Detailed information for compound 1571658

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 658.913 | Formula: C40H58N4O4
  • H donors: 0 H acceptors: 4 LogP: 10.6 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(n1ccnc1C)OC[C@@]12CC[C@H]([C@@H]2[C@@H]2[C@](CC1)(C)[C@]1(C)CC[C@@H]3[C@]([C@H]1CC2)(C)CC[C@@H](C3(C)C)OC(=O)n1ccnc1C)C(=C)C
  • InChi: 1S/C40H58N4O4/c1-25(2)28-12-17-40(24-47-34(45)43-22-20-41-26(43)3)19-18-38(8)29(33(28)40)10-11-31-37(7)15-14-32(48-35(46)44-23-21-42-27(44)4)36(5,6)30(37)13-16-39(31,38)9/h20-23,28-33H,1,10-19,24H2,2-9H3/t28-,29+,30-,31+,32-,33+,37-,38+,39+,40+/m0/s1
  • InChiKey: AWISEXXGVHMSEU-COEVCNOISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi notch-like transmembrane receptor 0.0019 0.0022 0.0023
Plasmodium falciparum glutathione reductase 0.0018 0.0021 0.0029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0074 0.0074
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2984 0.723 1
Leishmania major carbamoyl-phosphate synthase, putative 0.0355 0.0839 0.0832
Echinococcus multilocularis neurogenic locus notch protein 0.0019 0.0022 0.0022
Schistosoma mansoni rab6-interacting 0.0022 0.003 0.003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0056 0.0078
Brugia malayi 6-phosphofructokinase 0.0122 0.0273 0.0282
Brugia malayi Cytochrome P450 family protein 0.0014 0.001 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.001 0.001
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0034 0.0035
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0559 0.1334 0.35
Echinococcus granulosus RUN 0.0022 0.003 0.003
Loa Loa (eye worm) animal heme peroxidase 0.0059 0.012 0.0124
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0273 0.1582
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0025
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0092 0.1385
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0015 0.0015
Brugia malayi phosphofructokinase 0.0122 0.0273 0.0282
Brugia malayi Calcium binding EGF domain containing protein 0.0019 0.0022 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0021 0.0014
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1571 0.3794 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0022 0.0022
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0021 0.0221
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0559 0.1334 0.35
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0021 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0041 0.0042
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0703 0.1686 1
Entamoeba histolytica hypothetical protein 0.004 0.0074 0.04
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0144 0.0327 0.032
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0559 0.1334 0.3481
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0024 0.0012
Brugia malayi hypothetical protein 0.004 0.0074 0.0077
Schistosoma mansoni cell polarity protein 0.0019 0.0022 0.0022
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0021 0.0007
Brugia malayi Calcium binding EGF domain containing protein 0.0019 0.0022 0.0023
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0021 0.0029
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0144 0.0327 0.0327
Onchocerca volvulus 0.0027 0.0041 0.0306
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0303 0.0699
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0021 0.0014
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.027 0.0662
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.027 0.0662
Echinococcus granulosus protein jagged 2 0.0019 0.0022 0.0022
Loa Loa (eye worm) Notch2 0.0019 0.0022 0.0023
Brugia malayi Muscle positioning protein 4 0.0019 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0122 0.0273 0.8222
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0058 0.0057
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0056 0.0056
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0559 0.1334 0.35
Loa Loa (eye worm) notch protein 0.0019 0.0022 0.0023
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1571 0.3794 1
Brugia malayi EGF-like domain containing protein 0.0019 0.0022 0.0023
Trypanosoma brucei cytochrome P450, putative 0.0014 0.001 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0021 0.0014
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.4124 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0025
Brugia malayi 6-phosphofructokinase 0.0122 0.0273 0.0282
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0127 0.0127
Schistosoma mansoni peroxidasin 0.0059 0.012 0.0119
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.003
Mycobacterium tuberculosis Probable reductase 0.0121 0.027 0.0662
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0355 0.0839 0.1142
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0144 0.0327 0.0518
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Schistosoma mansoni slit 0.0019 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.019 0.0438 0.0438
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0041 0.02
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.003 0.003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0056 0.0078
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0144 0.0327 0.0812
Trypanosoma brucei unspecified product 0.1033 0.2486 0.2481
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0559 0.1334 0.1334
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0092 0.0107
Mycobacterium ulcerans hypothetical protein 0.0144 0.0327 0.0839
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1571 0.3794 0.6133
Entamoeba histolytica DNA repair and recombination protein, putative 0.0029 0.0048 0.0241
Echinococcus granulosus bloom syndrome protein 0.0024 0.0034 0.0034
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0144 0.0327 0.0518
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0144 0.0327 0.0518
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0056 0.1156
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0797
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0144 0.0327 0.0327
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0144 0.0327 0.0327
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0041 0.0082
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0058 0.0057
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0273 0.0283
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1571 0.3794 0.3794
Brugia malayi EGF-like domain containing protein 0.0019 0.0022 0.0023
Loa Loa (eye worm) glutathione reductase 0.0053 0.0105 0.0109
Brugia malayi Cadherin domain containing protein 0.0019 0.0022 0.0023
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0144 0.0327 0.032
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0105 0.0105
Onchocerca volvulus Peroxidasin homolog 0.0059 0.012 0.1619
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0041 0.0082
Brugia malayi EGF-like domain containing protein 0.0019 0.0022 0.0023
Brugia malayi Flap endonuclease-1 0.0029 0.0047 0.0049
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0021 0.0007
Echinococcus granulosus protein jagged 1 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0144 0.0327 0.0339
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0144 0.0327 0.032
Schistosoma mansoni pyruvate carboxylase 0.1571 0.3794 0.3794
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0025
Echinococcus granulosus neurogenic locus notch protein 0.0019 0.0022 0.0022
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0019 0.0022 0.000000056864
Echinococcus multilocularis notch 0.0019 0.0022 0.0022
Schistosoma mansoni notch 0.0019 0.0022 0.0022
Toxoplasma gondii pyruvate carboxylase 0.1571 0.3794 0.3794
Schistosoma mansoni peroxidasin 0.0059 0.012 0.0119
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0021 0.0029
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0144 0.0327 0.0518
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0056 0.0103
Brugia malayi Animal haem peroxidase family protein 0.0059 0.012 0.0124
Echinococcus granulosus protein jagged 1 0.0019 0.0022 0.0022
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0029 0.0048 0.0041
Leishmania major cytochrome p450-like protein 0.0014 0.001 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.027 0.0662
Echinococcus granulosus fibropellin Ia 0.0019 0.0022 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0074 0.0074
Schistosoma mansoni aspartate carbamoyltransferase 0.0355 0.0839 0.0839
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0047 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0021 0.0022
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0047 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0022
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0144 0.0327 0.0518
Brugia malayi EGF-like domain containing protein 0.0019 0.0022 0.0023
Mycobacterium ulcerans pyruvate carboxylase 0.1571 0.3794 1
Entamoeba histolytica hypothetical protein, conserved 0.0029 0.0048 0.0241
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0021 0.0014
Echinococcus granulosus neurogenic locus notch protein 0.0019 0.0022 0.0022
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0144 0.0327 0.0432
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0047 0.0238
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0559 0.1334 0.3447
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0027 0.0041 0.0082
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0105 0.0105
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0021 0.0029
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1571 0.3794 0.379
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0034 0.0034
Brugia malayi Blistered cuticle protein 3 0.0059 0.012 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0041 0.02
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0273 0.4315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0058 0.0057
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0056 0.0056
Echinococcus multilocularis protein jagged 1 0.0019 0.0022 0.0022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0303 0.0749
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0021 0.0021
Onchocerca volvulus 0.0059 0.012 0.1619
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0047 0.0065
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.003 0.002
Brugia malayi glutathione reductase 0.0053 0.0105 0.0109
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0559 0.1334 0.35
Echinococcus granulosus neural cadherin 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0559 0.1334 0.35
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0022
Echinococcus granulosus neurogenic locus protein delta 0.0019 0.0022 0.0022
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0144 0.0327 0.032
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0144 0.0327 0.0839
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0041 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0025
Schistosoma mansoni lipoxygenase 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0074 0.0074
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0021 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0041 0.0082
Brugia malayi Carboxyl transferase domain containing protein 0.3979 0.9649 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.003 0.003
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0144 0.0327 0.0763
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0042
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0273 0.0266
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0273 0.0273
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0303 0.0749
Echinococcus multilocularis neurogenic locus protein delta 0.0019 0.0022 0.0022
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0047 0.0044
Loa Loa (eye worm) animal heme peroxidase 0.0059 0.012 0.0124
Entamoeba histolytica hypothetical protein 0.004 0.0074 0.04
Toxoplasma gondii thioredoxin reductase 0.0053 0.0105 0.0105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.0544 0.0564
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0144 0.0327 0.0895
Brugia malayi Doublecortin family protein 0.0022 0.003 0.0031
Plasmodium falciparum glutathione reductase 0.0053 0.0105 0.0145
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0559 0.1334 0.2149
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0559 0.1334 0.2149
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0797
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0797
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0056 0.0797
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0797
Giardia lamblia Rrm3p helicase 0.0029 0.0048 0.0282
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0031
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0559 0.1334 0.1334
Echinococcus granulosus flap endonuclease 1 0.0029 0.0047 0.0047
Onchocerca volvulus 0.0059 0.012 0.1619
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0559 0.1334 0.2149
Echinococcus multilocularis 6 phosphofructokinase 0.0122 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.4124 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0014
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0144 0.0327 0.0812
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0355 0.0839 0.2192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0273 0.1582
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0056 0.0056
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0034 0.0441
Chlamydia trachomatis biotin carboxylase 0.1426 0.3443 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Loa Loa (eye worm) hypothetical protein 0.0144 0.0327 0.0339
Schistosoma mansoni polycystin 1-related 0.0022 0.003 0.003
Schistosoma mansoni notch 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1571 0.3794 0.379
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.003 0.003
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0559 0.1334 0.3838
Brugia malayi Animal haem peroxidase family protein 0.0059 0.012 0.0124
Mycobacterium ulcerans 6-phosphofructokinase 0.0122 0.0273 0.0695
Echinococcus multilocularis neural cadherin 0.0019 0.0022 0.0022
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0144 0.0327 0.0327
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0105 0.0124
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0559 0.1334 0.1334
Leishmania major trypanothione reductase 0.0053 0.0105 0.0098
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0144 0.0327 0.0452
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0041 0.0034
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0273 0.1582
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0056 0.0333
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0041 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0024 0.0039
Plasmodium vivax glutathione reductase, putative 0.0053 0.0105 0.0124
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.003 0.003
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0019 0.0022 0.0022
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0144 0.0327 0.0518
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0144 0.0327 0.032
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0105 0.0159
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0144 0.0327 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0048 0.0659
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0029 0.0048 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0041 0.0082
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0273 0.4315
Loa Loa (eye worm) acetyltransferase 0.0163 0.0372 0.0385
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0041 0.02
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Brugia malayi follicle stimulating hormone receptor 0.026 0.0608 0.063
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0019 0.0022 0.0023
Brugia malayi Animal haem peroxidase family protein 0.0059 0.012 0.0124
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1571 0.3794 0.6133
Loa Loa (eye worm) RecQ helicase 0.0024 0.0034 0.0036
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0559 0.1334 0.35
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0144 0.0327 0.0327
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Onchocerca volvulus Dual oxidase homolog 0.0059 0.012 0.1619
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0144 0.0327 0.0327
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1571 0.3794 1
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0144 0.0327 0.0812
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0021 0.0021
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0056 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Echinococcus multilocularis neurogenic locus protein delta 0.0019 0.0022 0.0022
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0144 0.0327 0.0895
Brugia malayi Animal haem peroxidase family protein 0.0059 0.012 0.0124
Schistosoma mansoni notch 0.0019 0.0022 0.0022
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.3979 0.9649 1
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0056 0.0056
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0122 0.0273 0.0668
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0559 0.1334 0.3447
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0055 0.0054
Loa Loa (eye worm) phosphofructokinase 0.0122 0.0273 0.0283
Onchocerca volvulus Peroxidasin homolog 0.0059 0.012 0.1619
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0144 0.0327 0.0339
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0047 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0022
Echinococcus multilocularis protein jagged 1 0.0019 0.0022 0.0022
Trypanosoma brucei trypanothione reductase 0.0053 0.0105 0.0098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Echinococcus granulosus 6 phosphofructokinase 0.0122 0.0273 0.0273
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.0361 0.036
Echinococcus multilocularis slit 2 protein 0.0019 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.019 0.0438 0.0438
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0355 0.0839 0.0839
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0041 0.0053
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0021 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0797
Brugia malayi Cadherin domain containing protein 0.0019 0.0022 0.0023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0041 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0041 0.0042
Brugia malayi hypothetical protein 0.0022 0.003 0.0031
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0144 0.0327 0.0452
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0009 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0058 0.0057
Schistosoma mansoni septate junction protein 0.0019 0.0022 0.0022
Brugia malayi Pre-SET motif family protein 0.0034 0.0058 0.006
Echinococcus multilocularis Biotin lipoyl attachment 0.0144 0.0327 0.0327
Plasmodium falciparum carbamoyl phosphate synthetase 0.0355 0.0839 0.116
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0559 0.1334 0.1334
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0024 0.001
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.0372 0.0385
Loa Loa (eye worm) hypothetical protein 0.0034 0.0058 0.006
Onchocerca volvulus Peroxidase homolog 0.0059 0.012 0.1619
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0029 0.0048 0.0041
Treponema pallidum pyruvate carboxylase subunit B 0.0144 0.0327 1
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0105 0.0109
Echinococcus multilocularis neurogenic locus notch protein 4 0.0019 0.0022 0.0022
Echinococcus multilocularis fibropellin Ia 0.0019 0.0022 0.0022
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0127 0.0127
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0047 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0022 0.0003
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0021 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0273 0.4315
Plasmodium falciparum thioredoxin reductase 0.0018 0.0021 0.0029
Schistosoma mansoni acetyl-CoA carboxylase 0.4124 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.027 0.0662
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0041 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0022 0.0003
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0144 0.0327 0.0339
Echinococcus multilocularis fat cadherin tumor suppressor 0.0019 0.0022 0.0022
Echinococcus multilocularis peroxidasin 0.0059 0.012 0.0119
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0144 0.0327 0.0452
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.0372 0.0371
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.0372 0.0371
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0797
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0355 0.0839 0.1347
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0144 0.0327 0.0812
Echinococcus granulosus delta-like protein 1 0.0019 0.0022 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0273 0.4315
Brugia malayi Pre-SET motif family protein 0.0234 0.0544 0.0564
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0273 0.0273
Trypanosoma cruzi acetyl-CoA carboxylase 0.2553 0.6182 1
Echinococcus granulosus notch 0.0019 0.0022 0.0022
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1571 0.3794 0.3794
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0122 0.0273 0.0618
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0021 0.0021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.026 0.0608 0.063
Trypanosoma brucei acetyl-CoA carboxylase 0.4124 1 1
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0559 0.1334 0.3481
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1571 0.3794 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0144 0.0327 0.032
Entamoeba histolytica hypothetical protein 0.004 0.0074 0.04
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0029 0.0048 0.0041
Loa Loa (eye worm) animal heme peroxidase 0.0059 0.012 0.0124
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0047 0.004
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0029 0.0048 0.0041
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0083 0.045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0042
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.4124 1 1
Onchocerca volvulus Peroxidase homolog 0.0059 0.012 0.1619
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0144 0.0327 0.0327
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0092 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0041 0.0034
Brugia malayi GCC2 and GCC3 family protein 0.0019 0.0022 0.0023
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0047 0.0649
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0144 0.0327 0.0432
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0144 0.0327 0.032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1571 0.3794 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0034 0.0441
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0092 0.1385
Echinococcus granulosus protein jagged 2 0.0019 0.0022 0.0022
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0144 0.0327 0.0839
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0027 0.0038
Trichomonas vaginalis set domain proteins, putative 0.0266 0.0622 1
Brugia malayi EGF-like domain containing protein 0.0019 0.0022 0.0023
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0144 0.0327 0.0339
Schistosoma mansoni lipoxygenase 0.0062 0.0127 0.0127
Plasmodium vivax SET domain protein, putative 0.0034 0.0058 0.0058
Leishmania major carboxylase, putative 0.1571 0.3794 0.379
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0021 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0058 0.0057
Brugia malayi Thioredoxin reductase 0.0053 0.0105 0.0109
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.027 0.0612
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0703 0.1686 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0144 0.0327 0.0339
Brugia malayi Peroxidasin 0.0059 0.012 0.0124
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0144 0.0327 0.0812
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1571 0.3794 1
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.001 0.0004
Giardia lamblia High cysteine protein 0.0019 0.0022 0.0132
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0047 0.0279
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0355 0.0839 0.0832
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.003 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.001 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0022 0.0003
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0029 0.0048 0.0066
Plasmodium falciparum thioredoxin reductase 0.0053 0.0105 0.0145
Echinococcus multilocularis neurogenic locus notch protein 0.0019 0.0022 0.0022
Brugia malayi Delta serrate ligand family protein 0.0019 0.0022 0.0023
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0024 0.0034
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0355 0.0839 0.2168
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0559 0.1334 0.1328
Echinococcus multilocularis geminin 0.019 0.0438 0.0438
Schistosoma mansoni rab6-interacting 0.0022 0.003 0.003
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1571 0.3794 0.3794
Echinococcus multilocularis RUN 0.0022 0.003 0.003
Echinococcus granulosus slit 2 protein 0.0019 0.0022 0.0022
Schistosoma mansoni notch 0.0019 0.0022 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0 0.000000000010947
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Schistosoma mansoni loxhd1 0.0022 0.003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0022 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0021 0.0029
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0144 0.0327 0.0895
Brugia malayi hypothetical protein 0.0059 0.012 0.0124
Leishmania major acetyl-CoA carboxylase, putative 0.4124 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0009 0.0009
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0144 0.0327 0.032
Schistosoma mansoni notch 0.0019 0.0022 0.0022
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0029 0.0048 0.0048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0014
Echinococcus granulosus geminin 0.019 0.0438 0.0438
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0559 0.1334 0.3481
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.027 0.0662
Onchocerca volvulus 0.0059 0.012 0.1619
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0144 0.0327 0.0518
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0144 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Schistosoma mansoni laminin gamma-3 chain 0.0019 0.0022 0.0022
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0056 0.0103
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0144 0.0327 0.0895
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0144 0.0327 0.0327
Onchocerca volvulus Chorion peroxidase homolog 0.0059 0.012 0.1619
Schistosoma mansoni notch 0.0019 0.0022 0.0022
Loa Loa (eye worm) blistered cuticle protein 3 0.0059 0.012 0.0124
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Plasmodium falciparum flap endonuclease 1 0.0029 0.0047 0.0065
Toxoplasma gondii EGF family domain-containing protein 0.0019 0.0022 0.0022
Brugia malayi hypothetical protein 0.0022 0.003 0.0031
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0355 0.0839 0.1347
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2984 0.723 1
Echinococcus multilocularis protein jagged 2 0.0019 0.0022 0.0022
Leishmania major ATP-dependent phosphofructokinase 0.0122 0.0273 0.0266
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1571 0.3794 0.379
Brugia malayi EGF-like domain containing protein 0.0019 0.0022 0.0023
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0559 0.1334 0.1328
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0083 0.049
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0273 0.0283
Toxoplasma gondii carbamoylphosphate synthetase 0.0355 0.0839 0.0839
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0021 0.0029
Brugia malayi EGF-like domain containing protein 0.0019 0.0022 0.0023
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0144 0.0327 0.0327
Loa Loa (eye worm) doublecortin family protein 0.0022 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1571 0.3794 1
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1571 0.3794 0.3794
Brugia malayi Animal haem peroxidase family protein 0.0059 0.012 0.0124
Echinococcus granulosus neurogenic locus notch protein 4 0.0019 0.0022 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0303 0.0749
Onchocerca volvulus 0.0034 0.0058 0.0585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0058 0.0057
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.003 0.0041
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.001 0.0004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0041 0.0082
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0092 0.0092
Brugia malayi Calcium binding EGF domain containing protein 0.0019 0.0022 0.0023
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0144 0.0327 0.0763
Entamoeba histolytica hypothetical protein 0.004 0.0074 0.04
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.003 0.003
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0029 0.0048 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0042
Onchocerca volvulus Neurogenic locus notch homolog 0.0019 0.0022 0.000000056864
Echinococcus granulosus Biotin lipoyl attachment 0.0144 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0031
Onchocerca volvulus 0.0022 0.003 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0021 0.0022
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0559 0.1334 0.1328
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0029 0.0048 0.0048
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0105 0.0223
Loa Loa (eye worm) animal heme peroxidase 0.0059 0.012 0.0124
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0559 0.1334 0.3447
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0021 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.0124
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0273 0.043
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0144 0.0327 0.0327
Loa Loa (eye worm) CYP4Cod1 0.0014 0.001 0.001
Echinococcus granulosus peroxidasin 0.0059 0.012 0.0119
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0355 0.0839 0.0839
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0083 0.0114
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0021 0.0022
Schistosoma mansoni flap endonuclease-1 0.0026 0.004 0.004
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0144 0.0327 0.0327
Brugia malayi Cytochrome P450 family protein 0.0014 0.001 0.001
Onchocerca volvulus 0.0266 0.0622 1
Schistosoma mansoni hypothetical protein 0.0029 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0023
Onchocerca volvulus 0.0022 0.003 0.0124

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 30 uM Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay ChEMBL. 20494586
IC50 (functional) > 30 uM Cytotoxicity against human Jurkat cells after 72 hrs by XTT assay ChEMBL. 20494586
IC50 (functional) > 30 uM Cytotoxicity against human HeLa cells after 72 hrs by MTT assay ChEMBL. 20494586
IC50 (functional) > 30 uM Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay ChEMBL. 20494586
Inhibition (binding) Inhibition of DNA topoisomerase 1-mediated relaxation of supercoiled plasmid DNA at 100 uM after 3 hrs by gel electrophoresis ChEMBL. 20494586

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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