Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldo-keto reductase-like protein | 0.0062 | 0.9825 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0062 | 0.9825 | 0.9825 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.9825 | 0.9825 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.9825 | 0.9825 |
Schistosoma mansoni | jumonji domain containing protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0044 | 0.5819 | 0.5819 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0063 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 0.9825 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.9825 | 0.9825 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1997 | 0.2032 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1997 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.9825 | 0.9825 |
Leishmania major | prostaglandin f synthase, putative | 0.0062 | 0.9825 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 0.9825 | 0.9825 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 0.9825 | 0.9825 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.1997 | 0.2032 |
Onchocerca volvulus | 0.0062 | 0.9825 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Onchocerca volvulus | 0.0062 | 0.9825 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.1997 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0062 | 0.9825 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1997 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 0.9825 | 1 |
Onchocerca volvulus | 0.0062 | 0.9825 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.9825 | 0.9825 |
Brugia malayi | hypothetical protein | 0.0027 | 0.1997 | 0.1997 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 0.9825 | 1 |
Onchocerca volvulus | 0.0062 | 0.9825 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1997 | 0.1997 |
Mycobacterium ulcerans | oxidoreductase | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.9825 | 0.9825 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1997 | 0.2032 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.9825 | 0.9825 |
Echinococcus multilocularis | aldehyde reductase | 0.0044 | 0.5819 | 0.5819 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.1997 | 0.2032 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.9825 | 0.9825 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0062 | 0.9825 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0062 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.9825 | 0.9825 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 0.9825 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 0.9825 | 0.9825 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0062 | 0.9825 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.9825 | 0.9825 |
Trypanosoma cruzi | aldo-keto reductase | 0.0062 | 0.9825 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0062 | 0.9825 | 0.9825 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.1997 | 0.2032 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0062 | 0.9825 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0044 | 0.5819 | 0.5922 |
Schistosoma mansoni | pol-related | 0.0062 | 0.9825 | 0.9825 |
Onchocerca volvulus | 0.0062 | 0.9825 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.9825 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0062 | 0.9825 | 1 |
Giardia lamblia | Aldose reductase | 0.0062 | 0.9825 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.9825 | 0.9825 |
Trypanosoma brucei | prostaglandin f synthase | 0.0062 | 0.9825 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 0.9825 | 1 |
Giardia lamblia | Aldose reductase | 0.0062 | 0.9825 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 0.9825 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.9825 | 0.9825 |
Onchocerca volvulus | 0.0062 | 0.9825 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 8 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.