Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 163 aa | 133 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | rotamase | 0.004 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.9608 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.004 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.2981 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.9608 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.2981 | 0.3103 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.004 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.2981 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0039 | 0.9608 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.2981 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0039 | 0.9608 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.2981 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.2981 | 0.5 |
Echinococcus granulosus | expressed protein | 0.004 | 1 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0039 | 0.9608 | 1 |
Echinococcus multilocularis | expressed protein | 0.004 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Trichomonas vaginalis | rotamase, putative | 0.0039 | 0.9608 | 0.9442 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2981 | 0.3103 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.9608 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 2.1331 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.