Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.3387 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3387 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.3387 | 0.3387 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.3387 | 0.3387 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.3387 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.3387 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.3387 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.3387 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.3387 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.3387 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.3387 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Max_Activity_Concent (functional) | 0.38 uM | PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.