Detailed information for compound 1571100

Basic information

Technical information
  • TDR Targets ID: 1571100
  • Name: [2-[(2-chloro-4,6-dimethylphenyl)amino]-2-oxo ethyl] 7-methyl-[1,2,4]triazolo[1,5-a]pyrimid ine-2-carboxylate
  • MW: 373.794 | Formula: C17H16ClN5O3
  • H donors: 1 H acceptors: 5 LogP: 2.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1c(C)cc(cc1Cl)C)COC(=O)c1nc2n(n1)c(C)ccn2
  • InChi: 1S/C17H16ClN5O3/c1-9-6-10(2)14(12(18)7-9)20-13(24)8-26-16(25)15-21-17-19-5-4-11(3)23(17)22-15/h4-7H,8H2,1-3H3,(H,20,24)
  • InChiKey: VZJRGZIICWILSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(2-chloro-4,6-dimethyl-phenyl)amino]-2-oxo-ethyl] 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate
  • 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid [2-[(2-chloro-4,6-dimethylphenyl)amino]-2-oxoethyl] ester
  • 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid [2-[(2-chloro-4,6-dimethyl-phenyl)amino]-2-keto-ethyl] ester
  • T5283841
  • ZINC03362166

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.1054 0.1614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0149 0.0133
Trichomonas vaginalis rotamase, putative 0.0032 0.0681 0.0905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0428 0.0537
Echinococcus multilocularis transcription factor btf3 0.0034 0.076 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0428 0.0537
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0623 0.0501
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0075 0.0026
Entamoeba histolytica hypothetical protein 0.0105 0.2995 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.1054 0.0938
Brugia malayi Cytochrome P450 family protein 0.0044 0.1063 0.1379
Schistosoma mansoni hypothetical protein 0.0329 1 1
Schistosoma mansoni hypothetical protein 0.01 0.2838 0.2746
Brugia malayi hypothetical protein 0.0158 0.4638 0.6649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0498 0.064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0454 0.0554
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0484 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0426 0.0536
Schistosoma mansoni rotamase 0.0032 0.0704 0.0584
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.1054 0.6879
Echinococcus granulosus lamin 0.0052 0.1333 0.1267
Brugia malayi intermediate filament protein 0.0052 0.1333 0.1776
Schistosoma mansoni transcription factor btf3 0.0034 0.076 0.064
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0075 0.0026
Echinococcus granulosus survival motor neuron protein 1 0.023 0.6911 0.6887
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.4255 0.6115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1089 0.1416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0506 0.0651
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.1054 0.1432
Echinococcus multilocularis geminin 0.0329 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0777 0.628
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.076 0.6142
Schistosoma mansoni hypothetical protein 0.0031 0.0662 0.0541
Giardia lamblia GTOR 0.0043 0.1054 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0506 0.0651
Echinococcus multilocularis Ankyrin 0.0014 0.0132 0.0057
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.1054 0.1614
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0704 0.092
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.1924 0.1863
Echinococcus granulosus Ankyrin 0.0014 0.0132 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0705 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0075 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0623 0.0501
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1387 0.9049
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0075 0.0609
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0149 0.1204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1089 0.1021
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0149 0.1204
Schistosoma mansoni hypothetical protein 0.0031 0.0662 0.0541
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0777 0.628
Loa Loa (eye worm) hypothetical protein 0.0025 0.0484 0.0598
Onchocerca volvulus 0.003 0.0623 0.0797
Trichomonas vaginalis set domain proteins, putative 0.0231 0.6942 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1237 0.1699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0428 0.0537
Schistosoma mansoni cpg binding protein 0.003 0.0619 0.0497
Schistosoma mansoni hypothetical protein 0.0105 0.2995 0.2904
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.6064 0.8762
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0149 0.0021
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0075 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0426 0.0536
Echinococcus multilocularis expressed protein 0.0032 0.0704 0.0634
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.076 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0606 0.0796
Echinococcus granulosus single minded 2 0.0035 0.0783 0.0713
Onchocerca volvulus 0.0035 0.0783 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0855 0.1158
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0128 0.0053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0662 0.0859
Loa Loa (eye worm) intermediate filament protein 0.0052 0.1333 0.1839
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0681 0.5503
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0075 0.0492
Loa Loa (eye worm) hypothetical protein 0.0098 0.2758 0.3924
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0128 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.076 0.1019
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1532 0.1468
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.1333 0.1776
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.2758 0.3877
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.076 0.1019
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.1237 1
Schistosoma mansoni hypothetical protein 0.0031 0.0662 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0775 0.1043
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0681 0.4442
Leishmania major protein kinase, putative 0.0012 0.0075 0.0492
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0662 0.0591
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0571 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0705 0.0941
Brugia malayi PAS domain containing protein 0.0047 0.1166 0.1531
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.1054 0.8524
Schistosoma mansoni transcription factor LCR-F1 0.0105 0.2995 0.2904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1054 0.1447
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0385 0.0312
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0385 0.0312
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0623 0.4063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1532 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0132 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0662 0.0591
Toxoplasma gondii NAC domain-containing protein 0.0034 0.076 0.4957
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0783 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0775 0.1043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1089 0.1021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0149 0.0133
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0258 0.2085
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0075 0.0609
Loa Loa (eye worm) hypothetical protein 0.0014 0.0128 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0075 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0576 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0705 0.0941
Loa Loa (eye worm) hypothetical protein 0.0052 0.1333 0.1839
Entamoeba histolytica hypothetical protein 0.0105 0.2995 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.1054 0.8524
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.076 0.6142
Leishmania major basic transcription factor 3a, putative 0.0034 0.076 0.4957
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1532 1
Echinococcus multilocularis musashi 0.0052 0.1333 0.1267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1089 0.1021
Brugia malayi hypothetical protein 0.0049 0.1237 0.1635
Echinococcus multilocularis GPCR, family 2 0.0031 0.0662 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0498 0.064
Echinococcus granulosus lamin dm0 0.0052 0.1333 0.1267
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0681 0.4442
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.1237 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.076 0.2229
Onchocerca volvulus 0.0028 0.0569 0.0718
Brugia malayi Pre-SET motif family protein 0.0203 0.6064 0.8752
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0704 0.085
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1532 0.1423
Entamoeba histolytica hypothetical protein 0.0034 0.076 0.0341
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1532 0.1468
Echinococcus granulosus cpg binding protein 0.003 0.0619 0.0548
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.057 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0704 0.0939
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0149 0.0108
Onchocerca volvulus 0.0232 0.6946 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0705 0.0941
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.1166 0.1052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0662 0.0859
Brugia malayi Uncoordinated protein 44 0.0014 0.0128 0.000000093517
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0623 0.0551
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.1054 0.8524
Entamoeba histolytica hypothetical protein 0.0105 0.2995 1
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0 0.5
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0681 0.5503
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1089 0.1021
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0128 0.0077
Schistosoma mansoni cpg binding protein 0.0028 0.0569 0.0447
Onchocerca volvulus 0.0052 0.1333 0.183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.2758 0.3924
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.1054 0.1366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0506 0.0651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0623 0.0501
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1532 0.1423
Brugia malayi hypothetical protein 0.0032 0.0689 0.0828
Echinococcus granulosus intermediate filament protein 0.0052 0.1333 0.1267
Schistosoma mansoni hypothetical protein 0.0022 0.0385 0.026
Echinococcus granulosus GPCR family 2 0.0031 0.0662 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0149 0.0133
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0105 0.2995 0.2942
Loa Loa (eye worm) hypothetical protein 0.0014 0.0132 0.0082
Trichomonas vaginalis rotamase, putative 0.0032 0.0704 0.0939
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0484 0.0412
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0571 0.0653
Brugia malayi beta-NAC-like protein 0.0034 0.076 0.0931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1089 0.0973
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0662 0.0591
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0569 0.0722
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0149 0.1204
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1532 0.5
Schistosoma mansoni lamin 0.0052 0.1333 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.076 0.1019
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0149 0.1204
Schistosoma mansoni hypothetical protein 0.0329 1 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0075 0.0026
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0149 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0775 0.1043
Leishmania major protein kinase, putative 0.0012 0.0075 0.0492
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0149 0.0031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0623 0.0551
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.1333 0.1839
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1585 0.1476
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1165 0.1528
Schistosoma mansoni hypothetical protein 0.0031 0.0662 0.0541
Echinococcus granulosus transcription factor btf3 0.0034 0.076 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0775 0.1043
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0149 0.0972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0775 0.1043
Schistosoma mansoni intermediate filament proteins 0.0052 0.1333 0.122
Loa Loa (eye worm) hypothetical protein 0.0158 0.4638 0.6675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0149 0.0133
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0075 0.0026
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0128 0.0053
Brugia malayi Protein kinase domain containing protein 0.0014 0.0128 0.000000093517
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0075 0.0026
Echinococcus multilocularis lamin dm0 0.0052 0.1333 0.1267
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.1237 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1788 0.2447
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.1237 0.8071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1054 0.1447
Schistosoma mansoni single-minded 0.0047 0.1166 0.1052
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0075 0.0026
Schistosoma mansoni hypothetical protein 0.0047 0.1165 0.105
Brugia malayi CXXC zinc finger family protein 0.0028 0.0569 0.065
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0623 0.0551
Entamoeba histolytica hypothetical protein 0.0105 0.2995 1
Onchocerca volvulus 0.0047 0.1165 0.1585
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.076 0.6142
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.1054 0.6879
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.1237 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1089 0.1482
Brugia malayi hypothetical protein 0.023 0.6911 1
Brugia malayi Death domain containing protein 0.0014 0.0128 0.000000093517
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.1924 0.1863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0428 0.0537
Brugia malayi hypothetical protein 0.0105 0.2995 0.4227
Schistosoma mansoni hypothetical protein 0.0067 0.1788 0.1681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1089 0.0973
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0662 0.0788
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0128 0.0053
Brugia malayi Pre-SET motif family protein 0.003 0.0623 0.0729
Schistosoma mansoni lamin 0.0052 0.1333 0.122
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.0075 0.5
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0149 0.0074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0454 0.0554
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1532 1
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0783 0.0966
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0705 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1054 0.1447
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1532 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0705 0.0941
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0075 0.0609
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0128 0.0053
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0128 0.000000064252
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0075 0.0026
Echinococcus granulosus expressed protein 0.0032 0.0704 0.0634
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0075 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0426 0.0536
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.6911 0.6887
Brugia malayi hypoxia-induced factor 1 0.0146 0.4255 0.6085
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0075 0.0026
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0336 0.2719
Echinococcus multilocularis lamin 0.0052 0.1333 0.1267
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0777 0.5068
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0075 0.0026
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0705 0.4602
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.1054 0.0986
Echinococcus multilocularis cpg binding protein 0.003 0.0619 0.0548
Loa Loa (eye worm) hypothetical protein 0.0051 0.1303 0.1796
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0075 0.0609
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.1054 0.8524
Loa Loa (eye worm) hypothetical protein 0.003 0.0623 0.0801
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.1063 0.1445
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.1237 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1089 0.0973
Mycobacterium leprae Possible regulatory protein 0.0012 0.0075 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0681 0.5503
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.2758 0.3877
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0149 0.0972
Loa Loa (eye worm) ICD-1 protein 0.0034 0.076 0.1001
Echinococcus granulosus death domain containing protein 0.0014 0.0128 0.0053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1532 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0149 0.0133
Onchocerca volvulus 0.0052 0.1333 0.183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0662 0.0788
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.1054 0.0986
Loa Loa (eye worm) hypothetical protein 0.0067 0.1788 0.2505
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0662 0.0591
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.1237 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0105 0.2995 0.2942
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0623 0.0501
Leishmania major hypothetical protein, conserved 0.0049 0.1237 0.8071
Loa Loa (eye worm) hypothetical protein 0.023 0.6911 1
Schistosoma mansoni cpg binding protein 0.003 0.0619 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0705 0.0941
Schistosoma mansoni survival motor neuron protein 0.0047 0.1165 0.105

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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