Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0118 | 0.2754 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0118 | 0.2754 | 0.2754 |
Schistosoma mansoni | nuclear hormone receptor | 0.0118 | 0.2754 | 0.2544 |
Onchocerca volvulus | 0.0118 | 0.2754 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0118 | 0.2754 | 0.2754 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0118 | 0.2754 | 0.2544 |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0056 | 0.0288 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0118 | 0.2754 | 0.2544 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0062 | 0.0548 | 0.0272 |
Brugia malayi | nuclear receptor RXR | 0.0056 | 0.0283 | 0.0283 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0118 | 0.2754 | 0.2544 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0301 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0118 | 0.2754 | 0.2754 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0118 | 0.2754 | 0.2544 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0118 | 0.2754 | 0.2544 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0118 | 0.2754 | 0.2544 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.0548 | 0.0548 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | steroid hormone receptor | 0.0118 | 0.2754 | 0.2754 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0118 | 0.2754 | 0.2544 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0056 | 0.0288 | 0.5 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0056 | 0.0283 | 0.0283 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0062 | 0.0548 | 0.0272 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | nuclear receptor NHR-88 | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0548 | 0.0548 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0056 | 0.0288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0548 | 0.0548 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0056 | 0.0288 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0118 | 0.2754 | 0.2544 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0056 | 0.0283 | 0.0283 |
Brugia malayi | nuclear receptor RXR | 0.0062 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0118 | 0.2754 | 0.2754 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0301 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0548 | 0.0548 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0062 | 0.0548 | 0.0272 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | nuclear receptor NHR-88 | 0.0118 | 0.2754 | 0.2754 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0056 | 0.0288 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0056 | 0.0283 | 0.0283 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0062 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0548 | 0.0548 |
Brugia malayi | nuclear receptor NHR-67 | 0.0056 | 0.0283 | 0.0283 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Brugia malayi | ecdysone receptor | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0118 | 0.2754 | 0.2544 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0056 | 0.0288 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0118 | 0.2754 | 0.2544 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0118 | 0.2754 | 0.2544 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0118 | 0.2754 | 0.2544 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0118 | 0.2754 | 0.2754 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0056 | 0.0288 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0118 | 0.2754 | 0.2754 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0118 | 0.2754 | 0.2544 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Brugia malayi | nuclear hormone receptor | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0118 | 0.2754 | 0.2544 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0118 | 0.2754 | 0.2544 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0118 | 0.2754 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0118 | 0.2754 | 0.2754 |
Echinococcus granulosus | FTZ F1 alpha | 0.0118 | 0.2754 | 0.2544 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0062 | 0.0548 | 0.0272 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0118 | 0.2754 | 0.2754 |
Schistosoma mansoni | coup transcription factor | 0.0118 | 0.2754 | 0.2544 |
Schistosoma mansoni | thyroid hormone receptor | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0118 | 0.2754 | 0.2754 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | DR-78 | 0.0056 | 0.0283 | 0.0283 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0056 | 0.0288 | 0.5 |
Brugia malayi | tailless protein | 0.0056 | 0.0283 | 0.0283 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0118 | 0.2754 | 0.2544 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0056 | 0.0283 | 0.0283 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0118 | 0.2754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0056 | 0.0283 | 0.0283 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0118 | 0.2754 | 0.2544 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0301 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0118 | 0.2754 | 0.2544 |
Schistosoma mansoni | thyroid hormone receptor | 0.0118 | 0.2754 | 0.2544 |
Brugia malayi | conserved hypotetical protein | 0.0056 | 0.0283 | 0.0283 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0056 | 0.0288 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | nuclear hormone receptor | 0.0056 | 0.0283 | 0.0283 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0056 | 0.0283 | 0.0283 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0118 | 0.2754 | 0.2544 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0056 | 0.0283 | 0.0283 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0056 | 0.0288 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0118 | 0.2754 | 0.2754 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0118 | 0.2754 | 0.2754 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0056 | 0.0288 | 0.5 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0056 | 0.0283 | 0.0283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.