Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0062 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0709 | 0.0709 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0062 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 1 | 0.5 | |
Echinococcus granulosus | hypothetical protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0709 | 0.0709 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0062 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 1 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0062 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0062 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0709 | 0.0709 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 1 | 0.5 |
Onchocerca volvulus | 0.0062 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0062 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0709 | 0.0709 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 1 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0062 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Onchocerca volvulus | 0.0062 | 1 | 0.5 | |
Trypanosoma cruzi | aldo-keto reductase | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24.5 uM | Inhibition of WNV NS2B-NS3 protease | ChEMBL. | 19572550 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.