Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0465 | 0.1523 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0401 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0465 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0794 | 0.9282 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0465 | 0.1523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 28 uM | Growth inhibition in apoptosis-sensitive human MCF7 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 29 uM | Growth inhibition in apoptosis-resistant human A549 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 30 uM | Growth inhibition in apoptosis-resistant human T98G after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 31 uM | Growth inhibition in mouse B16F10 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 32 uM | Growth inhibition in apoptosis-sensitive human PC3 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 49 uM | Growth inhibition in apoptosis-resistant human SK-MEL-28 after 3 days by MTT assay | ChEMBL. | 21888390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.