Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0225 | 0.2772 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2117 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0008 | 0.0008 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0225 | 0.2772 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2117 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0488 | 0.176 |
Brugia malayi | 4-hydroxyphenylpyruvate dioxygenase family protein | 0.0176 | 0.2117 | 0.2117 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0488 | 0.176 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0071 | 0.0704 | 0.0704 |
Brugia malayi | hypothetical protein | 0.0103 | 0.1136 | 0.1136 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.0761 | 1 | 1 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0176 | 0.2117 | 1 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0603 | 0.7873 | 0.7873 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1686 | 0.1686 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0071 | 0.0704 | 0.0559 |
Plasmodium vivax | glyoxalase I, putative | 0.0761 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0488 | 0.176 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0488 | 0.176 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0071 | 0.0704 | 0.0559 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0071 | 0.0704 | 0.0559 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0761 | 1 | 1 |
Schistosoma mansoni | hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) | 0.0071 | 0.0704 | 0.2541 |
Toxoplasma gondii | glyoxalase family protein | 0.0176 | 0.2117 | 0.1994 |
Mycobacterium tuberculosis | Conserved protein | 0.0176 | 0.2117 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0225 | 0.2772 | 0.2772 |
Mycobacterium tuberculosis | Conserved protein | 0.0176 | 0.2117 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1686 | 0.1686 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0071 | 0.0704 | 0.0559 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0028 | 0.0118 | 0.0118 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0176 | 0.2117 | 1 |
Echinococcus multilocularis | hydroxyacylglutathione hydrolase | 0.0071 | 0.0704 | 0.2541 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2117 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0298 | 0.0298 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.0071 | 0.0704 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0555 | 0.0555 |
Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.0071 | 0.0704 | 0.2541 |
Schistosoma mansoni | 4-hydroxyphenylpyruvate dioxygenase | 0.0176 | 0.2117 | 0.7637 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0176 | 0.2117 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0555 | 0.0555 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0176 | 0.2117 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1686 | 0.1686 |
Onchocerca volvulus | Putative protein | 0.0176 | 0.2117 | 0.1727 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0555 | 0.0555 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0488 | 0.176 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2117 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.2117 | 1 |
Brugia malayi | Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. | 0.0071 | 0.0704 | 0.0704 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0488 | 0.0488 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0225 | 0.2772 | 1 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.0071 | 0.0704 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0154 | 0.0154 |
Mycobacterium leprae | conserved hypothetical protein | 0.0176 | 0.2117 | 1 |
Schistosoma mansoni | gynecophoral canal protein | 0.0176 | 0.2117 | 0.7637 |
Brugia malayi | hypothetical protein | 0.003 | 0.0154 | 0.0154 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0555 | 0.0555 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0603 | 0.7873 | 0.7873 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 1 | 1 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.0761 | 1 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0761 | 1 | 1 |
Toxoplasma gondii | glyoxalase I, putative | 0.0761 | 1 | 1 |
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.0176 | 0.2117 | 0.2117 |
Plasmodium vivax | glyoxalase I, putative | 0.0176 | 0.2117 | 0.1994 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0488 | 0.0488 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0488 | 0.176 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2117 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0298 | 0.1075 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0176 | 0.2117 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0176 | 0.2117 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0488 | 0.176 |
Plasmodium falciparum | glyoxalase I | 0.0176 | 0.2117 | 0.1994 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2117 | 1 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0071 | 0.0704 | 0.0559 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0176 | 0.2117 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0761 | 1 | 1 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase cytoplasmic | 0.0028 | 0.0118 | 0.0118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.