Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0055 | 0.2668 | 0.2165 |
Trypanosoma brucei | ornithine decarboxylase | 0.0066 | 0.376 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0055 | 0.2668 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0055 | 0.2668 | 0.6497 |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0066 | 0.376 | 1 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0066 | 0.376 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2668 | 0.6497 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0055 | 0.2668 | 0.6497 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0034 | 0.0642 | 0.0642 |
Trypanosoma cruzi | p450 reductase, putative | 0.0055 | 0.2668 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0028 | 0.004 | 0.004 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0055 | 0.2668 | 0.2165 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0066 | 0.376 | 1 |
Schistosoma mansoni | lipoxygenase | 0.013 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0055 | 0.2668 | 0.3554 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0055 | 0.2668 | 0.3554 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0066 | 0.376 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0055 | 0.2668 | 0.6497 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0055 | 0.2668 | 0.3554 |
Leishmania major | p450 reductase, putative | 0.0055 | 0.2668 | 0.3554 |
Brugia malayi | Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein | 0.0066 | 0.376 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0055 | 0.2668 | 0.5 |
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0066 | 0.376 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.013 | 1 | 1 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0066 | 0.376 | 1 |
Giardia lamblia | Ornithine decarboxylase | 0.0066 | 0.376 | 1 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0066 | 0.376 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0034 | 0.0642 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.376 | 0.5 | |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0066 | 0.376 | 1 |
Loa Loa (eye worm) | pyridoxal-dependent decarboxylase | 0.0066 | 0.376 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0055 | 0.2668 | 0.2165 |
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0066 | 0.376 | 0.5 |
Leishmania major | ornithine decarboxylase, putative | 0.0066 | 0.376 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0055 | 0.2668 | 0.2668 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0066 | 0.376 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0055 | 0.2668 | 0.2165 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0066 | 0.376 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0055 | 0.2668 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0091 | 0.62 | 0.62 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.