Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | 0.0047 | 0 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0354 | 0.0354 |
Echinococcus granulosus | acetylcholinesterase | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0278 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0354 | 0.0354 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0354 | 0.0354 |
Onchocerca volvulus | 0.0047 | 0 | 0.5 | |
Onchocerca volvulus | 0.0047 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0354 | 0.0354 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0569 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0569 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0278 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0278 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0354 | 0.0354 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0354 | 0.0354 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0354 | 0.0354 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0278 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0354 | 0.0354 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0278 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0569 | 0.0569 |
Echinococcus granulosus | acetylcholinesterase | 0.0278 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0278 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0278 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0569 | 0.0569 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0354 | 0.0354 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0047 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.