Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Echinococcus granulosus | acetylcholinesterase | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0285 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Onchocerca volvulus | 0.0048 | 0.0696 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.0696 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0285 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0696 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0285 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0696 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0696 | 0.0696 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0285 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0696 | 0.0696 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0696 | 0.0696 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0696 | 0.0696 |
Brugia malayi | Carboxylesterase family protein | 0.0285 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0048 | 0.0696 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0696 | 0.0696 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Onchocerca volvulus | 0.0048 | 0.0696 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0048 | 0.0696 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0696 | 0.0696 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0048 | 0.0696 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0285 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0285 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.0696 | 0.5 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0696 | 0.0696 |
Onchocerca volvulus | 0.0048 | 0.0696 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0048 | 0.0696 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.