Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.4755 | 0.3699 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0114 | 0.4744 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0173 | 0.8756 | 0.815 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0189 | 0.9839 | 0.976 |
Trypanosoma brucei | trypanothione reductase | 0.0191 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0173 | 0.8756 | 0.5217 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0114 | 0.4744 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0173 | 0.8756 | 0.9501 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0159 | 0.7827 | 0.6768 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0168 | 0.8443 | 0.8141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0173 | 0.8756 | 0.9501 |
Plasmodium falciparum | lysophospholipase, putative | 0.0173 | 0.8756 | 0.815 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0114 | 0.4744 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0191 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0098 | 0.3687 | 0.0612 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0173 | 0.8756 | 0.9501 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0177 | 0.9044 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0092 | 0.3276 | 0.1976 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0098 | 0.3687 | 0.0612 |
Plasmodium falciparum | lysophospholipase, putative | 0.0173 | 0.8756 | 0.815 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0098 | 0.3687 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0191 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0098 | 0.3687 | 0.0751 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0168 | 0.8443 | 0.7684 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0189 | 0.9839 | 0.976 |
Plasmodium vivax | glutathione reductase, putative | 0.0191 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0098 | 0.3687 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0098 | 0.3687 | 0.0612 |
Plasmodium vivax | PST-A protein | 0.0173 | 0.8756 | 0.815 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0191 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0173 | 0.8756 | 0.815 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0168 | 0.8443 | 0.8141 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0098 | 0.3687 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0168 | 0.8443 | 0.7684 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0168 | 0.8443 | 0.7684 |
Plasmodium falciparum | esterase, putative | 0.0173 | 0.8756 | 0.815 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0159 | 0.7827 | 0.6768 |
Plasmodium falciparum | lysophospholipase, putative | 0.0177 | 0.9044 | 0.8578 |
Plasmodium falciparum | glutathione reductase | 0.0191 | 1 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0168 | 0.8443 | 0.8958 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0173 | 0.8756 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0092 | 0.3276 | 0.3741 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0159 | 0.7827 | 0.6768 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0173 | 0.8756 | 0.9501 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0173 | 0.8756 | 0.815 |
Loa Loa (eye worm) | glutathione reductase | 0.0191 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0177 | 0.9044 | 0.8578 |
Schistosoma mansoni | DNA topoisomerase II | 0.0168 | 0.8443 | 0.7684 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0173 | 0.8756 | 0.815 |
Leishmania major | monoglyceride lipase, putative | 0.0173 | 0.8756 | 0.815 |
Leishmania major | DNA topoisomerase ii | 0.0159 | 0.7827 | 0.6768 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0189 | 0.9839 | 0.976 |
Toxoplasma gondii | thioredoxin reductase | 0.0191 | 1 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0173 | 0.8756 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0173 | 0.8756 | 0.9501 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0191 | 1 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0168 | 0.8443 | 0.7684 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0191 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0191 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0159 | 0.7827 | 0.6768 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0177 | 0.9044 | 1 |
Plasmodium falciparum | esterase, putative | 0.0177 | 0.9044 | 0.8578 |
Plasmodium vivax | lysophospholipase, putative | 0.0177 | 0.9044 | 0.8578 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0168 | 0.8443 | 0.8129 |
Mycobacterium ulcerans | hypothetical protein | 0.0173 | 0.8756 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0191 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0173 | 0.8756 | 0.9501 |
Giardia lamblia | DNA topoisomerase II | 0.016 | 0.7848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.4755 | 0.3699 |
Brugia malayi | Thioredoxin reductase | 0.0191 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0173 | 0.8756 | 0.5217 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0189 | 0.9839 | 0.976 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0173 | 0.8756 | 0.9501 |
Plasmodium vivax | unspecified product | 0.0177 | 0.9044 | 0.8578 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0173 | 0.8756 | 0.9501 |
Plasmodium falciparum | thioredoxin reductase | 0.0191 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0173 | 0.8756 | 0.815 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0092 | 0.3276 | 0.7054 |
Brugia malayi | Probable DNA topoisomerase II | 0.0168 | 0.8443 | 0.8141 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0098 | 0.3687 | 0.0612 |
Plasmodium falciparum | esterase, putative | 0.0177 | 0.9044 | 0.8578 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0168 | 0.8443 | 0.7684 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.