Detailed information for compound 1571176

Basic information

Technical information
  • TDR Targets ID: 1571176
  • Name: T5293864
  • MW: 264.3 | Formula: C12H12N2O3S
  • H donors: 1 H acceptors: 2 LogP: 1.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccccc1CC1SC(=NC1=O)N
  • InChi: 1S/C12H12N2O3S/c1-17-11(16)8-5-3-2-4-7(8)6-9-10(15)14-12(13)18-9/h2-5,9H,6H2,1H3,(H2,13,14,15)
  • InChiKey: NKJWVPGBQASBFE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major p450 reductase, putative 0.0025 0.0429 0.131
Brugia malayi flavodoxin family protein 0.0025 0.0429 0.071
Echinococcus granulosus dna polymerase eta 0.0046 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.0046 0.1058 0.1751
Plasmodium falciparum nitric oxide synthase, putative 0.0025 0.0429 0.1288
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0588 0.0796
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0652 0.206
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.3008 0.4315
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0415 0.0659
Loa Loa (eye worm) hypothetical protein 0.0018 0.0232 0.0384
Onchocerca volvulus Cathepsin L homolog 0.0012 0.004 0.0058
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.004 0.0067
Loa Loa (eye worm) ctsf protein 0.0012 0.004 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.028 0.0809
Loa Loa (eye worm) hypothetical protein 0.0018 0.0232 0.0384
Onchocerca volvulus 0.0012 0.004 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.028 0.0809
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0588 0.1813
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.6041 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0025 0.0429 0.131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1213 0.2007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0602 0.0602
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0415 0.0659
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1213 0.2007
Plasmodium vivax flavodoxin domain containing protein 0.0022 0.0345 0.101
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.3008 0.4979
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0232 0.0636
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0415 0.1263
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0173 0.0173
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.028 0.0809
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.004 0.0067
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0588 0.1813
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0731 0.1211
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0588 0.0796
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0415 0.0687
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.3008 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0499 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.004 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0415 0.1263
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0025 0.0429 0.131
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0232 0.0636
Loa Loa (eye worm) hypothetical protein 0.0035 0.0731 0.1211
Loa Loa (eye worm) hypothetical protein 0.0051 0.1213 0.2007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0415 0.0757
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0588 0.1844
Mycobacterium ulcerans DNA polymerase IV 0.002 0.028 0.0174
Schistosoma mansoni cytochrome P450 reductase 0.0025 0.0429 0.1426
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.3008 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0012 0.004 0.004
Brugia malayi 6-phosphofructokinase 0.0111 0.3008 0.4979
Brugia malayi Cathepsin L-like precursor 0.0012 0.004 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0098 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0098 0.0194
Onchocerca volvulus 0.0028 0.0514 0.0744
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0025 0.0429 0.0709
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0415 0.1263
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0025 0.0429 0.0429
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0015 0.0147 0.0489
Loa Loa (eye worm) FAD binding domain-containing protein 0.0015 0.0147 0.0243
Echinococcus granulosus lamin 0.0028 0.0514 0.0514
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.028 0.028
Onchocerca volvulus 0.0012 0.004 0.0058
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.1058 0.3428
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.028 0.0349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0173 0.0173
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0025 0.0429 0.131
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.028 0.0277
Brugia malayi Pre-SET motif family protein 0.0213 0.6041 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.004 0.0067
Leishmania major DNA polymerase eta, putative 0.0046 0.1058 0.3428
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0012 0.004 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0588 0.0796
Toxoplasma gondii flavodoxin domain-containing protein 0.0012 0.0058 0.0283
Onchocerca volvulus 0.0012 0.004 0.0058
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.004 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.028 0.0809
Leishmania major DNA polymerase kappa, putative 0.002 0.028 0.0809
Loa Loa (eye worm) fibroinase 0.0012 0.004 0.0067
Echinococcus granulosus GPCR family 2 0.0016 0.0173 0.0173
Echinococcus multilocularis lamin 0.0028 0.0514 0.0514
Brugia malayi 6-phosphofructokinase 0.0111 0.3008 0.4979
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.028 0.0809
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.004 0.004
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0022 0.0345 0.0443
Brugia malayi Pre-SET motif family protein 0.0031 0.0602 0.0997
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.028 0.0809
Loa Loa (eye worm) hypothetical protein 0.0025 0.0429 0.071
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0025 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0024 0.0415 0.0687
Loa Loa (eye worm) hypothetical protein 0.0018 0.0232 0.0384
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.028 0.0464
Loa Loa (eye worm) FAD binding domain-containing protein 0.0025 0.0429 0.071
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.3008 1
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0588 0.8953
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.028 0.0809
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0173 0.0286
Echinococcus granulosus methionine synthase reductase 0.0015 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0098 0.0194
Brugia malayi phosphofructokinase 0.0111 0.3008 0.4979
Brugia malayi FAD binding domain containing protein 0.0015 0.0147 0.0243
Echinococcus multilocularis GPCR, family 2 0.0016 0.0173 0.0173
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0173 0.0173
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0415 0.0659
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.3008 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.3008 0.4315
Schistosoma mansoni hypothetical protein 0.0016 0.0173 0.0575
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.004 0.0134
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.3008 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Trichomonas vaginalis set domain proteins, putative 0.0242 0.6918 1
Trichomonas vaginalis sulfite reductase, putative 0.0025 0.0429 0.0565
Echinococcus multilocularis lamin dm0 0.0028 0.0514 0.0514
Schistosoma mansoni lamin 0.0028 0.0514 0.171
Schistosoma mansoni hypothetical protein 0.0016 0.0173 0.0575
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0415 0.0687
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0415 0.0687
Loa Loa (eye worm) hypothetical protein 0.0013 0.0089 0.0147
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0173 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0514 0.0852
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0025 0.0429 0.131
Onchocerca volvulus 0.0242 0.6918 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0514 0.0852
Schistosoma mansoni hypothetical protein 0.0016 0.0173 0.0575
Loa Loa (eye worm) hypothetical protein 0.0024 0.0415 0.0687
Loa Loa (eye worm) hypothetical protein 0.0024 0.0415 0.0687
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0602 0.2003
Onchocerca volvulus 0.0028 0.0514 0.0744
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.3008 0.3008
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.3008 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0012 0.004 0.0134
Trypanosoma cruzi p450 reductase, putative 0.0025 0.0429 0.131
Plasmodium vivax SET domain protein, putative 0.0031 0.0602 0.1862
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.3008 0.4315
Leishmania major cytochrome P450 reductase, putative 0.0022 0.0345 0.1027
Echinococcus multilocularis cysteine protease 0.0012 0.004 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0588 0.0796
Loa Loa (eye worm) hypothetical protein 0.0031 0.0602 0.0997
Echinococcus multilocularis musashi 0.0028 0.0514 0.0514
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0415 0.1263
Trypanosoma brucei unspecified product 0.0014 0.0098 0.0194
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0602 0.0602
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.028 0.0349
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0514 0.0852
Echinococcus granulosus dna polymerase kappa 0.002 0.028 0.028
Schistosoma mansoni intermediate filament proteins 0.0028 0.0514 0.171
Brugia malayi Cathepsin L-like precursor 0.0012 0.004 0.0067
Brugia malayi Cathepsin L-like precursor 0.0012 0.004 0.0067
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0132 0.0219
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0415 0.0659
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0025 0.0429 0.131
Echinococcus granulosus cathepsin L 0.0012 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0035 0.0731 0.2431
Loa Loa (eye worm) phosphofructokinase 0.0111 0.3008 0.4979
Giardia lamblia Hypothetical protein 0.0022 0.0345 0.2107
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Plasmodium vivax unspecified product 0.0113 0.3058 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0588 0.1813
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.3008 0.4315
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0588 0.1813
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.3008 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0588 0.8953
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.028 0.0809
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0602 0.2003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0089 0.0089
Brugia malayi intermediate filament protein 0.0028 0.0514 0.0852
Echinococcus multilocularis dna polymerase kappa 0.002 0.028 0.028
Echinococcus multilocularis dna polymerase eta 0.0046 0.1058 0.1058
Onchocerca volvulus Cathepsin L homolog 0.0012 0.004 0.0058
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.028 0.0277
Leishmania major DNA polymerase eta, putative 0.0032 0.0652 0.206
Brugia malayi Cathepsin L-like precursor 0.0012 0.004 0.0067
Echinococcus multilocularis cathepsin L 0.0012 0.004 0.004
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0588 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Echinococcus multilocularis cysteine protease 0.0012 0.004 0.004
Onchocerca volvulus 0.0051 0.12 0.1735
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.3008 1
Onchocerca volvulus 0.0012 0.004 0.0058
Echinococcus granulosus intermediate filament protein 0.0028 0.0514 0.0514
Plasmodium vivax vivapain-1 0.0113 0.3058 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0132 0.0219
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.3008 1
Onchocerca volvulus 0.0031 0.0602 0.0871
Brugia malayi FAD binding domain containing protein 0.0025 0.0429 0.071
Mycobacterium ulcerans hypothetical protein 0.0024 0.0415 0.0659
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0173 0.0286
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.004 0.0067
Brugia malayi Cathepsin L-like precursor 0.0012 0.004 0.0067
Plasmodium falciparum cysteine proteinase falcipain 1 0.0113 0.3058 1
Trypanosoma brucei unspecified product 0.002 0.028 0.0809
Onchocerca volvulus 0.0012 0.004 0.0058
Echinococcus granulosus cathepsin L cysteine protease 0.0012 0.004 0.004
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.004 0.004
Schistosoma mansoni DNA polymerase eta 0.0046 0.1058 0.3516
Echinococcus granulosus lamin dm0 0.0028 0.0514 0.0514
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0415 0.0659
Schistosoma mansoni hypothetical protein 0.0016 0.0173 0.0575
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.12 0.3991
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0025 0.0429 0.0429
Loa Loa (eye worm) cysteine protease 0.0012 0.004 0.0067
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.004 0.004
Onchocerca volvulus Cathepsin F homolog 0.0012 0.004 0.0058
Trypanosoma brucei unspecified product 0.0014 0.0098 0.0194
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0025 0.0429 0.1288
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0025 0.0429 0.131
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.3008 0.4979
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0652 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0415 0.1263
Mycobacterium ulcerans DNA polymerase IV 0.002 0.028 0.0174
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0588 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1213 0.2007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0602 0.9196
Toxoplasma gondii flavodoxin domain-containing protein 0.0012 0.0058 0.0283
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.028 0.0464
Loa Loa (eye worm) hypothetical protein 0.0018 0.0232 0.0384
Onchocerca volvulus 0.0024 0.0415 0.06
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0588 0.0796
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.3008 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.028 0.028
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0588 0.0796
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0588 0.0796
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.004 0.0134
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0588 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.1058 0.3428
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0514 0.0852
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0588 0.8953
Plasmodium vivax unspecified product 0.0105 0.2835 0.9259
Schistosoma mansoni diflavin oxidoreductase 0.0012 0.0058 0.0191
Echinococcus granulosus cathepsin l cysteine peptidase 0.0012 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0074 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0602 0.2003
Echinococcus multilocularis methionine synthase reductase 0.0015 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.3008 0.3008
Giardia lamblia Nitric oxide synthase, inducible 0.0022 0.0345 0.2107
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.1058 0.1751
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.028 0.0932
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.0286
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0025 0.0429 0.0429
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0569 0.0569
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0415 0.0659
Echinococcus granulosus cathepsin l1 0.0012 0.004 0.004
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0602 0.0602
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0232 0.0105
Schistosoma mansoni NADPH flavin oxidoreductase 0.0012 0.0063 0.021
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.028 0.0932
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.028 0.0809
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0012 0.004 0.0134
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.3008 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0025 0.0429 0.131
Echinococcus granulosus cysteine protease 0.0012 0.004 0.004
Echinococcus multilocularis tumor protein p63 0.0346 1 1
Brugia malayi Cathepsin L-like precursor 0.0012 0.004 0.0067
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0025 0.0429 0.131
Onchocerca volvulus 0.0012 0.004 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0602 0.2003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0074 0.0122
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0415 0.1263
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0232 0.1933
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.028 0.0809
Schistosoma mansoni lamin 0.0028 0.0514 0.171
Loa Loa (eye worm) hypothetical protein 0.0051 0.12 0.1987
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.3008 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0232 0.0384
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0415 0.0757
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0173 0.0173
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0415 0.0659
Onchocerca volvulus 0.0012 0.004 0.0058

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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