Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.1523 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.029 | 0.9282 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0146 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.017 | 0.1523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 98 uM | Inhibition of human Plasminogen activator inhibitor 1 using HRP substrate after 30 mins by chromogenic assay | ChEMBL. | 21880486 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.