Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.0078 | 0.2087 | 0.3277 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.2035 | 0.3195 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0078 | 0.2087 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0146 | 0.6325 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0053 | 0.0496 | 0.1148 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.2035 | 0.3195 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0111 | 0.4168 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0111 | 0.4168 | 0.6579 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.7024 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0146 | 0.6325 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0146 | 0.6325 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.7024 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0047 | 0.0092 | 0.0145 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0146 | 0.6325 | 1 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0496 | 0.0755 |
Echinococcus granulosus | thymidylate synthase | 0.0111 | 0.4168 | 0.6579 |
Brugia malayi | thymidylate synthase | 0.0111 | 0.4168 | 0.6579 |
Echinococcus multilocularis | insulin receptor | 0.0047 | 0.0092 | 0.0145 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0047 | 0.0092 | 0.0113 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0111 | 0.4168 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.7024 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0047 | 0.0092 | 0.0113 |
Mycobacterium ulcerans | thymidylate synthase | 0.0111 | 0.4168 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0047 | 0.0092 | 0.0113 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0045 | 0.002 | 0.0032 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.2035 | 0.3195 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.2087 | 0.3277 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.2087 | 0.3277 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0496 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0045 | 0.002 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0078 | 0.2087 | 0.3277 |
Echinococcus multilocularis | thymidylate synthase | 0.0111 | 0.4168 | 0.659 |
Echinococcus granulosus | insulin receptor | 0.0047 | 0.0092 | 0.0113 |
Onchocerca volvulus | 0.0111 | 0.4168 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0047 | 0.0092 | 0.0113 |
Trypanosoma brucei | pteridine reductase 1 | 0.0201 | 0.9832 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0111 | 0.4168 | 0.6579 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0047 | 0.0092 | 0.0113 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0157 | 0.7024 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0146 | 0.6325 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.