Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0163 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0163 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0086 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0163 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1071 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0086 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0163 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0163 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0163 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0163 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0163 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0163 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0163 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0163 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0163 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0163 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0086 | 0.1071 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0163 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0163 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0163 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0163 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0163 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0163 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0163 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0163 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0086 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0163 | 1 | 1 |
Onchocerca volvulus | 0.0163 | 1 | 1 | |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0086 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0163 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0163 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0163 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0163 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0163 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0086 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0163 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0163 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0163 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0163 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0163 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0163 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0086 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0163 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0163 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0086 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0163 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0163 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0163 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.