Detailed information for compound 157281

Basic information

Technical information
  • TDR Targets ID: 157281
  • Name: (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5, 7,9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thi azol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[ 14.1.0]heptadecane-8,12-dione
  • MW: 507.683 | Formula: C27H41NO6S
  • H donors: 2 H acceptors: 5 LogP: 4.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1O[C@@H](C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C(=O)C([C@H](C1)O)(C)C)C)O)C)/C(=C/c1csc(n1)C)/C
  • InChi: 1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
  • InChiKey: QXRSDHAAWVKZLJ-PVYNADRNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)vinyl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-quinone
  • epothilone B
  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[1-methyl-2-(2-methylthiazol-4-yl)vinyl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[1-methyl-2-(2-methyl-4-thiazolyl)vinyl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[1-methyl-2-(2-methylthiazol-4-yl)vinyl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-quinone
  • 152044-54-7
  • C12154
  • Epothilon B
  • NSC684363
  • (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
  • LMPK01000046
  • nchembio853-comp4
  • EPO 906
  • EPO-906
  • NCI60_030305
  • 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE
  • (-)-Epothilone B
  • 4,17-Dioxabicyclo(1410)heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (1S,3S,7S,10R,11S,12S,16R)-
  • 4,17-Dioxabicyclo(1410)heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (1S-(1R*,3R*(E),7R*,10S*,11R*,12R*,16S*))-
  • (−)-Epothilone B
  • E2656_SIGMA
  • EPO906
  • EpoB
  • Patupilone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Starlite/ChEMBL References
Mycobacterium leprae probable proteasome (alpha subunit) PrcA Curated by TDR Targets References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 1, group I, member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. Get druggable targets OG5_234682 All targets in OG5_234682
Mycobacterium leprae probable proteasome (alpha subunit) PrcA Get druggable targets OG5_234682 All targets in OG5_234682
Mycobacterium ulcerans proteasome PrcA Get druggable targets OG5_234682 All targets in OG5_234682
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 400 aa 29.8 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 390 aa 24.6 %
Brugia malayi Nuclear hormone receptor E75 Nuclear receptor subfamily 1 group I member 2   431 aa 359 aa 22.0 %
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 Nuclear receptor subfamily 1 group I member 2   431 aa 440 aa 23.0 %
Brugia malayi ecdysteroid receptor nuclear receptor subfamily 1, group I, member 2 434 aa 427 aa 25.1 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 379 aa 24.5 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 381 aa 26.2 %
Brugia malayi photoreceptor-specific nuclear receptor Nuclear receptor subfamily 1 group I member 2   431 aa 378 aa 25.1 %
Schistosoma mansoni retinoic acid receptor RXR Nuclear receptor subfamily 1 group I member 2   431 aa 412 aa 25.5 %
Brugia malayi nuclear hormone receptor Nuclear receptor subfamily 1 group I member 2   431 aa 394 aa 26.4 %
Echinococcus granulosus ecdysone induced protein 78C Nuclear receptor subfamily 1 group I member 2   431 aa 348 aa 28.2 %
Onchocerca volvulus C-mannosyltransferase dpy-19 homolog Nuclear receptor subfamily 1 group I member 2   431 aa 397 aa 29.2 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 417 aa 24.0 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma japonicum Probable nuclear hormone receptor HR3, putative Nuclear receptor subfamily 1 group I member 2   431 aa 487 aa 24.4 %
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Brugia malayi ecdysteroid receptor Nuclear receptor subfamily 1 group I member 2   431 aa 394 aa 26.9 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 424 aa 24.1 %
Echinococcus multilocularis ecdysone induced protein 78C Nuclear receptor subfamily 1 group I member 2   431 aa 348 aa 28.2 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 378 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Brugia malayi Dopamine receptor 0.00571872 0.00718684 0.00581661
Brugia malayi Glycosyl hydrolases family 38 protein 0.00508241 0.00532443 0.00395162
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis carbonic anhydrase 0.132594 0.378535 0.402553
Echinococcus multilocularis adam 0.00574831 0.00727342 0.00629212
Echinococcus granulosus fibrillin 2 0.00574831 0.00727342 0.00775177
Echinococcus granulosus biogenic amine 5HT receptor 0.00571872 0.00718684 0.00765949
Echinococcus granulosus allatostatin A receptor 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Echinococcus granulosus neuropeptide Y receptor 0.00571872 0.00718684 0.00765949
Onchocerca volvulus 0.00574831 0.00727342 0.00152446
Schistosoma mansoni carbonic anhydrase-related 0.132594 0.378535 0.402553
Leishmania major fatty acid elongase, putative 0.0800631 0.224784 0.234493
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni elongation of fatty acids protein 1 0.0228646 0.0573708 0.0597627
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni hypothetical protein 0.00571872 0.00718684 0.00619971
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Brugia malayi RE15519p 0.00571872 0.00718684 0.00581661
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Echinococcus granulosus 7TM GPCR rhodopsin 0.00571872 0.00718684 0.00765949
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00571872 0.00718684 0.00619971
Brugia malayi Integrin beta pat-3 precursor 0.24061 0.694685 0.694264
Brugia malayi G-protein coupled receptor 0.00571872 0.00718684 0.00581661
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.132594 0.378535 0.377678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Schistosoma mansoni serine/threonine protein kinase 0.0251229 0.0639806 0.0668176
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00571872 0.00718684 0.00619971
Trypanosoma cruzi heat shock protein 85, putative 0.0067284 0.0101421 0.0101049
Brugia malayi Serotonin receptor 0.00571872 0.00718684 0.00581661
Echinococcus granulosus biogenic amine 5HT receptor 0.00571872 0.00718684 0.00765949
Trypanosoma brucei Fatty acid elongase 0.0800631 0.224784 0.231258
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus granulosus g protein coupled receptor 0.00571872 0.00718684 0.00765949
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00571872 0.00718684 0.00619971
Echinococcus granulosus rhodopsin orphan GPCR 0.00571872 0.00718684 0.00765949
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00571872 0.00718684 0.00581661
Brugia malayi EGF-like domain containing protein 0.00574831 0.00727342 0.00590331
Giardia lamblia Neurogenic locus Notch protein precursor 0.00574831 0.00727342 0.302378
Loa Loa (eye worm) hypothetical protein 0.132594 0.378535 0.378229
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.323841 0.938292 0.938262
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Echinococcus granulosus integrin beta 2 0.177707 0.510575 0.544154
Trypanosoma brucei carbonic anhydrase-like protein 0.323841 0.938292 1
Schistosoma mansoni endoplasmin 0.0067284 0.0101421 0.00935391
Trypanosoma cruzi heat shock protein, putative 0.00751691 0.0124499 0.0125663
Echinococcus granulosus tm gpcr rhodopsin 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0800631 0.224784 0.593704
Plasmodium vivax heat shock protein 86, putative 0.0067284 0.0101421 0.0446392
Onchocerca volvulus 0.0219131 0.0545858 0.83458
Giardia lamblia Tenascin-like 0.00574831 0.00727342 0.302378
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Schistosoma mansoni alpha-1 adrenergic receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) neuropeptide F receptor 0.00571872 0.00718684 0.00669716
Leishmania major fatty acid elongase, putative 0.0800631 0.224784 0.234493
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis heat shock protein 90 0.00532349 0.00603004 0.00496502
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) heat shock protein 75 0.00751691 0.0124499 0.0119628
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00571872 0.00718684 0.00619971
Plasmodium falciparum heat shock protein 90, putative 0.00745216 0.0122604 0.0321004
Brugia malayi G-protein coupled receptor 0.00571872 0.00718684 0.00581661
Loa Loa (eye worm) G-protein coupled receptor 0.00571872 0.00718684 0.00669716
Trypanosoma cruzi fatty acid elongase, putative 0.0219131 0.0545858 0.0575052
Onchocerca volvulus 0.0219131 0.0545858 0.83458
Echinococcus multilocularis rho associated protein kinase 0.0251229 0.0639806 0.0668176
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Schistosoma mansoni biogenic amine receptor 0.00571872 0.00718684 0.00619971
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Trichomonas vaginalis endoplasmin, putative 0.00464201 0.00403542 0.303199
Echinococcus granulosus rhodopsin orphan GPCR 0.00571872 0.00718684 0.00765949
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00571872 0.00718684 0.00581661
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Schistosoma mansoni adenoreceptor 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis dro:myosuppressin receptor 0.00571872 0.00718684 0.00619971
Brugia malayi neuropeptide F receptor 0.00571872 0.00718684 0.00581661
Trypanosoma brucei Fatty acid elongase 0.0219131 0.0545858 0.0478842
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0800631 0.224784 0.224402
Echinococcus multilocularis carbonic anhydrase 0.132594 0.378535 0.402553
Echinococcus granulosus orexin receptor type 2 0.00571872 0.00718684 0.00765949
Schistosoma mansoni biogenic amine receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis fmrfamide receptor 0.00571872 0.00718684 0.00619971
Schistosoma mansoni cathepsin D (A01 family) 0.0125813 0.0272729 0.0276382
Loa Loa (eye worm) hypothetical protein 0.00574831 0.00727342 0.00678378
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.132594 0.378535 0.377678
Trypanosoma cruzi Heat shock protein 83, putative 0.0067284 0.0101421 0.0101049
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00571872 0.00718684 0.00619971
Brugia malayi sulfakinin receptor protein 0.00571872 0.00718684 0.00581661
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.00426711 0.00293815 0.00166494
Brugia malayi follicle stimulating hormone receptor 0.00571872 0.00718684 0.00581661
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Toxoplasma gondii hypothetical protein 0.00574831 0.00727342 0.018922
Echinococcus granulosus heat shock protein 90 0.0067284 0.0101421 0.0108091
Echinococcus multilocularis fibrillin 2 0.00574831 0.00727342 0.00629212
Schistosoma mansoni amine GPCR 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0368744 0.0983756 0.0979309
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0837647 0.235618 0.235241
Schistosoma mansoni opsin-like receptor 0.00571872 0.00718684 0.00619971
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0228646 0.0573708 0.0508848
Echinococcus granulosus neuropeptide s receptor 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00571872 0.00718684 0.00619971
Echinococcus granulosus rhodopsin orphan GPCR 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis integrin beta 2 0.177707 0.510575 0.543483
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Echinococcus granulosus alpha 1A adrenergic receptor 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni opsin-like receptor 0.00571872 0.00718684 0.00619971
Schistosoma mansoni myosin xvIII 0.00571872 0.00718684 0.00619971
Trichomonas vaginalis heat shock protein, putative 0.00464201 0.00403542 0.303199
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00571872 0.00718684 0.00765949
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.00532349 0.00603004 0.00642661
Loa Loa (eye worm) aspartic protease BmAsp-2 0.00426711 0.00293815 0.00244637
Brugia malayi EGF-like domain containing protein 0.00574831 0.00727342 0.00590331
Loa Loa (eye worm) fatty acid elongation protein 3 0.0219131 0.0545858 0.0541195
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0800631 0.224784 0.593704
Loa Loa (eye worm) GNS1/SUR4 family protein 0.344924 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.00751691 0.0124499 0.0118172
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00571872 0.00718684 0.00669716
Giardia lamblia High cysteine protein 0.00574831 0.00727342 0.302378
Leishmania major carbonic anhydrase-like protein 0.323841 0.938292 1
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Schistosoma mansoni elongation of fatty acids protein 1 0.0219131 0.0545858 0.0567902
Echinococcus multilocularis neuropeptide FF receptor 2 0.00571872 0.00718684 0.00619971
Treponema pallidum heat shock protein 90 0.00538824 0.00621954 0.5
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.00426711 0.00293815 0.00746583
Schistosoma mansoni carbonic anhydrase-related 0.132594 0.378535 0.402553
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Schistosoma mansoni neuropeptide receptor 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis sex peptide receptor 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00571872 0.00718684 0.00619971
Onchocerca volvulus 0.0251229 0.0639806 1
Echinococcus granulosus carbonic anhydrase 0.132594 0.378535 0.40343
Plasmodium falciparum endoplasmin, putative 0.00464201 0.00403542 0.0103654
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00571872 0.00718684 0.00619971
Schistosoma mansoni carbonic anhydrase-related 0.132594 0.378535 0.402553
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Echinococcus granulosus g protein coupled receptor 0.00571872 0.00718684 0.00765949
Schistosoma mansoni neuropeptide receptor 0.00571872 0.00718684 0.00619971
Echinococcus granulosus tm gpcr rhodopsin 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) TYRA-2 protein 0.00571872 0.00718684 0.00669716
Echinococcus granulosus somatostatin receptor 0.00571872 0.00718684 0.00765949
Brugia malayi putative neuropeptide receptor 0.00571872 0.00718684 0.00581661
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00571872 0.00718684 0.00581661
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00571872 0.00718684 0.00619971
Trypanosoma cruzi heat shock protein 85, putative 0.0067284 0.0101421 0.0101049
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.00426711 0.00293815 0.00313138
Giardia lamblia Grp94/Hsp90 0.00538824 0.00621954 0.0460862
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Trichomonas vaginalis hypothetical protein 0.00574831 0.00727342 0.672673
Echinococcus multilocularis neuropeptides capa receptor 0.00571872 0.00718684 0.00619971
Trypanosoma cruzi heat shock protein 85, putative 0.0067284 0.0101421 0.0101049
Trypanosoma cruzi heat shock protein 90, putative 0.0067284 0.0101421 0.0101049
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.323841 0.938292 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00571872 0.00718684 0.00765949
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0219131 0.0545858 0.242456
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00571872 0.00718684 0.00619971
Giardia lamblia Neurogenic locus notch-like protein 0.00574831 0.00727342 0.302378
Schistosoma mansoni heat shock protein 0.0067284 0.0101421 0.00935391
Echinococcus multilocularis neuropeptide receptor A26 0.00571872 0.00718684 0.00619971
Echinococcus granulosus hypothetical protein 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00571872 0.00718684 0.00619971
Giardia lamblia Tenascin precursor 0.00574831 0.00727342 0.302378
Schistosoma mansoni hypothetical protein 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni neuropeptide f receptor 76f 0.00571872 0.00718684 0.00619971
Echinococcus granulosus peptide allatostatin:somatostatin 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00571872 0.00718684 0.00669716
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.129023 0.368084 1
Loa Loa (eye worm) hypothetical protein 0.0368744 0.0983756 0.0979309
Schistosoma mansoni fatty acid acyl transferase-related 0.0228646 0.0573708 0.0597627
Echinococcus multilocularis elongation of very long chain fatty acids 0.0219131 0.0545858 0.0567902
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.129023 0.368084 1
Echinococcus multilocularis carbonic anhydrase II 0.323841 0.938292 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni neuropeptide F-like receptor 0.00571872 0.00718684 0.00619971
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis elongation of very long chain fatty acids 0.0228646 0.0573708 0.0597627
Brugia malayi ORL1-like opioid receptor 0.00571872 0.00718684 0.00581661
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00571872 0.00718684 0.00669716
Toxoplasma gondii heat shock protein 75, putative 0.00751691 0.0124499 0.0326011
Echinococcus multilocularis heat shock protein 90 0.0067284 0.0101421 0.00935391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0800631 0.224784 0.593704
Leishmania major fatty acid elongase, putative 0.0800631 0.224784 0.234493
Plasmodium vivax aspartyl proteinase, putative 0.00426711 0.00293815 0.012575
Trypanosoma cruzi fatty acid elongase, putative 0.0219131 0.0545858 0.0575052
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis g protein coupled receptor 0.00571872 0.00718684 0.00619971
Entamoeba histolytica heat shock protein 90, putative 0.0067284 0.0101421 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00571872 0.00718684 0.00619971
Echinococcus granulosus elongation of very long chain fatty acids 0.0219131 0.0545858 0.0581757
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Echinococcus granulosus dro:myosuppressin receptor 0.00571872 0.00718684 0.00765949
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0228646 0.0573708 0.151307
Echinococcus granulosus G protein coupled receptor 139 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis G-protein coupled receptor, putative 0.00571872 0.00718684 0.00619971
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Echinococcus multilocularis G protein coupled receptor 139 0.00571872 0.00718684 0.00619971
Echinococcus granulosus fmrfamide receptor 0.00571872 0.00718684 0.00765949
Trypanosoma cruzi heat shock protein 85, putative 0.00532349 0.00603004 0.0057193
Echinococcus granulosus rhodopsin orphan GPCR 0.00571872 0.00718684 0.00765949
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0219131 0.0545858 0.0532809
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0219131 0.0545858 0.83458
Loa Loa (eye worm) fatty acid elongation protein 3 0.0219131 0.0545858 0.0541195
Brugia malayi Tachykinin-like peptides receptor 99D 0.00571872 0.00718684 0.00581661
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Trichomonas vaginalis heat shock protein, putative 0.00538824 0.00621954 0.552419
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.323841 0.938292 1
Trichomonas vaginalis heat shock protein, putative 0.00538824 0.00621954 0.552419
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.132594 0.378535 0.378229
Echinococcus multilocularis fibrillin 1 0.00574831 0.00727342 0.00629212
Trypanosoma brucei Long chain fatty acyl elongase 0.0228646 0.0573708 0.0508848
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Schistosoma mansoni amine GPCR 0.00571872 0.00718684 0.00619971
Plasmodium vivax plasmepsin IV, putative 0.00426711 0.00293815 0.012575
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Brugia malayi Endoplasmin precursor 0.0067284 0.0101421 0.0087759
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.132594 0.378535 0.377678
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) hypothetical protein 0.00574831 0.00727342 0.00678378
Brugia malayi Fatty acid elongation protein 3 0.0800631 0.224784 0.223714
Entamoeba histolytica heat shock protein 90, putative 0.0067284 0.0101421 1
Echinococcus multilocularis protein jagged 2 0.00574831 0.00727342 0.00629212
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00571872 0.00718684 0.00581661
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.323841 0.938292 0.938207
Onchocerca volvulus 0.0250605 0.0637977 0.99678
Schistosoma mansoni hypothetical protein 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00571872 0.00718684 0.00619971
Giardia lamblia Tenascin-37 0.00574831 0.00727342 0.302378
Echinococcus multilocularis fmrfamide receptor 0.00571872 0.00718684 0.00619971
Echinococcus granulosus carbonic anhydrase II 0.323841 0.938292 1
Schistosoma mansoni histamine h1 receptor 0.00571872 0.00718684 0.00619971
Toxoplasma gondii heat shock protein 90, putative 0.0067284 0.0101421 0.0265025
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Loa Loa (eye worm) endoplasmin 0.0067284 0.0101421 0.00965383
Loa Loa (eye worm) hypothetical protein 0.00574831 0.00727342 0.00678378
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.323841 0.938292 1
Brugia malayi Hsp90 protein 0.00751691 0.0124499 0.011087
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Brugia malayi neuropeptide F receptor 0.00571872 0.00718684 0.00581661
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Schistosoma mansoni hypothetical protein 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00373415 0.00137825 0.000885699
Brugia malayi hypothetical protein 0.0368744 0.0983756 0.0971312
Echinococcus multilocularis heat shock protein 0.0067284 0.0101421 0.00935391
Echinococcus granulosus neuropeptide FF receptor 2 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) ELO-9 protein 0.0219131 0.0545858 0.0541195
Schistosoma mansoni neuropeptide receptor 0.00571872 0.00718684 0.00619971
Trypanosoma cruzi heat shock protein 90, putative 0.00532349 0.00603004 0.0057193
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00571872 0.00718684 0.00619971
Brugia malayi G protein-coupled receptor F59B2.13 0.00571872 0.00718684 0.00581661
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0228646 0.0573708 0.254852
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Schistosoma mansoni elongation of fatty acids protein 1 0.0219131 0.0545858 0.0567902
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Trypanosoma brucei heat shock protein 84, putative 0.00751691 0.0124499 0.00248652
Echinococcus multilocularis carbonic anhydrase 0.132594 0.378535 0.402553
Loa Loa (eye worm) hypothetical protein 0.132594 0.378535 0.378229
Trypanosoma brucei Fatty acid elongase 0.0219131 0.0545858 0.0478842
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.00751691 0.0124499 0.0926699
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Echinococcus granulosus carbonic anhydrase 0.132594 0.378535 0.40343
Echinococcus granulosus g protein coupled receptor 0.00571872 0.00718684 0.00765949
Schistosoma mansoni elongation of fatty acids protein 1 0.0228646 0.0573708 0.0597627
Trypanosoma cruzi fatty acid elongase, putative 0.0800631 0.224784 0.239026
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00571872 0.00718684 0.00669716
Leishmania major fatty acid elongase, putative 0.0228646 0.0573708 0.054879
Plasmodium vivax heat shock protein 90, putative 0.00751691 0.0124499 0.0549114
Echinococcus multilocularis g protein coupled receptor 0.00571872 0.00718684 0.00619971
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Echinococcus granulosus rhodopsin orphan GPCR 0.00571872 0.00718684 0.00765949
Echinococcus granulosus neuropeptides capa receptor 0.00571872 0.00718684 0.00765949
Schistosoma mansoni amine GPCR 0.00571872 0.00718684 0.00619971
Brugia malayi G protein-coupled receptor 0.00571872 0.00718684 0.00581661
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Echinococcus granulosus rho-associated protein kinase 1 0.0251229 0.0639806 0.0681883
Echinococcus granulosus neuropeptides capa receptor 0.00571872 0.00718684 0.00765949
Echinococcus granulosus 7tm_1 domain containing protein 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) fatty acid elongation protein 3 0.0800631 0.224784 0.224402
Echinococcus multilocularis neuropeptide Y receptor 0.00571872 0.00718684 0.00619971
Leishmania major heat shock protein, putative 0.00751691 0.0124499 0.00668443
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) hypothetical protein 0.00574831 0.00727342 0.00678378
Loa Loa (eye worm) hypothetical protein 0.132594 0.378535 0.378229
Echinococcus granulosus sex peptide receptor 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) mannosidase 0.00373415 0.00137825 0.000885699
Loa Loa (eye worm) hypothetical protein 0.00426711 0.00293815 0.00244637
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Echinococcus granulosus heat shock protein 90 0.00532349 0.00603004 0.00642661
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) heat shock protein 90 0.0067284 0.0101421 0.00965383
Plasmodium falciparum plasmepsin VI 0.00426711 0.00293815 0.00746583
Toxoplasma gondii hypothetical protein 0.132594 0.378535 1
Trypanosoma cruzi fatty acid elongase, putative 0.0219131 0.0545858 0.0575052
Brugia malayi AKH receptor 0.00571872 0.00718684 0.00581661
Echinococcus granulosus endoplasmin 0.00538824 0.00621954 0.00662858
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Echinococcus granulosus alpha mannosidase 2 0.00343169 0.000492984 0.000525406
Schistosoma mansoni heat shock protein 0.0067284 0.0101421 0.00935391
Schistosoma mansoni heat shock protein 0.00751691 0.0124499 0.0118172
Trichomonas vaginalis heat shock protein, putative 0.00532349 0.00603004 0.530796
Echinococcus multilocularis neuropeptide receptor 0.00571872 0.00718684 0.00619971
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.00574831 0.00727342 0.672673
Echinococcus multilocularis allatostatin A receptor 0.00571872 0.00718684 0.00619971
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Echinococcus multilocularis somatostatin receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Brugia malayi Serotonin receptor 0.143085 0.409241 0.408426
Schistosoma mansoni biogenic amine (5HT) receptor 0.00571872 0.00718684 0.00619971
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Giardia lamblia High cysteine protein 0.00574831 0.00727342 0.302378
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Brugia malayi fatty acid elongation protein 3 0.0219131 0.0545858 0.0532809
Brugia malayi GNS1/SUR4 family protein 0.344924 1 1
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Echinococcus multilocularis g protein coupled receptor 0.00571872 0.00718684 0.00619971
Echinococcus granulosus adam 0.00574831 0.00727342 0.00775177
Schistosoma mansoni integrin beta subunit 0.140832 0.402648 0.428289
Echinococcus multilocularis orexin receptor type 2 0.00571872 0.00718684 0.00619971
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.00538824 0.00621954 0.5
Plasmodium falciparum plasmepsin I 0.00426711 0.00293815 0.00746583
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00571872 0.00718684 0.00619971
Echinococcus granulosus neuropeptide receptor 0.00571872 0.00718684 0.00765949
Echinococcus granulosus rhodopsin orphan GPCR 0.00571872 0.00718684 0.00765949
Plasmodium falciparum plasmepsin II 0.00426711 0.00293815 0.00746583
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.00751691 0.0124499 0.0132687
Schistosoma mansoni hypothetical protein 0.132594 0.378535 0.402553
Leishmania major fatty acid elongase, putative 0.0219131 0.0545858 0.0518911
Brugia malayi fatty acid elongation protein 3 0.0219131 0.0545858 0.0532809
Echinococcus granulosus tachykinin peptides receptor 99D 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis neuropeptide s receptor 0.00571872 0.00718684 0.00619971
Brugia malayi larval opioid receptor 0.00571872 0.00718684 0.00581661
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus granulosus heat shock protein 0.0067284 0.0101421 0.0108091
Loa Loa (eye worm) integrin beta-2 0.24061 0.694685 0.694535
Giardia lamblia hypothetical protein 0.00574831 0.00727342 0.302378
Trypanosoma cruzi fatty acid elongase, putative 0.0219131 0.0545858 0.0575052
Schistosoma mansoni mannosidase alpha class 2a 0.00508241 0.00532443 0.00421189
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) hypothetical protein 0.00373415 0.00137825 0.000885699
Schistosoma mansoni biogenic amine receptor 0.00571872 0.00718684 0.00619971
Schistosoma mansoni endoplasmin 0.0067284 0.0101421 0.00935391
Echinococcus granulosus neuropeptide receptor 0.00571872 0.00718684 0.00765949
Echinococcus multilocularis serotonin receptor 0.00571872 0.00718684 0.00619971
Schistosoma mansoni growth hormone secretagogue receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) fatty acid elongation protein 3 0.0219131 0.0545858 0.0541195
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00571872 0.00718684 0.00619971
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00571872 0.00718684 0.00765949
Brugia malayi Putative carbonic anhydrase 5 precursor 0.323841 0.938292 0.938207
Echinococcus granulosus neuropeptide receptor A26 0.00571872 0.00718684 0.00765949
Toxoplasma gondii aspartyl protease ASP1 0.00426711 0.00293815 0.00746583
Echinococcus granulosus carbonic anhydrase 0.132594 0.378535 0.40343
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00426711 0.00293815 0.00166494
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0800631 0.224784 1
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.00373415 0.00137825 0.00146889
Loa Loa (eye worm) melatonin receptor type 1A 0.00571872 0.00718684 0.00669716
Echinococcus multilocularis g-protein coupled receptor 0.00571872 0.00718684 0.00619971
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Trichomonas vaginalis heat shock protein, putative 0.0067284 0.0101421 1
Trypanosoma cruzi fatty acid elongase, putative 0.0800631 0.224784 0.239026
Brugia malayi EGF-like domain containing protein 0.00574831 0.00727342 0.00590331
Echinococcus multilocularis neuropeptide Y receptor 0.00571872 0.00718684 0.00619971
Plasmodium falciparum heat shock protein 90 0.0067284 0.0101421 0.0265025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0228646 0.0573708 0.054879
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.323841 0.938292 1
Trypanosoma cruzi fatty acid elongase, putative 0.0228646 0.0573708 0.0604755
Giardia lamblia Tenascin-X 0.00574831 0.00727342 0.302378
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus granulosus g-protein coupled receptor 0.00571872 0.00718684 0.00765949
Toxoplasma gondii GNS1/SUR4 family protein 0.0800631 0.224784 0.593704
Echinococcus granulosus serotonin receptor 0.00571872 0.00718684 0.00765949
Schistosoma mansoni carbonic anhydrase 0.132594 0.378535 0.402553
Echinococcus multilocularis neuropeptides capa receptor 0.00571872 0.00718684 0.00619971
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) hypothetical protein 0.00508241 0.00532443 0.00483382
Brugia malayi EGF-like domain containing protein 0.00574831 0.00727342 0.00590331
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0219131 0.0545858 0.83458
Brugia malayi Protein kinase domain containing protein 0.0837647 0.235618 0.234563
Schistosoma mansoni neuropeptide F-like receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) G-protein coupled receptor 0.00571872 0.00718684 0.00669716
Echinococcus granulosus neuropeptide Y receptor 0.00571872 0.00718684 0.00765949
Trypanosoma cruzi fatty acid elongase, putative 0.0800631 0.224784 0.239026
Brugia malayi Dopamine receptor protein 2 0.00571872 0.00718684 0.00581661
Trypanosoma cruzi fatty acid elongase, putative 0.0800631 0.224784 0.239026
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis alpha mannosidase 2 0.00508241 0.00532443 0.00421189
Brugia malayi putative neuropeptide receptor NPR1 0.00571872 0.00718684 0.00581661
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Plasmodium falciparum carbonic anhydrase 0.132594 0.378535 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00571872 0.00718684 0.00619971
Schistosoma mansoni cathepsin D (A01 family) 0.0125813 0.0272729 0.0276382
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Echinococcus granulosus tm gpcr rhodopsin 0.00571872 0.00718684 0.00765949
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00571872 0.00718684 0.00619971
Brugia malayi Kelch motif family protein 0.0368744 0.0983756 0.0971312
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00571872 0.00718684 0.00619971
Mycobacterium ulcerans proteasome PrcA 0.129023 0.368084 1
Brugia malayi GnHR receptor homolog 0.00571872 0.00718684 0.00581661
Loa Loa (eye worm) hypothetical protein 0.0219131 0.0545858 0.0541195
Echinococcus granulosus elongation of very long chain fatty acids 0.0228646 0.0573708 0.0611438
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni biogenic amine (5HT) receptor 0.00571872 0.00718684 0.00619971
Echinococcus multilocularis serotonin receptor 0.00571872 0.00718684 0.00619971
Brugia malayi fatty acid elongation protein 3 0.0219131 0.0545858 0.0532809
Brugia malayi hypothetical protein 0.00571872 0.00718684 0.00581661
Loa Loa (eye worm) carbonic anhydrase 3 0.323841 0.938292 0.938262
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni amine GPCR 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00571872 0.00718684 0.00619971
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.132594 0.378535 0.377678
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00571872 0.00718684 0.00619971
Brugia malayi fatty acid elongation protein 3 0.0219131 0.0545858 0.0532809
Schistosoma mansoni neuropeptide receptor 0.00571872 0.00718684 0.00619971
Giardia lamblia Heat shock protein HSP 90-alpha 0.0067284 0.0101421 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.132594 0.378535 0.377678
Brugia malayi Melatonin receptor type 1A 0.00571872 0.00718684 0.00581661
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.00373415 0.00137825 0.00146889
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00571872 0.00718684 0.00765949
Echinococcus granulosus fibrillin 1 0.00574831 0.00727342 0.00775177
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0219131 0.0545858 0.83458
Trypanosoma cruzi fatty acid elongase, putative 0.0228646 0.0573708 0.0604755
Echinococcus multilocularis neuropeptide receptor 0.00571872 0.00718684 0.00619971
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Loa Loa (eye worm) hypothetical protein 0.00571872 0.00718684 0.00669716
Toxoplasma gondii fatty acid elongase 0.0228646 0.0573708 0.151307
Plasmodium vivax endoplasmin, putative 0.0067284 0.0101421 0.0446392
Schistosoma mansoni opsin-like receptor 0.00571872 0.00718684 0.00619971
Toxoplasma gondii heat shock protein HSP90 0.0067284 0.0101421 0.0265025
Brugia malayi heat shock protein 90 0.0067284 0.0101421 0.0087759
Plasmodium falciparum plasmepsin IV 0.00426711 0.00293815 0.00746583
Echinococcus multilocularis endoplasmin 0.00538824 0.00621954 0.00516728
Brugia malayi GNS1/SUR4 family protein 0.0800631 0.224784 0.223714
Echinococcus multilocularis rhodopsin orphan GPCR 0.00571872 0.00718684 0.00619971
Brugia malayi Dopamine receptor protein 1 0.00571872 0.00718684 0.00581661
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.00426711 0.00293815 0.177994
Schistosoma mansoni amine GPCR 0.00571872 0.00718684 0.00619971
Leishmania major heat shock protein 83-1 0.0067284 0.0101421 0.00420837
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00571872 0.00718684 0.00581661

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 13.7 % Cell cycle arrest in human SNU398 cells assessed as accumulation at G1 phase at 100 nM after 24 hrs by FACS analysis (Rvb = 55.8%) ChEMBL. 22320354
CC50 > 6.25 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 0.00409 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (ADMET) = 0.01 uM Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis ChEMBL. 20966043
EC50 (functional) = 0.67 uM Concentrations required to induce 50 percent polymerization of porcine brain-derived micro-tubule protein ChEMBL. 11133086
EC50 (functional) > 1.25 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (ADMET) = 12.6 uM Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis ChEMBL. 20966043
EC50 (ADMET) = 31.6 uM Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay ChEMBL. 20966043
ED50 (functional) = 0.0015 uM Cytotoxicity against human MCF7 cells by phototoxicity labeling study ChEMBL. 19428248
Efficacy (ADMET) = 62.5 % Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis relative to rifampicin ChEMBL. 20966043
Efficacy (ADMET) = 89.9 % Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay relative to SR12813 ChEMBL. 20966043
Efficacy (ADMET) = 102.9 % Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis relative to dexamethasone ChEMBL. 20966043
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -10 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 0 ng ml-1 Cytotoxicity against L929 fibroblast cell line; Weak cytotoxic activity. ChEMBL. 9873670
IC50 (ADMET) = 1 ng/ml Cytotoxicity against mouse L929 cells ChEMBL. 11473410
IC50 (functional) = 0.13 nM Inhibitory concentration against ovarian carcinoma 1A9 cell growth ChEMBL. 16134928
IC50 (functional) = 0.13 nM Inhibitory concentration against ovarian carcinoma 1A9 cell growth ChEMBL. 16134928
IC50 (functional) = 0.18 nM Concentration required to inhibit the growth of paclitaxel-resistant human epidermoid carcinoma cells KB-8511 by 50 percent (72 h exposure) ChEMBL. 11133086
IC50 (functional) = 0.18 nM Concentration required to inhibit the growth of paclitaxel-resistant human epidermoid carcinoma cells KB-8511 by 50 percent (72 h exposure) ChEMBL. 11133086
IC50 (functional) = 0.19 nM Concentration required to inhibit the growth of paclitaxel-sensitive human epidermoid carcinoma cells KB-31 by 50 percent (72 h exposure) ChEMBL. 11133086
IC50 (functional) = 0.19 nM Concentration required to inhibit the growth of paclitaxel-sensitive human epidermoid carcinoma cells KB-31 by 50 percent (72 h exposure) ChEMBL. 11133086
IC50 (functional) = 0.31 nM Inhibitory concentration against beta-tubulin mutant 1A9PTX22 cell line ChEMBL. 16134928
IC50 (functional) = 0.31 nM Inhibitory concentration against beta-tubulin mutant 1A9PTX22 cell line ChEMBL. 16134928
IC50 (functional) = 1 nM Inhibitory concentration against beta-tubulin mutant 1A9PTX10 cell growth ChEMBL. 16134928
IC50 (functional) = 1 nM Inhibitory concentration against beta-tubulin mutant 1A9PTX10 cell growth ChEMBL. 16134928
IC50 (functional) = 5 nM Antiproliferative activity against human SNU398 cells ChEMBL. 22320354
IC50 (functional) = 0.9550639284084556 uM SANGER: Inhibition of human DOK cell growth in a cell viability assay. ChEMBL. No reference
IC50 (functional) > 10 uM Antiproliferative activity against exponentially growing adherent human HCC1937 cells assessed as inhibition of cell proliferation after 72 hrs by luminescence detection based ATPlite assay ChEMBL. 25872984
Inhibition (functional) = 0 % Antiproliferative activity against exponentially growing adherent human HCC1937 cells assessed as inhibition of cell proliferation at 10 uM after 72 hrs by luminescence detection based ATPlite assay ChEMBL. 25872984
Potency (functional) 0.0013 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.0013 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.0112 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element beta-lactamase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0573 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.3498 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
TP (functional) = 98 % Percent polymorphism of tubulin by the compound ChEMBL. 16134928
TP (functional) = 98 % Percent polymorphism of tubulin by the compound ChEMBL. 16134928
Tubulin polymerization (functional) = 90 % Induction of polymerization of porcine brain-derived microtubule protein by 2 microM epothilone B ChEMBL. 11133086

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783
Mus musculus ChEMBL23 11473410
Homo sapiens ChEMBL23 11133086

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 255693  
Annotator: crowther@u.washington.edu Comment: 2007-12-28 References: 16468985

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

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