Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0157 | 0.0825 | 0.0825 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0199 | 0.1142 | 0.3142 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.0011 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0199 | 0.1142 | 0.8524 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0312 | 0.2004 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0074 | 0.0191 | 0.0191 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.0752 | 0.3643 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.2004 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0199 | 0.1142 | 0.8524 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.3547 | 0.9758 |
Schistosoma mansoni | lipoxygenase | 0.0225 | 0.134 | 0.134 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.0879 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0526 | 0.3635 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0225 | 0.134 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0312 | 0.2004 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0526 | 0.3635 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0539 | 0.3734 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0074 | 0.0191 | 0.0527 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0074 | 0.0191 | 0.0527 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.2004 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0247 | 0.1513 | 0.1513 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.0879 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0199 | 0.1142 | 0.3142 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0199 | 0.1142 | 0.1142 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0225 | 0.134 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | In vitro inhibition of estrogen-induced proliferation of cultured T-47D human breast cancer cells, at a concentration of 0.1 microM | ChEMBL. | 10522700 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.