Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.1153 | 0.1271 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0296 | 0.0296 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0473 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0296 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.1153 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.1153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7043 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0846 | 0.0846 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.068 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0668 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.1153 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0976 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0296 | 0.0296 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8356 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.