Detailed information for compound 1571594

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.458 | Formula: C21H20N2O6S
  • H donors: 2 H acceptors: 6 LogP: 2.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OS(=O)(=O)O.COc1ccc2c(c1Cc1c(OC)ccc3c1cccn3)cccn2
  • InChi: 1S/C21H18N2O2.H2O4S/c1-24-20-9-7-18-14(5-3-11-22-18)16(20)13-17-15-6-4-12-23-19(15)8-10-21(17)25-2;1-5(2,3)4/h3-12H,13H2,1-2H3;(H2,1,2,3,4)
  • InChiKey: WQEMHDJMFOQPIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0236 0.2561 0.4005
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.8479 0.8479
Echinococcus granulosus tubulin alpha chain 0.0397 0.4626 0.5456
Trypanosoma brucei beta tubulin 0.0286 0.3204 0.5011
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.0903 0.1412
Loa Loa (eye worm) tubulin alpha-3 chain 0.0235 0.2539 0.3971
Schistosoma mansoni nAChR subunit 0.0124 0.1106 0.1305
Loa Loa (eye worm) ACC-1 protein 0.0124 0.1106 0.173
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0334 0.3816 0.3816
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Trypanosoma brucei alpha tubulin 0.0397 0.4626 0.7235
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0235 0.2539 0.3971
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0236 0.2561 0.4005
Echinococcus multilocularis glycine receptor subunit beta 0.0124 0.1106 0.1106
Schistosoma mansoni alpha tubulin 0.0397 0.4626 0.5456
Echinococcus granulosus peroxisome assembly protein 26 0.0397 0.4626 0.5456
Trichomonas vaginalis tubulin epsilon chain, putative 0.0534 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Onchocerca volvulus 0.0057 0.0249 0.0653
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Echinococcus multilocularis tubulin alpha chain 0.0397 0.4626 0.4626
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0124 0.1106 0.1106
Trypanosoma brucei tubulin delta chain 0.0124 0.1117 0.1747
Leishmania major beta tubulin 0.0534 0.6394 1
Toxoplasma gondii alpha tubulin TUBA1 0.0397 0.4626 0.7235
Loa Loa (eye worm) GABA receptor subunit 0.0067 0.0372 0.0582
Toxoplasma gondii alpha-tubulin I, putative 0.0397 0.4626 0.7235
Onchocerca volvulus 0.0057 0.0249 0.0653
Trichomonas vaginalis tubulin alpha chain, putative 0.0534 0.6394 1
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0361 0.4163 0.491
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0272 0.3024 0.473
Loa Loa (eye worm) hypothetical protein 0.0194 0.201 0.3144
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0334 0.3816 0.3816
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0057 0.0249 0.0249
Trichomonas vaginalis tubulin epsilon chain, putative 0.0534 0.6394 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0124 0.1106 0.1305
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2424 0.3532
Loa Loa (eye worm) transcription factor SMAD2 0.0111 0.0951 0.1487
Schistosoma mansoni tubulin subunit alpha 0.0397 0.4626 0.5456
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Echinococcus multilocularis tubulin alpha 1C chain 0.0397 0.4626 0.4626
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0124 0.1106 0.173
Brugia malayi hypothetical protein 0.0057 0.0249 0.039
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.8479 1
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0361 0.4163 0.4163
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0124 0.1117 0.1747
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0334 0.3816 0.3816
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0124 0.1106 0.173
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Echinococcus multilocularis geminin 0.0521 0.6229 0.6229
Trichomonas vaginalis tubulin, putative 0.0162 0.1602 0.2506
Echinococcus granulosus beta tubulin 0.0534 0.6394 0.7541
Echinococcus granulosus histone lysine N methyltransferase Ez 0.047 0.5567 0.6566
Loa Loa (eye worm) tubulin alpha 2 0.0272 0.3024 0.473
Loa Loa (eye worm) hypothetical protein 0.0107 0.0896 0.1401
Trichomonas vaginalis tubulin beta chain, putative 0.0397 0.4626 0.7235
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.029 0.0454
Schistosoma mansoni alpha tubulin 0.0397 0.4626 0.5456
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.0372 0.0582
Echinococcus granulosus tubulin beta 1 chain 0.0534 0.6394 0.7541
Trypanosoma brucei epsilon tubulin 0.0286 0.3204 0.5011
Echinococcus granulosus Tubulin beta 2C chain 0.0534 0.6394 0.7541
Leishmania major beta tubulin 0.0534 0.6394 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0286 0.3204 0.5011
Echinococcus multilocularis Tubulin beta 2C chain 0.0534 0.6394 0.6394
Loa Loa (eye worm) tubulin alpha chain 0.0397 0.4626 0.7235
Loa Loa (eye worm) BEN-1 protein 0.0534 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Brugia malayi Tubulin alpha-2 chain 0.0397 0.4626 0.7235
Leishmania major beta tubulin 0.0534 0.6394 1
Echinococcus multilocularis tubulin subunit beta 0.0534 0.6394 0.6394
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0256 0.04
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.047 0.5567 0.5567
Trichomonas vaginalis tubulin alpha chain, putative 0.0286 0.3204 0.5011
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0124 0.1106 0.173
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Echinococcus granulosus Tubulin alpha 1 chain 0.0397 0.4626 0.5456
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Loa Loa (eye worm) hypothetical protein 0.0272 0.3024 0.473
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.0903 0.1054
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.1527 0.5846
Brugia malayi excitatory GABA receptor EXP-1A 0.0124 0.1106 0.173
Echinococcus granulosus tubulin beta 4A class IVa 0.0534 0.6394 0.7541
Brugia malayi hypothetical protein 0.0057 0.0249 0.039
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0124 0.1106 0.173
Leishmania major beta tubulin 0.0534 0.6394 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0107 0.0126
Onchocerca volvulus 0.0067 0.0372 0.0976
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2424 0.3791
Schistosoma mansoni nAChR subunit 0.0124 0.1106 0.1305
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0124 0.1106 0.173
Echinococcus multilocularis tubulin alpha chain 0.0397 0.4626 0.4626
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.0903 0.1412
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0124 0.1106 0.173
Leishmania major hypothetical protein, conserved 0.007 0.0412 0.0644
Loa Loa (eye worm) hypothetical protein 0.0107 0.0896 0.1401
Trypanosoma brucei tubulin gamma chain 0.0286 0.3204 0.5011
Onchocerca volvulus Netrin receptor homolog 0.0236 0.2561 0.671
Echinococcus granulosus tubulin alpha chain 0.0397 0.4626 0.5456
Loa Loa (eye worm) tubulin beta chain 0.0124 0.1117 0.1747
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2424 0.3532
Loa Loa (eye worm) SET domain-containing protein 0.047 0.5567 0.8706
Echinococcus granulosus tubulin alpha 3 chain 0.0397 0.4626 0.5456
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0194 0.201 0.2371
Toxoplasma gondii beta-1 tubulin, putative 0.0534 0.6394 1
Trypanosoma cruzi tubulin delta chain 0.0124 0.1117 0.1747
Leishmania major beta tubulin 0.0534 0.6394 1
Treponema pallidum cell division protein FtsZ 0.0124 0.1117 1
Plasmodium vivax tubulin gamma chain, putative 0.0286 0.3204 0.5011
Onchocerca volvulus Putative nachr subunit 0.0334 0.3816 1
Leishmania major beta tubulin 0.0534 0.6394 1
Schistosoma mansoni enhancer of zeste ezh 0.047 0.5567 0.6566
Schistosoma mansoni tubulin subunit delta 0.0124 0.1117 0.1317
Loa Loa (eye worm) tubulin alpha-2 chain 0.0397 0.4626 0.7235
Trypanosoma brucei epsilon tubulin 0.0286 0.3204 0.5011
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2424 0.3791
Trichomonas vaginalis tubulin gamma chain, putative 0.0534 0.6394 1
Echinococcus granulosus tubulin alpha chain 0.0397 0.4626 0.5456
Trypanosoma cruzi tubulin gamma chain 0.0286 0.3204 0.5011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0256 0.04
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0124 0.1106 0.1305
Giardia lamblia Beta tubulin 0.0534 0.6394 1
Leishmania major gamma-tubulin 0.0286 0.3204 0.5011
Giardia lamblia Alpha-tubulin 0.0397 0.4626 0.7119
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0903 0.1065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Trichomonas vaginalis tubulin beta chain, putative 0.0162 0.1602 0.2506
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Echinococcus multilocularis tubulin delta chain 0.0124 0.1117 0.1117
Trichomonas vaginalis tubulin beta chain, putative 0.0397 0.4626 0.7235
Leishmania major beta tubulin 0.0534 0.6394 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0256 0.098
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Plasmodium vivax tubulin epsilon chain, putative 0.0286 0.3204 0.5011
Trypanosoma brucei beta tubulin 0.0534 0.6394 1
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Trichomonas vaginalis tubulin beta chain, putative 0.0397 0.4626 0.7235
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0124 0.1106 0.173
Brugia malayi Cation transporter family protein 0.0194 0.201 0.3144
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0067 0.0372 0.0582
Echinococcus multilocularis Tubulin beta 2C chain 0.0534 0.6394 0.6394
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0057 0.0249 0.039
Schistosoma mansoni nAChR subunit 0.0124 0.1106 0.1305
Echinococcus granulosus glycine receptor subunit alpha 1 0.0124 0.1106 0.1305
Loa Loa (eye worm) tubulin beta-1 chain 0.0534 0.6394 1
Entamoeba histolytica tubulin alpha-1 chain 0.0397 0.4626 0.7119
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0124 0.1106 0.1305
Mycobacterium leprae cell division protein FtsZ 0.0124 0.1117 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Schistosoma mansoni acetylcholine receptor-related 0.0057 0.0249 0.0294
Brugia malayi hypothetical protein 0.0057 0.0249 0.039
Brugia malayi Uncoordinated protein 44 0.0236 0.2561 0.4005
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0334 0.3816 0.5968
Loa Loa (eye worm) tubulin beta-4 chain 0.0534 0.6394 1
Echinococcus granulosus netrin receptor unc 5 0.0236 0.2561 0.302
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0124 0.1106 0.1106
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0256 0.04
Schistosoma mansoni tubulin subunit gamma 0.0286 0.3204 0.3778
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0534 0.6394 0.6394
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0107 0.0167
Echinococcus granulosus tubulin alpha 0.0286 0.3204 0.3778
Echinococcus granulosus tubulin alpha 1C chain 0.0397 0.4626 0.5456
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0124 0.1106 0.173
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0057 0.0249 0.0294
Onchocerca volvulus 0.0124 0.1106 0.2899
Echinococcus granulosus glycine receptor subunit alpha 1 0.0124 0.1106 0.1305
Leishmania major beta tubulin 0.0534 0.6394 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0107 0.0126
Entamoeba histolytica tubulin alpha chain, putative 0.0397 0.4626 0.7119
Loa Loa (eye worm) hypothetical protein 0.0051 0.0169 0.0265
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Echinococcus granulosus Tubulin alpha 1 chain 0.0397 0.4626 0.5456
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.0412 0.0644
Loa Loa (eye worm) alpha-tubulin 0.0397 0.4626 0.7235
Schistosoma mansoni ankyrin 23/unc44 0.0236 0.2561 0.302
Echinococcus granulosus Tubulin beta 2C chain 0.0534 0.6394 0.7541
Brugia malayi Protein kinase domain containing protein 0.0108 0.0903 0.1412
Loa Loa (eye worm) BEN-1 protein 0.0534 0.6394 1
Leishmania major beta tubulin 0.0534 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4626 0.7235
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.029 0.0454
Echinococcus multilocularis Tubulin alpha 1 chain 0.0397 0.4626 0.4626
Schistosoma mansoni tubulin subunit beta 0.0534 0.6394 0.7541
Echinococcus multilocularis Tubulin beta 2C chain 0.0534 0.6394 0.6394
Schistosoma mansoni tubulin subunit epsilon 0.0286 0.3204 0.3778
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0124 0.1106 0.1305
Onchocerca volvulus 0.0067 0.0372 0.0976
Schistosoma mansoni nAChR subunit 0.0124 0.1106 0.1305
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.2424 0.3791
Onchocerca volvulus 0.0194 0.201 0.5268
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0124 0.1106 0.1305
Loa Loa (eye worm) ACC-1 protein 0.0124 0.1106 0.173
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.2424 0.3532
Brugia malayi SET domain containing protein 0.047 0.5567 0.8706
Echinococcus multilocularis dual specificity 0.0108 0.0903 0.0903
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0236 0.2561 0.302
Brugia malayi Cation transporter family protein 0.0124 0.1106 0.173
Leishmania major beta tubulin 0.0534 0.6394 1
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0361 0.4163 0.491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0107 0.0126
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Schistosoma mansoni hypothetical protein 0.0521 0.6229 0.7347
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0124 0.1117 1
Onchocerca volvulus 0.0051 0.0169 0.0444
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Echinococcus granulosus tubulin alpha chain 0.0397 0.4626 0.5456
Brugia malayi Tubulin beta chain 0.0162 0.1602 0.2506
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Echinococcus granulosus tubulin subunit TubB 0.0397 0.4626 0.5456
Echinococcus multilocularis tubulin alpha chain 0.0397 0.4626 0.4626
Trypanosoma cruzi epsilon tubulin, putative 0.0286 0.3204 0.5011
Schistosoma mansoni tubulin subunit alpha 0.0397 0.4626 0.5456
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0272 0.3024 0.473
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0067 0.0372 0.0439
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Echinococcus multilocularis tubulin epsilon chain 0.0286 0.3204 0.3204
Loa Loa (eye worm) hypothetical protein 0.0137 0.1276 0.1996
Trypanosoma cruzi epsilon tubulin, putative 0.0286 0.3204 0.5011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0256 0.04
Echinococcus granulosus dual specificity 0.0108 0.0903 0.1065
Echinococcus multilocularis beta tubulin 0.0534 0.6394 0.6394
Leishmania major beta tubulin 0.0534 0.6394 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0124 0.1117 0.1747
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0124 0.1106 0.1305
Echinococcus granulosus Tubulin beta 2C chain 0.0534 0.6394 0.7541
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.0903 0.1412
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Leishmania major beta tubulin 0.0534 0.6394 1
Brugia malayi alpha-tubulin 0.0397 0.4626 0.7235
Trichomonas vaginalis tubulin gamma chain, putative 0.0286 0.3204 0.5011
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0903 0.1412
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0236 0.2561 0.2561
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0903 0.1412
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Onchocerca volvulus 0.0124 0.1106 0.2899
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0124 0.1106 0.1106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0107 0.0167
Trypanosoma cruzi zeta tubulin, putative 0.0124 0.1117 0.1747
Schistosoma mansoni tubulin subunit beta 0.0534 0.6394 0.7541
Schistosoma mansoni nAChR subunit 0.0124 0.1106 0.1305
Schistosoma mansoni hypothetical protein 0.0521 0.6229 0.7347
Leishmania major beta tubulin 0.0534 0.6394 1
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.1117 0.1747
Leishmania major beta tubulin 0.0534 0.6394 1
Echinococcus granulosus microtubule associated protein 2 0.0696 0.8479 1
Brugia malayi Tubulin gamma chain 0.0286 0.3204 0.5011
Echinococcus granulosus tubulin alpha chain 0.0397 0.4626 0.5456
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0057 0.0249 0.039
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0124 0.1117 0.1747
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0256 0.04
Brugia malayi MH2 domain containing protein 0.0111 0.0951 0.1487
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Onchocerca volvulus 0.0226 0.2424 0.6352
Giardia lamblia Epsilon tubulin 0.0124 0.1117 0.1402
Echinococcus granulosus beta tubulin 0.0534 0.6394 0.7541
Plasmodium vivax tubulin alpha chain, putative 0.0397 0.4626 0.7235
Echinococcus multilocularis tubulin alpha 3 chain 0.0397 0.4626 0.4626
Schistosoma mansoni ap endonuclease 0.0058 0.0256 0.0302
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0057 0.0249 0.039
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0256 0.04
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0286 0.3204 0.5011
Trichomonas vaginalis tubulin epsilon chain, putative 0.0124 0.1117 0.1747
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Echinococcus multilocularis tubulin alpha chain 0.0397 0.4626 0.4626
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0124 0.1106 0.173
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0057 0.0249 0.0249
Entamoeba histolytica protein kinase, putative 0.0108 0.0903 0.1054
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0256 0.04
Schistosoma mansoni tubulin subunit beta 0.0534 0.6394 0.7541
Echinococcus granulosus tubulin epsilon chain 0.0286 0.3204 0.3778
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Echinococcus granulosus tubulin subunit beta 0.0534 0.6394 0.7541
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.0454
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2424 0.3791
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.029 0.0454
Loa Loa (eye worm) tubulin alpha chain 0.0397 0.4626 0.7235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0107 0.0126
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0124 0.1106 0.173
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0124 0.1106 0.173
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0057 0.0249 0.039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0256 0.0302
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0334 0.3816 0.5968
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0256 0.1056
Schistosoma mansoni neurotransmitter gated ion channel 0.0067 0.0372 0.0439
Echinococcus multilocularis tumor protein p63 0.0347 0.3985 0.3985
Leishmania major beta tubulin 0.0534 0.6394 1
Giardia lamblia Delta tubulin 0.0124 0.1117 0.1402
Echinococcus multilocularis tubulin alpha 3 chain 0.0397 0.4626 0.4626
Loa Loa (eye worm) hypothetical protein 0.0334 0.3816 0.5968
Brugia malayi tubulin alpha-2 chain 0.0397 0.4626 0.7235
Echinococcus granulosus tumor protein p63 0.0347 0.3985 0.4699
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0162 0.1602 0.2506
Plasmodium vivax delta tubulin, putative 0.0124 0.1117 0.1747
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0124 0.1106 0.173
Trichomonas vaginalis tubulin beta chain, putative 0.0534 0.6394 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0397 0.4626 0.4626
Plasmodium falciparum alpha tubulin 2 0.0397 0.4626 0.7119
Entamoeba histolytica tubulin family protein 0.0534 0.6394 1
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Brugia malayi beta-tubulin, identical 0.0534 0.6394 1
Echinococcus granulosus tubulin alpha 3 chain 0.0397 0.4626 0.5456
Schistosoma mansoni hypothetical protein 0.0236 0.2561 0.302
Echinococcus granulosus nAChR subunit 0.0124 0.1106 0.1305
Echinococcus granulosus geminin 0.0521 0.6229 0.7347
Trichomonas vaginalis tubulin, putative 0.0162 0.1602 0.2506
Mycobacterium tuberculosis Cell division protein FtsZ 0.0124 0.1117 0.4275
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2424 0.3791
Schistosoma mansoni tubulin subunit alpha 0.0397 0.4626 0.5456
Giardia lamblia Alpha-tubulin 0.0397 0.4626 0.7119
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0124 0.1106 0.173
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0256 0.04
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0067 0.0372 0.0582
Brugia malayi Cation transporter family protein 0.0124 0.1106 0.173
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0124 0.1106 0.173
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.1117 0.1747
Mycobacterium ulcerans cell division protein FtsZ 0.0124 0.1117 0.4607
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.2612 1
Trypanosoma brucei alpha tubulin 0.0397 0.4626 0.7235
Echinococcus multilocularis tubulin gamma 1 chain 0.0286 0.3204 0.3204
Brugia malayi Immunoglobulin I-set domain containing protein 0.0236 0.2561 0.4005
Entamoeba histolytica hypothetical protein 0.0067 0.0372 0.019
Loa Loa (eye worm) MH2 domain-containing protein 0.0111 0.0951 0.1487
Giardia lamblia Gamma tubulin 0.0286 0.3204 0.4803
Giardia lamblia Beta tubulin 0.0534 0.6394 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0412 0.0644
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0124 0.1106 0.1305
Schistosoma mansoni alpha tubulin 0.0397 0.4626 0.5456
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0057 0.0249 0.039
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.0372 0.0582
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.2424 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0057 0.0249 0.039
Echinococcus granulosus Tubulin beta 2C chain 0.0534 0.6394 0.7541
Loa Loa (eye worm) hypothetical protein 0.0235 0.2539 0.3971
Echinococcus multilocularis tubulin alpha 1C chain 0.0397 0.4626 0.4626
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0124 0.1106 0.1106
Giardia lamblia Beta tubulin 0.0534 0.6394 1
Brugia malayi Tubulin beta chain 0.0124 0.1117 0.1747
Trichomonas vaginalis tubulin epsilon chain, putative 0.0397 0.4626 0.7235
Schistosoma mansoni nAChR subunit 0.0057 0.0249 0.0294
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2424 0.3791
Schistosoma mansoni ap endonuclease 0.0058 0.0256 0.0302
Schistosoma mansoni acetylcholine receptor subunit beta 0.0057 0.0249 0.0294
Schistosoma mansoni tumor necrosis factor receptor related 0.0361 0.4163 0.491
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0361 0.4163 0.4163
Echinococcus multilocularis tubulin alpha chain 0.0397 0.4626 0.4626
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0057 0.0249 0.0249
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0045 0.0071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0124 0.1106 0.173
Brugia malayi Tubulin beta-1 chain 0.0534 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Toxoplasma gondii exonuclease III APE 0.0058 0.0256 0.04
Trypanosoma brucei beta tubulin 0.0534 0.6394 1
Schistosoma mansoni tubulin subunit beta 0.0534 0.6394 0.7541
Trypanosoma cruzi tubulin delta chain 0.0124 0.1117 0.1747
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0169 0.02
Echinococcus multilocularis tubulin beta 1 chain 0.0534 0.6394 0.6394
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0412 0.0644
Plasmodium vivax tubulin beta chain, putative 0.0534 0.6394 1
Brugia malayi follicle stimulating hormone receptor 0.0235 0.2537 0.3968
Loa Loa (eye worm) tubulin alpha 2 0.011 0.0937 0.1466
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Echinococcus multilocularis Tubulin beta 2C chain 0.0534 0.6394 0.6394
Plasmodium falciparum tubulin delta chain, putative 0.0124 0.1117 0.1402
Trypanosoma brucei zeta tubulin 0.0124 0.1117 0.1747
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0071
Schistosoma mansoni hypothetical protein 0.0041 0.0045 0.0053
Loa Loa (eye worm) alpha-tubulin 0.0397 0.4626 0.7235
Onchocerca volvulus 0.0162 0.1602 0.4199
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0124 0.1106 0.1305
Leishmania major delta tubulin, putative 0.0124 0.1117 0.1747
Trichomonas vaginalis tubulin beta chain, putative 0.0397 0.4626 0.7235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0107 0.0107
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Loa Loa (eye worm) hypothetical protein 0.0236 0.2561 0.4005
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0124 0.1106 0.1106
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0334 0.3816 0.4501
Schistosoma mansoni nAChR subunit 0.0124 0.1106 0.1305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Trypanosoma brucei beta tubulin 0.0534 0.6394 1
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0057 0.0249 0.039
Onchocerca volvulus 0.0057 0.0249 0.0653
Leishmania major beta tubulin 0.0534 0.6394 1
Loa Loa (eye worm) acetylcholine receptor protein 0.0057 0.0249 0.039
Trichomonas vaginalis tubulin, putative 0.0124 0.1117 0.1747
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Echinococcus multilocularis Ankyrin 0.0236 0.2561 0.2561
Schistosoma mansoni tubulin subunit beta 0.0534 0.6394 0.7541
Echinococcus granulosus Ankyrin 0.0236 0.2561 0.302
Entamoeba histolytica hypothetical protein 0.0108 0.0903 0.1054
Echinococcus granulosus alpha tubulin 0.0397 0.4626 0.5456
Onchocerca volvulus 0.0194 0.201 0.5268
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0124 0.1106 0.1106
Trichomonas vaginalis tubulin beta chain, putative 0.0397 0.4626 0.7235
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Echinococcus multilocularis hypothetical protein 0.0397 0.4626 0.4626
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0067 0.0372 0.0439
Loa Loa (eye worm) LGC-31 protein 0.0124 0.1106 0.173
Schistosoma mansoni tubulin subunit beta 0.0124 0.1117 0.1317
Brugia malayi Death domain containing protein 0.0236 0.2561 0.4005
Trichomonas vaginalis tubulin gamma chain, putative 0.0124 0.1117 0.1747
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0124 0.1106 0.1305
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Brugia malayi Tubulin alpha-2 chain 0.0397 0.4626 0.7235
Schistosoma mansoni netrin receptor unc5 0.0236 0.2561 0.302
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Echinococcus granulosus Tubulin beta 2C chain 0.0534 0.6394 0.7541
Echinococcus granulosus glycine receptor subunit alpha 1 0.0124 0.1106 0.1305
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0124 0.1106 0.173
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.1602 0.2506
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.1602 0.2506
Loa Loa (eye worm) hypothetical protein 0.0194 0.201 0.3144
Schistosoma mansoni tubulin subunit beta 0.0534 0.6394 0.7541
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0057 0.0249 0.039
Leishmania major alpha tubulin 0.0397 0.4626 0.7235
Trypanosoma cruzi beta tubulin, putative 0.0534 0.6394 1
Loa Loa (eye worm) tubulin beta chain 0.0534 0.6394 1
Entamoeba histolytica tubulin gamma chain 0.0286 0.3204 0.4803
Brugia malayi tubulin alpha chain - mouse 0.0397 0.4626 0.7235
Brugia malayi hypothetical protein 0.0057 0.0249 0.039
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0124 0.1106 0.173
Brugia malayi Cell division protein ftsZ 0.0124 0.1117 0.1747
Plasmodium falciparum tubulin epsilon chain, putative 0.0286 0.3204 0.4803
Echinococcus granulosus tubulin gamma 1 chain 0.0286 0.3204 0.3778
Echinococcus multilocularis tubulin alpha 0.0286 0.3204 0.3204
Trichomonas vaginalis tubulin, putative 0.0534 0.6394 1
Echinococcus granulosus tubulin delta chain 0.0124 0.1117 0.1317
Trichomonas vaginalis tubulin epsilon chain, putative 0.0397 0.4626 0.7235
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0256 0.0256
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0194 0.201 0.2371
Echinococcus multilocularis Tubulin alpha 1 chain 0.0397 0.4626 0.4626
Onchocerca volvulus 0.0124 0.1106 0.2899
Leishmania major epsilon tubulin, putative 0.0286 0.3204 0.5011
Leishmania major beta tubulin 0.0534 0.6394 1
Loa Loa (eye worm) tubulin gamma chain 0.0286 0.3204 0.5011
Loa Loa (eye worm) beta-tubulin 0.0534 0.6394 1
Echinococcus granulosus nAChR subunit 0.0067 0.0372 0.0439
Echinococcus granulosus Tubulin alpha 1 chain 0.0397 0.4626 0.5456
Echinococcus granulosus glycine receptor subunit beta 0.0124 0.1106 0.1305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0107 0.0126
Trypanosoma brucei beta tubulin 0.0534 0.6394 1
Echinococcus multilocularis nAChR subunit 0.0067 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.2424 0.3791
Loa Loa (eye worm) hypothetical protein 0.0067 0.0372 0.0582
Schistosoma mansoni tubulin subunit alpha 0.0124 0.1117 0.1317
Trypanosoma cruzi zeta tubulin, putative 0.0124 0.1117 0.1747
Plasmodium falciparum alpha tubulin 1 0.0397 0.4626 0.7119
Trypanosoma brucei zeta tubulin, putative 0.0124 0.1117 0.1747
Brugia malayi Tubulin alpha chain 0.0397 0.4626 0.7235
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0334 0.3816 0.4501
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0412 0.0644
Trypanosoma brucei alpha tubulin 0.0397 0.4626 0.7235
Echinococcus granulosus tubulin alpha 1C chain 0.0397 0.4626 0.5456
Echinococcus granulosus glycine receptor subunit beta 0.0124 0.1106 0.1305
Echinococcus multilocularis Tubulin beta 2C chain 0.0534 0.6394 0.6394
Trichomonas vaginalis tubulin beta chain, putative 0.0397 0.4626 0.7235
Echinococcus multilocularis tubulin subunit TubB 0.0397 0.4626 0.4626
Schistosoma mansoni nAChR subunit 0.0124 0.1106 0.1305
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0107 0.0107
Brugia malayi Tubulin alpha chain 0.0124 0.1117 0.1747
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0057 0.0249 0.0294
Onchocerca volvulus 0.0194 0.201 0.5268
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.1602 0.2506
Entamoeba histolytica tubulin family protein 0.0534 0.6394 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0397 0.4626 0.7235
Leishmania major beta tubulin 0.0534 0.6394 1
Brugia malayi Protein kinase domain containing protein 0.0237 0.2568 0.4016
Loa Loa (eye worm) tubulin beta-2A chain 0.0534 0.6394 1
Echinococcus multilocularis glycine receptor subunit beta 0.0124 0.1106 0.1106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.2537 0.3968
Echinococcus multilocularis netrin receptor unc 5 0.0236 0.2561 0.2561
Toxoplasma gondii beta tubulin 0.0534 0.6394 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0057 0.0249 0.0294
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0124 0.1106 0.173
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0124 0.1106 0.173
Schistosoma mansoni neurotransmitter gated ion channel 0.0057 0.0249 0.0294
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0256 0.04
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Plasmodium vivax tubulin alpha chain, putative 0.0397 0.4626 0.7235
Echinococcus multilocularis beta tubulin 0.0534 0.6394 0.6394
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0412 0.0644
Trypanosoma cruzi alpha tubulin, putative 0.0397 0.4626 0.7235
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2424 0.3791
Trypanosoma brucei alpha tubulin, putative 0.0162 0.1602 0.2506
Echinococcus multilocularis Tubulin alpha 1 chain 0.0397 0.4626 0.4626
Loa Loa (eye worm) hypothetical protein 0.0124 0.1106 0.173
Plasmodium falciparum tubulin gamma chain 0.0286 0.3204 0.4803
Echinococcus multilocularis nAChR subunit 0.0124 0.1106 0.1106
Leishmania major zeta tubulin, putative 0.0124 0.1117 0.1747
Echinococcus granulosus death domain containing protein 0.0236 0.2561 0.302
Toxoplasma gondii beta-tubulin, putative 0.0534 0.6394 1
Brugia malayi hypothetical protein 0.0057 0.0249 0.039
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0236 0.2561 0.302
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0124 0.1106 0.173
Entamoeba histolytica protein kinase, putative 0.0108 0.0903 0.1054
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0334 0.3816 0.4501
Trypanosoma brucei epsilon tubulin 0.0286 0.3204 0.5011
Trypanosoma brucei alpha tubulin 0.0397 0.4626 0.7235
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.039
Loa Loa (eye worm) tubulin alpha 2 0.0272 0.3024 0.473
Plasmodium falciparum tubulin beta chain 0.0534 0.6394 1
Schistosoma mansoni nAChR subunit 0.0057 0.0249 0.0294
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0124 0.1106 0.1106

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.475 uM PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] ChEMBL. No reference
IC50 (functional) 9.3 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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