Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1589 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0141 | 0.0604 | 0.5294 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Toxoplasma gondii | methionine aminopeptidase | 0.1589 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1589 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1589 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative | 0.0127 | 0.0514 | 0.0423 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0069 | 0.0134 | 0.004 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.1007 | 0.6223 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0881 | 0.5407 | 0.8689 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 1 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0127 | 0.0514 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0387 | 0.2197 | 0.1774 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.1007 | 0.6223 | 0.6018 |
Trypanosoma cruzi | aminopeptidase P, putative | 0.0127 | 0.0514 | 0.0423 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.1007 | 0.6223 | 0.6018 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0141 | 0.0604 | 0.5294 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1589 | 1 | 1 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1589 | 1 | 1 |
Onchocerca volvulus | Dipeptidase C homolog | 0.0127 | 0.0514 | 0.3687 |
Toxoplasma gondii | methionine aminopeptidase | 0.1007 | 0.6223 | 0.6018 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0127 | 0.0514 | 0.3687 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.0582 | 0.3465 | 0.3111 |
Entamoeba histolytica | hypothetical protein | 0.0164 | 0.0749 | 0.6931 |
Schistosoma mansoni | peptidase | 0.0127 | 0.0514 | 0.0825 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0133 | 0.0552 | 0.0041 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3403 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0206 | 0.1022 | 0.0936 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0206 | 0.1022 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.0127 | 0.0514 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0206 | 0.1022 | 1 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0387 | 0.2197 | 0.1774 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.1218 | 0.0742 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0099 | 0.0332 | 0.646 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0345 | 0.1924 | 0.1847 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 0.6018 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0552 | 0.0462 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.1007 | 0.6223 | 0.6018 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0387 | 0.2197 | 0.353 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0881 | 0.5407 | 0.5158 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0206 | 0.1022 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | DNA-binding protein | 0.0127 | 0.0514 | 0.0423 |
Entamoeba histolytica | aminopeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | hypothetical protein | 0.0236 | 0.1218 | 0.1218 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0127 | 0.0514 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | initiation factor 2-associated protein. | 0.0127 | 0.0514 | 0.0513 |
Onchocerca volvulus | 0.0127 | 0.0514 | 0.3687 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.1218 | 0.0742 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0206 | 0.1022 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3403 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0206 | 0.1022 | 0.1022 |
Toxoplasma gondii | hypothetical protein | 0.0582 | 0.3465 | 0.3111 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Trypanosoma brucei | Facilitates chromatin transcription complex subunit spt16 | 0.0127 | 0.0514 | 0.0384 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | aminopeptidase P1, putative | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Onchocerca volvulus | FACT complex subunit SPT16 homolog | 0.0127 | 0.0514 | 0.3687 |
Trypanosoma brucei | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0384 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1589 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0158 | 0.0064 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.1233 | 0.1261 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3376 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0133 | 0.0552 | 0.0552 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Chlamydia trachomatis | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | Pax transcription factor protein 2 | 0.0263 | 0.1393 | 0.1393 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Onchocerca volvulus | 0.0263 | 0.1393 | 1 | |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0069 | 0.0134 | 0.0134 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1589 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0164 | 0.0749 | 0.6931 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0263 | 0.1393 | 0.131 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Trypanosoma brucei | Xaa-Pro aminopeptidase, putative | 0.0127 | 0.0514 | 0.0384 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0133 | 0.0552 | 0.0041 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1218 | 0.1134 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0881 | 0.5407 | 0.5158 |
Leishmania major | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3111 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0069 | 0.0134 | 0.0216 |
Entamoeba histolytica | peptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0091 | 0.028 | 0.1637 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0181 | 0.0863 | 0.0863 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0199 | 0.0982 | 0.9555 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0206 | 0.1022 | 0.0936 |
Plasmodium vivax | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3111 |
Treponema pallidum | methionine aminopeptidase (map) | 0.1007 | 0.6223 | 1 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0127 | 0.0514 | 0.0513 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0127 | 0.0514 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3 nM | Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand. | ChEMBL. | 1322987 |
Ki (binding) | = 2200 nM | Binding affinity of the compound against PCP receptor | ChEMBL. | 1322987 |
Ki (binding) | = 3698 nM | Binding affinity of the compound against sigma opioid receptor using [3H]-(+)-3-PPP as radioligand. | ChEMBL. | 1322987 |
Ratio (binding) | = 0.596 | Ratio of binding affinities of pcp receptor(ki(nM)) to sigma opioid receptor(ki(nM)) | ChEMBL. | 1322987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.