Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.33 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1455 | 0.3956 | 0.3956 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0359 | 0.0369 | 0.0369 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0455 | 0.0682 | 0.5 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0359 | 0.0369 | 0.0369 |
Entamoeba histolytica | thymidine kinase, putative | 0.0247 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.1455 | 0.3956 | 0.3841 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1455 | 0.3956 | 0.3841 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3058 | 0.9208 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.3058 | 0.9208 | 1 |
Onchocerca volvulus | 0.3058 | 0.9208 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.33 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.3058 | 0.9208 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.33 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.33 | 1 | 0.5 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0359 | 0.0369 | 0.0369 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1455 | 0.3956 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3058 | 0.9208 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3058 | 0.9208 | 1 |
Giardia lamblia | Thymidine kinase | 0.0247 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.3058 | 0.9208 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.3058 | 0.9208 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.33 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.3058 | 0.9208 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0359 | 0.0369 | 0.0369 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.