Detailed information for compound 1571095

Basic information

Technical information
  • TDR Targets ID: 1571095
  • Name: 3,4-dimethyl-6-[2-(trifluoromethyl)phenyl]-[1 ,2]oxazolo[3,4-d]pyridazin-7-one
  • MW: 309.243 | Formula: C14H10F3N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.82 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn(c2ccccc2C(F)(F)F)c(=O)c2c1c(C)on2
  • InChi: 1S/C14H10F3N3O2/c1-7-11-8(2)22-19-12(11)13(21)20(18-7)10-6-4-3-5-9(10)14(15,16)17/h3-6H,1-2H3
  • InChiKey: HQFBHRIPFFFPEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dimethyl-6-[2-(trifluoromethyl)phenyl]isoxazolo[3,4-d]pyridazin-7-one
  • 3,4-dimethyl-6-[2-(trifluoromethyl)phenyl]-7-isoxazolo[3,4-d]pyridazinone
  • 3,4-dimethyl-6-[2-(trifluoromethyl)phenyl]-6,7-dihydroisoxazolo[3,4-d]pyridazin-7-one
  • MLS000833978
  • SMR000461497
  • ZINC00123469

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0719 0.1447
Schistosoma mansoni hypothetical protein 0.053 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0452 0.0403
Echinococcus multilocularis transcription factor btf3 0.0038 0.0518 0.0469
Schistosoma mansoni hypothetical protein 0.0034 0.0452 0.0368
Schistosoma mansoni hypothetical protein 0.0034 0.0452 0.0368
Echinococcus multilocularis musashi 0.0058 0.091 0.0863
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0425 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0425 0.0341
Echinococcus granulosus cpg binding protein 0.0033 0.0422 0.0373
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0452 0.0403
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0743 0.0695
Brugia malayi hypothetical protein 0.0051 0.0775 0.1486
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.091 0.1839
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0051 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0518 0.1019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0529 0.1043
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0518 0.3938
Loa Loa (eye worm) hypothetical protein 0.0109 0.1882 0.3924
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0102 0.005
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0719 0.5466
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0176 0.1337
Loa Loa (eye worm) hypothetical protein 0.0079 0.1316 0.2711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0529 0.1043
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.1316 1
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0 0.5
Brugia malayi PAS domain containing protein 0.0052 0.0796 0.1531
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0051 0.0391
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0465 0.3529
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0475 0.0425
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0535 0.0966
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0743 0.0695
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0719 0.0671
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0425 0.3228
Brugia malayi hypoxia-induced factor 1 0.0162 0.2904 0.6085
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0389 0.0339
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1046 0.1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0413 0.0796
Trichomonas vaginalis rotamase, putative 0.0036 0.0481 0.094
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.4717 0.4689
Loa Loa (eye worm) hypothetical protein 0.0057 0.0889 0.1796
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0102 0.0772
Entamoeba histolytica hypothetical protein 0.0152 0.2718 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0465 0.3529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0102 0.0031
Brugia malayi Pre-SET motif family protein 0.0226 0.4139 0.8752
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1882 0.3877
Schistosoma mansoni survival motor neuron protein 0.0052 0.0795 0.0714
Onchocerca volvulus 0.0031 0.0388 0.0718
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0465 0.3529
Echinococcus multilocularis geminin 0.053 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0529 0.1043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0345 0.0651
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0087 0.000000043673
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0087 0.0076
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0087 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.2718 0.268
Brugia malayi beta-NAC-like protein 0.0038 0.0518 0.0931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0425 0.0341
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0719 0.5466
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0087 0.0077
Schistosoma mansoni rotamase 0.0036 0.0481 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0292 0.0537
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0102 0.0108
Echinococcus granulosus transcription factor btf3 0.0038 0.0518 0.0469
Brugia malayi hypothetical protein 0.0079 0.1316 0.2655
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0719 0.0638
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0518 0.0239
Schistosoma mansoni hypothetical protein 0.0152 0.2718 0.2654
Brugia malayi CXXC zinc finger family protein 0.0031 0.0388 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0529 0.1043
Echinococcus granulosus lamin 0.0058 0.091 0.0863
Echinococcus granulosus lamin dm0 0.0058 0.091 0.0863
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0051 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0584 0.1158
Schistosoma mansoni hypothetical protein 0.0034 0.0452 0.0368
Echinococcus granulosus single minded 2 0.0039 0.0535 0.0486
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0452 0.0788
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.1316 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0051 0.0391
Echinococcus multilocularis Ankyrin 0.0016 0.009 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0051 0.0026
Onchocerca volvulus 0.0033 0.0425 0.0797
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1882 0.3877
Schistosoma mansoni cpg binding protein 0.0033 0.0422 0.0338
Loa Loa (eye worm) hypothetical protein 0.0027 0.031 0.0554
Schistosoma mansoni intermediate filament proteins 0.0058 0.091 0.083
Brugia malayi hypothetical protein 0.0256 0.4717 1
Onchocerca volvulus 0.0052 0.0795 0.1585
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0425 0.0375
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0087 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0743 0.0661
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0481 0.0941
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1046 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0291 0.0536
Loa Loa (eye worm) hypothetical protein 0.0028 0.033 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0518 0.1019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1046 1
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0051 0.0026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0452 0.0403
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1882 0.3924
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0051 0.0026
Loa Loa (eye worm) hypothetical protein 0.0027 0.031 0.0554
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0452 0.0859
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0051 0.5
Brugia malayi Cytochrome P450 family protein 0.0049 0.0726 0.1379
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0102 0.0772
Echinococcus granulosus expressed protein 0.0036 0.0481 0.0432
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0518 0.1001
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.2904 0.6115
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0719 0.1131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0425 0.0341
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.033 0.028
Trichomonas vaginalis rotamase, putative 0.0035 0.0465 0.0905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0481 0.0941
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1046 0.7945
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1046 0.0967
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0051 0.0391
Loa Loa (eye worm) hypothetical protein 0.0256 0.4717 1
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.2718 0.2654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0719 0.1366
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0726 0.1445
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0481 0.085
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0087 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0388 0.0722
Leishmania major hypothetical protein, conserved 0.0079 0.1316 1
Brugia malayi Protein kinase domain containing protein 0.0015 0.0087 0.000000093517
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0481 0.092
Echinococcus granulosus Ankyrin 0.0016 0.009 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.1316 1
Giardia lamblia GTOR 0.0048 0.0719 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0051 0.0026
Loa Loa (eye worm) hypothetical protein 0.0034 0.0452 0.0859
Echinococcus granulosus GPCR family 2 0.0034 0.0452 0.0403
Loa Loa (eye worm) hypothetical protein 0.0058 0.091 0.1839
Schistosoma mansoni hypothetical protein 0.0034 0.0452 0.0368
Schistosoma mansoni single-minded 0.0052 0.0796 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0481 0.0941
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0051 0.0391
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.1313 0.1268
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0518 0.1019
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1046 0.7945
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0743 0.0695
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0082
Onchocerca volvulus 0.0257 0.4741 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0292 0.0537
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0743 0.0661
Leishmania major protein kinase, putative 0.0014 0.0051 0.0391
Echinococcus multilocularis lamin dm0 0.0058 0.091 0.0863
Loa Loa (eye worm) hypothetical protein 0.0074 0.122 0.2505
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0051 0.0026
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0719 0.1131
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0946 0.719
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0719 0.5466
Brugia malayi intermediate filament protein 0.0058 0.091 0.1776
Brugia malayi Death domain containing protein 0.0015 0.0087 0.000000093517
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0475 0.0425
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.1313 0.1268
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0452 0.0403
Entamoeba histolytica hypothetical protein 0.0152 0.2718 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0051 0.0026
Schistosoma mansoni lamin 0.0058 0.091 0.083
Entamoeba histolytica hypothetical protein 0.0038 0.0518 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0481 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0345 0.0651
Loa Loa (eye worm) hypothetical protein 0.0175 0.3166 0.6675
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0465 0.3529
Schistosoma mansoni cpg binding protein 0.0031 0.0388 0.0304
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.122 0.2447
Trichomonas vaginalis set domain proteins, putative 0.0257 0.4738 1
Entamoeba histolytica hypothetical protein 0.0152 0.2718 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0292 0.0537
Schistosoma mansoni cpg binding protein 0.0033 0.0422 0.0338
Loa Loa (eye worm) hypothetical protein 0.0033 0.0425 0.0801
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.1316 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0051 0.0026
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0051 0.0391
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0051 0.0026
Echinococcus multilocularis GPCR, family 2 0.0034 0.0452 0.0403
Echinococcus multilocularis expressed protein 0.0036 0.0481 0.0432
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1046 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0292 0.0537
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0077
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0743 0.1482
Schistosoma mansoni hypothetical protein 0.0112 0.1937 0.1866
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.039 0.0725
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0719 0.5466
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0102 0.0772
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.053 0.4027
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.1316 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0102 0.0133
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0518 0.3938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0102 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1046 1
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0535 0.0486
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0051 0.0026
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0425 0.0375
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.1316 1
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0465 0.3529
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0102 0.005
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0518 0.3938
Brugia malayi Uncoordinated protein 44 0.0015 0.0087 0.000000093517
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.053 0.4027
Loa Loa (eye worm) intermediate filament protein 0.0058 0.091 0.1839
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.033 0.028
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.009 0.0003
Schistosoma mansoni hypothetical protein 0.0036 0.0475 0.0391
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.053 0.4027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0393 0.0753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0743 0.0661
Onchocerca volvulus 0.0058 0.091 0.183
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0102 0.0772
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0719 0.1432
Onchocerca volvulus 0.0058 0.091 0.183
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.1316 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0719 0.0671
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0518 0.3938
Brugia malayi hypothetical protein 0.0152 0.2718 0.5683
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0518 0.1048
Brugia malayi hypothetical protein 0.0175 0.3166 0.665
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.039 0.0653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0102 0.0133
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0051 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0481 0.0941
Leishmania major protein kinase, putative 0.0014 0.0051 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0291 0.0536
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.2718 0.268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0102 0.0133
Entamoeba histolytica hypothetical protein 0.0152 0.2718 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0102 0.0772
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0795 0.1528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0481 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0345 0.0651
Echinococcus multilocularis cpg binding protein 0.0033 0.0422 0.0373
Echinococcus multilocularis lamin 0.0058 0.091 0.0863
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1046 0.5
Schistosoma mansoni hypothetical protein 0.053 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0102 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.091 0.1776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.034 0.064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0743 0.0695
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0452 0.0788
Echinococcus granulosus intermediate filament protein 0.0058 0.091 0.0863
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1046 0.1
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0796 0.0715
Leishmania major basic transcription factor 3a, putative 0.0038 0.0518 0.3938
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0087 0.0036
Onchocerca volvulus 0.0039 0.0535 0.103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0743 0.1416
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0719 0.5466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0291 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0529 0.1043
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.023 0.1744
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0719 0.5466
Schistosoma mansoni transcription factor btf3 0.0038 0.0518 0.0435
Brugia malayi Pre-SET motif family protein 0.0033 0.0425 0.0729
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0425 0.0341
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0481 0.3656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0481 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0481 0.094
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.4717 0.4689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0719 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.034 0.064
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0051 0.0026
Mycobacterium leprae Possible regulatory protein 0.0014 0.0051 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.1082 0.1003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.4139 0.8762
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0102 0.0772
Schistosoma mansoni hypothetical protein 0.0074 0.122 0.1143
Schistosoma mansoni lamin 0.0058 0.091 0.083
Schistosoma mansoni hypothetical protein 0.0052 0.0795 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0719 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0102 0.0133
Echinococcus granulosus death domain containing protein 0.0015 0.0087 0.0036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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