Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.6268 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.6268 | 0.6268 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.611 | 0.611 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0644 | 0.0644 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.6268 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.3172 | 0.3172 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.086 | 0.086 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.1828 | 0.1828 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3172 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.7467 | 0.7467 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.5321 | 0.5321 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.1171 | 0.1171 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3172 | 0.3172 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0.0644 | 0.0644 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 1 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0936 | 0.0936 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.1536 | 0.1536 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.086 | 0.086 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3184 | 0.3184 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.086 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3484 | 0.3484 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.6268 | 0.6268 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3172 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.1171 | 0.1171 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.3172 | 0.3172 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.1301 | 0.1301 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.6205 | 0.6205 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.1301 | 0.1301 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.6205 | 0.6205 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.086 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4011 | 0.4011 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.086 | 0.086 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.1171 | 0.1171 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.6268 | 0.6268 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.3172 | 0.3172 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.086 | 0.086 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.6205 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.3172 | 0.3172 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.6268 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0644 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3476 | 0.3476 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.6551 | 0.6551 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.1536 | 0.1536 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.086 | 0.086 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.086 | 0.086 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.611 | 0.611 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3172 | 0.5 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.086 | 0.086 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.7994 | 0.7994 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3776 | 0.3776 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.6205 | 0.6205 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.6268 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.0644 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0644 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.6205 | 0.9889 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.6268 | 0.6268 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.1536 | 0.1536 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3172 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.6205 | 0.6205 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3184 | 0.3184 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.