Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Alpha-1d adrenergic receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Bos taurus | Alpha-1a adrenergic receptor | Starlite/ChEMBL | References |
Mesocricetus auratus | Alpha-1b adrenergic receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0329 | 0.3954 | 0.5 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0256 | 0.2253 | 0.4171 |
Echinococcus granulosus | proteasome prosome macropain | 0.0329 | 0.3954 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0256 | 0.2253 | 0.5699 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0329 | 0.3954 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0256 | 0.2253 | 0.5699 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0329 | 0.3954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0535 | 0.099 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0256 | 0.2253 | 0.5699 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0329 | 0.3954 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0329 | 0.3954 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0182 | 0.0535 | 0.1353 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0256 | 0.2253 | 0.5699 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0329 | 0.3954 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0256 | 0.2253 | 0.5699 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.5403 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0329 | 0.3954 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0329 | 0.3954 | 0.6183 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0392 | 0.5403 | 0.8447 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0329 | 0.3954 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0256 | 0.2253 | 0.3523 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0329 | 0.3954 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0329 | 0.3954 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0182 | 0.0535 | 0.1353 |
Echinococcus multilocularis | serotonin receptor | 0.0182 | 0.0535 | 0.1353 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0329 | 0.3954 | 0.3954 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0329 | 0.3954 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0392 | 0.5403 | 0.5403 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0256 | 0.2253 | 0.5699 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0329 | 0.3954 | 1 |
Schistosoma mansoni | amine GPCR | 0.0434 | 0.6396 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0256 | 0.2253 | 0.2253 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0329 | 0.3954 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0256 | 0.2253 | 0.5699 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0256 | 0.2253 | 0.5699 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0182 | 0.0535 | 0.0836 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0256 | 0.2253 | 0.5699 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0256 | 0.2253 | 0.5699 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0329 | 0.3954 | 0.7319 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0535 | 0.099 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0256 | 0.2253 | 0.5699 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0329 | 0.3954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.5403 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0256 | 0.2253 | 0.5699 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.99 nM | Displacement of [3H]-prazosin (0.3 nM) from bovine Alpha-1A adrenergic receptor expressed in BHK cells | ChEMBL. | 12519065 |
Ki (binding) | = 0.99 nM | Displacement of [3H]-prazosin (0.3 nM) from bovine Alpha-1A adrenergic receptor expressed in BHK cells | ChEMBL. | 12519065 |
Ki (binding) | = 3.2 nM | Displacement of [3H]-prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells | ChEMBL. | 12519065 |
Ki (binding) | = 3.2 nM | Displacement of [3H]-prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells | ChEMBL. | 12519065 |
Ki (binding) | = 6.3 nM | Ability to displace [3H]-prazosin (0.25 nM) from whole brain of rat alpha-1 adrenergic receptor | ChEMBL. | 12519065 |
Ki (binding) | = 6.3 nM | Ability to displace [3H]-prazosin (0.25 nM) from whole brain of rat alpha-1 adrenergic receptor | ChEMBL. | 12519065 |
Ki (binding) | = 9 nM | Displacement of [3H]-prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells | ChEMBL. | 12519065 |
Ki (binding) | = 9 nM | Displacement of [3H]-prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells | ChEMBL. | 12519065 |
Ki (binding) | = 160 nM | Ability to displace [3H]-5-CT (2.0 nM) from HeLa cells of human 5-hydroxytryptamine 1A receptor | ChEMBL. | 12519065 |
Ki (binding) | = 160 nM | Ability to displace [3H]-5-CT (2.0 nM) from HeLa cells of human 5-hydroxytryptamine 1A receptor | ChEMBL. | 12519065 |
Ki (binding) | = 340 nM | Ability to displace [3H]-5-CT (1.5 nM) from HeLa cells of human 5-hydroxytryptamine 1B receptor | ChEMBL. | 12519065 |
Ki (binding) | = 340 nM | Ability to displace [3H]-5-CT (1.5 nM) from HeLa cells of human 5-hydroxytryptamine 1B receptor | ChEMBL. | 12519065 |
Ki (binding) | = 920 nM | Displacement of [3H]-YM-09151-2 (0.06 nM) from human Dopamine receptor D4 expressed in CHO cells | ChEMBL. | 12519065 |
Ki (binding) | = 920 nM | Displacement of [3H]-YM-09151-2 (0.06 nM) from human Dopamine receptor D4 expressed in CHO cells | ChEMBL. | 12519065 |
Ki (binding) | = 1200 nM | Ability to displace [3H]-spiperone (0.3 nM) from CHO cells of human Dopamine receptor D3 | ChEMBL. | 12519065 |
Ki (binding) | = 1200 nM | Displacement of [3H]-ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptors | ChEMBL. | 12519065 |
Ki (binding) | = 1200 nM | Ability to displace [3H]-spiperone (0.3 nM) from CHO cells of human Dopamine receptor D3 | ChEMBL. | 12519065 |
Ki (binding) | = 1200 nM | Displacement of [3H]-ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptors | ChEMBL. | 12519065 |
Ki (binding) | > 2900 nM | Displacement of [3H]-spiperone (0.5 nM) from rat corpus striatum dopamine D2 receptor | ChEMBL. | 12519065 |
Ki (binding) | > 2900 nM | Displacement of [3H]-spiperone (0.5 nM) from rat corpus striatum dopamine D2 receptor | ChEMBL. | 12519065 |
Ki (binding) | > 4200 nM | Ability to displace [3H]-mesulergine (0.5 nM) from CHO cells of human 5-hydroxytryptamine 2C receptor | ChEMBL. | 12519065 |
Ki (binding) | > 4200 nM | Ability to displace [3H]-mesulergine (0.5 nM) from CHO cells of human 5-hydroxytryptamine 2C receptor | ChEMBL. | 12519065 |
NT (binding) | Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1; NT denotes not tested | ChEMBL. | 12519065 | |
NT (binding) | 0 | Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1; NT denotes not tested | ChEMBL. | 12519065 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.