Detailed information for compound 1570893

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 875.822 | Formula: C51H45Cl2N6O2P
  • H donors: 4 H acceptors: 3 LogP: 11.53 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: ClCCNP(=O)(Oc1ccc(cc1)/C/1=c/2\cc/c(=C(\c3ccc(cc3)C)/C3=N/C(=C(\c4[nH]c(/C(=C/5\N=C1C=C5)/c1ccc(cc1)C)cc4)/c1ccc(cc1)C)/C=C3)/[nH]2)NCCCl
  • InChi: 1S/C51H45Cl2N6O2P/c1-32-4-10-35(11-5-32)48-40-20-22-42(56-40)49(36-12-6-33(2)7-13-36)44-24-26-46(58-44)51(38-16-18-39(19-17-38)61-62(60,54-30-28-52)55-31-29-53)47-27-25-45(59-47)50(43-23-21-41(48)57-43)37-14-8-34(3)9-15-37/h4-27,56,59H,28-31H2,1-3H3,(H2,54,55,60)/b48-40-,48-41-,49-42-,49-44-,50-43-,50-45-,51-46-,51-47-
  • InChiKey: XLWZHBKUSLEWCV-PRWUXVGQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0032 0.0213 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Echinococcus multilocularis inositol monophosphatase 1 0.0084 0.0859 0.0853
Echinococcus multilocularis protoporphyrinogen oxidase 0.0056 0.0517 0.051
Plasmodium falciparum cysteine proteinase falcipain 1 0.0214 0.2475 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.9755 0.9754
Brugia malayi SWIRM domain containing protein 0.0056 0.0517 0.0659
Schistosoma mansoni hypothetical protein 0.0036 0.0266 0.0243
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.01 0.001
Brugia malayi hypothetical protein 0.0048 0.041 0.0517
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0091 0.0083
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.1061 0.1054
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.01 0.0011
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0022 0.0091 0.001
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.01 0.0061
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.041 0.1015
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.01 0.001
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.01 0.001
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.041 0.0403
Mycobacterium leprae Conserved hypothetical protein 0.0024 0.0115 0.0106
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.01 0.0062
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0328 0.0321
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0102 0.1076 0.1069
Brugia malayi Cathepsin L-like precursor 0.0022 0.0091 0.0089
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Schistosoma mansoni nuclear receptor 0.0048 0.041 0.0387
Mycobacterium tuberculosis Probable oxidoreductase 0.0034 0.0237 0.0213
Loa Loa (eye worm) hypothetical protein 0.0058 0.0541 0.0785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.01 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0462
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0102 0.1076 0.1069
Plasmodium vivax vivapain-3 0.0022 0.0091 0.0004
Schistosoma mansoni inositol monophosphatase 0.0084 0.0859 0.0837
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.1202 0.1196
Mycobacterium ulcerans oxidoreductase 0.0056 0.0517 0.0441
Echinococcus multilocularis aldehyde reductase 0.0024 0.0115 0.0108
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.01 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0318 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0318 0.0682
Brugia malayi nuclear receptor NHR-67 0.0048 0.041 0.0517
Loa Loa (eye worm) acetylcholinesterase 1 0.0079 0.08 0.1159
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0237 0.0439
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0711 0.6402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0711 0.0705
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Brugia malayi cytochrome P450 0.0023 0.01 0.0101
Echinococcus multilocularis cysteine protease 0.0022 0.0091 0.0083
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0091 0.001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0859 0.7925
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.01 0.001
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0404 0.0398
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.01 0.0061
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.01 0.0061
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0024 0.0017
Echinococcus granulosus aldehyde reductase 0.0024 0.0115 0.0108
Schistosoma mansoni zinc finger protein 0.0048 0.041 0.0387
Brugia malayi Cytochrome P450 family protein 0.0023 0.01 0.0101
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0056 0.0517 0.2865
Echinococcus granulosus geminin 0.0166 0.1881 0.1875
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0102 0.1076 0.1069
Toxoplasma gondii aldose reductase, putative 0.0034 0.0237 0.1521
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.1061 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0056 0.0517 0.051
Schistosoma mansoni nuclear hormone receptor 0.0048 0.041 0.0387
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0091 0.0067
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.041 0.0594
Echinococcus multilocularis cysteine protease 0.0022 0.0091 0.0083
Brugia malayi amine oxidase, flavin-containing family protein 0.0056 0.0517 0.0659
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0102 0.1076 0.1069
Onchocerca volvulus 0.0041 0.0318 0.0725
Echinococcus multilocularis 0.0056 0.0517 0.051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0318 0.0295
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0318 0.0462
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0404 0.0398
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.01 0.0061
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0091 0.0131
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1061 0.2901
Onchocerca volvulus 0.0034 0.0237 0.0466
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.1061 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0318 0.0303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0462
Echinococcus granulosus aldo keto reductase 0.0034 0.0237 0.023
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.3378 1
Brugia malayi hypothetical protein 0.0056 0.0517 0.0659
Brugia malayi Cytochrome P450 family protein 0.0042 0.0334 0.0415
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0084 0.0859 0.0795
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0474 0.0451
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0056 0.0517 0.1791
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0102 0.1076 0.1069
Brugia malayi nuclear receptor RXR 0.0048 0.041 0.0517
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.01 0.0103
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.01 0.0061
Echinococcus multilocularis aldo keto reductase 0.0034 0.0237 0.023
Giardia lamblia Aldose reductase 0.0034 0.0237 0.0459
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0091 0.0083
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.1061 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0237 0.0285
Schistosoma mansoni thyroid hormone receptor 0.0374 0.4464 0.445
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0334 0.2519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Loa Loa (eye worm) fibroinase 0.0022 0.0091 0.0131
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.3031 0.3307
Brugia malayi tailless protein 0.0048 0.041 0.0517
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.01 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0318 0.096
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0237 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.1076 0.1408
Trypanosoma cruzi UDP-galactopyranose mutase 0.0056 0.0517 0.4397
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.01 0.011
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1061 0.2901
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0056 0.0517 0.1791
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.01 0.0103
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0711 0.0642
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0034 0.0237 0.0946
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.0481 0.0474
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.041 0.0387
Mycobacterium tuberculosis Conserved protein 0.0041 0.0318 0.0303
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.01 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0102 0.1076 0.156
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0349 0.0342
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.1061 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0474 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0462
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.01 0.011
Echinococcus multilocularis aldo keto reductase 0.0034 0.0237 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0091 0.001
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Echinococcus multilocularis musashi 0.0032 0.0213 0.0206
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0181 0.0945
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Brugia malayi ecdysteroid receptor 0.0102 0.1076 0.1408
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0462
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0056 0.0517 0.0441
Plasmodium vivax unspecified product 0.02 0.2298 0.9259
Onchocerca volvulus Bile acid receptor homolog 0.0102 0.1076 0.3132
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0102 0.1076 0.1069
Echinococcus granulosus lysine specific histone demethylase 1A 0.0056 0.0517 0.051
Loa Loa (eye worm) hypothetical protein 0.0054 0.0481 0.0698
Onchocerca volvulus 0.0048 0.041 0.1015
Brugia malayi nuclear receptor NHR-88 0.0048 0.041 0.0517
Schistosoma mansoni hypothetical protein 0.0166 0.1881 0.1861
Echinococcus granulosus ATP binding cassette sub family G 0.0022 0.009 0.0082
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0334 0.0484
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0859 0.7925
Echinococcus granulosus inositol monophosphatase 1 0.0084 0.0859 0.0853
Brugia malayi Nuclear hormone receptor-like 1 0.057 0.6898 0.9204
Onchocerca volvulus 0.0041 0.0318 0.0725
Brugia malayi hypothetical protein 0.0029 0.0181 0.0211
Brugia malayi photoreceptor-specific nuclear receptor 0.0102 0.1076 0.1408
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0091 0.0004
Echinococcus granulosus hypothetical protein 0.0034 0.0237 0.023
Brugia malayi nuclear hormone receptor 0.0048 0.041 0.0517
Schistosoma mansoni cpg binding protein 0.0032 0.0214 0.019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0237 0.0344
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0711 0.0738
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0917 0.0895
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0481 0.0458
Schistosoma mansoni steroid hormone receptor ad4bp 0.0102 0.1076 0.1054
Trichomonas vaginalis set domain proteins, putative 0.0276 0.3236 0.9405
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.1061 0.1054
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0273 0.3203 0.3198
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0318 0.0682
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.041 0.1015
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0318 0.0682
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.041 0.0403
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.01 0.0061
Plasmodium vivax vivapain-2 0.0022 0.0091 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0102 0.1076 0.156
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1061 0.2901
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0462
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0711 0.0689
Echinococcus granulosus acetylcholinesterase 0.0079 0.08 0.0793
Loa Loa (eye worm) hypothetical protein 0.0082 0.0829 0.1201
Loa Loa (eye worm) oxidoreductase 0.0034 0.0237 0.0344
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0034 0.0237 0.1521
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0091 0.0083
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.1061 0.1054
Toxoplasma gondii ABC1 family protein 0.0041 0.0318 0.2357
Brugia malayi hypothetical protein 0.0019 0.0052 0.0037
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Echinococcus granulosus carboxylesterase 5A 0.0079 0.08 0.0793
Loa Loa (eye worm) ABC transporter 0.0019 0.0048 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0254 0.023
Trypanosoma brucei prostaglandin f synthase 0.0034 0.0237 0.1521
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0056 0.0517 0.1791
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0091 0.0089
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.01 0.0011
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3378 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0546 0.4695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0254 0.023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.041 0.0594
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0056 0.0517 0.0749
Brugia malayi MAP kinase sur-1 0.01 0.1061 0.1388
Trypanosoma cruzi UDP-galactopyranose mutase 0.0056 0.0517 0.4397
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0349 0.0326
Echinococcus granulosus FTZ F1 alpha 0.0102 0.1076 0.1069
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0102 0.1076 0.1408
Onchocerca volvulus 0.0034 0.0237 0.0466
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.041 0.0403
Leishmania major aldo-keto reductase-like protein 0.0034 0.0237 0.1521
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.01 0.001
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0084 0.0859 0.7925
Echinococcus multilocularis 0.0023 0.01 0.0092
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.1061 1
Echinococcus granulosus cathepsin l1 0.0022 0.0091 0.0083
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0239 0.0232
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.01 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0024 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0631 0.0608
Loa Loa (eye worm) glutaminase 2 0.0292 0.3435 0.498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0237 0.0439
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.01 0.001
Brugia malayi Pre-SET motif family protein 0.0035 0.0254 0.0307
Echinococcus multilocularis peregrin 0.0034 0.0239 0.0232
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0239 0.0625
Mycobacterium ulcerans dehydrogenase 0.0056 0.0517 0.0441
Echinococcus granulosus GPCR family 2 0.0017 0.0024 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.041 0.0403
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.1061 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.1076 0.1069
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Schistosoma mansoni aldo-keto reductase 0.0034 0.0237 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0318 0.0311
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.01 0.0061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0474 0.0467
Brugia malayi Cathepsin L-like precursor 0.0022 0.0091 0.0089
Brugia malayi glutaminase DH11.1 0.0292 0.3435 0.4567
Trypanosoma cruzi cysteine proteinase, putative 0.0022 0.0091 0.001
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Echinococcus granulosus cpg binding protein 0.0032 0.0214 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0711 0.0642
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0239 0.0232
Trypanosoma brucei aldo-keto reductase, putative 0.0034 0.0237 0.1521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0474 0.0603
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Loa Loa (eye worm) hypothetical protein 0.0032 0.0213 0.0309
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0079 0.08 0.0778
Mycobacterium ulcerans oxidoreductase 0.0034 0.0237 0.0153
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0181 0.0385
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0091 0.0003
Schistosoma mansoni lamin 0.0032 0.0213 0.019
Brugia malayi Cathepsin L-like precursor 0.0022 0.0091 0.0089
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0102 0.1076 0.156
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.041 0.0517
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0829 0.0806
Onchocerca volvulus 0.0032 0.0213 0.039
Brugia malayi CXXC zinc finger family protein 0.003 0.0192 0.0225
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0318 0.0682
Brugia malayi Nuclear hormone receptor E75 0.0048 0.041 0.0517
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0028 0.0041
Trichomonas vaginalis esterase, putative 0.0041 0.0318 0.0682
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.01 0.0045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.1202 0.1196
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.01 0.0061
Onchocerca volvulus 0.0041 0.0318 0.0725
Loa Loa (eye worm) hypothetical protein 0.0054 0.0481 0.0698
Echinococcus multilocularis ATP binding cassette sub family G 0.0022 0.009 0.0082
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Loa Loa (eye worm) oxidoreductase 0.0034 0.0237 0.0344
Loa Loa (eye worm) oxidoreductase 0.0034 0.0237 0.0344
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.057 0.6898 1
Loa Loa (eye worm) ctsf protein 0.0022 0.0091 0.0131
Echinococcus granulosus aldo keto reductase 0.0034 0.0237 0.023
Echinococcus multilocularis lamin dm0 0.0032 0.0213 0.0206
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.1076 0.1408
Brugia malayi Cytochrome P450 family protein 0.0023 0.01 0.0101
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0181 0.0945
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0254 0.0246
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.3378 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0334 0.0253
Brugia malayi beta-lactamase family protein 0.0041 0.0318 0.0394
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.0481 0.0474
Schistosoma mansoni inositol monophosphatase 0.0084 0.0859 0.0837
Echinococcus granulosus ATP binding cassette sub family G 0.0022 0.009 0.0082
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Echinococcus granulosus cathepsin L cysteine protease 0.0022 0.0091 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.01 0.0144
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0075 0.075 0.0781
Onchocerca volvulus 0.0082 0.0829 0.2346
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0254 0.023
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.01 0.0045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0213 0.0309
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0263
Echinococcus granulosus acetylcholinesterase 0.0079 0.08 0.0793
Echinococcus granulosus ATP binding cassette sub family G 0.0022 0.009 0.0082
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0237 0.0439
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0028 0.0006
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0084 0.0859 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0474 0.0688
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Brugia malayi Cathepsin L-like precursor 0.0022 0.0091 0.0089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0318 0.0295
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0829 0.0822
Loa Loa (eye worm) carboxylesterase 0.0079 0.08 0.1159
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Mycobacterium leprae Probable lipase LipE 0.0041 0.0318 0.1504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0474 0.0467
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1061 0.2901
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.2822 0.4091
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0273 0.3203 0.3198
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0229 0.0222
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0091 0.0089
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0334 0.0484
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0239 0.1535
Entamoeba histolytica aldose reductase, putative 0.0034 0.0237 0.0449
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0475 0.0604
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.01 0.0103
Echinococcus granulosus lamin dm0 0.0032 0.0213 0.0206
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Brugia malayi beta-lactamase 0.0041 0.0318 0.0394
Leishmania major hypothetical protein, conserved 0.0029 0.0181 0.0945
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0802 0.9775 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0254 0.1688
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1555 0.1514
Echinococcus granulosus aldo keto reductase 0.0034 0.0237 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0091 0.001
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0091 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.041 0.0403
Echinococcus multilocularis ATP binding cassette sub family G 0.0022 0.009 0.0082
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0206 0.0299
Loa Loa (eye worm) hypothetical protein 0.0056 0.0517 0.0749
Echinococcus multilocularis thyroid hormone receptor alpha 0.0374 0.4464 0.446
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.01 0.001
Loa Loa (eye worm) glutaminase 0.0292 0.3435 0.498
Onchocerca volvulus Alhambra homolog 0.0034 0.0239 0.0471
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0318 0.0303
Schistosoma mansoni hypothetical protein 0.0018 0.0045 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0084 0.0859 0.2299
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0091 0.0067
Trypanosoma cruzi aldo/keto reductase, putative 0.0034 0.0237 0.1521
Plasmodium vivax unspecified product 0.0214 0.2475 1
Brugia malayi PHD-finger family protein 0.0034 0.0239 0.0287
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.01 0.0061
Echinococcus multilocularis GPCR, family 2 0.0017 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0079 0.08 0.1159
Schistosoma mansoni glutaminase 0.0292 0.3435 0.3419
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0091 0.0067
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.01 0.0103
Echinococcus multilocularis aldo keto reductase 0.0034 0.0237 0.023
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0091 0.0067
Echinococcus granulosus lamin 0.0032 0.0213 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0102 0.1076 0.1408
Brugia malayi hypothetical protein 0.0054 0.0481 0.0612
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0091 0.0131
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0859 0.7925
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Leishmania major cytochrome p450-like protein 0.0042 0.0334 0.2519
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.0481 0.0458
Schistosoma mansoni nuclear receptor 0.0048 0.041 0.0387
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0035
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0318 0.0311
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0091 0.0083
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0091 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0474 0.0451
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0102 0.1076 0.3132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0475 0.0689
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.01 0.001
Brugia malayi conserved hypotetical protein 0.0048 0.041 0.0517
Schistosoma mansoni cpg binding protein 0.003 0.0192 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0318 0.0682
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.01 0.0061
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0075 0.075 0.4467
Brugia malayi Pre-SET motif family protein 0.0242 0.2822 0.3746
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.01 0.0061
Schistosoma mansoni amine oxidase 0.0056 0.0517 0.0494
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.041 0.0517
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.01 0.001
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.1076 0.1069
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.01 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0091 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0266 0.0386
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0334 0.2519
Schistosoma mansoni nuclear hormone receptor 0.0048 0.041 0.0387
Schistosoma mansoni hypothetical protein 0.0273 0.3203 0.3187
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0462
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0318 0.0303
Schistosoma mansoni hypothetical protein 0.0034 0.0239 0.0215
Onchocerca volvulus Protein ultraspiracle homolog 0.0102 0.1076 0.3132
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0102 0.1076 0.1408
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0213 0.0309
Mycobacterium tuberculosis Conserved protein 0.0041 0.0318 0.0303
Echinococcus multilocularis cpg binding protein 0.0032 0.0214 0.0207
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Mycobacterium ulcerans lipase LipD 0.0041 0.0318 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.041 0.0594
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0213 0.0253
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0084 0.0859 0.2299
Echinococcus multilocularis FTZ F1 alpha 0.0102 0.1076 0.1069
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0058 0.054 0.4634
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Brugia malayi hypothetical protein 0.0054 0.0481 0.0612
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0318 0.0303
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.01 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0102 0.1076 0.1408
Trypanosoma cruzi cysteine protease, putative 0.0022 0.0091 0.001
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0056 0.0517 0.1791
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.01 0.0061
Entamoeba histolytica hypothetical protein 0.0023 0.01 0.0032
Onchocerca volvulus 0.0032 0.0213 0.039
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.01 0.0061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0254 0.0246
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0318 0.0236
Schistosoma mansoni ABC transporter 0.0019 0.0048 0.0024
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0237 0.0439
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0091 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0181 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0517 0.1791
Schistosoma mansoni pol-related 0.0034 0.0237 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Schistosoma mansoni hypothetical protein 0.0023 0.01 0.0076
Onchocerca volvulus 0.003 0.0192 0.0324
Trypanosoma cruzi cysteine proteinase, putative 0.0022 0.0091 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0102 0.1076 0.1054
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0091 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3378 1
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0517 0.1791
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Schistosoma mansoni aldo-keto reductase 0.0034 0.0237 0.0214
Plasmodium vivax SET domain protein, putative 0.0035 0.0254 0.0688
Schistosoma mansoni cytochrome P450 0.0023 0.01 0.0076
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0181 0.0385
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0192 0.0279
Mycobacterium tuberculosis Conserved protein 0.0041 0.0318 0.0303
Onchocerca volvulus 0.0034 0.0237 0.0466
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0063 0.0039
Echinococcus multilocularis aldo keto reductase 0.0034 0.0237 0.023
Echinococcus multilocularis microtubule associated protein 2 0.082 1 1
Echinococcus granulosus peregrin 0.0034 0.0239 0.0232
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0102 0.1076 0.1054
Onchocerca volvulus 0.0056 0.0517 0.1354
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0318 0.2357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.1076 0.1069
Schistosoma mansoni hypothetical protein 0.0166 0.1881 0.1861
Loa Loa (eye worm) cysteine protease 0.0022 0.0091 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.01 0.0061
Trichomonas vaginalis glutaminase, putative 0.0292 0.3435 1
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0318 0.2357
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0102 0.1076 0.1054
Mycobacterium ulcerans beta-lactamase 0.0041 0.0318 0.0236
Echinococcus granulosus cathepsin L 0.0022 0.0091 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.01 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0102 0.1076 0.1408
Schistosoma mansoni amine oxidase 0.0056 0.0517 0.0494
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0091 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1061 0.1039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0517 0.0749
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.01 0.0061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0102 0.1076 0.1054
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0102 0.1076 0.156
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.041 0.0403
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Schistosoma mansoni RAR-like nuclear receptor 0.0102 0.1076 0.1054
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.041 0.0403
Echinococcus multilocularis lamin 0.0032 0.0213 0.0206
Schistosoma mansoni intermediate filament proteins 0.0032 0.0213 0.019
Giardia lamblia Kinase, CMGC MAPK 0.01 0.1061 0.2961
Echinococcus multilocularis acetylcholinesterase 0.0079 0.08 0.0793
Brugia malayi jmjC domain containing protein 0.0112 0.1202 0.1577
Plasmodium vivax vivapain-2 0.0022 0.0091 0.0004
Brugia malayi beta-lactamase family protein 0.0041 0.0318 0.0394
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0102 0.1076 0.1069
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.01 0.0061
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0318 0.0303
Loa Loa (eye worm) oxidoreductase 0.0034 0.0237 0.0344
Leishmania major cytochrome p450-like protein 0.0023 0.01 0.0103
Brugia malayi Nuclear hormone receptor-like 1 0.057 0.6898 0.9204
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0091 0.0004
Leishmania major prostaglandin f synthase, putative 0.0034 0.0237 0.1521
Plasmodium falciparum protoporphyrinogen oxidase 0.0056 0.0517 0.1791
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.041 0.0403
Plasmodium falciparum phd finger protein, putative 0.0034 0.0239 0.0625
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0091 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0711 0.0689
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.041 0.0403
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0024 0.0035
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0239 0.1535
Toxoplasma gondii histone lysine-specific demethylase 0.0056 0.0517 0.4397
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.01 0.001
Loa Loa (eye worm) cytochrome P450 0.0023 0.01 0.0144
Loa Loa (eye worm) steroid hormone receptor 0.0102 0.1076 0.156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0102 0.1076 0.1408
Onchocerca volvulus 0.0102 0.1076 0.3132
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.041 0.0517
Echinococcus multilocularis cathepsin L 0.0022 0.0091 0.0083
Trypanosoma brucei protein kinase, putative 0.01 0.1061 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0254 0.023
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0181 0.0945
Loa Loa (eye worm) DR-78 0.0048 0.041 0.0594
Loa Loa (eye worm) hypothetical protein 0.0079 0.08 0.1159
Brugia malayi nuclear hormone receptor 0.0102 0.1076 0.1408
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0368
Mycobacterium leprae conserved hypothetical protein 0.0023 0.01 0.0005
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0802 0.9775 1
Echinococcus multilocularis carboxylesterase 5A 0.0079 0.08 0.0793
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0237 0.0439
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0334 0.2519
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Brugia malayi Carboxylesterase family protein 0.0079 0.08 0.1039
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Entamoeba histolytica aldose reductase, putative 0.0034 0.0237 0.0449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Trichomonas vaginalis inositol monophosphatase, putative 0.0084 0.0859 0.2299
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0034 0.0237 0.1521
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0091 0.001
Loa Loa (eye worm) hypothetical protein 0.0565 0.6826 0.9897
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0102 0.1076 0.1069
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0072
Loa Loa (eye worm) inositol-1 0.0084 0.0859 0.1246
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0711 0.6402
Brugia malayi ABC transporter family protein 0.0019 0.0048 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0374 0.4464 0.445
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1555 0.1673
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.069 0.1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0102 0.1076 0.1054
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0746 0.9074 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0091 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0102 0.1076 0.156
Leishmania major cathepsin L-like protease 0.0022 0.0091 0.001
Onchocerca volvulus 0.0034 0.0237 0.0466
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0022 0.009 0.0066
Trypanosoma cruzi aldo-keto reductase 0.0034 0.0237 0.1521
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0829 0.1077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0024 0.0017
Onchocerca volvulus 0.0034 0.0237 0.0466
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0102 0.1076 0.1054
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0085 0.0081
Echinococcus granulosus ecdysone induced protein 78C 0.0102 0.1076 0.1069
Echinococcus granulosus cysteine protease 0.0022 0.0091 0.0083
Brugia malayi hypothetical protein 0.0048 0.041 0.0517
Loa Loa (eye worm) hypothetical protein 0.0054 0.0481 0.0698
Brugia malayi Cathepsin L-like precursor 0.0022 0.0091 0.0089
Mycobacterium ulcerans hypothetical protein 0.0041 0.0318 0.0236
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Onchocerca volvulus 0.0048 0.041 0.1015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0711 0.0705
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.041 0.0387
Loa Loa (eye worm) hypothetical protein 0.0054 0.0481 0.0698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.041 0.0517
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.1061 1
Brugia malayi Bromodomain containing protein 0.0034 0.0239 0.0287
Schistosoma mansoni microtubule-associated protein tau 0.082 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0056 0.0517 0.0523
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0102 0.1076 0.156
Loa Loa (eye worm) hypothetical protein 0.0054 0.0481 0.0698
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.01 0.0103
Brugia malayi Cytochrome P450 family protein 0.0042 0.0334 0.0415
Brugia malayi nuclear receptor RXR 0.0054 0.0481 0.0612
Brugia malayi jmjC domain containing protein 0.0043 0.0349 0.0435
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.01 0.0103
Brugia malayi ecdysone receptor 0.0048 0.041 0.0517
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0056 0.0517 0.0494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0474 0.0467
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0266 0.0325
Giardia lamblia PHD finger protein 15 0.0034 0.0239 0.0463
Giardia lamblia Aldose reductase 0.0034 0.0237 0.0459
Brugia malayi Carboxylesterase family protein 0.0079 0.08 0.1039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0102 0.1076 0.1069
Toxoplasma gondii cathepsin CPL 0.0022 0.0091 0.001
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.01 0.001
Echinococcus multilocularis acetylcholinesterase 0.0079 0.08 0.0793
Onchocerca volvulus 0.0276 0.3236 1
Entamoeba histolytica aldose reductase, putative 0.0034 0.0237 0.0449
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.01 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0102 0.1076 0.1069
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0237 0.0285
Echinococcus granulosus mitogen activated protein kinase 0.01 0.1061 0.1054
Brugia malayi Cathepsin L-like precursor 0.0022 0.0091 0.0089
Schistosoma mansoni coup transcription factor 0.0102 0.1076 0.1054
Onchocerca volvulus 0.0035 0.0254 0.0518
Leishmania major hypothetical protein, conserved 0.0041 0.0318 0.2357
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0091 0.001
Loa Loa (eye worm) beta-lactamase 0.0041 0.0318 0.0462
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0091 0.0067
Entamoeba histolytica cysteine proteinase 1, putative 0.0022 0.0091 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3378 0.9828
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.01 0.011
Chlamydia trachomatis protoporphyrinogen oxidase 0.0056 0.0517 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0517 0.0749
Echinococcus multilocularis geminin 0.0166 0.1881 0.1875
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0102 0.1076 0.156
Loa Loa (eye worm) hypothetical protein 0.0053 0.0475 0.0689
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0318 0.0303
Echinococcus multilocularis ATP binding cassette sub family G 0.0022 0.009 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.1076 0.1408
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0084 0.0859 0.2341
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.01 0.0061
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0056 0.0517 0.0494
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.01 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0254 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.1076 0.1408
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0181 0.0945
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0711 0.0642
Leishmania major cytochrome p450-like protein 0.0023 0.01 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0091 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Onchocerca volvulus 0.0034 0.0237 0.0466
Brugia malayi Nuclear hormone receptor-like 1 0.0618 0.7492 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0056 0.0517 0.051
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.041 0.0403
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0829 0.0822
Brugia malayi Inositol-1 0.0084 0.0859 0.1118
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1555 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0318 0.1504
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.1061 1
Entamoeba histolytica cysteine proteinase 2 0.0022 0.0091 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0237 0.023
Mycobacterium ulcerans glutaminase 0.0292 0.3435 0.3454
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.1076 0.1069
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0517 0.0523
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.041 0.0403
Loa Loa (eye worm) oxidoreductase 0.0034 0.0237 0.0344
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0239 0.0346
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.1076 0.1408
Schistosoma mansoni retinoic acid receptor RXR 0.0102 0.1076 0.1054
Entamoeba histolytica cysteine protease, putative 0.0022 0.0091 0.0003
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.01 0.001
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0318 0.0303
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.041 0.0403
Brugia malayi intermediate filament protein 0.0032 0.0213 0.0253
Loa Loa (eye worm) hypothetical protein 0.0102 0.1076 0.156
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0349 0.0506
Loa Loa (eye worm) hypothetical protein 0.0022 0.0091 0.0131
Loa Loa (eye worm) hypothetical protein 0.0056 0.0517 0.0749
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0239 0.0215
Schistosoma mansoni cpg binding protein 0.0032 0.0214 0.019
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0594
Brugia malayi steroid hormone receptor 0.0102 0.1076 0.1408
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0237 0.0439
Brugia malayi nuclear receptor NHR-88 0.0102 0.1076 0.1408
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0859 0.7925
Loa Loa (eye worm) hypothetical protein 0.0056 0.0517 0.0749
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0091 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0102 0.1076 0.1408
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0474 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0102 0.1076 0.1408
Plasmodium vivax vivapain-1 0.0214 0.2475 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0318 0.0394
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.041 0.0387
Schistosoma mansoni nuclear hormone receptor 0.0102 0.1076 0.1054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0239 0.0346
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0237 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.1076 0.1408
Brugia malayi Nuclear hormone receptor E75 0.0048 0.041 0.0517
Leishmania major UDP-galactopyranose mutase 0.0056 0.0517 0.4397
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0091 0.0089
Mycobacterium ulcerans monoamine oxidase 0.0056 0.0517 0.0441
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.1061 0.1538
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.01 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0091 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0318 0.2357
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0334 0.0484
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0349 0.0326
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0237 0.0285
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.01 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0475 0.0604
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0237 0.023
Echinococcus granulosus intermediate filament protein 0.0032 0.0213 0.0206

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 11.42 uM Cytotoxicity against human Bel7402 cells after 48 hrs in the dark by MTT assay ChEMBL. 19942325

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19942325

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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