Detailed information for compound 1572173

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.432 | Formula: C23H23NO5
  • H donors: 0 H acceptors: 2 LogP: 4.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C\1/N(C)c2c(C1(C)C)cccc2)COC(=O)C1COc2c(O1)cccc2
  • InChi: 1S/C23H23NO5/c1-23(2)16-8-4-5-9-17(16)24(3)21(23)12-15(25)13-28-22(26)20-14-27-18-10-6-7-11-19(18)29-20/h4-12,20H,13-14H2,1-3H3/b21-12+
  • InChiKey: AEYNIXBPOYMAJR-CIAFOILYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0013 0.0054 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0013 0.0054 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0457 0.0455
Echinococcus granulosus neuropeptide receptor A26 0.0079 0.0851 0.085
Echinococcus granulosus FTZ F1 alpha 0.0013 0.0054 0.0053
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0082 0.0081
Onchocerca volvulus 0.0079 0.0851 0.4917
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0851 0.085
Onchocerca volvulus 0.0079 0.0851 0.4917
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0013 0.0054 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Onchocerca volvulus 0.0079 0.0851 0.4917
Brugia malayi ORL1-like opioid receptor 0.0079 0.0851 0.2686
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0013 0.0054 0.0029
Brugia malayi PAS domain containing protein 0.0048 0.0472 0.1491
Loa Loa (eye worm) hypothetical protein 0.0046 0.0445 0.1402
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0025 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0457 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0054 0.0171
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0445 1
Onchocerca volvulus 0.0079 0.0851 0.4917
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0419 0.0395
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Onchocerca volvulus 0.0033 0.0287 0.1485
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0013 0.0054 0.0166
Onchocerca volvulus 0.0067 0.0704 0.4024
Echinococcus multilocularis Ankyrin 0.0015 0.007 0.0069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0419 0.1014
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0079 0.0851 0.2686
Echinococcus granulosus dnaJ subfamily B 0.0416 0.4943 0.4943
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0054 0.0029
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0851 0.085
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0079 0.0851 0.2686
Schistosoma mansoni lipoxygenase 0.0082 0.0886 0.0863
Loa Loa (eye worm) doublecortin family protein 0.002 0.013 0.0405
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.013 0.0618
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0079 0.0851 0.0828
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0851 0.085
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0054 0.0171
Schistosoma mansoni hypothetical protein 0.0079 0.0851 0.0828
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0086 0.0273
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.0043
Onchocerca volvulus 0.0079 0.0851 0.4917
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Brugia malayi Steroid receptor seven-up type 2 0.0013 0.0054 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.013
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0079 0.0851 0.085
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0445 0.0444
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Echinococcus granulosus neuroligin 0.0046 0.0445 0.0444
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0233
Onchocerca volvulus 0.0079 0.0851 0.4917
Loa Loa (eye worm) hypothetical protein 0.0161 0.184 0.5806
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0313 0.0987
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0445 0.1096
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0069 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0086 0.0273
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0851 0.085
Echinococcus multilocularis serotonin receptor 0.0079 0.0851 0.085
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0025 0.0024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0207 0.0205
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0851 0.085
Schistosoma mansoni biogenic amine receptor 0.0079 0.0851 0.0828
Loa Loa (eye worm) hypothetical protein 0.0046 0.0445 0.1402
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0054 0.0053
Brugia malayi hypothetical protein 0.0148 0.1686 0.5324
Schistosoma mansoni steroid hormone receptor ad4bp 0.0013 0.0054 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0013 0.0054 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0457 0.0455
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0851 0.0828
Echinococcus granulosus death domain containing protein 0.0015 0.0069 0.0067
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0419 0.922
Brugia malayi Carboxylesterase family protein 0.0046 0.0445 0.1405
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0054 0.0053
Brugia malayi G-protein coupled receptor 0.0079 0.0851 0.2686
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0323 0.6977
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0323 0.7461
Echinococcus multilocularis somatostatin receptor 0.0079 0.0851 0.085
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0323 0.7461
Echinococcus multilocularis GPCR, family 2 0.0016 0.0086 0.0085
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0118 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0184 0.3769
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0079 0.0851 0.0828
Brugia malayi Tachykinin-like peptides receptor 99D 0.0079 0.0851 0.2686
Schistosoma mansoni histamine h1 receptor 0.0079 0.0851 0.0828
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0851 0.0828
Onchocerca volvulus 0.0079 0.0851 0.4917
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0851 0.085
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0445 0.0444
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0025 0.0024
Echinococcus granulosus neuropeptide receptor 0.0079 0.0851 0.085
Onchocerca volvulus 0.0079 0.0851 0.4917
Echinococcus multilocularis g-protein coupled receptor 0.0079 0.0851 0.085
Chlamydia trachomatis glutamine binding protein 0.0019 0.0118 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0457 0.0432
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0184 0.2211
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0025 0.0024
Echinococcus granulosus g protein coupled receptor 0.0079 0.0851 0.085
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0445 0.0421
Echinococcus multilocularis carboxylesterase 5A 0.027 0.3167 0.3167
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0851 0.085
Echinococcus granulosus hypothetical protein 0.0079 0.0851 0.085
Onchocerca volvulus 0.0046 0.0445 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0851 0.085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0507 0.1598
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0323 0.6977
Brugia malayi Melatonin receptor type 1A 0.0079 0.0851 0.2686
Brugia malayi hypothetical protein 0.0161 0.184 0.5808
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.013 0.0128
Echinococcus multilocularis neuroligin 0.0046 0.0445 0.0444
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0419 0.1014
Echinococcus multilocularis orexin receptor type 2 0.0079 0.0851 0.085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0851 0.085
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0079 0.0851 0.085
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0079 0.0851 0.085
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0445 0.0421
Echinococcus multilocularis acetylcholinesterase 0.027 0.3167 0.3167
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni transcription factor btf3 0.0036 0.0323 0.0299
Brugia malayi intermediate filament protein 0.0033 0.0287 0.0905
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0184 0.0272
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Brugia malayi nuclear hormone receptor 0.0013 0.0054 0.0171
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0079 0.0851 0.085
Echinococcus granulosus dro:myosuppressin receptor 0.0079 0.0851 0.085
Onchocerca volvulus 0.0013 0.0054 0.007
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0799 0.0797
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0207 0.0205
Echinococcus multilocularis jun protein 0.0085 0.0926 0.0925
Loa Loa (eye worm) carboxylesterase 0.0046 0.0445 0.1402
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0184 0.2211
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0419 0.0418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0054 0.0171
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0851 0.085
Brugia malayi G protein-coupled receptor 0.0079 0.0851 0.2686
Mycobacterium ulcerans beta-lactamase 0.0043 0.0419 0.922
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0851 0.2683
Schistosoma mansoni netrin receptor unc5 0.0015 0.0069 0.0043
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0851 0.0828
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.013 0.0128
Brugia malayi hypothetical protein 0.0067 0.0704 0.2222
Brugia malayi Serotonin receptor 0.0079 0.0851 0.2686
Brugia malayi beta-lactamase family protein 0.0043 0.0419 0.1323
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Echinococcus granulosus intermediate filament protein 0.0033 0.0287 0.0285
Mycobacterium ulcerans hypothetical protein 0.0043 0.0419 0.922
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0184 0.2211
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0013 0.0054 0.0029
Schistosoma mansoni hypothetical protein 0.0173 0.1984 0.1964
Schistosoma mansoni amine GPCR 0.0079 0.0851 0.0828
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0085
Schistosoma mansoni loxhd1 0.002 0.013 0.0104
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0079 0.0851 0.0828
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0578
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0287 0.0901
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni cpg binding protein 0.0031 0.0267 0.0242
Echinococcus multilocularis acetylcholinesterase 0.027 0.3167 0.3167
Schistosoma mansoni RAR-like nuclear receptor 0.0013 0.0054 0.0029
Schistosoma mansoni hypothetical protein 0.0079 0.0851 0.0828
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0069 0.0067
Onchocerca volvulus 0.0043 0.0419 0.2291
Echinococcus granulosus cpg binding protein 0.0031 0.0267 0.0265
Echinococcus granulosus G protein coupled receptor 139 0.0079 0.0851 0.085
Echinococcus granulosus RUN 0.002 0.013 0.0128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0507 0.1602
Schistosoma mansoni lamin 0.0033 0.0287 0.0262
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0118 0.0232
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Schistosoma mansoni hypothetical protein 0.0069 0.0732 0.0709
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0287 0.0905
Schistosoma mansoni biogenic amine receptor 0.0079 0.0851 0.0828
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0851 0.085
Onchocerca volvulus 0.002 0.013 0.0529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0256
Schistosoma mansoni hypothetical protein 0.0079 0.0851 0.0828
Loa Loa (eye worm) hypothetical protein 0.0046 0.0445 0.1402
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Brugia malayi Carboxylesterase family protein 0.0046 0.0445 0.1405
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0926 0.0925
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni lipoxygenase 0.0117 0.1314 0.1292
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0079 0.0851 0.2683
Onchocerca volvulus 0.0079 0.0851 0.4917
Schistosoma mansoni acetylcholinesterase 0.0046 0.0445 0.0421
Schistosoma mansoni jun-related protein 0.0069 0.0732 0.0709
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.1689 0.5329
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0025 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0013 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Echinococcus granulosus neuropeptide FF receptor 2 0.0079 0.0851 0.085
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0851 0.0828
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0419 0.1323
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis cpg binding protein 0.0031 0.0267 0.0265
Loa Loa (eye worm) hypothetical protein 0.0033 0.0287 0.0901
Brugia malayi G protein-coupled receptor F59B2.13 0.0079 0.0851 0.2686
Onchocerca volvulus Huntingtin homolog 0.0148 0.1686 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0013 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Brugia malayi GnHR receptor homolog 0.0079 0.0851 0.2686
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0323 0.6903
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0419 0.9351
Brugia malayi Dopamine receptor protein 1 0.0079 0.0851 0.2686
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0054 0.0171
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0457 0.1438
Schistosoma mansoni single-minded 0.0048 0.0472 0.0448
Toxoplasma gondii ABC1 family protein 0.0043 0.0419 0.398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0013 0.0054 0.0166
Schistosoma mansoni cpg binding protein 0.0031 0.0267 0.0242
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0321 0.032
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0851 0.085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0457 0.1441
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0851 0.085
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0851 0.0828
Loa Loa (eye worm) TYRA-2 protein 0.0079 0.0851 0.2683
Brugia malayi hypothetical protein 0.002 0.013 0.0409
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Mycobacterium ulcerans hypothetical protein 0.0024 0.0184 0.2211
Loa Loa (eye worm) hypothetical protein 0.0032 0.0279 0.0878
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0184 0.2211
Echinococcus granulosus somatostatin receptor 0.0079 0.0851 0.085
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0419 0.1014
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0079 0.0851 0.2686
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.1314 0.1313
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0926 0.0925
Brugia malayi beta-lactamase family protein 0.0043 0.0419 0.1323
Loa Loa (eye worm) hypothetical protein 0.0035 0.0313 0.0983
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0851 0.085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0184 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0323 0.6977
Brugia malayi Carboxylesterase family protein 0.0046 0.0445 0.1405
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0851 0.085
Schistosoma mansoni polycystin 1-related 0.002 0.013 0.0104
Brugia malayi Doublecortin family protein 0.002 0.013 0.0409
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Schistosoma mansoni hypothetical protein 0.0416 0.4943 0.493
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.1319
Loa Loa (eye worm) steroid hormone receptor 0.0013 0.0054 0.0166
Echinococcus multilocularis sex peptide receptor 0.0079 0.0851 0.085
Schistosoma mansoni cpg binding protein 0.0029 0.0246 0.0222
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0851 0.085
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0419 0.1014
Onchocerca volvulus Huntingtin homolog 0.0148 0.1686 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0344
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0013 0.0054 0.0029
Onchocerca volvulus 0.0079 0.0851 0.4917
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0445 0.0421
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0344
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0344
Echinococcus granulosus neuropeptide receptor 0.0079 0.0851 0.085
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0445 0.0421
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0054 0.0171
Echinococcus granulosus g protein coupled receptor 0.0079 0.0851 0.085
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0013 0.0054 0.0171
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0445 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0419 0.9351
Plasmodium falciparum LCCL domain-containing protein 0.002 0.013 0.0895
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0079 0.0851 0.0828
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.027 0.3167 0.315
Echinococcus granulosus tachykinin peptides receptor 99D 0.0079 0.0851 0.085
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0323 0.1017
Echinococcus granulosus geminin 0.0173 0.1984 0.1983
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0184 0.3769
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0061
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0419 0.1014
Brugia malayi Death domain containing protein 0.0015 0.0069 0.0217
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0578
Echinococcus granulosus serotonin receptor 0.0079 0.0851 0.085
Onchocerca volvulus 0.002 0.013 0.0529
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0184 0.2211
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0445 0.0444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0013 0.0054 0.0166
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0851 0.085
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0025 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0013 0.0054 0.0166
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Brugia malayi putative neuropeptide receptor NPR1 0.0079 0.0851 0.2686
Onchocerca volvulus 0.0043 0.0419 0.2291
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0082 0.0081
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0118 0.0062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0013 0.0054 0.007
Brugia malayi beta-lactamase 0.0043 0.0419 0.1323
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0851 0.085
Brugia malayi Dopamine receptor 0.0079 0.0851 0.2686
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0013 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Brugia malayi bZIP transcription factor family protein 0.0085 0.0926 0.2924
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0184 0.0582
Brugia malayi hypothetical protein 0.002 0.013 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0013 0.0054 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0457 0.0432
Loa Loa (eye worm) hypothetical protein 0.0046 0.0445 0.1402
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0419 0.1014
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.013 0.0128
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0445 0.0444
Onchocerca volvulus 0.0046 0.0445 0.2449
Echinococcus granulosus jun protein 0.0085 0.0926 0.0925
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0507 0.1602
Loa Loa (eye worm) hypothetical protein 0.002 0.013 0.0405
Loa Loa (eye worm) hypothetical protein 0.0046 0.0445 0.1402
Echinococcus multilocularis neuropeptide s receptor 0.0079 0.0851 0.085
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.011 0.8972
Echinococcus granulosus sex peptide receptor 0.0079 0.0851 0.085
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0799 0.0797
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0445 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0184 0.2211
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0851 0.085
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0118 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0851 0.0828
Brugia malayi photoreceptor-specific nuclear receptor 0.0013 0.0054 0.0171
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0851 0.085
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0085
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0419 0.1014
Brugia malayi larval opioid receptor 0.0079 0.0851 0.2686
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0246 0.0774
Onchocerca volvulus 0.0046 0.0445 0.2449
Schistosoma mansoni hypothetical protein 0.0035 0.0313 0.0288
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0085
Loa Loa (eye worm) acetylcholinesterase 1 0.027 0.3167 1
Echinococcus granulosus acetylcholinesterase 0.027 0.3167 0.3167
Schistosoma mansoni growth hormone secretagogue receptor 0.0079 0.0851 0.0828
Echinococcus granulosus lamin 0.0033 0.0287 0.0285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0054 0.0053
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0851 0.2683
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0054 0.0029
Brugia malayi Carboxylesterase family protein 0.027 0.3167 1
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0851 0.085
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0419 0.0418
Brugia malayi nuclear receptor NHR-88 0.0013 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0083 0.0898 0.2831
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0079 0.0851 0.085
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Schistosoma mansoni adenoreceptor 0.0079 0.0851 0.0828
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.013 0.0128
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0079 0.0851 0.085
Echinococcus granulosus ecdysone induced protein 78C 0.0013 0.0054 0.0053
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0323 1
Brugia malayi Serotonin receptor 0.0079 0.0851 0.2686
Schistosoma mansoni gliotactin 0.0046 0.0445 0.0421
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0043 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0419 0.9351
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Onchocerca volvulus 0.0079 0.0851 0.4917
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0013 0.0054 0.0053
Onchocerca volvulus 0.0046 0.0445 0.2449
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0644 0.062
Brugia malayi neuropeptide F receptor 0.0079 0.0851 0.2686
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0069 0.0213
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0851 0.0828
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0233
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0445 0.1096
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0103 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0054 0.0171
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0013 0.0054 0.0166
Brugia malayi RE15519p 0.0079 0.0851 0.2686
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0851 0.085
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0013 0.0054 0.0053
Schistosoma mansoni alpha-1 adrenergic receptor 0.0079 0.0851 0.0828
Leishmania major basic transcription factor 3a, putative 0.0036 0.0323 0.7461
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0344
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Loa Loa (eye worm) hypothetical protein 0.002 0.013 0.0405
Schistosoma mansoni neuropeptide f receptor 76f 0.0079 0.0851 0.0828
Onchocerca volvulus 0.0033 0.0287 0.1485
Echinococcus granulosus glutamate receptor 2 0.0011 0.0025 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0851 0.085
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.1319
Echinococcus granulosus Ankyrin 0.0015 0.007 0.0069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0851 0.0828
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0217
Loa Loa (eye worm) carboxylesterase 0.027 0.3167 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0419 0.0395
Schistosoma mansoni opsin-like receptor 0.0079 0.0851 0.0828
Schistosoma mansoni intermediate filament proteins 0.0033 0.0287 0.0262
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0043 0.013
Loa Loa (eye worm) melatonin receptor type 1A 0.0079 0.0851 0.2683
Brugia malayi neuropeptide F receptor 0.0079 0.0851 0.2686
Echinococcus multilocularis lamin 0.0033 0.0287 0.0285
Brugia malayi G-protein coupled receptor 0.0079 0.0851 0.2686
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0445 0.0444
Mycobacterium ulcerans lipase LipD 0.0043 0.0419 0.922
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0344
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0069 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0013 0.0054 0.0171
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0564 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0419 1
Onchocerca volvulus 0.0079 0.0851 0.4917
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0269
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0419 1
Brugia malayi sulfakinin receptor protein 0.0079 0.0851 0.2686
Schistosoma mansoni hypothetical protein 0.0173 0.1984 0.1964
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.1319
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0079 0.0851 0.085
Entamoeba histolytica hypothetical protein 0.0036 0.0323 1
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0321 0.6302
Brugia malayi CXXC zinc finger family protein 0.0029 0.0246 0.0778
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0419 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0103 0.0322
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0419 0.9351
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0013 0.0054 0.0053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0086 0.0269
Schistosoma mansoni neuropeptide receptor 0.0079 0.0851 0.0828
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0079 0.0851 0.085
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0184 0.0582
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi ecdysteroid receptor 0.0013 0.0054 0.0171
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0025 0.0024
Echinococcus granulosus 7TM GPCR rhodopsin 0.0079 0.0851 0.085
Leishmania major hypothetical protein, conserved 0.0043 0.0419 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0046 0.0445 0.1402
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0025 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Echinococcus granulosus carboxylesterase 5A 0.027 0.3167 0.3167
Onchocerca volvulus 0.0043 0.0419 0.2291
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0079 0.0851 0.2686
Schistosoma mansoni coup transcription factor 0.0013 0.0054 0.0029
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis thyroid hormone receptor alpha 0.0013 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0148 0.1686 0.5321
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0321 0.1015
Onchocerca volvulus 0.0024 0.0184 0.0863
Loa Loa (eye worm) carboxylesterase 0.0046 0.0445 0.1402
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0054 0.0053
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0851 0.085
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0079 0.0851 0.2683
Schistosoma mansoni biogenic amine receptor 0.0079 0.0851 0.0828
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0079 0.0851 0.0828
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0472 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0851 0.085
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0079 0.0851 0.2686
Onchocerca volvulus Protein ultraspiracle homolog 0.0013 0.0054 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0457 0.0455
Onchocerca volvulus 0.0079 0.0851 0.4917
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.007 0.0045
Brugia malayi Carboxylesterase family protein 0.0046 0.0445 0.1405
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis neuropeptide FF receptor 2 0.0079 0.0851 0.085
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0419 0.1319
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0184 0.2211
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0578
Loa Loa (eye worm) hypothetical protein 0.0148 0.1686 0.5321
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0851 0.0828
Mycobacterium tuberculosis Conserved protein 0.0043 0.0419 0.1014
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0851 0.085
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.1314 0.1313
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0184 0.0582
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus GPCR family 2 0.0016 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus multilocularis musashi 0.0033 0.0287 0.0285
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Onchocerca volvulus Bile acid receptor homolog 0.0013 0.0054 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.1319
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0419 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0079 0.0851 0.0828
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0851 0.2683
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0025 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0013 0.0054 0.0053
Brugia malayi Protein kinase domain containing protein 0.0015 0.0069 0.0217
Brugia malayi Dopamine receptor protein 2 0.0079 0.0851 0.2686
Echinococcus multilocularis transcription factor btf3 0.0036 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni neuropeptide receptor 0.0079 0.0851 0.0828
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0851 0.085
Schistosoma mansoni neuropeptide receptor 0.0079 0.0851 0.0828
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0085
Trichomonas vaginalis esterase, putative 0.0043 0.0419 0.9351
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0184 0.3769
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0851 0.085
Schistosoma mansoni rab6-interacting 0.002 0.013 0.0104
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.013 0.0128
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0445 0.0421
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.4943 0.4943
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0013 0.0054 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0419 0.9351
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0851 0.085
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0851 0.085
Schistosoma mansoni amine GPCR 0.0079 0.0851 0.0828
Loa Loa (eye worm) hypothetical protein 0.027 0.3167 1
Echinococcus granulosus lamin dm0 0.0033 0.0287 0.0285
Schistosoma mansoni rab6-interacting 0.002 0.013 0.0104
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0079 0.0851 0.085
Echinococcus multilocularis geminin 0.0173 0.1984 0.1983
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0184 0.3769
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3261 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0851 0.0828
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.027 0.3167 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0079 0.0851 0.2683
Echinococcus granulosus single minded 2 0.0035 0.0321 0.032
Echinococcus multilocularis G protein coupled receptor 139 0.0079 0.0851 0.085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0013 0.0054 0.0053
Schistosoma mansoni lamin 0.0033 0.0287 0.0262
Echinococcus granulosus allatostatin A receptor 0.0079 0.0851 0.085
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0043 0.0041
Mycobacterium tuberculosis Conserved protein 0.0043 0.0419 0.1014
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0069 0.0159
Schistosoma mansoni amine GPCR 0.0079 0.0851 0.0828
Onchocerca volvulus 0.0046 0.0445 0.2449
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0851 0.085
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.013 0.0128
Schistosoma mansoni amine GPCR 0.0079 0.0851 0.0828
Schistosoma mansoni hypothetical protein 0.002 0.013 0.0104
Echinococcus granulosus g-protein coupled receptor 0.0079 0.0851 0.085
Schistosoma mansoni myosin xvIII 0.0079 0.0851 0.0828
Echinococcus multilocularis RUN 0.002 0.013 0.0128
Loa Loa (eye worm) beta-lactamase 0.0043 0.0419 0.1319
Onchocerca volvulus 0.0079 0.0851 0.4917
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0013 0.0054 0.0053
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0079 0.0851 0.4917
Echinococcus granulosus g protein coupled receptor 0.0079 0.0851 0.085
Schistosoma mansoni amine GPCR 0.0079 0.0851 0.0828
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0851 0.085
Onchocerca volvulus Neuropeptide F receptor homolog 0.0079 0.0851 0.4917
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.1319
Echinococcus granulosus fmrfamide receptor 0.0079 0.0851 0.085
Echinococcus granulosus neuropeptide s receptor 0.0079 0.0851 0.085
Onchocerca volvulus 0.0079 0.0851 0.4917
Echinococcus multilocularis G-protein coupled receptor, putative 0.0079 0.0851 0.085
Brugia malayi follicle stimulating hormone receptor 0.0079 0.0851 0.2686
Brugia malayi hypothetical protein 0.0079 0.0851 0.2686
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Echinococcus granulosus 7tm_1 domain containing protein 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0051 0.0507 0.1598
Brugia malayi beta-NAC-like protein 0.0036 0.0323 0.1021
Echinococcus granulosus transcription factor btf3 0.0036 0.0323 0.0322
Mycobacterium leprae Probable lipase LipE 0.0043 0.0419 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0457 0.0455
Brugia malayi hypothetical protein 0.0046 0.0445 0.1405
Loa Loa (eye worm) hypothetical protein 0.0046 0.0445 0.1402
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0166
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0054 0.0029
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0118 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0287 0.0901
Echinococcus multilocularis serotonin receptor 0.0079 0.0851 0.085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0013 0.0054 0.0171
Brugia malayi hypoxia-induced factor 1 0.0148 0.1689 0.5331
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0445 0.1096
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0079 0.0851 0.0828
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus peptide allatostatin:somatostatin 0.0079 0.0851 0.085
Onchocerca volvulus 0.0079 0.0851 0.4917
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0207 0.0205
Echinococcus multilocularis neuropeptide receptor A26 0.0079 0.0851 0.085
Brugia malayi steroid hormone receptor 0.0013 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0213
Echinococcus multilocularis allatostatin A receptor 0.0079 0.0851 0.085
Schistosoma mansoni opsin-like receptor 0.0079 0.0851 0.0828
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0054 0.0029
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0445 0.0444
Echinococcus granulosus alpha 1A adrenergic receptor 0.0079 0.0851 0.085
Brugia malayi Uncoordinated protein 44 0.0015 0.0069 0.0217
Schistosoma mansoni opsin-like receptor 0.0079 0.0851 0.0828
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0061
Mycobacterium tuberculosis Conserved protein 0.0043 0.0419 0.1014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0013 0.0054 0.0166
Onchocerca volvulus 0.0079 0.0851 0.4917
Onchocerca volvulus 0.0035 0.0321 0.1696
Brugia malayi Carboxylesterase family protein 0.027 0.3167 1
Schistosoma mansoni neuropeptide receptor 0.0079 0.0851 0.0828
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0013 0.0054 0.0029
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0013 0.0054 0.0029
Echinococcus granulosus orexin receptor type 2 0.0079 0.0851 0.085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0851 0.085
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0079 0.0851 0.0828
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0851 0.085
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0043 0.0041
Schistosoma mansoni hypothetical protein 0.0079 0.0851 0.0828
Echinococcus granulosus acetylcholinesterase 0.027 0.3167 0.3167
Onchocerca volvulus 0.0029 0.0246 0.124
Echinococcus multilocularis FTZ F1 alpha 0.0013 0.0054 0.0053
Schistosoma mansoni retinoic acid receptor RXR 0.0013 0.0054 0.0029
Loa Loa (eye worm) hypothetical protein 0.0079 0.0851 0.2683
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.1319
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0184 0.3769
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0419 0.922
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0851 0.085
Echinococcus multilocularis lamin dm0 0.0033 0.0287 0.0285
Brugia malayi putative neuropeptide receptor 0.0079 0.0851 0.2686
Brugia malayi AKH receptor 0.0079 0.0851 0.2686

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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