytes ChEMBL. 7636841
LD50 (ADMET) = 42 mg kg-1 LD50 for actute lethality is defined as the dose that resulted in the death of 50% of the animals 1 hr after treatment. ChEMBL. 7636841
Ratio (binding) = 23000 Ratio of the inhibitory concentrations of the compound against BuChE and AChE ChEMBL. 7636841
Safety index (functional) = 105 Safety index is the ratio of acute lethality LD50 to extracellular AchE ED50. ChEMBL. 7636841
Selectivity index (functional) = 65 Selectivity index is the ratio of salivation ED50 to extracellular AchE ED50. ChEMBL. 7636841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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