Detailed information for compound 1572020

Basic information

Technical information
  • TDR Targets ID: 1572020
  • Name: N-(3-morpholin-4-ylpropyl)-2-[2-oxo-3-(phenyl methyl)imidazolidin-1-yl]acetamide
  • MW: 360.451 | Formula: C19H28N4O3
  • H donors: 1 H acceptors: 2 LogP: 0.37 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1CCN(C1=O)Cc1ccccc1)NCCCN1CCOCC1
  • InChi: 1S/C19H28N4O3/c24-18(20-7-4-8-21-11-13-26-14-12-21)16-23-10-9-22(19(23)25)15-17-5-2-1-3-6-17/h1-3,5-6H,4,7-16H2,(H,20,24)
  • InChiKey: PPLBUOPFKIAMRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-morpholinopropyl)-2-[2-oxo-3-(phenylmethyl)imidazolidin-1-yl]acetamide
  • N-(3-morpholinopropyl)-2-[2-oxo-3-(phenylmethyl)-1-imidazolidinyl]acetamide
  • 2-[3-(benzyl)-2-keto-imidazolidin-1-yl]-N-(3-morpholinopropyl)acetamide
  • N-(3-morpholin-4-ylpropyl)-2-[2-oxo-3-(phenylmethyl)imidazolidin-1-yl]ethanamide
  • MLS000522447
  • SMR000127714
  • ChemDiv3_015240

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium activated potassium channel 0.0032 0.0141 0.0324
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0032 0.0141 0.5254
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.012 0.0672 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0239 0.0555
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0086 0.3412
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0067 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0067 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0125 0.07 0.1653
Toxoplasma gondii transporter, cation channel family protein 0.0032 0.0141 0.1797
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0032 0.0141 0.0334
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0038 0.0034
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0141 0.0137
Echinococcus multilocularis transfer RNA-Gly 0.0032 0.0141 0.0137
Loa Loa (eye worm) patched family protein 0.0018 0.0057 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0719 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0165 0.2063
Echinococcus granulosus sterol regulatory element binding protein 0.0128 0.0719 0.169
Toxoplasma gondii transporter, cation channel family protein 0.0032 0.0141 0.1797
Onchocerca volvulus 0.012 0.0672 1
Onchocerca volvulus 0.012 0.0672 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.2025
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0187 0.2273
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0141 0.0324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0239 0.12
Mycobacterium ulcerans hypothetical protein 0.0048 0.0239 0.3213
Onchocerca volvulus 0.0048 0.0239 0.3511
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.012 0.0672 0.0669
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.071 0.4235 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0141 0.1614
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0067 0.0148
Loa Loa (eye worm) voltage-dependent calcium channel 0.0032 0.0141 0.0324
Plasmodium vivax importin-beta 2, putative 0.0028 0.0118 0.5507
Brugia malayi nuclear hormone receptor 0.002 0.0067 0.0148
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0141 0.0324
Echinococcus multilocularis sodium leak channel non selective protein 0.0032 0.0141 0.0137
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0239 0.3336
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0141 0.0137
Brugia malayi topoisomerase 0.004 0.0187 0.0432
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Schistosoma mansoni hypothetical protein 0.0032 0.0141 0.0334
Echinococcus granulosus snurportin 1 0.03 0.176 0.415
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0067 0.0148
Echinococcus granulosus potassium large conductance calcium activated 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0038 0.008
Echinococcus multilocularis GPCR, family 2 0.0031 0.0135 0.0131
Echinococcus multilocularis protein dispatched 1 0.0146 0.0828 0.0824
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0062 0.1379
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0032 0.0141 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0633 1
Entamoeba histolytica hypothetical protein 0.0023 0.0086 0.0306
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0141 0.0324
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0032 0.0141 0.2053
Onchocerca volvulus 0.0018 0.0057 0.0793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus multilocularis carboxylesterase 5A 0.071 0.4235 0.4232
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0239 0.12
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0165 0.8602
Loa Loa (eye worm) RNA binding protein 0.0125 0.07 0.1645
Toxoplasma gondii exonuclease III APE 0.0019 0.0062 0.0472
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Echinococcus granulosus importin subunit beta 1 0.0028 0.0118 0.0269
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0141 0.0324
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0141 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0067 0.0148
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0033 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.2273
Brugia malayi hypothetical protein 0.004 0.0187 0.0432
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0239 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.2583
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0032 0.0141 0.0324
Schistosoma mansoni thyroid hormone receptor 0.002 0.0067 0.0158
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0141 0.0137
Loa Loa (eye worm) patched family protein 0.0018 0.0057 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0239 0.3213
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0033 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.1848
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0004 0.001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0062 0.0136
Loa Loa (eye worm) hypothetical protein 0.0067 0.0353 0.0824
Echinococcus granulosus TRP transient receptor potential channel 0.0032 0.0141 0.0324
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0715 0.1689
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.2025
Brugia malayi hypothetical protein 0.0073 0.0389 0.091
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0141 0.0324
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) oxidoreductase 0.0014 0.0033 0.0069
Echinococcus multilocularis two pore calcium channel protein 2 0.0032 0.0141 0.0137
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Onchocerca volvulus 0.012 0.0672 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0141 0.0324
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0057 0.154
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0239 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0141 0.0334
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0239 0.0555
Brugia malayi voltage-dependent calcium channel 0.0032 0.0141 0.0324
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0032 0.0141 0.0324
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0032 0.0141 0.0324
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0062 0.1848
Loa Loa (eye worm) voltage-gated potassium channel 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0069
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0032 0.0141 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0125 0.07 0.1653
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.031 0.0723
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.2583
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.006 0.0132
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0067 0.0937
Loa Loa (eye worm) hypothetical protein 0.071 0.4235 1
Schistosoma mansoni DNA ligase IV 0.004 0.0187 0.0441
Loa Loa (eye worm) hypothetical protein 0.0048 0.0239 0.0555
Brugia malayi Myosin head containing protein 0.0018 0.0057 0.0125
Echinococcus multilocularis protein patched 0.0128 0.0719 0.0715
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0141 0.0324
Schistosoma mansoni topbp1 0.004 0.0187 0.0441
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0125 0.07 0.1653
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0033 0.0069
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0141 0.0137
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0033 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0067 0.0158
Onchocerca volvulus 0.0018 0.0057 0.0793
Echinococcus multilocularis calcium activated potassium channel 0.0032 0.0141 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.046
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0143 0.0139
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0067 0.0158
Brugia malayi hypothetical protein 0.0018 0.0057 0.0125
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0239 0.3213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0067 0.0148
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0187 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0067 0.0158
Loa Loa (eye worm) TAR-binding protein 0.0125 0.07 0.1645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0038 0.009
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0141 0.0334
Schistosoma mansoni hypothetical protein 0.03 0.176 0.4155
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0432
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0141 0.0324
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0032 0.0141 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0067 0.0148
Mycobacterium tuberculosis Carboxylesterase LipT 0.012 0.0672 1
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0187 0.0441
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0187 1
Echinococcus multilocularis expressed conserved protein 0.0279 0.1635 0.1632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0141 0.0137
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0222 0.0218
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0032 0.0141 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0222 0.0218
Brugia malayi Patched related family protein 4 0.0018 0.0057 0.0125
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0118 0.1406
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0032 0.0141 0.0324
Brugia malayi Patched related family protein 10 0.0018 0.0057 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0135 0.031
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0118 0.5507
Brugia malayi nuclear receptor RXR 0.001 0.0011 0.0016
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Onchocerca volvulus 0.0048 0.0237 0.3491
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0141 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0067 0.0148
Brugia malayi Carboxylesterase family protein 0.012 0.0672 0.158
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0141 0.0324
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0073 0.0163
Leishmania major hypothetical protein, unknown function 0.0032 0.0141 0.5254
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0032 0.0141 0.0324
Brugia malayi ion channel NompC 0.0032 0.0141 0.0324
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0239 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0128 0.0719 0.169
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0141 0.0324
Schistosoma mansoni hypothetical protein 0.0165 0.0945 0.2232
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0033 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0067 0.0063
Schistosoma mansoni voltage-dependent calcium channel 0.0032 0.0141 0.0334
Echinococcus granulosus acetylcholinesterase 0.071 0.4235 1
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Patched protein homolog 1 0.0018 0.0057 0.0125
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0067 0.0063
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0297 0.1744 0.4113
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0135 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0182
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.07 0.1645
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0141 0.0137
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0033 0.0079
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0062 0.0058
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0016
Brugia malayi RNA binding protein 0.0125 0.07 0.1645
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0033 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0062 0.0136
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0067 0.0148
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0067 0.0148
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0222 0.0515
Toxoplasma gondii patched family protein 0.0018 0.0057 0.0393
Echinococcus multilocularis shaker cognate 0.0032 0.0141 0.0137
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0141 0.0334
Echinococcus granulosus ryanodine receptor 44f 0.0032 0.0141 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0125 0.07 0.1653
Loa Loa (eye worm) acetylcholinesterase 1 0.071 0.4235 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0033 0.0182
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0004 0.001
Echinococcus granulosus voltage gated hydrogen channel 1 0.0032 0.0141 0.0324
Onchocerca volvulus 0.0014 0.0033 0.044
Leishmania major GTP-binding protein, putative 0.0021 0.0073 0.1928
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0141 0.0334
Echinococcus multilocularis sodium channel protein 0.0032 0.0141 0.0137
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0067 0.0148
Echinococcus granulosus tar DNA binding protein 0.0125 0.07 0.1645
Schistosoma mansoni ran 0.0021 0.0073 0.0172
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0118 0.0114
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0067 0.0148
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0032 0.0141 0.0324
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0302 0.1772 0.4185
Leishmania major importin beta-1 subunit, putative 0.0023 0.0086 0.2547
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0141 0.1797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0222 0.0515
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0067 0.0148
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0067 0.0148
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0067 0.0063
Schistosoma mansoni 60S ribosomal protein L21 0.0032 0.0141 0.0334
Echinococcus granulosus two pore calcium channel protein 2 0.0032 0.0141 0.0324
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0239 0.12
Brugia malayi hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Toxoplasma gondii patched family protein 0.0018 0.0057 0.0393
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.2273
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0011 0.0016
Treponema pallidum DNA ligase (lig) 0.004 0.0187 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0141 0.0137
Echinococcus granulosus FTZ F1 alpha 0.002 0.0067 0.0148
Onchocerca volvulus 0.006 0.031 0.4576
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0067 0.0148
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0163
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0033 0.0049
Toxoplasma gondii patched family protein 0.0018 0.0057 0.0393
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0187 0.2398
Echinococcus granulosus tumor protein p63 0.0327 0.1924 0.4539
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0141 0.0334
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0141 0.1797
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0118 0.5507
Brugia malayi protein C24B5.3 0.0018 0.0057 0.0125
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0141 0.0324
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0141 0.0324
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0067 0.0148
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Echinococcus multilocularis tumor protein p63 0.0327 0.1924 0.1921
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0182
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0239 0.0555
Loa Loa (eye worm) hypothetical protein 0.0098 0.054 0.1266
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.031
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0073 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.2273
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0135 0.031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0067 0.0148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0067 0.0148
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0033 0.0182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0141 0.0137
Schistosoma mansoni hypothetical protein 0.0123 0.0691 0.1632
Schistosoma mansoni two-pore calcium channel 0.0032 0.0141 0.0334
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0141 0.0324
Schistosoma mansoni zinc finger protein 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0432
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0067 0.0063
Echinococcus multilocularis two pore calcium channel protein 1 0.0032 0.0141 0.0137
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0032 0.0141 0.0324
Echinococcus multilocularis short transient receptor potential channel 6 0.0032 0.0143 0.0139
Schistosoma mansoni cpg binding protein 0.006 0.031 0.0732
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) histone methyltransferase 0.0019 0.006 0.0132
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0353 0.0824
Loa Loa (eye worm) voltage-gated potassium channel 0.0032 0.0141 0.0324
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0297 0.1744 1
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0141 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.054 0.1266
Echinococcus granulosus sodium channel protein 0.0032 0.0141 0.0324
Echinococcus granulosus geminin 0.0165 0.0945 0.2225
Schistosoma mansoni cpg binding protein 0.0063 0.033 0.078
Echinococcus multilocularis geminin 0.0165 0.0945 0.0942
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0141 0.0137
Echinococcus granulosus sodium leak channel non selective protein 0.0032 0.0141 0.0324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.012 0.0672 0.1588
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0141 0.0324
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Onchocerca volvulus 0.0014 0.0033 0.044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0135 0.031
Brugia malayi CXXC zinc finger family protein 0.006 0.031 0.0723
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0187 1
Brugia malayi hypothetical protein 0.012 0.0672 0.158
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0016
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0032 0.0141 0.0137
Giardia lamblia Replication factor C, subunit 1 0.004 0.0187 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0187 0.2273
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0222 0.0515
Toxoplasma gondii transporter, cation channel family protein 0.0032 0.0141 0.1797
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) voltage-gated calcium channel 0.0032 0.0141 0.0324
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0062 0.0617
Echinococcus granulosus nibrin 0.004 0.0187 0.0432
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0165 0.8602
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0237 0.0561
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0011 0.0025
Schistosoma mansoni vesicular amine transporter 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.0036 0.0165 0.0381
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0032 0.0141 0.0334
Brugia malayi Niemann-Pick C1 protein precursor 0.0297 0.1744 0.4113
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0062 0.1848
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0187 0.2554
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0239 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0141 0.0324
Loa Loa (eye worm) calcium channel 0.0032 0.0141 0.0324
Echinococcus granulosus family S9 non peptidase ue S09 family 0.012 0.0672 0.158
Brugia malayi RNA, U transporter 1 0.008 0.0431 0.1008
Echinococcus multilocularis conserved hypothetical protein 0.0032 0.0141 0.0137
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Onchocerca volvulus Protein patched homolog 0.0018 0.0057 0.0793
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.032
Onchocerca volvulus 0.0014 0.0033 0.044
Entamoeba histolytica hypothetical protein 0.0073 0.0389 0.2079
Schistosoma mansoni gliotactin 0.012 0.0672 0.1588
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.001
Brugia malayi Patched related family protein 12 0.0018 0.0057 0.0125
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0141 0.0137
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0032 0.0141 0.7039
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0187 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0067 0.0158
Echinococcus granulosus BC026374 protein S09 family 0.012 0.0672 0.158
Schistosoma mansoni hypothetical protein 0.0067 0.0353 0.0833
Onchocerca volvulus 0.0018 0.0057 0.0793
Loa Loa (eye worm) hypothetical protein 0.0036 0.0165 0.0381
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.0146
Schistosoma mansoni topbp1 0.004 0.0187 0.0441
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus multilocularis tar DNA binding protein 0.0125 0.07 0.0696
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.012 0.0672 0.158
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0067 0.0063
Toxoplasma gondii hypothetical protein 0.0032 0.0141 0.1797
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0067 0.0148
Echinococcus granulosus cpg binding protein 0.0063 0.033 0.0772
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Echinococcus granulosus carboxylesterase 5A 0.071 0.4235 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.012 0.0672 0.158
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0032 0.0141 0.0324
Onchocerca volvulus 0.0032 0.0141 0.2053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0141 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0016
Entamoeba histolytica hypothetical protein 0.004 0.0187 0.0896
Echinococcus multilocularis potassium large conductance calcium activated 0.0032 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0135 0.0131
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0432
Brugia malayi steroid hormone receptor 0.002 0.0067 0.0148
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0033 0.0069
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0141 0.0334
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0059 0.0129
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0032 0.0141 0.0334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.2025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0062 0.1848
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0067 0.0158
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0032 0.0141 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0016
Brugia malayi cation channel family protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) carboxylesterase 0.012 0.0672 0.158
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0032 0.0141 0.7039
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0141 0.0137
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0067 0.0937
Echinococcus multilocularis snurportin 1 0.03 0.176 0.1756
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0038 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0389 0.0919
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0182
Brugia malayi DKFZp564C0469 protein 0.004 0.0187 0.0432
Echinococcus multilocularis acetylcholinesterase 0.071 0.4235 0.4232
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.0187 0.2554
Echinococcus multilocularis BC026374 protein (S09 family) 0.012 0.0672 0.0669
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0086 0.0808
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0032 0.0141 0.0324
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0067 0.0148
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0135 0.0131
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0141 0.0334
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0067 0.0937
Leishmania major hypothetical protein, conserved 0.0032 0.0141 0.5254
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Brugia malayi hypothetical protein 0.001 0.0011 0.0016
Schistosoma mansoni transient receptor potential channel 4 0.0032 0.0141 0.0334
Echinococcus granulosus dnaJ subfamily B 0.0406 0.2397 0.5656
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.012 0.0672 0.158
Echinococcus granulosus Protein patched homolog 1 0.0128 0.0719 0.169
Brugia malayi hypothetical protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.012 0.0672 0.158
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0143 0.0328
Onchocerca volvulus 0.0018 0.0057 0.0793
Schistosoma mansoni importin beta-1 0.0028 0.0118 0.0278
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0073 0.066
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.2273
Brugia malayi CHE-14 protein 0.0128 0.0719 0.169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.2025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.006 0.0056
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0156 0.0892 0.21
Schistosoma mansoni ran 0.0021 0.0073 0.0172
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0032 0.0141 0.0324
Brugia malayi olfactory channel protein osm-9 0.0032 0.0143 0.0328
Entamoeba histolytica hypothetical protein 0.0073 0.0389 0.2079
Schistosoma mansoni thyroid hormone receptor 0.002 0.0067 0.0158
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0033 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0032 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0269
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0033 0.0182
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0032 0.0141 0.0324
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0141 0.0137
Trichomonas vaginalis spcc417.12 protein, putative 0.012 0.0672 0.9325
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0067 0.0063
Schistosoma mansoni acetylcholinesterase 0.012 0.0672 0.1588
Loa Loa (eye worm) ryanodine receptor 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.032
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0141 0.0324
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.07 0.1645
Schistosoma mansoni coup transcription factor 0.002 0.0067 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.1848
Echinococcus granulosus replication factor c subunit 1 0.004 0.0187 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0067 0.0148
Entamoeba histolytica hypothetical protein 0.0073 0.0389 0.2079
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0239 0.0555
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0187 0.0432
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.0025
Plasmodium vivax patched family protein, putative 0.0018 0.0057 0.154
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0239 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0032 0.0141 0.7039
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0187 0.0432
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.2397 0.2394
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0067 0.0158
Echinococcus multilocularis acetylcholinesterase 0.071 0.4235 0.4232
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0141 0.0324
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Echinococcus granulosus neuroligin 0.012 0.0672 0.158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0141 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0067 0.0148
Toxoplasma gondii patched family protein 0.0018 0.0057 0.0393
Echinococcus granulosus para nitrobenzyl esterase 0.012 0.0672 0.158
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0239 0.3213
Onchocerca volvulus 0.0018 0.0057 0.0793
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0141 0.0324
Schistosoma mansoni patched 1 0.0128 0.0719 0.1698
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0067 0.0148
Schistosoma mansoni transient receptor potential channel 0.0032 0.0141 0.0334
Schistosoma mansoni hypothetical protein 0.0406 0.2397 0.5661
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0222 0.0515
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0141 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0033 0.0182
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0004 0.001
Schistosoma mansoni neuroligin 3 (S09 family) 0.012 0.0672 0.1588
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Transient-receptor-potential like protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Echinococcus granulosus transient receptor potential gamma protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0148
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0067 0.0158
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Onchocerca volvulus 0.0014 0.0033 0.044
Echinococcus granulosus hypothetical protein 0.0032 0.0141 0.0324
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0141 0.1614
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0067 0.0158
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0141 0.0137
Brugia malayi ecdysteroid receptor 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Schistosoma mansoni hypothetical protein 0.0123 0.0691 0.1632
Loa Loa (eye worm) carboxylesterase 0.012 0.0672 0.158
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0067 0.0148
Toxoplasma gondii hypothetical protein 0.0018 0.0057 0.0393
Loa Loa (eye worm) hypothetical protein 0.012 0.0672 0.158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0239 0.3336
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0187 0.7464
Brugia malayi hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0067 0.0148
Toxoplasma gondii hypothetical protein 0.0032 0.0141 0.1797
Loa Loa (eye worm) hypothetical protein 0.0036 0.0165 0.0381
Onchocerca volvulus 0.012 0.0672 1
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0141 0.0137
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.2583
Schistosoma mansoni transient receptor potential channel 0.0032 0.0143 0.0337
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0032 0.0141 0.7039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0141 0.0324
Echinococcus multilocularis para nitrobenzyl esterase 0.012 0.0672 0.0669
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0187 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0182
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0143 0.0328
Brugia malayi Carboxylesterase family protein 0.012 0.0672 0.158
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.0128 0.0719 0.169
Schistosoma mansoni hypothetical protein 0.0123 0.0691 0.1632
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.012 0.0672 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0032 0.0141 0.2053
Echinococcus granulosus two pore calcium channel protein 1 0.0032 0.0141 0.0324
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0141 0.0324
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0062 0.0136
Brugia malayi nuclear receptor NHR-88 0.002 0.0067 0.0148
Echinococcus multilocularis cpg binding protein 0.0063 0.033 0.0327
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Onchocerca volvulus 0.0018 0.0057 0.0793
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Schistosoma mansoni transient receptor potential channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0032 0.0141 0.0324
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0165 0.2207
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0062 0.0443
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0187 0.0183
Echinococcus granulosus GPCR family 2 0.0031 0.0135 0.031
Echinococcus granulosus short transient receptor potential channel 6 0.0032 0.0141 0.0324
Echinococcus multilocularis sterol regulatory element binding protein 0.0128 0.0719 0.0715
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0389 0.0385
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0033 0.0182
Brugia malayi protein C24B5.3 0.0018 0.0057 0.0125
Echinococcus multilocularis Niemann Pick C1 protein 0.0297 0.1744 0.1741
Brugia malayi hypothetical protein 0.004 0.0187 0.0432
Brugia malayi cation channel family protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.012 0.0672 0.158
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0067 0.0063
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0187 0.2273
Schistosoma mansoni nuclear hormone receptor 0.002 0.0067 0.0158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.012 0.0672 0.1588
Brugia malayi hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0067 0.0148
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0239 0.3213
Echinococcus multilocularis nibrin 0.004 0.0187 0.0183
Loa Loa (eye worm) patched family protein 0.0018 0.0057 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0222 0.0524
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0141 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0125 0.07 0.1653
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0239 0.3213
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Onchocerca volvulus Protein patched homolog 0.0018 0.0057 0.0793
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0141 0.0137
Brugia malayi Carboxylesterase family protein 0.071 0.4235 1
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0187 1
Brugia malayi Carboxylesterase family protein 0.012 0.0672 0.158
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0141 0.0324
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0141 0.0137
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0141 0.0334
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0073 0.2583
Schistosoma mansoni ryanodine receptor related 0.0032 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0048 0.0237 0.0551
Echinococcus multilocularis neuroligin 0.012 0.0672 0.0669
Echinococcus multilocularis Niemann Pick C1 protein 0.0425 0.2515 0.2512
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0135 0.031
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0032 0.0141 0.0324
Loa Loa (eye worm) patched family protein 0.0018 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Echinococcus granulosus expressed conserved protein 0.0279 0.1635 0.3856
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0141 0.0324
Brugia malayi Importin beta-1 subunit 0.0028 0.0118 0.0269
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0389 0.091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.054 0.1266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Echinococcus multilocularis short transient receptor potential channel 6 0.0032 0.0141 0.0137
Schistosoma mansoni calcium-activated potassium channel 0.0032 0.0141 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0067 0.0148
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0141 0.0324
Loa Loa (eye worm) ion channel NompC 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0432
Loa Loa (eye worm) hypothetical protein 0.071 0.4235 1
Schistosoma mansoni hypothetical protein 0.0073 0.0389 0.0919
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0141 0.0324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0062 0.0166
Echinococcus multilocularis ryanodine receptor 44f 0.0032 0.0141 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0324
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0187 0.2273
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0141 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0033 0.0069
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0141 0.0324
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0239 0.0555
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0067 0.0148
Entamoeba histolytica hypothetical protein 0.0073 0.0389 0.2079
Plasmodium falciparum importin beta, putative 0.0028 0.0118 0.5507
Schistosoma mansoni hypothetical protein 0.0165 0.0945 0.2232
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.2273
Loa Loa (eye worm) hypothetical protein 0.0036 0.0165 0.0381
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0141 0.0137
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0086 0.0808
Trichomonas vaginalis ran, putative 0.0021 0.0073 0.0623
Echinococcus granulosus Niemann Pick C1 protein 0.0297 0.1744 0.4113
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0141 0.0324
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0141 0.0334
Onchocerca volvulus 0.004 0.0187 0.2732
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0239 0.3213
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0141 0.0334
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.012 0.0672 0.9325
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0141 0.0334
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.054 0.1266
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0141 0.0324
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0143 0.0139
Loa Loa (eye worm) hypothetical protein 0.012 0.0672 0.158
Schistosoma mansoni hypothetical protein 0.0123 0.0691 0.1632
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.012 0.0672 0.1588
Schistosoma mansoni cpg binding protein 0.0063 0.033 0.078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0165 0.0381
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0141 0.0324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0067 0.0158
Brugia malayi Patched family protein 0.0018 0.0057 0.0125
Brugia malayi Carboxylesterase family protein 0.012 0.0672 0.158
Onchocerca volvulus 0.0018 0.0057 0.0793
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0141 0.0324
Entamoeba histolytica Ran family GTPase 0.0021 0.0073 0.0231
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0032 0.0141 0.0137
Echinococcus granulosus acetylcholinesterase 0.071 0.4235 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0187 0.0896
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.2583
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0901
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0187 1
Schistosoma mansoni voltage-gated ion channel 0.0032 0.0141 0.0334
Chlamydia trachomatis DNA ligase 0.004 0.0187 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0032 0.0141 0.0137
Onchocerca volvulus 0.002 0.0067 0.0937
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0187 0.2273
Echinococcus granulosus Niemann Pick C1 protein 0.0425 0.2515 0.5935
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0011 0.0007
Brugia malayi TAR-binding protein 0.0125 0.07 0.1645
Schistosoma mansoni BC026374 protein (S09 family) 0.012 0.0672 0.1588
Loa Loa (eye worm) carboxylesterase 0.071 0.4235 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0432
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0086 0.0808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.176 0.415
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0239 0.3213
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0163
Echinococcus granulosus shaker cognate 0.0032 0.0141 0.0324
Brugia malayi Carboxylesterase family protein 0.071 0.4235 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0038 0.0034
Brugia malayi hypothetical protein 0.001 0.0011 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0222 0.0524
Mycobacterium ulcerans carboxylesterase, LipT 0.012 0.0672 1
Loa Loa (eye worm) patched family protein 0.0018 0.0057 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0222 0.0524
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0141 0.0334
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0125
Onchocerca volvulus 0.012 0.0672 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0033 0.0069
Echinococcus granulosus short transient receptor potential channel 6 0.0032 0.0143 0.0328

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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