Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0419 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0419 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0419 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0419 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0419 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0419 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0419 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0419 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0419 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0419 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0419 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0419 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0419 | 0.5 | 0.5 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0419 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0419 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0259 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.