Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0577 | 1 | 1 |
Onchocerca volvulus | 0.0097 | 0.0721 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0097 | 0.0721 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0097 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | carboxylesterase | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0097 | 0.0721 | 0.0721 |
Brugia malayi | Carboxylesterase family protein | 0.0097 | 0.0721 | 0.0721 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0097 | 0.0721 | 0.5 |
Onchocerca volvulus | 0.0097 | 0.0721 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0097 | 0.0721 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Brugia malayi | Carboxylesterase family protein | 0.0097 | 0.0721 | 0.0721 |
Brugia malayi | Carboxylesterase family protein | 0.0097 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Brugia malayi | Carboxylesterase family protein | 0.0577 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0097 | 0.0721 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0097 | 0.0721 | 0.5 |
Onchocerca volvulus | 0.0097 | 0.0721 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0577 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0097 | 0.0721 | 0.5 |
Onchocerca volvulus | 0.0097 | 0.0721 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Echinococcus multilocularis | acetylcholinesterase | 0.0577 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Echinococcus granulosus | acetylcholinesterase | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0097 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0721 | 0.0721 |
Onchocerca volvulus | 0.0097 | 0.0721 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.