Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3331 | 0.3314 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.075 | 0.0726 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2501 | 0.1893 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2225 | 0.1595 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.075 | 0.0916 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.075 | 0.0726 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2501 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.2501 | 0.2482 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2225 | 0.1595 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3331 | 0.4632 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3331 | 0.3314 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.01 | 0.0139 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.2501 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3331 | 0.4557 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.2501 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.075 | 0.1042 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.075 | 0.1042 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.2501 | 0.2482 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0724 | 0.1007 |
Echinococcus multilocularis | musashi | 0.0027 | 0.075 | 0.0726 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3331 | 0.4557 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2501 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2225 | 0.2205 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2225 | 0.2205 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2225 | 0.2997 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3331 | 0.2791 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3331 | 0.2791 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3331 | 0.2791 |
Brugia malayi | hypothetical protein | 0.0151 | 0.7192 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.7192 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2225 | 0.2205 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.075 | 0.0726 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Onchocerca volvulus | 0.0151 | 0.7192 | 1 | |
Echinococcus multilocularis | lamin | 0.0027 | 0.075 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0026 | 0.0036 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2501 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2225 | 0.2205 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2501 | 0.1893 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3331 | 0.4632 |
Echinococcus granulosus | lamin | 0.0027 | 0.075 | 0.0726 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2225 | 0.1595 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.075 | 0.0916 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3331 | 0.2791 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.075 | 0.1042 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3331 | 0.4557 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2225 | 0.3094 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3331 | 0.2791 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.2501 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3331 | 0.4632 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0046 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.