Detailed information for compound 1572003

Basic information

Technical information
  • TDR Targets ID: 1572003
  • Name: 1-methyl-6H-pyrido[4,3-b]carbazole
  • MW: 232.28 | Formula: C16H12N2
  • H donors: 1 H acceptors: 1 LogP: 3.97 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nccc2c1cc1c(c2)[nH]c2c1cccc2
  • InChi: 1S/C16H12N2/c1-10-13-9-14-12-4-2-3-5-15(12)18-16(14)8-11(13)6-7-17-10/h2-9,18H,1H3
  • InChiKey: NAFCMTKQACGNRU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • NSC142053

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Starlite/ChEMBL No references
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAD54-like (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) BRM protein Get druggable targets OG5_127595 All targets in OG5_127595
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans DNA helicase Get druggable targets OG5_127595 All targets in OG5_127595
Echinococcus granulosus DNA repair and recombination protein RAD54B Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) type III restriction enzyme Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) BRM protein Get druggable targets OG5_127595 All targets in OG5_127595
Brugia malayi recombination factor GdRad54 Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi Type III restriction enzyme, res subunit family protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum DNA repair and recombination protein RAD54B, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii Arabidopsis thaliana BRAHMA ortholog-related Get druggable targets OG5_127595 All targets in OG5_127595
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Neospora caninum hypothetical protein Get druggable targets OG5_127595 All targets in OG5_127595
Neospora caninum SNF2 family N-terminal domain-containing protein (EC 2.7.11.1), related Get druggable targets OG5_127595 All targets in OG5_127595
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Cryptosporidium parvum SWI/SNF related putative transcriptional regulator ATpase Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum ko:K01529 SMARCA2, SNF2L2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [EC Get druggable targets OG5_127595 All targets in OG5_127595
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans transcriptional regulator Get druggable targets OG5_127595 All targets in OG5_127595
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Theileria parva DNA repair protein rad54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis global transcription activator snf2l2 Get druggable targets OG5_127595 All targets in OG5_127595
Trichomonas vaginalis lymphoid specific helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Plasmodium knowlesi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni helicase Get druggable targets OG5_127595 All targets in OG5_127595
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Toxoplasma gondii SWI2/SNF2 Brahma-like putative Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum IPR000299,Band 4.1,domain-containing Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Neospora caninum hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium hominis DNA repair protein RAD54-like Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania major DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium parvum brahma like protein with a HSA domain, SNF2 like helicase and a bromo domain Get druggable targets OG5_127595 All targets in OG5_127595
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum DEAD/DEAH box helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii SWI2/SNF2 Brahma-like putative Get druggable targets OG5_127595 All targets in OG5_127595
Trypanosoma congolense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax DEAD/DEAH helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Echinococcus granulosus dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi BRM protein Get druggable targets OG5_127595 All targets in OG5_127595
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus global transcription activator snf2l2 Get druggable targets OG5_127595 All targets in OG5_127595
Trypanosoma brucei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax DNA repair protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium yoelii DNA repair protein RAD54-like-related Get druggable targets OG5_127098 All targets in OG5_127098
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum ko:K01529 RAD54L, GdRAD54; RAD54-like [EC:3.6.1.-], putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans DNA helicase Get druggable targets OG5_127595 All targets in OG5_127595
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium falciparum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei gambiense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium berghei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum RAD54 like SWI/SNF2 ATpase Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans transcriptional regulator Get druggable targets OG5_127595 All targets in OG5_127595
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ATP-dependent RNA helicase DDX1, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi DEAD/DEAH helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Schistosoma japonicum Homeotic gene regulator, putative Get druggable targets OG5_127595 All targets in OG5_127595
Leishmania infantum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei DEAD/DEAH helicase, putative Get druggable targets OG5_127595 All targets in OG5_127595
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Leishmania major hypothetical protein, conserved RAD54-like (S. cerevisiae) 747 aa 633 aa 24.2 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0373 0.2254
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0373 0.0713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.1375 0.2634
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0124 0.0752
Schistosoma mansoni hypothetical protein 0.0014 0 0.0002
Schistosoma mansoni nuclear receptor 0.0029 0.0373 0.2254
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.1375 0.832
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0124 0.0752
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0124 1
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0124 1
Brugia malayi hypothetical protein 0.0043 0.0725 0.1388
Onchocerca volvulus 0.0226 0.5221 1
Echinococcus granulosus global transcription activator snf2l2 0.0081 0.1653 0.4227
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.1375 0.832
Echinococcus granulosus FTZ F1 alpha 0.007 0.1375 0.3517
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.5221 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0123 0.0316
Leishmania major hypothetical protein, conserved 0.007 0.137 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0725 0.1853
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.1375 0.2634
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0373 0.0714
Entamoeba histolytica hypothetical protein 0.0119 0.2598 0.2019
Brugia malayi nuclear receptor NHR-88 0.0029 0.0373 0.0713
Echinococcus multilocularis Chromo domain 0.0014 0 0.0002
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.2598 0.2019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0373 0.2254
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0373 0.2254
Loa Loa (eye worm) BRM protein 0.0052 0.0931 0.1783
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.1375 0.2068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Brugia malayi ecdysone receptor 0.0029 0.0373 0.0713
Loa Loa (eye worm) hypothetical protein 0.007 0.1375 0.2634
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0657 0.3973
Giardia lamblia DNA repair protein RAD52 0.042 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0373 0.0953
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0657 0.3973
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0657 0.1679
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.5221 0.4847
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.1375 0.3517
Schistosoma mansoni hypothetical protein 0.0019 0.0123 0.0747
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.1375 0.832
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.137 1
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.1375 0.832
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.5221 1
Onchocerca volvulus Bile acid receptor homolog 0.0224 0.5163 0.9881
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0124 0.0752
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0373 0.0713
Loa Loa (eye worm) hypothetical protein 0.007 0.1375 0.2634
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.1375 0.2634
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Schistosoma mansoni hypothetical protein 0.0019 0.0123 0.0747
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0123 0.0747
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.1375 0.3517
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Schistosoma mansoni hypothetical protein 0.0043 0.0725 0.4385
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.3505 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.5221 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0124 0.0752
Loa Loa (eye worm) hypothetical protein 0.0041 0.0668 0.128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0373 0.0953
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.5221 0.5
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.137 0.2598
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.1375 0.832
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0657 0.3973
Loa Loa (eye worm) hypothetical protein 0.007 0.1375 0.2634
Loa Loa (eye worm) hypothetical protein 0.0041 0.0657 0.1258
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0124 0.0752
Brugia malayi nuclear receptor RXR 0.0029 0.0373 0.0713
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.1375 0.2634
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0373 0.0713
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.1375 0.832
Loa Loa (eye worm) hypothetical protein 0.007 0.1375 0.2634
Echinococcus multilocularis GPCR, family 2 0.0019 0.0123 0.0747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.1375 0.2634
Schistosoma mansoni nuclear hormone receptor 0.007 0.1375 0.832
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0373 0.2254
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0124 0.5
Brugia malayi hypothetical protein 0.0029 0.0373 0.0713
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.1375 0.3517
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.1375 0.2634
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0123 0.0236
Brugia malayi steroid hormone receptor 0.0213 0.4913 0.941
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0373 0.0713
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0124 0.0318
Loa Loa (eye worm) BRM protein 0.0042 0.0688 0.1317
Onchocerca volvulus 0.007 0.1375 0.2068
Echinococcus multilocularis FTZ F1 alpha 0.007 0.1375 0.832
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0657 0.1257
Brugia malayi nuclear hormone receptor 0.007 0.1375 0.2634
Brugia malayi hypothetical protein 0.0041 0.0657 0.1257
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.1375 0.2634
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.1375 0.832
Schistosoma mansoni hypothetical protein 0.0019 0.0123 0.0747
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0657 0.1258
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0373 0.0713
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.1375 0.832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.1375 0.2634
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.5221 1
Loa Loa (eye worm) steroid hormone receptor 0.0213 0.4913 0.941
Brugia malayi nuclear receptor NHR-88 0.007 0.1375 0.2634
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0124 0.0237
Echinococcus granulosus Chromo domain 0.0014 0 0.0001
Echinococcus granulosus thyroid hormone receptor alpha 0.0173 0.391 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1138 0.2179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.1375 0.2634
Schistosoma mansoni zinc finger protein 0.0029 0.0373 0.2254
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.1375 0.832
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.1375 0.2634
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0373 0.2254
Schistosoma mansoni hypothetical protein 0.0019 0.0123 0.0747
Loa Loa (eye worm) hypothetical protein 0.007 0.1375 0.2634
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Brugia malayi hypothetical protein 0.0029 0.0373 0.0713
Loa Loa (eye worm) hypothetical protein 0.0224 0.5163 0.989
Loa Loa (eye worm) hypothetical protein 0.0041 0.0657 0.1258
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0657 0.1257
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0373 0.0953
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.1375 0.2634
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.1375 0.3517
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.1375 0.832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.1375 0.2634
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.1375 0.832
Loa Loa (eye worm) hypothetical protein 0.007 0.1375 0.2634
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.5221 0.4847
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0373 0.0714
Brugia malayi BRM protein 0.0081 0.1653 0.3166
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.1375 0.2068
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0725 0.4385
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.5221 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Brugia malayi Steroid receptor seven-up type 2 0.007 0.1375 0.2634
Brugia malayi tailless protein 0.0029 0.0373 0.0713
Brugia malayi hypothetical protein 0.0041 0.0657 0.1257
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.1375 0.3517
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.137 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0668 0.128
Loa Loa (eye worm) DR-78 0.0029 0.0373 0.0714
Loa Loa (eye worm) hypothetical protein 0.0041 0.0657 0.1258
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.1375 0.832
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0373 0.0714
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.1375 0.3517
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0123 0.0237
Echinococcus granulosus GPCR family 2 0.0019 0.0123 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.1375 0.2634
Loa Loa (eye worm) hypothetical protein 0.0029 0.0373 0.0714
Loa Loa (eye worm) hypothetical protein 0.007 0.1375 0.2634
Schistosoma mansoni thyroid hormone receptor 0.007 0.1375 0.832
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.1375 0.2634
Brugia malayi nuclear receptor RXR 0.0041 0.0657 0.1257
Schistosoma mansoni coup transcription factor 0.007 0.1375 0.832
Schistosoma mansoni hypothetical protein 0.0041 0.0668 0.4043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0725 0.4385
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0373 0.2254
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.1375 0.2634
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.1375 0.2634
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.137 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0124 0.0237
Schistosoma mansoni helicase 0.0081 0.1653 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1138 0.2179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.1375 0.2634
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0373 0.2254
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.1375 0.3517
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1138 0.2179
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0373 0.2254
Loa Loa (eye worm) hypothetical protein 0.0041 0.0657 0.1258
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.137 0.2598
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0373 0.2254
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0124 0.5
Brugia malayi ecdysteroid receptor 0.0224 0.5163 0.989
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.1375 0.2634
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.1375 0.2634
Brugia malayi nuclear hormone receptor 0.0029 0.0373 0.0713
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.5221 1
Brugia malayi conserved hypotetical protein 0.0029 0.0373 0.0713
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0373 0.0713
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0124 0.0238
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0237
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0124 0.0752
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.5221 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.1375 0.2634
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0123 0.0236
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.1375 0.832
Echinococcus multilocularis global transcription activator snf2l2 0.0081 0.1653 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0657 0.1258
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.1375 0.832
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0373 0.0953
Schistosoma mansoni thyroid hormone receptor 0.007 0.1375 0.832
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.1375 0.832
Schistosoma mansoni nuclear receptor 0.0029 0.0373 0.2254
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0123 0.0316
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.5221 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1138 0.2179
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0373 0.2254
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0373 0.0953
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.1375 0.832
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.1375 0.3517
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0373 0.2254
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.1375 0.2634
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.1375 0.2634
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0123 0.0747
Brugia malayi nuclear receptor NHR-67 0.0029 0.0373 0.0713
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.1375 0.832

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.96 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 2.49 uM PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) = 5.874 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 2.59 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 3.18 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 52.5 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in a fluorescence-based, Lymphoid Phosphatase (PTPN22, LYP-1) selectivity Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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