Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0519 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0386 | 0.6782 | 0.6753 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0519 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0399 | 0.7109 | 0.6537 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0412 | 0.743 | 0.7408 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0174 | 0.1652 | 0.1579 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0412 | 0.743 | 0.7408 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.028 | 0.4222 | 0.4171 |
Loa Loa (eye worm) | hypothetical protein | 0.0399 | 0.7109 | 0.7109 |
Echinococcus multilocularis | fk506 binding protein | 0.0463 | 0.8652 | 0.8385 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0463 | 0.8652 | 0.864 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0519 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0463 | 0.8652 | 0.8385 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.028 | 0.4212 | 0.4161 |
Trichomonas vaginalis | immunophilin, putative | 0.0463 | 0.8652 | 0.864 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0463 | 0.8652 | 0.8385 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0463 | 0.8652 | 0.8385 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0245 | 0.338 | 0.207 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0337 | 0.5594 | 0.5555 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0413 | 0.7441 | 0.6934 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0174 | 0.1652 | 0.1579 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0386 | 0.6782 | 0.6753 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0174 | 0.1652 | 0.1579 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0412 | 0.743 | 0.7408 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0386 | 0.6782 | 0.6753 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0413 | 0.7441 | 0.6934 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0463 | 0.8652 | 0.8385 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0463 | 0.8652 | 0.8385 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0519 | 1 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0463 | 0.8652 | 0.5 |
Giardia lamblia | GTOR | 0.0519 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0463 | 0.8652 | 0.8385 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0463 | 0.8652 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0463 | 0.8652 | 0.864 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0215 | 0.2657 | 0.1204 |
Loa Loa (eye worm) | FKBP5 protein | 0.0463 | 0.8652 | 0.8652 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0399 | 0.7109 | 0.6537 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0307 | 0.4871 | 0.4826 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0386 | 0.6782 | 0.6753 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0463 | 0.8652 | 0.8385 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0519 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.028 | 0.4222 | 0.4171 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.031 | 0.4945 | 0.4901 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.031 | 0.4945 | 0.4901 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0463 | 0.8652 | 0.8385 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0174 | 0.1652 | 0.1579 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0463 | 0.8652 | 0.864 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0519 | 1 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0519 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0463 | 0.8652 | 0.8385 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0519 | 1 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0413 | 0.7441 | 0.6934 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0087 | 0.0087 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0443 | 0.8164 | 0.8147 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.031 | 0.4945 | 0.4901 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0307 | 0.4871 | 0.4826 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0174 | 0.1652 | 0.1652 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.028 | 0.4212 | 0.4161 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0348 | 0.5865 | 0.5829 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0463 | 0.8652 | 0.8385 |
Schistosoma mansoni | immunophilin | 0.0463 | 0.8652 | 0.8385 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.028 | 0.4222 | 0.4171 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0386 | 0.6782 | 0.6753 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0386 | 0.6782 | 0.6753 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0463 | 0.8652 | 0.8385 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0519 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0412 | 0.743 | 0.7408 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0139 | 0.081 | 0.0729 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0386 | 0.6782 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0463 | 0.8652 | 0.8385 |
Leishmania major | fk506-binding protein 1-like protein | 0.0463 | 0.8652 | 0.8385 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0463 | 0.8652 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.028 | 0.4222 | 0.4171 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0174 | 0.1652 | 0.1579 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0519 | 1 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0463 | 0.8652 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0386 | 0.6782 | 0.6753 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0463 | 0.8652 | 0.8652 |
Schistosoma mansoni | immunophilin | 0.0399 | 0.7109 | 0.6537 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.028 | 0.4212 | 0.4161 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0412 | 0.743 | 0.7408 |
Schistosoma mansoni | immunophilin | 0.0463 | 0.8652 | 0.8385 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0463 | 0.8652 | 0.8385 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC20 (functional) | = 0.012 uM | Dose required to produce 20% increase in effective refractory period in male ferret. | ChEMBL. | 11133100 |
Tension (functional) | = 0 % | Peak isometric tension during the basic stimulus trains (S1) during control and compound induced tension, expressed as percent control. | ChEMBL. | 11133100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.